Digital Commons Network^™

A Retrospective Cohort Study Of Myosteatosis And Quality Of Life In Head And Neck Cancer Patients., Amy L Shaver, Katia Noyes, Heather M Ochs-Balcom, Gregory Wilding, Andrew D Ray, Sung Jun Ma, Mark Farrugia, Anurag K Singh, Mary E Platek

Department of Medical Oncology Faculty Papers

Head and neck cancer (HNC) treatment-related morbidity can be detrimental to quality of life (QOL). Myosteatosis is associated with poor QOL in multiple cancers. If predictive of poor QOL trajectories, myosteatosis would be a tool for clinicians to determine which patients may require additional support during treatment. The purpose of this study was to determine if pretreatment myosteatosis is associated with a poor QOL trajectory following treatment completion.

METHODS: In a retrospective cohort design, myosteatosis was determined from pretreatment CT scans. Both physical and global QOL score was assessed through patient interview on follow-up appointment. Demographic, cancer-specific, and social covariates …

Device Design Modifications Informed By In Vitro Testing Of Bacterial Attachment Reduce Infection Rates Of Cochlear Implants In Clinical Practice, Lynne Turnbull, Roger Leigh, Rosalia Cavaliere, Sarah R Osvath, Laura M Nolan, Daniel Smyth, Kristien Verhoeven, Richard A Chole, Cynthia B Whitchurch

Open Access Publications

Recalcitrant chronic infections of implanted medical devices are often linked to the presence of biofilms. The prevention and treatment of medical device-associated infections is a major source of antibiotic use and driver of antimicrobial resistance globally. Lowering the incidence of infection in patients that receive implanted medical devices could therefore significantly improve antibiotic stewardship and reduce patient morbidity. Here we determined if modifying the design of an implantable medical device to reduce bacterial attachment, impacted the incidence of device-associated infections in clinical practice. Since the 1980s cochlear implants have provided long-term treatment of sensorineural hearing deficiency in hundreds of thousands …

Predictive Accuracy And Densitometric Analysis Of Point-Of-Care Immunoassay For Adenoviral Conjunctivitis, Spencer D Johnson, Mary K Migneco, Mathew S Margolis, Leonard W Haertter, Julia B Huecker, Richard S Buller, Gregory A Storch, Mae O Gordon, Et Al

Open Access Publications

Purpose: Accurate diagnosis of adenoviral conjunctivitis (Ad-Cs) is important for timely and appropriate patient management to reduce disease transmission. This study assessed the diagnostic accuracy of a commercially available point-of-care adenovirus immunoassay and determined whether its predictive accuracy is influenced by signal intensities of test result bands.

Methods: Point-of-care immunoassay (AdenoPlus) testing and quantitative polymerase chain reaction (qPCR) testing was performed on conjunctival swab samples obtained from eyes of 186 eligible adult participants with presumed infectious conjunctivitis and symptoms of ≤4 days. Masked observers assessed signal intensities of the immunoassay test and control bands using densitometry.

Results: Ad-Cs was confirmed …

The Micromorphology And Histochemistry Of Foliar Mixed Indumentum Of Leucas Lavandulaefolia (Lamiaceae), Y Naidoo, Thobekile Dladla, Yaser Hassan Dewir, Serisha Gangaram, Cm Naidoo, Hail Z. Rihan

School of Biological and Marine Sciences

Leucas lavandulaefolia Sm. (Lamiaceae) is an important medicinal plant with a broad spec-trum of pharmacological activities. This study aimed at characterizing the morphology, distribution, and chemical composition of the secretions of trichomes at different developmental stages on the leaves of L. lavandulaefolia, using light and electron microscopy. Morphological observations revealed the presence of bicellular non-glandular, glandular peltate, and capitate trichomes on both adaxial and abaxial leaf surfaces. The density of both non-glandular and glandular trichomes decreased with the progression of leaf development. Heads of peltate and short-stalked capitate trichomes were between 20.78–42.80 µm and 14.98–18.93 µm at different developmental stages. …

Understanding The Mechanistic Roles Of Integrin Alpha 6 In Tumor Development Using A Humanized Zebrafish (Danio Rerio) Model System, Ashley B. Williams

Honors College Theses

Present day cancer incidence and mortality rates indicate the need for effective cancer diagnostic tools and targeted cancer therapeutic strategies. Recent studies have focused on the biological pathways of cells and tumor microenvironments to identify putative biomarkers and potential drug targets as diagnostic and therapeutic tools. Human integrins, adhesion receptors, have become the focal points in these studies, specifically Integrin Alpha 6 (ITGA6) which has been implicated in major tumor progression roles: metastasis and angiogenesis. These characteristics make ITGA6 an excellent candidate for potential drug or diagnostic target, however, the mechanism by which ITGA6 facilitates tumor progression remains unclear. Cell …

Ageing Performance Of Biodegradable Pla For Durable Applications, Rohan Pujari

Theses

The durability of 2 commercially available injection mold grades and one extrusion grade of polylactic acid (PLA) was assessed. Here, the materials were exposed to elevated temperatures/humidity for a period of several weeks. Moisture absorption, molecular weight change, mechanical properties, crystallinity changes, and microscopic imaging were all monitored at regular intervals throughout the course of the combined heat and humidity ageing study. The conditions for the ageing study were set at 60°C and 45% relative humidity and all three PLA grades showed a significant increase in crystallinity and conversely reduced mechanical performance over the 68-day ageing period. Microscopic images of …

Barcoding Us Ants: Ozarks Region - Research Highlight, Megan Woltz

The Confluence

Ants are species diverse, widespread, and critically important to their environments. For many ant species, we do not have clear data on their ranges. Barcoding US Ants is a citizen science project run by the DNA Learning Center at Cold Spring Harbor Laboratory to collect and sequence DNA from ants from around the country (CSHL, 2020). The sequences are submitted to GenBank, the DNA sequence database (NIH 2020). We formed one of the Ozarks Region teams for the Barcoding US Ants project, contributing ants from riparian forests and grassy meadows in the St. Charles, MO area. We collected 8 ant …

Engineering The Surface Of Fe3o4 Nanoparticles For Catalytic And Magnetic Applications, Natalia Da Silva Moura

LSU Doctoral Dissertations

With the rapid depletion of the U.S. energy resources coupled with population growth, heat management technologies must be improved to sustain our quality of life. Precisely, in catalysis, it is estimated that only ~50% of the energy supplied to the reactor is used for product conversion due to dissipation losses. Among the emerging technologies with a promising reduction in heat losses is induction heating, offering targeted heat delivery with magnetic nanoparticles. Under alternating magnetic fields (AMF), these nanoparticles can absorb the energy from Radio-Frequency (RF) fields and dissipate it as heat on the nanoparticle surface. This in situ heat generation …

Understanding The Etiology Of Taproot Decline Of Soybean Caused By Xylaria Necrophora, José E. Ortiz Solórzano

LSU Master's Theses

Taproot decline (TRD) of soybean is caused by Xylaria necrophora. However, the mechanisms by which it infects soybean and produces symptoms are unknown. Symptoms of TRD include foliar interveinal chlorosis and necrosis and root necrosis, yet X. necrophora appears to be restricted to the roots. While Xylaria species are predominantly wood decomposers, a few are pathogens. More importantly, they produce secondary metabolites (SMs) with multiple bioactivities, including phytotoxicity and antimicrobial activity. Preliminary experiments suggested that X. necrophora was producing SMs responsible for TRD symptoms. We evaluated cell-free culture filtrates (CFs) for phytotoxicity on soybeans, testing for changes in chlorophyll …

Wagon Tracks Volume 35, Issue 3 (May 2021)

Wagon Tracks

2 On the Cover: The Trail to Santa Fe by Ron Kil
4 Insights from your President
5 Joanne’s Jottings
2,5-6,9, 15,30 Trail News
7-9 Roots Run Deep on the Santa Fe Trail by Marcia Fox
10-14, 23-20 Diary of William Baskerville, Jr., on the Santa Fe Trail, 1854 by Joy L. Poole
16-17 2021 Symposium
31 In Memoriam: Davy Mitchell, Robbie Roberts
31 Chapter Reports 33 Membership Information
36 American Solar Car Challenge

Contributors

Ephemeris

No abstract provided.

Archaeological Field Work - A Neolithic Village, Larkin Kennedy

Ephemeris

No abstract provided.

Establishing Prison Libraries In Tanzania: Prospects And Challenges, Valeria Kyumana Dr

Library Philosophy and Practice (e-journal)

Despite the educational support role that libraries can play to prisoners in Tanzania as inmates can pursue long distance education and other formal or informal education, no prison in the country has yet to establish a library. This study, therefore, sets out to understand prospects of and challenges to establishing a prison library in Tanzania’s prisons taking two Dar es salaam-based central prisons dubbed X and Y as twin case studies. The study used an explorative qualitative research design to achieve its objectives. Data was collected from purposively and conveniently selected sample of using questionnaires, focus group discussions and in-depth …

Spartan Daily, August 24, 2021, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2021

Volume 157, Issue 2

The Effects Of The Ashley Treatment On Society And The Individual, Bailey R.M. Sims

The Mall

No abstract provided.

Psychology In The Hunger Games, Rosa E. Trippel

The Mall

No abstract provided.

The Mall: Writing From Butler University's First Year Seminar 2020-2021, The Mall Staff

The Mall

No abstract provided.

The Social Construction Of An Illness: When Religion Gets In The Way Of Health, Javraj Singh

The Mall

No abstract provided.

Gardner-Webb Campus Community, Including New Mascot Bo, Gathers For 2021 Fall Academic Convocation, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University President Dr. William M. Downs opened his remarks at the 2021 Fall Academic Convocation on Tuesday, Aug. 24, 2021, by expressing his gratefulness. “Thanks to the grace and glory of God, we are together again in this special place, celebrating the start of a new academic year,” he proclaimed. “Convocation is a calling together, a summoning, or a convening. It is a time-honored academic tradition at most universities.”

Comprehensive Characterization Of 536 Patient-Derived Xenograft Models Prioritizes Candidatesfor Targeted Treatment., Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Dennis A Dean, Rajesh Patidar, Li Chen, Matthew A Wyczalkowski, Reyka G Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A Van Tine, Cynthia X Ma, Rebecca Aft, Katherine C Fuh, Julie K Schwarz, Jose P Zevallos, Sidharth V Puram, John F Dipersio, Nci Pdxnet Consortium, Brandi Davis-Dusenbery, Matthew J Ellis, Michael T Lewis, Michael A Davies, Meenhard Herlyn, Bingliang Fang, Jack A Roth, Alana L Welm, Bryan E Welm, Funda Meric-Bernstam, Feng Chen, Ryan C Fields, Shunqiang Li, Ramaswamy Govindan, James H Doroshow, Jeffrey A Moscow, Yvonne A Evrard, Jeffrey Chuang, Benjamin J Raphael, Li Ding, Carol J Bult, Peter N Robinson

Faculty Research 2021

Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 patient-derived xenograft (PDX) models across 25 cancer types, together with mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared with human tumors, PDXs typically have higher purity and fit to investigate dynamic driver events and molecular properties via multiple time points from same case PDXs. Here, we report on dynamic genomic landscapes and pharmacogenomic associations, including associations between activating oncogenic events and drugs, correlations between whole-genome duplications …

Spatial Analysis Of Beaked Whale Foraging During Two 12 Khz Multibeam Echosounder Surveys, Hilary Kates Varghese, Kim Lowell, Jennifer L. Miksis-Olds, Nancy Dimarzio, Larry A. Mayer

Center for Coastal and Ocean Mapping

To add to the growing information about the effect of multibeam echosounder (MBES) operation on marine mammals, a study was conducted to assess the spatial foraging effort of Cuvier’s beaked whales during two MBES surveys conducted in January of 2017 and 2019 off of San Clemente Island, California. The MBES surveys took place on the Southern California Antisubmarine Warfare Range (SOAR), which contains an array of 89 hydrophones covering an area of approximately 1800 km2 over which foraging beaked whales were detected. A spatial autocorrelation analysis of foraging effort was conducted using the Moran’s I (global) and the Getis-Ord Gi∗ …

Spin Reorientation In Antiferromagnetic Layered Fept5p, Xin Gui, Madalynn Marshall, Ranuri S. Dissanayaka Mudiyanselage, Ryan A. Klein, Qiang Chen, Qiang Zhang, William Shelton, Haidong Zhou, Craig M. Brown, Huibo Cao, Martha Greenblatt, Weiwei Xie

Faculty Publications

FePt5P, a substitutional variant of the anti-CeCoIn5 structure type in the space group P4/mmm, was synthesized by a high-temperature solid-state method and structurally characterized by X-ray diffraction. FePt5P contains layers of FePt12 clusters formed by magnetically active Fe and heavy Pt with strong spin-orbit coupling (SOC); the layers are separated by P atoms. The various Fe-Pt distances in FePt12 clusters generate complex magnetic orders in FePt5P. According to temperature-dependent magnetic and specific heat measurements, FePt5P shows a stripe-type antiferromagnetic order at TN ≈ 90 K, which is also confirmed by resistivity measurements. Moreover, a spin reorientation occurs at ∼74 and …

Comparative Microbiome Analysis Of The Funfus Gardening Ant Species Trachymyrmex Arizonensis, Chase D. Rowan

Biology Theses

Fungus-growing ants (Attini: Formicidae) and their fungal cultivars participate in ant-fungus mutualism that share a 50-million-year-old coevolutionary history. Fungal cultures are grown in gardens alongside ants and a diverse collection of microbes that interact with both species in mutualistic, commensal, and antagonistic relationships. These microbes aid in digestion and detoxification of food, provide essential nutrients, help in nest hygiene, and play a dominant role in defense against pathogens and disease. Microbial communities of many model species have been shown to change in a laboratory setting as compared to their natural environment. High-throughput 16s sequencing of the V4 variable region was …

Does Epa Cause A Decrease In Inflammation Of Bend.3 Cells Through Ffar4?, Clay J. Weidenhamer

Masters Theses

Atherosclerosis is an inflammatory disease initiated by low and oscillatory shear stress on the endothelium. The inflammatory process recruits leukocytes to the vessel wall by expression of the adhesion molecule VCAM-1. Activation of the NF-κB inflammatory signaling pathway is responsible for the increase in VCM-1 expression. Omega 3 FAs, such as EPA, reduce the risk of atherosclerosis by decreasing this inflammatory response. The pathway by which omega 3 FAs is proposed to inhibit inflammation includes activating FFAR4 to decrease NF-κB activation thereby reducing expression of adhesion molecules. We hypothesized that treatment of endothelial cells with 30 μM EPA would decrease …

A Method For Space Archaeology Research: The International Space Station Archaeological Project, Justin St. P. Walsh, Alice C. Gorman

Art Faculty Articles and Research

How does a ‘space culture’ emerge and evolve, and how can archaeologists study such a phenomenon? The International Space Station Archaeological Project seeks to analyse the social and cultural context of an assemblage relating to the human presence in space. Drawing on concepts from contemporary archaeology, the project pursues a unique perspective beyond sociological or ethnographical approaches. Semiotic analysis of material culture and proxemic analysis of embodied space can be achieved using NASA's archives of documentation, images, video and audio media. Here, the authors set out a method for the study of this evidence. Understanding how individuals and groups use …

Triangle Journal News, Volume 7, Number 7

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. National News Editor: Mike Morgan. Contributors: David Bianco, Greg Bullard, Dr. Simon LeVay, Miss Page Turner, Butch Valentine. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal News, Volume 7, Number 9

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. National News Editor: Mike Morgan. Contributors: David Bianco, Bob Dumais, Dr. Simon LeVay, Miss Page Turner, Butch Valentine. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal News, Volume 8, Number 6

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. National News Editor: Mike Morgan. Contributors: David Bianco, Dr. Simon LeVay, Romeo St. Vicente, Butch Valentine, Churck Saylor. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal News, Volume 8, Number 10

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. National News Editor: Mike Morgan. Contributors: David Bianco, Dr. Simon LeVay, Romeo St. Vicente, Butch Valentine, Jim Maynard, Gary Coughlan, Chuck Saylor. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Triangle Journal News, Volume 8, Number 12

Triangle Journal News, 1990-2006

Co-Editors: Allen Cook, John Stilwell. Staff Writers: Vincent Astor, Ira L. King. Contributors: David Bianco, Dr. Simon LeVay, Romeo St. Vicente, Butch Valentine, Dottie Jones, Jim Norcross, Doyle Richmond. Production: Vincent Astor, Allen Cook, Bob Dumais, John Stilwell. Advertising: Vincent Astor, Bob Dumais.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.