Digital Commons Network^™

Impact Of Neutron Energy On Asteroid Deflection Performance, Lansing S. Horan Iv, Darren E. Holland, Megan Bruck Syal, James E. Bevins, Joseph W. Wasem

Faculty Publications

In the future, a hazardous asteroid will find itself on a collision course with Earth. For asteroids of moderate size or larger, a nuclear device is one of humanity's only technologies capable of mitigating this threat via deflection on a timescale of less than a decade. This work examined how the output neutron energy from a nuclear device standoff detonation affects the deflection of a notional asteroid that is 300 meters in diameter and composed of silicon dioxide at a bulk density of 1.855 g/cm³. 14.1 MeV and 1 MeV neutron energy sources were modeled in MCNP to …

Resilience For Multi-Filter All-Source Navigation Framework With Integrity, Jonathon S. Gipson, Robert C. Leishman

Faculty Publications

The Autonomous and Resilient Management of All-source Sensors (ARMAS) framework monitors residual-space test statistics across unique sensor-exclusion banks of filters, (known as subfilters) to provide a resilient, fault-resistant all-source navigation architecture with assurance. A critical assumption of this architecture, demonstrated in this paper, is fully overlapping state observability across all subfilters. All-source sensors, particularly those that only provide partial state information (altimeters, TDoA, AOB, etc.) do not intrinsically meet this requirement.
This paper presents a novel method to monitor real-time overlapping position state observability and introduces an "observability bank" within the ARMAS framework, known as Stable Observability Monitoring (SOM). SOM …

Local Bar Disaster Response: What You Need To Know To Develop A Successful Plan, Ryan V. Cox, Sarah M. Dingivan

Faculty Articles

No abstract provided.

Acceleration Of Boltzmann Collision Integral Calculation Using Machine Learning, Ian Holloway, Aihua W. Wood, Alexander Alekseenko

Faculty Publications

The Boltzmann equation is essential to the accurate modeling of rarefied gases. Unfortunately, traditional numerical solvers for this equation are too computationally expensive for many practical applications. With modern interest in hypersonic flight and plasma flows, to which the Boltzmann equation is relevant, there would be immediate value in an efficient simulation method. The collision integral component of the equation is the main contributor of the large complexity. A plethora of new mathematical and numerical approaches have been proposed in an effort to reduce the computational cost of solving the Boltzmann collision integral, yet it still remains prohibitively expensive for …

Modeling And Simulation Techniques Used In High Strain Rate Projectile Impact, Derek G. Spear, Anthony N. Palazotto, Ryan A. Kemnitz

Faculty Publications

A series of computational models and simulations were conducted for determining the dynamic responses of a solid metal projectile impacting a target under a prescribed high strain rate loading scenario in three-dimensional space. The focus of this study was placed on two different modeling techniques within finite element analysis available in the Abaqus software suite. The first analysis technique relied heavily on more traditional Lagrangian analysis methods utilizing a fixed mesh, while still taking advantage of the finite difference integration present under the explicit analysis approach. A symmetry reduced model using the Lagrangian coordinate system was also developed for comparison …

Boolean Network Control With Ideals, Ian H. Dinwoodie

Mathematics and Statistics Faculty Publications and Presentations

A method is given for finding controls to transition an initial state x0 to a target set in deterministic or stochastic Boolean network control models. The algorithms use multivariate polynomial algebra. Examples illustrate the application.

Simulations Of Single- And Two-Tone Tm-Doped Optical Fiber Laser Amplifiers, Tathagata Goswami, J. Grosek, Jay Gopalakrishnan

Mathematics and Statistics Faculty Publications and Presentations

This work uses numerical simulations of a thulium-doped optical fiber amplifier to predict various performance characteristics such as peak temperatures, expected output powers and efficiencies, presence of amplified spontaneous emission (ASE), and transverse mode instability (TMI) onset power thresholds. Single- and two-tone configurations are studied. In the latter case, the two laser sources are separated in frequency by the amount that corresponds to the peak Raman gain, and a few seed ratios at various total seed powers are examined. The goal is to provide the field with pertinent information on what is feasible for this type of amplifier.

Torsion And Curvature In Continuously Defective Solid Crystals, Marek Z. Elźanowski

Mathematics and Statistics Faculty Publications and Presentations

I show how one can utilize the concept of a canonical connection on a homogeneous space to describe defectiveness of a continuous elastic crystal solid.

An International Study Of Interobserver Variability Of “String Sign” Of Pancreatic Cysts Among Experienced Endosonographers, Seifeldin Hakim, Emmanuel Coronel, Graciela M Nogueras González, Philip S Ge, Suresh T Chari, Nirav Thosani, Srinivas Ramireddy, Ricardo Badillo, Tomas Davee, Marc F Catalano, Robert J Sealock, Sreeram Parupudi, Lyndon V Hernandez, Virendra Joshi, Atsushi Irisawa, Surinder Rana, Sundeep Lakhtakia, Peter Vilmann, Adrian Saftoiu, Siyu Sun, Marc Giovannini, Matthew H Katz, Michael P Kim, Manoop S Bhutani

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: No single optimal test reliably determines the pancreatic cyst subtype. Following EUS-FNA, the "string sign" test can differentiate mucinous from nonmucinous cysts. However, the interobserver variability of string sign results has not been studied.

METHODS: An experienced endosonographer performed EUS-FNA of pancreatic cysts on different patients and was recorded on video performing the string sign test for each. The videos were shared internationally with 14 experienced endosonographers, with a survey for each video: "Is the string sign positive?" and "If the string sign is positive, what is the length of the formed string?" Also asked "What is …

An International Study Of Interobserver Variability Of “String Sign” Of Pancreatic Cysts Among Experienced Endosonographers, Wanda Phipatanakul, David T Mauger, Theresa W Guilbert, Leonard B Bacharier, Sandy Durrani, Daniel J Jackson, Fernando D Martinez, Anne M Fitzpatrick, Amparito Cunningham, Susan Kunselman, Lisa M Wheatley, Cindy Bauer, Carla M Davis, Bob Geng, Kirsten M Kloepfer, Craig Lapin, Andrew H Liu, Jacqueline A Pongracic, Stephen J Teach, James Chmiel, Jonathan M Gaffin, Matthew Greenhawt, Meera R Gupta, Peggy S Lai, Robert F Lemanske, Wayne J Morgan, William J Sheehan, Jeffrey Stokes, Peter S Thorne, Hans C Oettgen, Elliot Israel

Faculty, Staff and Students Publications

Asthma remains one of the most important challenges to pediatric public health in the US. A large majority of children with persistent and chronic asthma demonstrate aeroallergen sensitization, which remains a pivotal risk factor associated with the development of persistent, progressive asthma throughout life. In individuals with a tendency toward Type 2 inflammation, sensitization and exposure to high concentrations of offending allergens is associated with increased risk for development of, and impairment from, asthma. The cascade of biological responses to allergens is primarily mediated through IgE antibodies and their production is further stimulated by IgE responses to antigen exposure. In …

Case Report: Dupilumab Successfully Controls Severe Eczema In A Child With Elevated Ige Levels And Recurrent Skin Infections, Tejas P Joshi, Sara Anvari, Meera R Gupta, Carla M Davis, Joud Hajjar

Faculty, Staff and Students Publications

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and …

Meta-Analysis Comparing Outcomes Of Catheter Ablation For Ventricular Arrhythmia In Ischemic Versus Nonischemic Cardiomyopathy, Indranill Basu-Ray, Dibbendhu Khanra, Sumit K Shah, Anindya Mukherjee, Sudhanva V Char, Bhavna Jain, T Jared Bunch, Michael Gold, Adedayo A Adeboye, Mohammad Saeed

Faculty, Staff and Students Publications

BACKGROUND: Catheter ablation is an effective treatment for ventricular arrhythmia (VA) in ischemic cardiomyopathy (ICM). However, results in non-ICM (NICM) patients are not satisfactory, and studies comparing differences between NICM and ICM are limited. We conducted a meta-analysis of procedural characteristics and long-term outcomes of catheter ablation for VA, comparing results between ICM and NICM.

METHODS: Studies in the PubMed, EMBASE, and Cochrane databases were systematically reviewed. Four studies reporting comparison of catheter ablation of VA between ICM and NICM were examined. The Newcastle-Ottawa Scale was used to appraise study quality. A random-effects model with inverse variance method was used …

Novel Mutations In The Gtpbp3 Gene For Mitochondrial Disease And Characteristics Of Related Phenotypic Spectrum: The First Three Cases From China, Hui-Ming Yan, Zhi-Mei Liu, Bei Cao, Victor Wei Zhang, Yi-Duo He, Zheng-Jun Jia, Hui Xi, Jing Liu, Fang Fang, Hua Wang

Faculty, Staff and Students Publications

Combined Oxidative Phosphorylation Deficiency 23 (COXPD23) caused by mutations in GTPBP3 gene is a rare mitochondrial disease, and this disorder identified from the Chinese population has not been described thus far. Here, we report a case series of three patients with COXPD23 caused by GTPBP3 mutations, from a severe to a mild phenotype. The main clinical features of these patients include lactic acidosis, myocardial damage, and neurologic symptoms. Whole genome sequencing and targeted panels of candidate human mitochondrial genome revealed that patient 1 was a compound heterozygote with novel mutations c.413C > T (p. A138V) and c.509_510del (p. E170Gfs∗42) in GTPBP3 …

Trace Element Concentrations In Blood And Scute Tissues From Wild And Captive Hawaiian Green Sea Turtles (Chelonia Mydas), Katherine R Shaw, Jennifer M Lynch, George H Balazs, T Todd Jones, Jeff Pawloski, Marc R Rice, Amanda D French, Jing Liu, George P Cobb, David M Klein

Faculty, Staff and Students Publications

Sea turtles are exposed to trace elements through water, sediment, and food. Exposure to these elements has been shown to decrease immune function, impair growth, and decrease reproductive output in wildlife. This study compares trace element concentrations in green turtles in captivity at Sea Life Park Hawaii (n = 6) to wild green turtles in Kapoho Bay, HI (n = 5 to 7). Blood and scute samples were collected and analyzed for eleven elements via inductively coupled plasma-mass spectrometry (ICP-MS). Selenium was significantly greater (p < 0.05) in the blood of captive turtles compared to wild turtles, while V, Ni, and Pb were significantly greater in the blood of wild turtles. In scute, V, Cu, Se, and Cr were significantly greater in captive turtles, while As was significantly greater in wild turtles. Pelleted food fed to the captive turtles and representative samples of the wild turtle diet were analyzed via ICP-MS to calculate trophic transfer factors and daily intake values. Wild turtles had greater estimated daily intake than captive turtles for all elements except Cu and Se. Because captive turtles are fed a diet very different from their wild counterparts, captive turtles do not represent control or reference samples for chemical exposure studies in wild turtles. No toxic thresholds are known for sea turtles, but rehabilitation and managed care facilities should monitor sea turtle elemental concentrations to ensure the animals’ health.

Distribution Of Calcium Volume, Density, Number, And Type Of Coronary Vessel With Calcified Plaque In South Asians In The Us And Other Race/Ethnic Groups: The Masala And Mesa Studies, Mahmoud Al Rifai, Alka M Kanaya, Namratha R Kandula, Miguel Cainzos-Achirica, Jaideep Patel, Matthew Budoff, Michael H Criqui, Michael J Blaha, Salim S Virani

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: South Asians (SA) experience disproportionately higher rates of atherosclerotic cardiovascular disease (ASCVD) events than non-Hispanic whites (NHW) and several other Asian groups. The coronary artery calcium (CAC) Agatston score may not capture the unique characteristics of coronary plaque in SA. We therefore evaluated the prevalence and patterns of advanced CAC measures (specific coronary vessel involvement, CAC volume and density) in SA versus other race/ethnicities.

METHODS: We combined data from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multi-Ethnic Study of Atherosclerosis (MESA) cohorts. We used multivariable-adjusted linear regression models to compare advanced CAC …

Kv13 Channel Up-Regulation In Peripheral Blood T Lymphocytes Of Patients With Multiple Sclerosis, Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P Sfikakis, Michael W Pennington, K George Chandy, Cornelia Poulopoulou

Faculty, Staff and Students Publications

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evidence links these channels to multiple sclerosis pathophysiology. Here we studied the electrophysiological properties and the transcriptional and translational expression of T lymphocyte Kv1.3 channels in multiple sclerosis, by combining patch clamp recordings, reverse transcription polymerase chain reaction and flow cytometry on freshly isolated peripheral blood T lymphocytes from two patient cohorts with multiple sclerosis, as well as from healthy …

Assessing An Academic Readiness Model In A Community College Occupational Program, Scott A. Hauert, Robert L. Moore, Quinton Nottingham

STEMPS Faculty Publications

This study assessed a localized academic readiness model that measures academic skills relevant to an occupational program and the institutional context. Enrollment in the program’s mandatory gateway course is contingent upon establishing academic readiness either: (1) possess an associate-level or higher degree; (2) achieve placement test scores that permit enrollment in college-level English composition/critical reading; or (3) complete developmental education prerequisites to permit enrollment in college-level English composition/critical reading. Using the gateway course performance for 112 students, the study explored whether any of the model’s criterions are significantly related to success in the gateway course and whether there is any …

Personal Goal Setting Behavior And Professional Outlooks Of Academic Library Employees, Leo Lo, Amelia Anderson

STEMPS Faculty Publications

Studies indicate correlations between personal goal-setting behaviors, performance and attitude in professional roles. An online study was developed and conducted in 2016 with academic library employees to better understand the goal-setting behavior of library employees in a particular context, via setting New Year’s resolutions, which is defined as "a decision to do something or to behave in a certain manner". Results show that nearly half (49.6 percent) of all respondents set New Year’s resolutions in 2016. Goals related to health and fitness topped the list of goals that were set, followed by occupational goals. Of those who felt unclear about …

Women Have A Lower Risk Of Nonalcoholic Fatty Liver Disease But A Higher Risk Of Progression Vs Men: A Systematic Review And Meta-Analysis, Maya Balakrishnan, Parth Patel, Sydney Dunn-Valadez, Cecilia Dao, Vinshi Khan, Hiba Ali, Laith El-Serag, Ruben Hernaez, Amy Sisson, Aaron P Thrift, Yan Liu, Hashem B El-Serag, Fasiha Kanwal

Library Staff Publications

BACKGROUND & AIMS: The risk of nonalcoholic fatty liver disease (NAFLD) and its progression may differ between men and women. We conducted a systematic review and meta-analysis to determine the relationship between sex and NAFLD, nonalcoholic steatohepatitis (NASH), and advanced NAFLD fibrosis.

METHODS: Studies reporting sex-stratified NAFLD prevalence among population-based samples and either NASH or advanced fibrosis among patients with biopsy-proven NAFLD were identified from MEDLINE, EMBASE, and Cochrane databases through December 2017. We calculated pooled relative risk ratios comparing women vs men for each outcome.

RESULTS: Our final analysis comprised 54 studies. Samples sizes were 62,239 for the NAFLD …

Developing A Post-Season Tissue Test For Rice Nitrogen Management, Kyle A. Hoegenauer, Trenton L. Roberts, Jarrod T. Hardke, Carrie C. Ortel, Nathan A. Slaton

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

No post-season analysis method currently exists for rice (Oryza sativa L.) to determine whether N was managed properly during the growing season. Our primary research objective was to determine whether post-season, rice stem N concentrations can be used to predict if sufficient or excessive N was available. Aboveground biomass samples were taken from N response trials at harvest. Stalks were separated into 5-cm segments starting at the soil surface and extending upward to 45 cm. One-half of the samples had all of the leaf material (leaves and leaf sheaths) removed, whereas the other half remained intact. All samples were analyzed …

Lawyers, Mistakes, And Moral Growth (Reviewing Mike H. Bassett, The Man In The Ditch: A Redemption Story For Today), Vincent R. Johnson

Faculty Articles

In the literature of legal ethics, relatively little is said about the psychic turmoil that lawyers face while anticipating or defending a grievance, malpractice claim, or criminal charge. Even less is said about how lawyers who are found guilty of violating professional standards should go about rebuilding their reputations and personal lives after such proceedings have run their course, often with embarrassing results having been made public. Against this bleak backdrop, a dazzlingly introspective and hopeful book about lawyers and their mistakes-and about their suffering and possible moral growth-has been published.

Model Rule 8.4(G) And The Profession's Core Values Problem, Michael Ariens

Faculty Articles

Model Rule 8.4(g) declares it misconduct for a lawyer to "engage in conduct that the lawyer knows or reasonably should know is harassment or discrimination on the basis of race, sex, religion, national origin, ethnicity, disability, age, sexual orientation, gender identity, marital status or socioeconomic status in conduct related to the practice of law." The American Bar Association (ABA) adopted the rule in 2016, in large part to effectuate the third of its four mission goals: Eliminate Bias and Enhance Diversity. The ABA adopted these goals in 2008, and they continue to serve as ABA's statement of its mission.

A …

Comparison Of Growth Performance And Meat Quality Traits Of Commercial Cross-Bred Pigs Versus The Large Black Pig Breed, Yongjie Wang, Keshari Thakali, Palika Morse, Sarah Shelby, Jinglong Chen, Jason Apple, Yan Huang

Animal Science Faculty Publications and Presentations

The meat quality of different pig breeds is associated with their different muscle tissue physiological processes, which involves a large variety of genes related with muscle fat and energy metabolism. Understanding the differences of biological processes of muscle after slaughter is helpful to reveal the meat quality development of different breeds. Therefore, eight native Large Black pigs (BP), with high fat content in meat, and seven cross-bred commercial pigs (CP), which had a high feed efficiency with high lean meat, were used to investigate the differences in their meat quality and RNA transcriptomes. The average daily gain (ADG) and hot …

Dietary Organic Acids Modulate Gut Microbiota And Improve Growth Performance Of Nursery Pigs, Xiaoyuan Wei, Kristopher A. Bottoms, Hans H. Stein, Laia Blavi, Casey L. Bradley, Jon Bergstrom, Joshua Knapp, Robert Story, Charles Maxwell, Tsungcheng Tsai, Jiangchao Zhao

Animal Science Faculty Publications and Presentations

Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative …

Unravelling The Potential Applications Of Extracellular Vesicles For The Clinical Management Of Melanoma Patients, Michael Edward Clark

Theses: Doctorates and Masters

Metastatic melanoma is the third most common cancer in Australia with global incidence increasing. After decades without effective systemic treatments for advanced melanoma, the advent of targeted and immune therapies has substantially improved patient survival. While this is encouraging, further research is needed as the majority of patients treated with targeted therapy ultimately develop drug resistance. Immunotherapy can achieve durable responses in many patients however, not all patients respond to current single or a combination of immune checkpoint inhibitors. Considering the cost and potential toxicities to patients being treated with these therapies, there is an urgent need to develop biomarkers …

On Keystroke Pattern Variability In Virtual Desktop Infrastructure, I Kuzminykh, B Ghita, A Silonosov

School of Engineering, Computing and Mathematics

No abstract provided.

A Bayesian Inverse Dynamic Approach For Impulsive Wave Loading Reconstruction: Theory, Laboratory And Field Application, Alessandro Antonini, Brownjohn Jm William, Darshana Dassanayake, Alison Raby, James Bassit, Athanasios Pappas, D D’Ayala

School of Engineering, Computing and Mathematics

The measurement of wave forces acting on marine structures is a complicated task, both during physical experiments and, even more so, in the field. Force transducers adopted in laboratory experiments require a minimum level of structural movement, thus violating the main assumption of fully rigid structure and introducing a dynamic response of the system. Sometimes the induced vibrations are so intense that they completely nullify the reliability of the experiments. On-site, it is even more complex, since there are no force transducers of the size and capacity able to measure such massive force intensity acting over the very large domain …

Compact Floating Wave Energy Converter Arrays: Inter-Device Mooring Connectivity And Performance, Ben Howey, Keri M. Collins, Martyn Hann, Gregorio Iglesias, Rui P.F. Gomes, João C.C. Henriques, Luís M.C. Gato, Deborah Greaves

School of Engineering, Computing and Mathematics

Achieving cost reduction in wave energy conversion is seen as essential to enabling the progress of the sector. Atutility scale in a wave farm, multiple devices are likely to be deployed in array configurations. Closely spaced,compact wave energy converter (WEC) arrays are a promising option for cost reduction, realising synergies inoperation and maintenance tasks and auxiliary installations, whilst achieving economies of scale. Mooring andanchorage systems are known to be a major component of the structural costs, and the use of interconnectinglines between neighbouring devices can reduce the number of anchors and minimise total line length. In thispaper, we present the …

A Review Of The Uk And British Channel Islands Practical Tidal Stream Energy Resource, Daniel Coles, Athanasios Angeloudis, Deborah Greaves, Gordon Hastie, Matthew Lewis, Lucas Mackie, James Mcnaughton, Jon Miles, Simon Neill, Matthew Piggott, Denise Risch, Beth Scott, Carol Sparling, Tim Stallard, Philipp Thies, Stuart Walker, David White, Richard Willden, Benjamin Williamson

School of Engineering, Computing and Mathematics

This review provides a critical, multi-faceted assessment of the practical contribution tidal stream energy can make to the UK and British Channel Islands future energy mix. Evidence is presented that broadly supports the latest national-scale practical resource estimate, of 34 TWh/year, equivalent to 11% of the UK’s current annual electricity demand. The size of the practical resource depends in part on the economic competitiveness of projects. In the UK, 124 MW of prospective tidal stream capacity is currently eligible to bid for subsidy support (MeyGen 1C, 80 MW; PTEC, 30 MW; and Morlais, 14 MW). It is estimated that the …

Hyperhidrosis Disease Severity Measure-Axillary (Hdsm-Ax): Evaluation Of Measurement Performance, Jeremy Hobart, Laurie Burke, Brandon Kirsch, Deepak Chadha

Peninsula Medical School

Background: Clinical trials of primary axillary hyperhidrosis (AHH) require rigorous measurement of AHH severity from the patient’s perspective. Previously, we reported conceptualization and item content development for the Hyperhidrosis Disease Severity Measure-Axillary (HDSM-Ax) scale.Objective: To evaluate the psychometric performance and estimate clinically meaningful change scores for the HDSM-Ax in a Phase IIb clinical study of sofpironium bromide gel for AHH.Method: HDSM-Ax measurement performance was analyzed in trial response data using two psychometric paradigms: Classical Test and Rasch Measurement Theories (CTT; RMT). HDSM-Ax meaningful change scores were estimated from anchor-based methods using two global summary questions of hyperhidrosis severity and the …