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Articles 75511 - 75540 of 75617
Full-Text Articles in Entire DC Network
Impact Of Ict Skills Upon Legal Professionals Of Lahore High Court Bar Association And Their Practice, Muhammad Jameel, Khurram Shahzad, Muhammad Tariq Dr., Muhammad Shahzad Chaudhry Dr.
Impact Of Ict Skills Upon Legal Professionals Of Lahore High Court Bar Association And Their Practice, Muhammad Jameel, Khurram Shahzad, Muhammad Tariq Dr., Muhammad Shahzad Chaudhry Dr.
Library Philosophy and Practice (e-journal)
Abstract:
Objective:
Objective of this research was to investigate the impact of ICT skills upon Legal Professionals of Lahore High Court Bar Association and their Practice.
Methodology:
In view of the suitability and usability as well as the previous studies conducted in the field, the survey research method was adopted for this study. The population of was Advocates of Lahore High Court, Pakistan. Simple random sampling technique was adopted to conduct this study. The survey questionnaire was adapted as a data collection tool for this study. After collection of data, a numerical analysis using SPSS was performed to present the …
Bibliometric Review On Inertial Sensors Based Position Estimation Using Sensor Fusion, Animesh Mishra, Hamshita Kancharlapalli, Ankit Kumar, Aditya Chauhan, Parag Narkhede
Bibliometric Review On Inertial Sensors Based Position Estimation Using Sensor Fusion, Animesh Mishra, Hamshita Kancharlapalli, Ankit Kumar, Aditya Chauhan, Parag Narkhede
Library Philosophy and Practice (e-journal)
Background: This paper analyzes the position estimation of UAV in a 3D environment, on the basis of inertial sensors and sensor fusion algorithm, done from the year 1994 to 2020. This paper contains various bibliometric analyses previously done on this topic.
Methods: The content for this topic was taken from the popular Scopus database. The Scopus provides many filters for searching databases with different document categories like document by year, country, etc. The research carried in this paper also includes co-authorship, citation analysis, etc.
Results: A total of 345 articles were obtained from the last 20 years, on the topic …
Remote Access Mechanism Exploring Electronic Databases In Law Schools In India: A Lifeline During Covid-19 Lockdown, Akash Singh
Remote Access Mechanism Exploring Electronic Databases In Law Schools In India: A Lifeline During Covid-19 Lockdown, Akash Singh
Library Philosophy and Practice (e-journal)
Bar Council of India under Section 4 of Advocates Act 1961 passed by Indian Parliament, governs legal education and practice in India. Law Schools are approved and governed under the rules framed by Bar Council of India. Currently, India has twenty three law schools apart from more than 2000 law departments and colleges in India. Lockdown of academic institutions due to COVID 19 interrupted educational and research activities in law schools too. The paper here and now showcases a comparative study of usage of electronic contents by their patrons during pre-lockdown and lockdown period by remote access mechanism. The paper …
Toward A Ubiquitous Learning Media: Encouraging Understanding By Virtual Reality-Based Learning, Idris Idris, Agus Purnomo, Bayu Kurniawan
Toward A Ubiquitous Learning Media: Encouraging Understanding By Virtual Reality-Based Learning, Idris Idris, Agus Purnomo, Bayu Kurniawan
Library Philosophy and Practice (e-journal)
The use of mainstream media is no longer attractive to students. They enjoy more and are more enthusiastic about virtual learning which provides the greatest possible opportunity for direct contact or as if to experience directly the object of the material being studied. This study aimed to develop an Android-based application with virtual reality (VR) in the material kingdom and Hindu-Buddhist heritage (SijarVi-information system of virtual reality-based learning). This product was intended to provide anti-mainstream learning media, which provides opportunities for students to be directly involved and see directly the object being studied. This development used research and development method …
Information And Communication Technology Projects And Management Information System In Nigerian Universities: A Design Reality Approach, Odomero E. Omohwovo, Wole M. Olatokun, Ifedapo R. Ojutawo, Josephine O. Okocha
Information And Communication Technology Projects And Management Information System In Nigerian Universities: A Design Reality Approach, Odomero E. Omohwovo, Wole M. Olatokun, Ifedapo R. Ojutawo, Josephine O. Okocha
Library Philosophy and Practice (e-journal)
This paper focuses on a design-reality gap assessment of selected information communication technology (ICT) projects in federal universities, South West of Nigeria. We determine the success and failure rates of the selected ICT projects based on the design-reality gap model dimensions: information, technology, processes, objectives and values, staffing and skills, management systems and structures, and so on. Thus, we adopt survey research design, including qualitative and quantitative methods of data collection in this paper. Moreover, we use purposive sampling technique in selecting the sample data. Five (5) heads of unit of the selected ICT projects responded to the questionnaire based …
Bibliometric Review On Applications Of Disease Detection Using Digital Image Processing Techniques, Jayant Jagtap, Rahil Sharma, Aryan Sinha, Nikhil Panda, Amulya Reddy
Bibliometric Review On Applications Of Disease Detection Using Digital Image Processing Techniques, Jayant Jagtap, Rahil Sharma, Aryan Sinha, Nikhil Panda, Amulya Reddy
Library Philosophy and Practice (e-journal)
Advances around the field of deep learning and cognitive computing have allowed mankind to look and solve the problems of the world in a completely new way. Deep learning has been making huge advancements in the field of healthcare, which most importantly focuses upon disease detection and disease prediction. Techniques such as these have been conceptualized the idea of early detection and economical ways of treating the predicted disease in particular. Still, it has been observed that there seems to be no change in the way diagnosis of a particular disease takes place even in the 21st generation of …
A Comparative Study Of India And Australia Open Access Repositories In Opendoar, Alekha Karadia, Dr. Jyotshna Sahoo
A Comparative Study Of India And Australia Open Access Repositories In Opendoar, Alekha Karadia, Dr. Jyotshna Sahoo
Library Philosophy and Practice (e-journal)
An open access repository or open archive is a digital platform that holds research output and provides free, immediate, and permanent access to research results for anyone to use, download and distribute. To facilitate open access such repositories must be interoperable according to the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH). Search engines harvest the content of open access repositories, constructing a database of worldwide, free of charge available research. OpenDOAR is the quality-assured, global Directory of Open Access Repositories. Its repositories provide free, open access to academic outputs and resources. This paper deals with Comparative analysis of India …
Bibliometric Review On Liver And Tumour Segmentation Using Deep Learning, Jayant Jagtap, Aamir Habeeb, Avinash Jha, Shrey Aggarwal, Khushi Gupta
Bibliometric Review On Liver And Tumour Segmentation Using Deep Learning, Jayant Jagtap, Aamir Habeeb, Avinash Jha, Shrey Aggarwal, Khushi Gupta
Library Philosophy and Practice (e-journal)
One of the major organs in the body is liver where tumors occur often. Malignant liver tumors pose a serious hazard to human life and health. Manual segmentation of the liver organ and tumor from computed tomography (CT) scans is difficult, time-consuming, and skewed to the clinician's experience, yet it is essential for hepatic surgical planning. However, due to the following considerations, segmenting liver tumors from computed tomography (CT) images is difficult: In CT pictures, the contrast between the liver tumor and healthy tissues is low, and the boundary is indistinct; the picture of the liver tumor is confusing, with …
Social Media Usage In The Academic Libraries: Current Trends And Challenges In Pakistan With Special Reference To Facebook, Shahzadi Humbhi, Shabbir Tareen, Alia Humbhi
Social Media Usage In The Academic Libraries: Current Trends And Challenges In Pakistan With Special Reference To Facebook, Shahzadi Humbhi, Shabbir Tareen, Alia Humbhi
Library Philosophy and Practice (e-journal)
The current study aims to investigate the usage of social networking sites (SNS) for promoting library resources and services in academic libraries as well as assessing the perception of library professionals regarding SNS (Facebook) and also identifying the challenges that prevent library professionals from promoting the resources and services of libraries through SNS. For this study primary data collected from 167 library professionals of the academic libraries. A structured questionnaire was used and a systematic sampling technique was adopted for data collection purposes. The results show that still the usage of social media is limited in the academic libraries of …
The Case Of Cited And Uncited Publications In The Field Of Reference Services: A Study, Sadaf Zia, Muzamil Mushtaq
The Case Of Cited And Uncited Publications In The Field Of Reference Services: A Study, Sadaf Zia, Muzamil Mushtaq
Library Philosophy and Practice (e-journal)
The endeavor of the present study is to identify and compare the characteristics of cited and uncited publications in the field of reference services. The phrase ‘reference service’ was searched in the document search tab of Scopus database and found 2612 results, which were limited to social science subject area and hence got 2021 results. The retrieved data was then restricted to journal source type and found 1900 results out of 2021. At last, the data was confined to library and information science journals in source titles and retrieved the actual data for the study i.e., 1861 number of articles. …
Satisfaction Of Visually Impaired Students With Resources And Services At Gc University Lahore, Pakistan, Abid Iqbal Iqbal, Khurram Shahzad, Samreen Lateef, Nazia Azeem
Satisfaction Of Visually Impaired Students With Resources And Services At Gc University Lahore, Pakistan, Abid Iqbal Iqbal, Khurram Shahzad, Samreen Lateef, Nazia Azeem
Library Philosophy and Practice (e-journal)
Purpose: This research's main goal was to know the resources and services being offered to the visually impaired students at GC University Lahore and their level of satisfaction with the facilities they are being provided.
Design/methodology/approach: Quantitative study design was opted to get the purpose of this research. Convenience Sampling technique was applied to get required results. 50 visually impaired students were chosen as a sample from the population of almost 300 special students who were currently enrolled in different disciplines at GC University Lahore. Required data was collected after having used close-ended interview technique because majority of the target …
E-Learning Enhancement, Status And Attitude Of Learners Towards Teaching Learning During Covid-19 Pandemic, Shweta Gupta, Shri Ram Pandey, Sujata Gupta
E-Learning Enhancement, Status And Attitude Of Learners Towards Teaching Learning During Covid-19 Pandemic, Shweta Gupta, Shri Ram Pandey, Sujata Gupta
Library Philosophy and Practice (e-journal)
The study explored the several dimensions of eLearning used by Indian Higher Institutions and presented insight into current eLearning pedagogy, infrastructures, services, and perceptions during the Covid-19 Pandemic. The study's findings reveal that Indian Academic institutions are unwilling to shift to the online mode for teaching, learning thoroughly. Pandemic forced them to adopt the e-learning pedagogy and tools. A majority of users still prefer the traditional classroom environment as compared to eLearning. Email, social media, and other communications tools became vital today. Email, traditionally used as a communication tool, is now a key player in delivering educational content. Social media …
Digital Library Usage During The Covid-19 Pandemic, Amy Pascalia Abra Asimah Mrs., Oliver Edward Dzogbede Dr., Selorm Akaba Dr.
Digital Library Usage During The Covid-19 Pandemic, Amy Pascalia Abra Asimah Mrs., Oliver Edward Dzogbede Dr., Selorm Akaba Dr.
Library Philosophy and Practice (e-journal)
Purpose: The purpose of the study is to analyse the effectiveness of digital library usage, the hindrances faced, and the satisfaction derived by students during the period of COVID-19 when all universities were closed down in Ghana.
Study design/methodology/approach: The researchers employed the survey method to collect data for analysis. Data collection was made with the use of semi-structured questionnaire displayed online for many respondents to access and respond. Based on the design employed, this study can be classified as quantitative. A total of 500 university students from the categories of undergraduate, masters, doctorate and others participated in …
Web Accessibility Of Indian University Library Website: An Evaluation With Wave Website Evaluation Tool, Anita Sharma, Ranjeet Kumar Choudhary Prof.
Web Accessibility Of Indian University Library Website: An Evaluation With Wave Website Evaluation Tool, Anita Sharma, Ranjeet Kumar Choudhary Prof.
Library Philosophy and Practice (e-journal)
The advent of new teaching-learning methods has brought a great demand for accessible educational websites. There is much research on the accessibility of the website on educational websites in recent years from different countries. A website serves as a communication channel for publishing information and services in higher education. It is expected that higher education institutions must provide access to their information resources and services to all its user in an equal manner irrespective of their physical disability. Hence, it should be mandatory for higher education institutions to include web accessibility as an important part of their websites. Libraries are …
Perception, Utilization And Purposes Of Using Cyberspace Information Resources And Services By Postgraduate Students, Faith O. Mesagan, Justina Ekere, Charles O. Omekwu, Mkpoikanke S. Otu, Chiedu Eseadi
Perception, Utilization And Purposes Of Using Cyberspace Information Resources And Services By Postgraduate Students, Faith O. Mesagan, Justina Ekere, Charles O. Omekwu, Mkpoikanke S. Otu, Chiedu Eseadi
Library Philosophy and Practice (e-journal)
This study was carried out to investigate postgraduate students’ perception, utilization and purposes of using cyberspace information resources and services in five federal universities in southwest Nigeria. The descriptive research design was adopted for this study. The purposive sampling technique was used to select a sample size of 1058 postgraduate students from five federal universities. Instrument for data collection include a well-structured questionnaire. The study witnessed a 95% return rate of the distributed questionnaire. The study used mean score () and Standard Deviation (SD) for data analysis. Results revealed that postgraduate students use cyberspace information resources and services for research …
Content Analysis Of Selected Iisers Library Websites In India: An Analytical Study, Sushanta Kumar Roy, Dr. Sukumar Mandal
Content Analysis Of Selected Iisers Library Websites In India: An Analytical Study, Sushanta Kumar Roy, Dr. Sukumar Mandal
Library Philosophy and Practice (e-journal)
The study analyzed the content of selected IISERs library websites data collected through the online survey of selected IISERs library websites with 57 checklists under general information, library website features, information on library resources, library services, web 2.0 features, web browser compatibility. The study presents IISER Mohali got the first rank with 48 points and IISER Bhopal and Pune on the second position with 46 points and IISER Kolkata got 37 points on third position IISER Thiruvananthapuram on the fourth position with 30 points.
Scholarly Research Trends Of State Universities Of Gujarat: A Bibliometric Study, Dr.Meghna Vyas, Dr Mayank J. Trivedi
Scholarly Research Trends Of State Universities Of Gujarat: A Bibliometric Study, Dr.Meghna Vyas, Dr Mayank J. Trivedi
Library Philosophy and Practice (e-journal)
The paper is describing bibliometric analysis of research publications of six state government universities of Gujarat during the year 2015-2019 indexed in SCOPUS database. The study exploring the various aspects of bibliometric analysis i.e. Number of publications and citation of the universities, the most productive author, the most productive publication source, the most preferred type of publication, the highest cited paper, and authorship pattern of 3825 bibliographic records. Analysis of the study is helpful to understand research output of the universities and which university has to do more effort to promote research activities and need to focus more on research …
Use Of Social Media In Collaborative Learning Among The Post Graduate Students Of Selected Universities In India, Abdul Baquee, Abuzar Hossain, R Sevukan
Use Of Social Media In Collaborative Learning Among The Post Graduate Students Of Selected Universities In India, Abdul Baquee, Abuzar Hossain, R Sevukan
Library Philosophy and Practice (e-journal)
Purpose – The very purpose of this research work is to explore the use of Social Media (SM) in collaborating learning among the postgraduate students of three central universities in India; University of Hyderabad (UoH), English and Foreign Language University (EFLU) and Pondicherry University (PU).
Design/Methodology - A descriptive random survey method is adhered to this study with a framed questionnaire to collect data from the postgraduate students of these three universities. A total of three hundred questionnaires (100 per university) are distributed individually out of it, two hundred and fifteen (71.66 %) questionnaires are retrieved back from the respondents. …
Leveraging Elasticity To Uncover The Role Of Rabinowitsch Suspension Through A Wavelike Conduit: Consolidated Blood Suspension Application, Sara I. Abdelsalam, A. Z. Zaher
Leveraging Elasticity To Uncover The Role Of Rabinowitsch Suspension Through A Wavelike Conduit: Consolidated Blood Suspension Application, Sara I. Abdelsalam, A. Z. Zaher
Basic Science Engineering
The present work presents a mathematical investigation of a Rabinowitsch suspension fluid through elastic walls with heat transfer under the effect of electroosmotic forces (EOFs). The governing equations contain empirical stress-strain equations of the Rabinowitsch fluid model and equations of fluid motion along with heat transfer. It is of interest in this work to study the effects of EOFs, which are rigid spherical particles that are suspended in the Rabinowitsch fluid, the Grashof parameter, heat source, and elasticity on the shear stress of the Rabinowitsch fluid model and flow quantities. The solutions are achieved by taking long wavelength approximation with …
Design Out Waste Framework For Achieving Sustainability In Public Housing Projects In Egypt, Ayman Ahmed Ezzat Othman, Laila Elsawaf
Design Out Waste Framework For Achieving Sustainability In Public Housing Projects In Egypt, Ayman Ahmed Ezzat Othman, Laila Elsawaf
Architectural Engineering
Due to the increasing population worldwide, Public housing projects (PHPs) have witnessed a rapid increase during the previous decades. Simultaneously, this generated a substantial amount of waste that represents roughly 40% of the solid waste produced by the construction industry every year. Being one of the significant phases of the construction process, the choices made during the design process play a crucial role towards increasing the solid waste created during the construction phase, which eventually affected the sustainability of the developed projects. This called for considering innovative strategies that reduce construction waste during the design process. This paper aims to …
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Turkish Journal of Biology
Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time. We utilised two independent RNA-seq datasets obtained from primary HCC tumours with matched normal tissues of 20 and 17 HCC patients, respectively. We quantified repeat …
Investigation Of The Efficacy Of Paclitaxel On Some Mirnas Profiles In Breast Cancer Stem Cells, Eli̇f Ertürk, Ferda Ari, Oğuzhan Akgün, Engi̇n Ulukaya, Cem İsmai̇l Küçükali̇, Şaki̇r Ümi̇t Zeybek
Investigation Of The Efficacy Of Paclitaxel On Some Mirnas Profiles In Breast Cancer Stem Cells, Eli̇f Ertürk, Ferda Ari, Oğuzhan Akgün, Engi̇n Ulukaya, Cem İsmai̇l Küçükali̇, Şaki̇r Ümi̇t Zeybek
Turkish Journal of Biology
Understanding of the functions of microRNAs in breast cancer and breast cancer stem cells have been a hope for the development of new molecular targeted therapies. Here, it is aimed to investigate the differences in the expression levels of let-7a, miR-10b, miR-21, miR-125b, miR-145, miR-155, miR-200c, miR-221, miR-222 and miR-335, which associated with gene and proteins in MCF-7 (parental) and MCF-7s (Mammosphere/stem cell-enriched population/CD44+/CD24-cells) cells treated with paclitaxel. MCF-7s were obtained from parental MCF-7 cells. Cytotoxic activity of paclitaxel was determined by ATP assay. Total RNA isolation and cDNA conversion were performed from the samples. Changes in expression levels of …
Characteristics And Clinical Significance Of Cd163+/Cd206+M2 Mono-Macrophage In The Bladder Cancer Microenvironment, Xiangjie Kong, Ming Zhu, Zhirong Wang, Zhuoqun Xu, Jianfeng Shao
Characteristics And Clinical Significance Of Cd163+/Cd206+M2 Mono-Macrophage In The Bladder Cancer Microenvironment, Xiangjie Kong, Ming Zhu, Zhirong Wang, Zhuoqun Xu, Jianfeng Shao
Turkish Journal of Biology
The tumor microenvironment may recruit monocytes, with a protumoral macrophage phenotype (M2) that plays an important role in solid tumor progression and metastasis. Therefore, it is necessary to understand the characteristics of these cells for cancer prevention and treatment. Bladder cancer tissue samples and paracarcinoma tissues samples were collected, and the expression of CD163+ cells in tumor tissues was observed. Then, we observed the expression of infiltrating CD45+CD14+CD163+ cell subset and analyzed the molecular expressions related to immunity and angiogenesis. C57/BL6 mice were inoculated subcutaneously, and dynamic changes of CD11b+F4/80+CD206+ mononuclear macrophages expression for tumor-bearing mice were detected. The results …
Screening Of The Small Molecule Library Of Meinox Enables The Identification Of Anticancer Compounds In Pathologically Distinct Cancers, Aynura Mammadova, Ari̇f Mermer, Fati̇h Kocabaş
Screening Of The Small Molecule Library Of Meinox Enables The Identification Of Anticancer Compounds In Pathologically Distinct Cancers, Aynura Mammadova, Ari̇f Mermer, Fati̇h Kocabaş
Turkish Journal of Biology
Small molecules are widely used for the modulation of the molecular basis of diseases. This makes them the perfect tool for discovering and developing new therapeutics. In this work, we have established a library of small molecules in house and characterized its molecular and druglike properties. We have shown that most small molecules have molecular weights less than 450. They have pharmaceutically relevant cLogP, cLogS, and druglikeness value distributions. In addition, Meinox's small molecule library contained small molecules with polar surface areas that are less than 60 square angstroms, suggesting their potent ability to cross the blood-brain barrier. Meinox's small …
Investigation Of Neuro-Inflammatory Parameters In A Cuprizone Induced Mouse Model Of Multiple Sclerosis, Ti̇muçi̇n Avşar, Gökçe Erdem, Gökhan Terzi̇oğlu, Eda Tahi̇r Turanli
Investigation Of Neuro-Inflammatory Parameters In A Cuprizone Induced Mouse Model Of Multiple Sclerosis, Ti̇muçi̇n Avşar, Gökçe Erdem, Gökhan Terzi̇oğlu, Eda Tahi̇r Turanli
Turkish Journal of Biology
Cuprizone, copper chelator, treatment of mouse is a toxic model of multiple sclerosis (MS) in which oligodendrocyte death, demyelination and remyelination can be observed. Understanding T and B cell subset as well as their cytokines involved in MS pathogenesis still requires further scrutiny to better understand immune component of MS. The study presented here, aimed to evaluate relevant cytokines, lymphocytes, and gene expressions profiles during demyelination and remyelination in the cuprizone mouse model of MS. Eighty male C57BL/6J mice fed with 0.2% cuprizone for eight weeks. Cuprizone has been removed from the diet in the following eight weeks. Cuprizone treated …
Phylostat: A Web-Based Tool To Analyze Paralogous Clade Divergencein Phylogenetic Trees, Eli̇f Özçeli̇k, Nurdan Kuru, Ogün Adebali̇
Phylostat: A Web-Based Tool To Analyze Paralogous Clade Divergencein Phylogenetic Trees, Eli̇f Özçeli̇k, Nurdan Kuru, Ogün Adebali̇
Turkish Journal of Biology
Phylogenetic trees are useful tools to infer evolutionary relationships between genetic entities. Phylogenetics enables not only evolution-based gene clustering but also the assignment of gene duplication and deletion events to the nodes when coupled with statistical approaches such as bootstrapping. However, extensive gene duplication and deletion events bring along a challenge in interpreting phylogenetic trees and require manual inference. In particular, there has been no robust method of determining whether one of the paralog clades systematically shows higher divergence following the gene duplication event as a sign of functional divergence. Here, we provide Phylostat, a graphical user interface that enables …
Classification Of Bladder Cancer Cell Lines According To Regulon Activity, Aleyna Eray, Serap Erkek Özhan
Classification Of Bladder Cancer Cell Lines According To Regulon Activity, Aleyna Eray, Serap Erkek Özhan
Turkish Journal of Biology
Bladder cancer is one of the most frequent cancers and causes more than 150.000 deaths each year. During the last decade, several studies provided important aspects about genomic characterization, consensus subgroup definition, and transcriptional regulation of bladder cancer. Still, much more research needs to be done to characterize molecular signatures of this cancer in depth. At this point, the use of bladder cancer cell lines is quite useful for the identification and test of new signatures. In this study, we classified the bladder cancer cell lines according to the activities of regulons implicated in the regulation of primary bladder tumors. …
Identifying Specific Matrix Metalloproteinase-2-Inhibiting Peptides Through Phage Display-Based Subtractive Screening, Ayli̇n Özdemi̇r Bahadir, Bertan Koray Balcioğlu, Müge Serhatli, Şeyma Işik, Berri̇n Erdağ
Identifying Specific Matrix Metalloproteinase-2-Inhibiting Peptides Through Phage Display-Based Subtractive Screening, Ayli̇n Özdemi̇r Bahadir, Bertan Koray Balcioğlu, Müge Serhatli, Şeyma Işik, Berri̇n Erdağ
Turkish Journal of Biology
Gelatinases A and B, which are members of the matrix metalloproteinase (MMP) family, play essential roles in cancer development and metastasis, as they can break down basal membranes. Therefore, the determination and inhibition of gelatinases is essential for cancer treatment. Peptides that can specifically block each gelatinase may, therefore, be useful for cancer treatment. In this study, subtractive panning was carried out using a 12-mer peptide library to identify peptides that block gelatinase A activity (MMP-2), which is a key pharmacological target. Using this method, 17 unique peptide sequences were determined. MMP-2 inhibition by these peptides was evaluated through zymogram …
Fluid Shear Stress And Endothelial Cells Synergistically Promote Osteogenesis Of Mesenchymal Stem Cells Via Integrin Ss1-Fak-Erk1/2 Pathway, Mingli Jiang, Qihua Shen, Yi Zhou, Wenxia Ren, Miaomiao Chai, Yan Zhou, Wen-Song Tan
Fluid Shear Stress And Endothelial Cells Synergistically Promote Osteogenesis Of Mesenchymal Stem Cells Via Integrin Ss1-Fak-Erk1/2 Pathway, Mingli Jiang, Qihua Shen, Yi Zhou, Wenxia Ren, Miaomiao Chai, Yan Zhou, Wen-Song Tan
Turkish Journal of Biology
Prevascularization and mechanical stimulation have been reported as effective methods for the construction of functional bone tissue. However, their combined effects on osteogenic differentiation and its mechanism remain to be explored. Here, the effects of fluid shear stress (FSS) on osteogenic differentiation of rat bone-marrow-derived mesenchymal stem cells (BMSCs) when cocultured with human umbilical vein endothelial cells (HUVECs) were investigated, and underlying signaling mechanisms were further explored. FSS stimulation for 1-4 h/day increased alkaline phosphatase (ALP) activity and calcium deposition in coculture systems and promoted the proliferation of cocultured cells. FSS stimulation for 2 h/day was selected as the optimized …