Digital Commons Network^™

Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin

Epidemiology and Environmental Health Faculty Publications

Background: African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical to understanding the genetic basis of the disease, as well as detecting at-risk individuals.

Methods: In a population comprising over 10,700 AAs treated for hypertension from the Genetics of Hypertension Associated Treatments (GenHAT) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) studies, we performed an inverse variance-weighted meta-analysis of incident stroke. Additionally, we tested the predictive accuracy of a polygenic risk score (PRS) derived from a European ancestral population in both GenHAT and REGARDS AAs …

1959 - May 12, Carolyn Brown Dodge

Carolyn Brown Dodge Letters

Carolyn Dodge resided in Ellensburg, Washington, in the Badger Pocket area on a farm with her family and her letters describe her daily life as a farm wife and later as the wife of a potato broker in the Quincy Basin. She also wrote letters to her cousin at her residences in Kittitas and Quincy, Washington, following her time in Ellensburg.

Nondestructive Detection Of Codling Moth Infestation In Apples Using Pixel-Based Nir Hyperspectral Imaging With Machine Learning And Feature Selection, Nader Ekramirad, Alfadhl Y. Khaled, Lauren E. Doyle, Julia R. Loeb, Kevin D. Donohue, Raul T. Villanueva, Akinbode A. Adedeji

Electrical and Computer Engineering Faculty Publications

Codling moth (CM) (Cydia pomonella L.), a devastating pest, creates a serious issue for apple production and marketing in apple-producing countries. Therefore, effective nondestructive early detection of external and internal defects in CM-infested apples could remarkably prevent postharvest losses and improve the quality of the final product. In this study, near-infrared (NIR) hyperspectral reflectance imaging in the wavelength range of 900–1700 nm was applied to detect CM infestation at the pixel level for three organic apple cultivars, namely Gala, Fuji and Granny Smith. An effective region of interest (ROI) acquisition procedure along with different machine learning and data processing …

Adopting Agility In Academia Through Pilot Projects, Omar Ochoa, Massood Towhidnejad

Papers

This innovate practice work in progress paper presents our initial findings about the application of agile process in the day to day operation of an academic department. The benefits of agile methods, which are processes that are lightweight and people-oriented, are well-known. Agile methods provide the ability to respond faster to the changing needs of stakeholders, improved product quality, team over individual goals, and better transparency. Therefore, one would expect adaption of the agile process within academic environment would be welcomed, however, unique issues exist within faculty that impact adoption; faculty have different goals that change through their tenure, and …

Personality Dimensions Of Male And Female Law Enforcement Recruits Related To Academy Success, Chantel Duda

Honors Theses

Research has found that male and female law enforcement recruits complete academy training at different rates, with female recruits typically completing at lower rates than male recruits. While the literature on the topic demonstrates a variety of training characteristics that explain some of the difference, it is possible that typical personality differences between men and women play a role in some of the unexplained disparities in academy passing rates. This study attempted to discern differences between personality characteristics among male and female academy recruits using survey data from two major metropolitan law enforcement academies. It was hypothesized that male cadets …

Studying The Behavioral Role Of The Kcnn2 Gene In Zebrafish Embryos, Gina Dragonette

Honors Theses

Introduction: Mutations in the KCNN2 gene have been linked to phenotypes of movement disorders and autism. The goal of this experiment was to use the CIUSPR-Cas9 system to create a deletion within the KCNN2 gene and to observe the effect on the expression of movement in zebra fish embryos.

Methods: Linearized Cas9 DNA and guide DNA underwent in vitm transcription (IVT) reactions to produce RNA to be injected into zebrafish embryos at the one cell stage. KCNN guide RNAs were produced for the KCNN2 and KCNN3 genes (to prevent KCNN3 protein function from compensating for loss ofKCNN2's protein function), and …

Unravelling Rubber Tree Growth By Integrating Gwas And Biological Network-Based Approaches, Felipe Roberto Francisco, Alexandre Hild Aono, Carla Cristina Da Silva, Paulo S. Gonçalves, Erivaldo J. Scaloppi Junior, Vincent Le Guen, Roberto Fritsche-Neto, Livia Moura Souza, Anete Pereira De Souza

Faculty Publications

Hevea brasiliensis (rubber tree) is a large tree species of the Euphorbiaceae family with inestimable economic importance. Rubber tree breeding programs currently aim to improve growth and production, and the use of early genotype selection technologies can accelerate such processes, mainly with the incorporation of genomic tools, such as marker-assisted selection (MAS). However, few quantitative trait loci (QTLs) have been used successfully in MAS for complex characteristics. Recent research shows the efficiency of genome-wide association studies (GWAS) for locating QTL regions in different populations. In this way, the integration of GWAS, RNA-sequencing (RNA-Seq) methodologies, coexpression networks and enzyme networks can …

Plastic, Pollution, Art, And The Caribbean, Celine Collazo

Theses and Dissertations

The impact of a growing ocean pollution problem can be seen on the trash-filled shores of Caribbean beaches. Through a contextualization of the work of three artists, Tony Capellán, Radamés ‘Juni’ Figueroa, and Alejandro Durán, this paper discusses the cause and effects of such detritus, and possibilities for change.

Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation Of Monocytes And Reduces Il-1Β Secretion By Urate Crystal Stimulated Gout Pbmcs, Sandy Elsayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid

Pharmacy Faculty Articles and Research

Objectives

To compare phagocytic activities of monocytes in peripheral blood mononuclear cells (PBMCs) from acute gout patients and normal subjects, examine monosodium urate monohydrate (MSU) crystal-induced IL-1β secretion ± recombinant human proteoglycan 4 (rhPRG4) or interleukin-1 receptor antagonist (IL-1RA), and study the anti-inflammatory mechanism of rhPRG4 in MSU stimulated monocytes.

Methods

Acute gout PBMCs were collected from patients in the Emergency Department and normal PBMCs were obtained from a commercial source. Monocytes in PBMCs were identified by flow cytometry. PBMCs were primed with Pam3CSK4 (1μg/mL) for 24h and phagocytic activation of monocytes was determined using fluorescently labeled latex beads. MSU …

December 21, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors, Hengky Chandrahalim, Jonathan W. Smith

AFIT Patents

A passive microscopic Fabry-Pérot Interferometer (FPI) sensor an optical fiber a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fighter that reflects a light signal back through the optical fiber. The reflected light is altered by refractive index changes in the three-dimensional structure that is subject to at least one of: (i) thermal radiation; and (ii) volatile organic compounds.

Guest Editorial: Mass Atrocity And Collective Healing: New Possibilities For Regenerating Communities, Scherto R. Gill

Genocide Studies and Prevention: An International Journal

This Special Issue brings together five articles from different disciplines. It aims to contribute to the emergent critical voices in research about collective trauma and collective healing by introducing novel perspectives and inviting further debates on the relevant issues evoked. For this reason, the Special Issue focuses on collective healing through a number of prisms. First, it delves into the notions of wounding and trauma, with a view to advance a well-argued theoretical framework for understanding collective healing. Second, it identifies underlying ethical pillars for collective healing, especially the principles of equality and well-being that affirm human dignity founded on …

Comprehensive And Context-Sensitive Neonatal Pain Assessment System And Methods Using Multiple Modalities, Ghadh Alzamzmi, Chih-Yun Pai, Dmitry Goldgof, Rangachar Kasturi, Terri Ashmeade, Yu Sun

USF Patents

A system and method of automatically assessing pediatric and neonatal pain using facial expressions along with crying sounds, body movement, and vital signs change to improve the diagnosis and treatment of pain in the pediatric patient population.

Machine-Learning Algorithms For Forecast-Informed Reservoir Operation (Firo) To Reduce Flood Damages, Manizhe Zarei, Omid Bozorg-Haddad, Sahar Baghban, Mohammad Delpasand, Erfan Goharian, Hugo A. Loaiciga

Faculty Publications

Water is stored in reservoirs for various purposes, including regular distribution, flood control, hydropower generation, and meeting the environmental demands of downstream habitats and ecosystems. However, these objectives are often in conflict with each other and make the operation of reservoirs a complex task, particularly during flood periods. An accurate forecast of reservoir inflows is required to evaluate water releases from a reservoir seeking to provide safe space for capturing high flows without having to resort to hazardous and damaging releases. This study aims to improve the informed decisions for reservoirs management and water prerelease before a flood occurs by …

A Visually Realistic Simulator For Autonomous Evtol Aircraft, Seth M. Nielsen

Theses and Dissertations

Electrically powered vertical takeoff and landing (eVTOL) aircraft could provide a new mode of air transportation of people and cargo that is low-cost, on-demand, and able to reach more areas than is possible with current technology. They have the unique ability to takeoff and land in congested spaces yet efficiently travel long distances which makes them a promising technology for applications such as rapid medical assistance, automated package delivery, or human transportation. This type of aircraft has only recently become a possibility, owing to advancements in battery technology, computing power, and sensor technologies, and thus support for eVTOLs is lacking …

Knowledge Management Processes As A Challenge Of Knowledge-Based Economy, Filip Tużnik

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

The article concerns the idea of knowledge and its innovative potential in the knowledge-based economy. The processes related to the knowledge transfer and knowledge management are often considered as factors determining the success in innovativeness. Knowledge management is also an important issue in inter-organizational cooperation since it considerably helps in the development of new technological solutions. The article provides research results on knowledge management conducted among enterprises and scientific units involved in cooperation under R&D projects co-financed by the Polish Federation of Engineering Associations and the National Centre for Research and Development.

Design And Analysis Of Flexible Insulated Pavement For Cold Region Applications, Zhuang Zhuo

Theses and Dissertations

Pavements in cold regions suffer from additional deterioration due to the influences of extreme climate on frost-susceptible subgrade layers. To address this problem, one efficient strategy is to add a thermal insulating layer above the frost-susceptible layer. This study aims to evaluate the insulating effects of four materials: XPS boards, tire chips, foamed glass aggregates, and foamed concrete. Large-scale insulated pavement boxes (1.2m×1.2m×0.8m) were constructed to compare the thermal performance of different materials. The thermal performance of each box was evaluated and graded based on indicators related to the short-term temperature decrease and long-term temperature variation.

Experimental results show that …

1977 December Memphis State University Commencement Program

Commencements

Program for the Winter convocation of the 66th commencement of Memphis State University at Memphis, Tennessee, held at the Mid-South Coliseum on December 17, 1977.

Exploring End-Users’ Digital Literacy Skills In The Islamia University Of Bahawalpur, Pakistan, Muhammad Younus, Muhammad Irfan Saleem

Library Philosophy and Practice (e-journal)

This study aimed to explore end-users’ digital literacy skills in the Islamia University of Bahawalpur, Pakistan. The study employed the quantitative research method to address the research questions. The quantitative data were collected from research students (M.Phil. and PhD) studying at different departments in the university through the questionnaire. The findings of the study suggest that the respondents had a high level of knowledge and skills to use the Internet, MS Word and computers. The participants were not aware of most of electronic resources. They possessed a low level of skills to retrieve digital information, produce and create digital contents, …

Focus, 2021, Fall, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

1963 - Nov. 11, Carolyn Brown Dodge

Carolyn Brown Dodge Letters

Carolyn Dodge resided in Ellensburg, Washington, in the Badger Pocket area on a farm with her family and her letters describe her daily life as a farm wife and later as the wife of a potato broker in the Quincy Basin. She also wrote letters to her cousin at her residences in Kittitas and Quincy, Washington, following her time in Ellensburg.

Cognitive Systems Engineering Models Applied To Cybersecurity, Tiffani Bragg

Theses

Cybersecurity is an increasing area of concern for organizations and individuals alike. The majority of successfully executed cyberattacks are a result of human error. One common type of attack that targets human users is phishing. In spite of this, there is a lack of research surrounding human implications on phishing behavior. Using an online survey platform with both phishing and legitimate emails, the present research examined the utility of various cognitive engineering models for modeling responses to these example emails. Using Signal Detection Theory (SDT) and Fuzzy Signal Detection Theory (Fuzzy SDT), the influence of familiarity with phishing and having …

Linking Migration To Community Resilience In The Receiving Basin Of A Large-Scale Water Transfer Project, Anna Erwin, Zhao Ma, Ruxandra Popovici, Emma Patricia Salas O’Brien, Laura Zanotti, Chelsea A. Silva, Eliseo Zeballos Zeballos, Jonathan Bauchet, Nelly Ramírez Calderón, Glenn Roberto Arce Larrea

Department of Agricultural Economics Faculty Publications

Large-scale water transfer projects (LWTPs) transfer water to urban and agricultural areas. The Majes-Siguas canal, established in 1983, is an LWTP that created a thriving agricultural area through irrigating the Majes district in the Atacama Desert of Peru. Like other LWTP receiving basins, the project has attracted an influx of migrants who work on the farms. At the same time, the Majes LWTP is the district’s only source of water and has an aging infrastructure which presents significant risks. While many studies critically analyze the consequences of LWTPs in water supply basins, few evaluate the resilience of communities living in …

An Instructional Guide To Environmental Campaigns For K-12 Schools, Erin Mccarty

University Honors Theses

Evidence suggests environmental education can correlate with both short- and long-term behavioral changes, but existing research on the effectiveness of popular environmental education tactics show mixed results. Qualitative research was used in this study to assess student engagement and behavioral change within the context of environmental education campaigns. Ideally, students exposed to environmental campaigns become more informed on environmental issues and adjust their behavior to align with the campaign’s objectives. However, only a portion of environmental campaigns have these desired effects on their students. Based on a preliminary literature review, I anticipated the defining catalyst on post-campaign behavioral engagement would …

Winter 2021

In The Loop

2021 Emmy Nominees; Animator Tapped by Cartoon Network; IndieCade Horizons 2021; Hack4Space; Security Daemons Prevail; Role Models: DePaul Originals Game Studio students build industry-level skills that benefit themselves and others; Frames and Fortune: Eugene Bush programmed his indie video studio with patience and planning; Reality Check: Heather Snyder Quinn augments reality to question systems of unchecked power

Co-Teaching Strategies: Improving Student Engagement By Increasing Opportunities To Respond, Janet E. Nutt

Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children

Research indicates that effective co-teaching using high leverage practices can maximize outcomes across content areas and positively affect student engagement. This paper discusses practical ways to increase student engagement by increasing opportunities to respond in a co-teaching setting. Specific examples are included for a secondary mathematics co-taught classroom, but the principles can be applied in any subject or setting. A proposed model of professional development and coaching to support effective questioning techniques and increase opportunities to respond is also discussed for the purposes of teacher training and professional development.

Sars-Cov-2 Ferritin Nanoparticle Vaccines Elicit Broad Sars Coronavirus Immunogenicity, M Gordon Joyce, Rita E Chen, James Brett Case, Michael S Diamond, Et Al

Open Access Publications

The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the long-term threat of emerging coronaviruses. Here, we design and characterize four categories of engineered nanoparticle immunogens that recapitulate the structural and antigenic properties of the prefusion SARS-CoV-2 spike (S), S1, and receptor-binding domain (RBD). These immunogens induce robust S binding, ACE2 inhibition, and authentic and pseudovirus neutralizing antibodies against SARS-CoV-2. A spike-ferritin nanoparticle (SpFN) vaccine elicits neutralizing titers (ID

Ccr2 Signaling Restricts Sars-Cov-2 Infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, Mehul S Suthar

Open Access Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current evidence suggests that severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined. Here, we characterize a mouse model of SARS-CoV-2 infection and find that early CCR2 signaling restricts the viral burden in the lung. We find that a recently developed mouse-adapted SARS-CoV-2 (MA-SARS-CoV-2) strain as well as the emerging B.1.351 variant trigger an inflammatory response in the lung characterized by the expression of …

Mathematical Modeling Of Stress Strain Behavior Of Newborn Mouse Aorta With Genetic Defects, Yufan Wu

Mechanical Engineering and Materials Science Independent Study

This project continues to fit the experimental data on the stress-strain behavior of newborn mice’s ascending aorta. The stress-strain behavior of newborn mouse aorta is highly nonlinear because of its unique composition of elastin and collagen in the arterial wall. To mathematically describe this behavior, more strain energy functions of different biological materials were used in fitting. Multiple error functions were used to improve accuracy. K-fold cross-validation was applied in regression to avoid overfitting. In addition to the data of aorta with elastin knockout, those of aorta with lysyl oxidase knockout and fibulin 4 knockout are also evaluated in this …

Kinematics And Kinetics Of Capacitated And Non-Capacitated Mouse Sperm, Alicia Gupte

Mechanical Engineering and Materials Science Independent Study

The differences in kinetic measurements of force, work, power, and torque are quantitativly observed between non-capacitated and capacitated sperm. Isomap, a nonlinear dimensionality reduction technique, is used to get higher resolution imaging data of the sperm videos. This allowed accurate calculations of spatial and temporal derivatives to calculate the kinetics of the flagella. The results showed no statistical significance between the kinetic measurements of non- capacitated and capacitated mouse sperm.