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2021

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A Sensor Fused Rear Cross Traffic Detection System Using Transfer Learning, Jungme Park, Wenchang Yu Sep 2021

A Sensor Fused Rear Cross Traffic Detection System Using Transfer Learning, Jungme Park, Wenchang Yu

Electrical & Computer Engineering Publications

Recent emerging automotive sensors and innovative technologies in Advanced Driver Assistance Systems (ADAS) increase the safety of driving a vehicle on the road. ADAS enhance road safety by providing early warning signals for drivers and controlling a vehicle accordingly to mitigate a collision. A Rear Cross Traffic (RCT) detection system is an important application of ADAS. Rear-end crashes are a frequently occurring type of collision, and approximately 29.7% of all crashes are rear-ended collisions. The RCT detection system detects obstacles at the rear while the car is backing up. In this paper, a robust sensor fused RCT detection system is …


A Sensor Fused Rear Cross Traffic Detection System Using Transfer Learning, Jungme Park, Wenchang Yu Sep 2021

A Sensor Fused Rear Cross Traffic Detection System Using Transfer Learning, Jungme Park, Wenchang Yu

Electrical & Computer Engineering Publications

Recent emerging automotive sensors and innovative technologies in Advanced Driver Assistance Systems (ADAS) increase the safety of driving a vehicle on the road. ADAS enhance road safety by providing early warning signals for drivers and controlling a vehicle accordingly to mitigate a collision. A Rear Cross Traffic (RCT) detection system is an important application of ADAS. Rear-end crashes are a frequently occurring type of collision, and approximately 29.7% of all crashes are rear-ended collisions. The RCT detection system detects obstacles at the rear while the car is backing up. In this paper, a robust sensor fused RCT detection system is …


Autonomic Nervous System Reactivity In Early Childhood: Developmental Patterns And Sociodemographic Predictors, Michelle Stephens Sep 2021

Autonomic Nervous System Reactivity In Early Childhood: Developmental Patterns And Sociodemographic Predictors, Michelle Stephens

Dissertations

Cardiac autonomic nervous system (ANS) measurements, respiratory sinus arrhythmia (RSA) and preejection period (PEP), are valid and reliable indicators of children's sensitivity to stressors in their environment; however, there are few studies of RSA and PEP measures in children younger than three years of age and no known studies of children at 18-months of age. This was a cohort study of racially- and ethnically-diverse, low-income children studied from birth through five years of age. At 18-months (n = 134) and 36-months (n = 102) of age, children completed a developmentally challenging protocol that simultaneously assessed their RSA and PEP under …


Hyperspectral Imaging Combined With Machine Learning For The Detection Of Fusiform Rust Disease Incidence In Loblolly Pine Seedlings, Piyush Pandey, Kitt G. Payn, Yuzhen Lu, Austin J. Heine, Trevor D. Walker, Juan J. Acosta, Sierra N. Young Sep 2021

Hyperspectral Imaging Combined With Machine Learning For The Detection Of Fusiform Rust Disease Incidence In Loblolly Pine Seedlings, Piyush Pandey, Kitt G. Payn, Yuzhen Lu, Austin J. Heine, Trevor D. Walker, Juan J. Acosta, Sierra N. Young

Civil and Environmental Engineering Faculty Publications

Loblolly pine is an economically important timber species in the United States, with almost 1 billion seedlings produced annually. The most significant disease affecting this species is fusiform rust, caused by Cronartium quercuum f. sp. fusiforme. Testing for disease resistance in the greenhouse involves artificial inoculation of seedlings followed by visual inspection for disease incidence. An automated, high-throughput phenotyping method could improve both the efficiency and accuracy of the disease screening process. This study investigates the use of hyperspectral imaging for the detection of diseased seedlings. A nursery trial comprising families with known in-field rust resistance data was conducted, and …


Burstiness And Stochasticity In The Malleability Of Physical Activity, Vincent Berardi, David Pincus, Evan Walker, Marc A. Adams Sep 2021

Burstiness And Stochasticity In The Malleability Of Physical Activity, Vincent Berardi, David Pincus, Evan Walker, Marc A. Adams

Psychology Faculty Articles and Research

This study examined whether patterns of self-organization in physical activity (PA) predicted long-term success in a yearlong PA intervention. Increased moderate to vigorous PA (MVPA) was targeted in insufficiently active adults (N = 512) via goal setting and financial reinforcement. The degree to which inverse power law distributions, which are reflective of self-organization, summarized (a) daily MVPA and (b) time elapsed between meeting daily goals (goal attainment interresponse times) was calculated. Goal attainment interresponse times were also used to calculate burstiness, the degree to which meeting daily goals clustered in time. Inverse power laws accurately summarized interresponse times, but …


Kenyon Collegian - September 9, 2021 Sep 2021

Kenyon Collegian - September 9, 2021

The Kenyon Collegian

No abstract provided.


Body Size, Trophic Position, And The Coupling Of Different Energy Pathways Across A Saltmarsh Landscape, Friedrich W. Keppeler, Jill A. Olin, Paola C. López-Duarte, Michael J. Polito, Linda M. Hooper-Bùi, Sabrina S. Taylor, Nancy N. Rabalais, F. Joel Fodrie, Brian J. Roberts, R. Eugene Turner, Charles W. Martin, Olaf P. Jensen Sep 2021

Body Size, Trophic Position, And The Coupling Of Different Energy Pathways Across A Saltmarsh Landscape, Friedrich W. Keppeler, Jill A. Olin, Paola C. López-Duarte, Michael J. Polito, Linda M. Hooper-Bùi, Sabrina S. Taylor, Nancy N. Rabalais, F. Joel Fodrie, Brian J. Roberts, R. Eugene Turner, Charles W. Martin, Olaf P. Jensen

Michigan Tech Publications, Part 1

Body size is considered an important structuring mechanism of food webs because consumers are usually larger and more mobile than their prey and may couple energy among habitats. We explored the links among trophic position (TP), body size, and the coupling of different energy channels (phytoplankton and C4-marsh plants) in a saltmarsh landscape in the northern Gulf of Mexico—a dynamic system considered weakly shaped by biotic interactions. Body size was positively associated with TP, and this relationship was stronger in the phytoplankton pathway vs. the C4-marsh pathway. There was a gradual increase in the coupling of phytoplankton and C4-marsh plants …


The Effects Of Aerobic-Resistance Training And Broccoli Supplementation On Plasma Dectin-1 And Insulin Resistance In Males With Type 2 Diabetes, Ayoub Saeidi, Mohammad Soltani, Ali Daraei, Hanieh Nohbaradar, Marjan Mosalman Haghighi, Nikoo Khosravi, Kelly E. Johnson, Ismail Laher, Anthony C. Hackney, Trisha Vandusseldorp, Hassane Zouhal Sep 2021

The Effects Of Aerobic-Resistance Training And Broccoli Supplementation On Plasma Dectin-1 And Insulin Resistance In Males With Type 2 Diabetes, Ayoub Saeidi, Mohammad Soltani, Ali Daraei, Hanieh Nohbaradar, Marjan Mosalman Haghighi, Nikoo Khosravi, Kelly E. Johnson, Ismail Laher, Anthony C. Hackney, Trisha Vandusseldorp, Hassane Zouhal

Faculty Articles

BACKGROUND: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). METHODS: Forty-four males with T2D were randomly allocated to four groups ( = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 …


September 9, 2021, James Madison University Sep 2021

September 9, 2021, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


The George-Anne, Georgia Southern University Sep 2021

The George-Anne, Georgia Southern University

The George-Anne

  • Remembering 9/11
  • Shenanigans Reopens
  • Donda is Here
  • News Briefs
  • Tik Tok challenge gone wrong
  • Henderson Library extends hours
  • Students still skeptical after FDA approval
  • GSU Wild Life Center
  • Small Businesses of GS Eagles
  • GS looks to reset after tight season opening win
  • Eagles deny Gardner-Webb comeback despite struggles
  • ONE wheelchair for 20,000+ students
  • Intersectionality for Queer students of color
  • The #FreeBritney movement
  • Market on Main
  • Ghost & Toast


Usability And Acceptability Of A Mobile App For Behavior Change And To Improve Immunization Coverage Among Children In Pakistan: A Mixed-Methods Study, Abdul Momin Kazi, Nazia Ahsan, Waliyah Mughis, Saima Jamal, Raheel Allana, Mehreen Raza, Sahrish Muneer, Muhammad Ayub Khan Mughal, Hussain Kalimuddin, Fareeha Sameen Sep 2021

Usability And Acceptability Of A Mobile App For Behavior Change And To Improve Immunization Coverage Among Children In Pakistan: A Mixed-Methods Study, Abdul Momin Kazi, Nazia Ahsan, Waliyah Mughis, Saima Jamal, Raheel Allana, Mehreen Raza, Sahrish Muneer, Muhammad Ayub Khan Mughal, Hussain Kalimuddin, Fareeha Sameen

Department of Paediatrics and Child Health

Background: Pakistan's immunization uptake rates are still significantly lower than anticipated despite several initiatives. Lack of awareness, forgetting about vaccination schedule, and vaccine misconception/misinformation are a few of the major drivers that mitigate the rates of immunization. The current COVID-19 pandemic emphasizes the importance of immunization. The significant reductions in regular childhood vaccination during pandemic have increased the risk of outbreaks of vaccine-preventable diseases. Concerns among parents over possibly exposing their children to COVID-19 during child visits may have contributed to the reported declines. Innovative and cost-effective mHealth interventions must be implemented in order to address the problem of inadequate …


Teratogenic Medication Usage In Primary Care Of Women Of Reproductive Age, Krys Foster, Md, Mph, Faafp Sep 2021

Teratogenic Medication Usage In Primary Care Of Women Of Reproductive Age, Krys Foster, Md, Mph, Faafp

Department of Family & Community Medicine Presentations and Grand Rounds

Introduction

  • Teratogenic medications are commonly prescribed to individuals with pregnancy potential
  • Despite knowledge of potential teratogenic effects, data suggest that effective communication regarding the risks and benefits of medication use in the context of the patient’s fertility goals remains inadequate
  • We will discuss recommendations for changes in education and healthcare delivery to facilitate thoughtful prescribing in this population

Learning Objectives

  • To review a common scenario faced by primary care physicians caring for individuals at risk of pregnancy
  • To recognize factors that might place certain patients at increased risk of teratogenic exposure in early pregnancy
  • To gain competence in assessing fertility …


Measurement Invariance Of The Scientific Curiosity Scale: A Comparative Study Across Gender And Governorate In The Omani Environment, Ahmed Alsubaei, Ehab M. Omara, Mahmoud M. Ibrahim Sep 2021

Measurement Invariance Of The Scientific Curiosity Scale: A Comparative Study Across Gender And Governorate In The Omani Environment, Ahmed Alsubaei, Ehab M. Omara, Mahmoud M. Ibrahim

Journal of Educational and Psychological Studies

هدفت الدراسة إلى التحقق من تكافؤ البنية العاملية بمستوياتها الأربعة (الشكلي، المتري، القياسي، ومستوى البواقي) لمقياس حب الاستطلاع العلمي عبر النوع الاجتماعي والمحافظة بسلطنة عُمان، وقد تكونت عينة الدراسة من657 طالبًا، و587 طالبة من التعليم الأساسي بالصفين التاسع والعاشر في ثلاث محافظات (مسقط، الشرقية شمال، الداخلية)، وتوصلت نتائج الدراسة إلى تحقق تكافؤ البنية العاملية بجميع مستوياتها، مما يعني إمكانية إجراء المقارنات بين المجموعات المختلفة محل الدراسة وفق النوع الاجتماعي والمحافظة. وقد أوصى الباحثون بإمكانية استخدام المقياس في دراسة الفروق بين الجنسين على مستوى المحافظات لمستوى حب الاستطلاع العلمي.


Invariant Natural Killer T-Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing And Antitumor Effects, Kristina Maas-Bauer, Juliane K Lohmeyer, Toshihito Hirai, Teresa Lopes Ramos, Furqan M Fazal, Ulrike M Litzenburger, Kathryn E Yost, Jessica V Ribado, Neeraja Kambham, Arielle S Wenokur, Po-Yu Lin, Maite Alvarez, Melissa Mavers, Jeanette Baker, Ami S Bhatt, Howard Y Chang, Federico Simonetta, Robert S Negrin Sep 2021

Invariant Natural Killer T-Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing And Antitumor Effects, Kristina Maas-Bauer, Juliane K Lohmeyer, Toshihito Hirai, Teresa Lopes Ramos, Furqan M Fazal, Ulrike M Litzenburger, Kathryn E Yost, Jessica V Ribado, Neeraja Kambham, Arielle S Wenokur, Po-Yu Lin, Maite Alvarez, Melissa Mavers, Jeanette Baker, Ami S Bhatt, Howard Y Chang, Federico Simonetta, Robert S Negrin

Faculty, Staff and Students Publications

Invariant natural killer T (iNKT) cells are a T-cell subset with potent immunomodulatory properties. Experimental evidence in mice and observational studies in humans indicate that iNKT cells have antitumor potential as well as the ability to suppress acute and chronic graft-versus-host-disease (GVHD). Murine iNKT cells differentiate during thymic development into iNKT1, iNKT2, and iNKT17 sublineages, which differ transcriptomically and epigenomically and have subset-specific developmental requirements. Whether distinct iNKT sublineages also differ in their antitumor effect and their ability to suppress GVHD is currently unknown. In this work, we generated highly purified murine iNKT sublineages, characterized their transcriptomic and epigenomic landscape, …


Contributor Notes Sep 2021

Contributor Notes

Floodwall Magazine

No abstract provided.


Writing Prompts On The Special Theme: Growth Sep 2021

Writing Prompts On The Special Theme: Growth

Floodwall Magazine

No abstract provided.


An Entomologist’S Love Letter, Jona L. Pedersen Sep 2021

An Entomologist’S Love Letter, Jona L. Pedersen

Floodwall Magazine

No abstract provided.


Reference Source And Services In Csir-Igib, Csir-Npl, Csir-Niscair, Csir-Nistads And Csir-Crri, Azad Hasan, Muzamil Mushtaq Sep 2021

Reference Source And Services In Csir-Igib, Csir-Npl, Csir-Niscair, Csir-Nistads And Csir-Crri, Azad Hasan, Muzamil Mushtaq

Library Philosophy and Practice (e-journal)

The purpose of the present study is to know the available reference sources and reference services provided by the select CSIR laboratory libraries situated at Delhi. The author use survey method and use questionnaire as a tool for data collection. A total number of 5 questionnaires personally distributed to the library In-charge and received total 5 questionnaires. The major findings of the study revealed that CSIR-NISCAIR library has highest number of collection i.e. 250000 and also has highest number of reference collection i.e.50000. All the select libraries have encyclopedia, dictionaries, government documents, yearbooks and Annuals in their reference collection in …


Intellectual Competency Development For The Students Of Technical Higher Education Institutions, Ilkhom Karimov Sep 2021

Intellectual Competency Development For The Students Of Technical Higher Education Institutions, Ilkhom Karimov

Central Asian Problems of Modern Science and Education

This article discusses the development of intellectual competencies of students in technical higher education, and it uncovers the content and essence of intellectual competence, important factors for the development of intellectual competence, the necessary factors and the formation of a competitive specialist, as well as the development of intellectual abilities of future professionals


Commonwealth Times 2021-09-08 Sep 2021

Commonwealth Times 2021-09-08

Commonwealth Times, 1969-

No abstract provided.


Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman Sep 2021

Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Health and Kinesiology Faculty Publications

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O2•−), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O2•− has been shown to decrease blood pressure in hypertensive animals. We have previously shown that MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin SOD mimic currently in clinical trials as a normal tissue protector for cancer patients undergoing radiation therapy, can scavenge O2•− and acutely decrease normotensive blood pressures. Herein, we hypothesized that BuOE decreases hypertensive blood pressures. Using angiotensin II (AngII)-hypertensive mice, we demonstrate that BuOE administered both intraperitoneally and …


Interventional Spine And Pain Procedure Credentialing: Guidelines From The American Society Of Pain & Neuroscience, Ramana K. Naidu, Rahul Chaturvedi, Alyson M. Engle, Pankaj Mehta, Brian Su, Krishnan Chakravarthy, Kasra Amirdelfan, Jeffrey Henn, Dawood Sayed, Jay S. Grider, Timothy Deer Sep 2021

Interventional Spine And Pain Procedure Credentialing: Guidelines From The American Society Of Pain & Neuroscience, Ramana K. Naidu, Rahul Chaturvedi, Alyson M. Engle, Pankaj Mehta, Brian Su, Krishnan Chakravarthy, Kasra Amirdelfan, Jeffrey Henn, Dawood Sayed, Jay S. Grider, Timothy Deer

Anesthesiology Faculty Publications

Background: The discipline of interventional pain management has changed significantly over the past decade with an expected greater evolution in the next decade. Not only have the number of procedures increased, some of the procedures that were created for spine surgeons are becoming more facile in the hands of the interventional pain physician. Such change has outpaced academic institutions, societies, and boards. When a pain physician is in the credentialing process for novel procedure privileges, it can leave the healthcare system in a challenging situation with little to base their decision upon.

Methods: This paper was developed by a consensus …


September 8, 2021 Faculty Senate Minutes, University Of South Carolina Sep 2021

September 8, 2021 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.


Government Royalties On Sales Of Pharmaceutical And Other Biomedical Products Developed With Substantial Public Funding: Illustrated With The Technology Transfer Of The Drug-Eluting Coronary Stent, Robert S. Danziger, John T. Scott Sep 2021

Government Royalties On Sales Of Pharmaceutical And Other Biomedical Products Developed With Substantial Public Funding: Illustrated With The Technology Transfer Of The Drug-Eluting Coronary Stent, Robert S. Danziger, John T. Scott

Dartmouth Scholarship

This study develops a detailed description of the successful technology transfer of an invention—the drug-eluting coronary stent—originating in intramural research within the National Institutes of Health. The history of the commercialization of the invention is used to illustrate a new policy, proposed and explained in this study, for the payment to the government of royalties on the sales of biomedical products developed with substantial public funding provided through indirect as well as direct funding avenues. The proposed policy addresses concerns about the high prices that taxpayers as consumers pay for biomedical products that were developed with funding from the taxpayers …


Dosimetric Validation Of A System To Treat Moving Tumors Using Scanned Ion Beams That Are Synchronized With Anatomical Motion, Michelle Lis, Wayne Newhauser, Marco Donetti, Moritz Wolf, Timo Steinsberger, Athena Paz, Christian Graeff Sep 2021

Dosimetric Validation Of A System To Treat Moving Tumors Using Scanned Ion Beams That Are Synchronized With Anatomical Motion, Michelle Lis, Wayne Newhauser, Marco Donetti, Moritz Wolf, Timo Steinsberger, Athena Paz, Christian Graeff

Faculty Publications

Purpose: The purpose of this study was to validate the dosimetric performance of scanned ion beam deliveries with motion-synchronization to heterogenous targets. Methods: A 4D library of treatment plans, comprised of up to 10 3D sub-plans, was created with robust and conventional 4D optimization methods. Each sub-plan corresponded to one phase of periodic target motion. The plan libraries were delivered to a test phantom, comprising plastic slabs, dosimeters, and heterogenous phantoms. This phantom emulated range changes that occur when treating moving tumors. Similar treatment plans, but without motion synchronization, were also delivered to a test phantom with a stationary target …


The Lumberjack, September 08, 2021 Sep 2021

The Lumberjack, September 08, 2021

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.


Predicting The Effect Of Indirect Cell Kill In The Treatment Of Multiple Brain Metastases Via Single-Isocenter/Multitarget Volumetric Modulated Arc Therapy Stereotactic Radiosurgery, Allison N. Palmiero, Denise Fabian, Marcus E. Randall, William St. Clair, Damodar Pokhrel Sep 2021

Predicting The Effect Of Indirect Cell Kill In The Treatment Of Multiple Brain Metastases Via Single-Isocenter/Multitarget Volumetric Modulated Arc Therapy Stereotactic Radiosurgery, Allison N. Palmiero, Denise Fabian, Marcus E. Randall, William St. Clair, Damodar Pokhrel

Radiation Medicine Faculty Publications

PURPOSE: Due to spatial uncertainty, patient setup errors are of major concern for radiosurgery of multiple brain metastases (m-bm) when using single-isocenter/multitarget (SIMT) volumetric modulated arc therapy (VMAT) techniques. However, recent clinical outcome studies show high rates of tumor local control for SIMT-VMAT. In addition to direct cell kill (DCK), another possible explanation includes the effects of indirect cell kill (ICK) via devascularization for a single dose of 15 Gy or more and by inducing a radiation immune intratumor response. This study quantifies the role of indirect cell death in dosimetric errors as a function of spatial patient setup uncertainty …


Submicron Metal 3d Printing By Ultrafast Laser Heating And Induced Ligand Transformation Of Nanocrystals, Chinmoy Podder, Xiangtao Gong, Xiaowei Yu, Wan Shou, Heng Pan Sep 2021

Submicron Metal 3d Printing By Ultrafast Laser Heating And Induced Ligand Transformation Of Nanocrystals, Chinmoy Podder, Xiangtao Gong, Xiaowei Yu, Wan Shou, Heng Pan

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Currently, light-based three-dimensional (3D) printing with submicron features is mainly developed based on photosensitive polymers or inorganic-polymer composite materials. To eliminate polymer/organic additives, a strategy for direct 3D assembly and printing of metallic nanocrystals without additives is presented. Ultrafast laser with intensity in the range of 1 x 1010 to 1 x 1012 W/cm2 is used to nonequilibrium heat nanocrystals and induce ligand transformation, which triggers the spontaneous fusion and localized assembly of nanocrystals. The process is due to the operation of hot electrons as confirmed by a strong dependence of the printing rate on laser pulse duration varied in …


Kelp Morphology And Herbivory Are Maintained Across Latitude Despite Geographic Shift In Kelp-Wounding Herbivores, Nicholas P. Burnett, Eric J. Armstrong, Rosemary Romero, Charlotte C. Runzel, Richelle L. Tanner Sep 2021

Kelp Morphology And Herbivory Are Maintained Across Latitude Despite Geographic Shift In Kelp-Wounding Herbivores, Nicholas P. Burnett, Eric J. Armstrong, Rosemary Romero, Charlotte C. Runzel, Richelle L. Tanner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Herbivores can drastically alter the morphology of macroalgae by directly consuming tissue and by inflicting structural wounds. Wounds can result in large amounts of tissue breaking away from macroalgae, amplifying the damage initially caused by herbivores. Herbivores that commonly wound macroalgae often occur over only a portion of a macroalga’s lifespan or geographic range. However, we know little about the influence of these periodic or regional occurrences of herbivores on the large-scale seasonal and geographical patterns of macroalgal morphology. We used the intertidal kelp Egregia menziesii to investigate how the kelp’s morphology and the prevalence of two prominent kelp-wounding herbivores …


Investigation Of The Role Of Hydrophobic Amino Acids On The Structure-Activity Relationship In Ponericin L1 From Neoponera Goeldii, Nicholas Patrick Schifano Sep 2021

Investigation Of The Role Of Hydrophobic Amino Acids On The Structure-Activity Relationship In Ponericin L1 From Neoponera Goeldii, Nicholas Patrick Schifano

Theses and Dissertations

Due to the increase prevalence of antimicrobial resistance (AMR) antibiotic alternatives have been of great interest. Antimicrobial peptides (AMPs) and polymers like polymethacrylates that mimic AMPs are two non-traditional antimicrobial agents that have been investigated thoroughly over the years as a potential solution to the AMR problem. This study will further the understanding of the L1 peptide by investigating the role hydrophobic amino acids have on the antimicrobial activity. Biophysical and microbiological techniques were utilized to show that the L1 hydrophobic derivative showed enhanced binding to anionic lipid bilayers while maintaining low hemolytic activity. This study also elucidates the effect …