Digital Commons Network^™

The Guardian, Week Of September 20, 2021, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of September 20, 2021. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

September 20, 2021

The Gavel Gazette

No abstract provided.

Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti

Theses and Dissertations

The use of biocompatible and biodegradable composite materials for biomedical applications has attracted the attention of many researchers in the past few years. In this study, we fabricated nanofibers of silk fibroin and cellulose and its derivatives to amalgamate their unique properties into a single material. The production of these nanofibers via electrospinning is of particular interest, and whereas several studies have been done on normal nanofibers, the formation of branched nanofibers is an exciting area not currently explored. Blend solutions are formed by dissolving silk and cellulose/cellulose acetate in formic acid separately and mixing to achieve the desired ratios. …

Navigating The Space Between Us, Robert Gould

PDXOpen: Open Educational Resources

Navigating the Space Between Us - Finding Connection, while Embracing the Continua of Difference: A Dilemma Driven Conflict Analysis was developed as an upper division undergraduate textbook for a conflict resolution CR 310U Values and Ethics course (required for a PSU bachelor's degree in CR) and adaptable to a conflict resolution CR 513 graduate course (required for PSU master's degree in CR). Its intended audience are students from Portland State University enrolled in a ten week, quarter system, though it is adaptable for a semester length course. The chapters are combined with other readings on conflict resolution values and ethics. …

Perron Theorem For Delay Differential Equations, William Barker

Theses and Dissertations

This note discusses results furthering the study of bounded solutions of non-homogeneous second-order differential equations with delay. The equation of interest has already been shown to possess unique bounded solutions in accordance to Perron's Theorem. We will determine the negativity of the solutions given a positive forcing term by establishing a uniform bound regarding small time delay.

The Immunotherapy Candidate Tnfsf4 May Help The Induction Of A Promising Immunological Response In Breast Carcinomas, Kai Li, Lei Ma, Ye Sun, Xiang Li, Hong Ren, Shou-Ching Tang, Xin Sun

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Immune checkpoint blockade, an immunotherapy, has been applied in multiple systemic malignancies and has improved overall survival to a relatively great extent; whether it can be applied in breast cancer remains unknown. We endeavored to explore possible factors that may influence immunotherapy outcomes in breast cancer using several public databases. The possible treatment target TNF superfamily member 4 (TNFSF4) was selected from many candidates based on its abnormal expression profile, survival-associated status, and ability to predict immune system reactions. For the first time, we identified the oncogenic features of TNFSF4 in breast carcinoma. TNFSF4 was revealed to be closely related …

Normative Dimensions Of Consenual Application Of Black Box Artificial Intelligence In Administrative Adjudication Of Benefits Claims, Frank Pasquale

Law and Contemporary Problems

No abstract provided.

Are Judges More Transparent Than Black Boxes? A Scheme To Improve Judicial Decision-Making By Establishing A Relationship With Mathematical Function Maximization, Wim De Mulder, Peggy Valcke, Geneviève Vanderstichele, Joke Baeck

Law and Contemporary Problems

No abstract provided.

The Future Of Zoonotic Risk Prediction, Colin J. Carlson, Maxwell J. Farrell, Zoe Grange, Barbara A. Han, Nardus Mollentze, Alexandra L. Phelan, Angela L. Rasmussen, Gregory F. Albery, Bernard Bett, David M. Brett-Major, Lily E. Cohen, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Kristian M. Forbes, Rory Gibb, Sam Halabi, Charlotte C. Hammer, Rebecca Katz, Jason Kindrachuk, Renata L. Muylaert, Felicia B. Nutter, Joseph Ogola, Kevin J. Olival, Michelle Rourke, Sadie J. Ryan, Noam Ross, Stephanie N. Seifert, Tarja Sironen, Claire J. Standley, Kishana Taylor, Marietjie Venter, Paul W. Webala

Faculty Publications

In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat to humans. To support the extensive task of laboratory characterization, scientists may increasingly rely on data-driven rubrics or machine learning models that learn from known zoonoses to identify which animal pathogens could someday pose a threat to global health. We synthesize the findings of an interdisciplinary workshop on zoonotic risk technologies to answer the following questions. What are the prerequisites, in terms of open …

Increasing The Spatial And Temporal Impact Of Ecological Research: A Roadmap For Integrating A Novel Terrestrial Process Into An Earth System Model, Emily Kyker-Snowman, Danica L. Lombardozzi, Gordon B. Bonan, Susan J. Cheng, Jeffrey S. Dukes, Serita D. Frey, Elin M. Jacobs, Risa Mcnellis, Joshua M. Rady, Nicholas G. Smith, R. Quinn Thomas, William R. Wieder, A. Stuart Grandy

Faculty Publications

Terrestrial ecosystems regulate Earth's climate through water, energy, and biogeochemical transformations. Despite a key role in regulating the Earth system, terrestrial ecology has historically been underrepresented in the Earth system models (ESMs) that are used to understand and project global environmental change. Ecology and Earth system modeling must be integrated for scientists to fully comprehend the role of ecological systems in driving and responding to global change. Ecological insights can improve ESM realism and reduce process uncertainty, while ESMs offer ecologists an opportunity to broadly test ecological theory and increase the impact of their work by scaling concepts through time …

Gaps In Public Awareness About Brca And Genetic Testing In Prostate Cancer: Social Media Landscape Analysis., Stacy Loeb, Philip Massey, Amy E. Leader, Sameer Thakker, Emily Falge, Sabina Taneja, Nataliya Byrne, Meredith Rose, Matthew Joy, Dawn Walter, Matthew S. Katz, Risa L. Wong, Preethi Selvan, Scott W. Keith, Veda N. Giri

Department of Medical Oncology Faculty Papers

BACKGROUND: Genetic testing, particularly for BRCA1/2, is increasingly important in prostate cancer (PCa) care, with impact on PCa management and hereditary cancer risk. However, the extent of public awareness and online discourse on social media is unknown, and presents opportunities to identify gaps and enhance population awareness and uptake of advances in PCa precision medicine.

OBJECTIVE: The objective of this study was to characterize activity and engagement across multiple social media platforms (Twitter, Facebook, and YouTube) regarding BRCA and genetic testing for PCa compared with breast cancer, which has a long history of public awareness, advocacy, and prominent social media …

Gaps In Public Awareness About Brca And Genetic Testing In Prostate Cancer: Social Media Landscape Analysis, Stacy Loeb, Philip Massey, Amy Leader, Sameer Thakker, Emily Falge, Sabina Taneja, Nataliya Byrne, Meredith Rose, Matthew Joy, Dawn Walter, Matthew S Katz, Risa L Wong, Preethi Selvan, Scott W Keith, Veda N. Giri

Department of Medical Oncology Faculty Papers

BACKGROUND: Genetic testing, particularly for BRCA1/2, is increasingly important in prostate cancer (PCa) care, with impact on PCa management and hereditary cancer risk. However, the extent of public awareness and online discourse on social media is unknown, and presents opportunities to identify gaps and enhance population awareness and uptake of advances in PCa precision medicine.

OBJECTIVE: The objective of this study was to characterize activity and engagement across multiple social media platforms (Twitter, Facebook, and YouTube) regarding BRCA and genetic testing for PCa compared with breast cancer, which has a long history of public awareness, advocacy, and prominent social media …

A Message From The Guest Editor, Valerie Imbruce, Adelaide Cagle

Binghamton University Undergraduate Journal

A message from the Guest Editor

Shallow Lake Physical-Ecological Process Modeling Platform (Lamp), Guangwei Zhu, Hongwei Wei, Tingfeng Yang, Wei Li, Kuanyi Li, Ruijie Shen, Shen Min, Jiangming Deng, Boqiang Qin

Bulletin of Chinese Academy of Sciences (Chinese Version)

Lake is an important component of inland water resource of China, and key ecological component of Mountain-RiverForest-Farmland-Lake-Grassland life community. Lake is also a perfect research unit for ecological theory owing to its relative clearly isolate ecosystem. Field observatory, controlled experiment, and numerical simulation are common research methods for limnology theory development and ecological restoration technology innovation. In shallow lakes, the lake ecosystem is very sensitive to the change of environmental condition. For example, changes of physical condition, such as wind-wave, could strongly influence the sediment-water interaction, light condition of water, and the growth of phytoplankton, and finally change the whole …

The New Parental Rights, Anne C. Dailey, Laura A. Rosenbury

Duke Law Journal

This Article sets forth a new model of parental rights designed to free children and families from the ideals of parent–child unity and family privacy that underlie the law’s expansive protection for parental rights. The law currently presumes that parents’ interests coincide with those of their children, creating an illusion of parent–child union that suppresses the very real ways in which children’s interests and identities, even at a young age, may depart from those of their parents. Expansive protection for parental rights also confines children to the private family, ignoring children’s broad range of interests beyond the family and thwarting …

Heat Exposure Effect On Ghanaian Mining Workers: A Mediated-Moderation Approach, Victor Fannam Nunfam, Ebenezer Afrifa-Yamoah

Research outputs 2014 to 2021

The lack of empirical evidence on the effect of heat exposure on the health and safety, productivity, psychological behaviour and social well-being outcomes of small- and large-scale mining workers in Africa has derailed concrete policy directions and interventions. An explanatory cross-sectional survey involving 320 small- and large-scale mining workers was used to assess this research gap. A path analysis was used to model health and safety, productivity, psychological behaviour and social well-being as a function of heat exposure, mediated and moderated by adaptation strategies and barriers, while controlling for age, gender, level of education, years of working experience and workplace …

Rapid Morphologic Changes To Microglial Cells And Upregulation Of Mixed Microglial Activation State Markers Induced By P2x7 Receptor Stimulation And Increased Intraocular Pressure, Keith E. Campagno, Wennan Lu, Assraa Jassim, Farraj Albalawi, Aurora Cenaj, Huen-Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez, Claire H. Mitchell

Health & Biomedical Sciences Faculty Publications

Background

The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed on microglial cells, we examined the morphological and molecular consequences of P2X7 receptor stimulation in vivo and in vitro and investigated the contribution of the P2X7 receptor in a model of increased intraocular pressure (IOP).

Methods

In vivo experiments involved intravitreal injections and both transient and sustained elevation of IOP. In vitro experiments were performed on isolated mouse retinal and brain microglial cells. …

Protein Cofactors And Substrate Influence Mg2+-Dependent Structural Changes In The Catalytic Rna Of Archaeal Rnase P, Ila A Marathe, Stella M Lai, Walter J Zahurancik, Michael G Poirier, Vicki H Wysocki, Venkat Gopalan

Faculty, Staff and Student Publications

The ribonucleoprotein (RNP) form of archaeal RNase P comprises one catalytic RNA and five protein cofactors. To catalyze Mg2+-dependent cleavage of the 5' leader from pre-tRNAs, the catalytic (C) and specificity (S) domains of the RNase P RNA (RPR) cooperate to recognize different parts of the pre-tRNA. While ∼250-500 mM Mg2+ renders the archaeal RPR active without RNase P proteins (RPPs), addition of all RPPs lowers the Mg2+ requirement to ∼10-20 mM and improves the rate and fidelity of cleavage. To understand the Mg2+- and RPP-dependent structural changes that increase activity, we used pre-tRNA cleavage and ensemble FRET assays to …

Structural Variants Are A Major Source Of Gene Expression Differences In Humans And Often Affect Multiple Nearby Genes, Alexandra J Scott, Colby Chiang, Ira M Hall

2020-Current year OA Pubs

Structural variants (SVs) are an important source of human genome diversity, but their functional effects are poorly understood. We mapped 61,668 SVs in 613 individuals from the GTEx project and measured their effects on gene expression. We estimate that common SVs are causal at 2.66% of eQTLs, a 10.5-fold enrichment relative to their abundance in the genome. Duplications and deletions were the most impactful variant types, whereas the contribution of mobile element insertions was small (0.12% of eQTLs, 1.9-fold enriched). Multitissue analysis of eQTLs revealed that gene-altering SVs show more constitutive effects than other variant types, with 62.09% of coding …

Adapting Tropical Forages To Low-Fertility Soils, Idupulapati M. Rao

IGC Proceedings (1977-2023)

Tropical forages growing in low-fertility acid soils usually increase the amount of dry matter partitioned to roots at the expense of shoot growth, but substantially different adaptive attributes to such soils have been found, both between and within species. By possessing the C₄ pathway of photosynthesis, grasses are more efficient than legumes in using N, Ca, and P, whereas legume roots are more efficient in extracting nutrients from low-fertility soils. Phosphorus uptake efficiency (mg of P uptake in shoot biomass per unit root length) of the legume Arachis pintoi is several times higher than that of the grass Brachiaria …

Adaptation Of Forage Species To Drought, D. J. Barker, J. R. Caradus

IGC Proceedings (1977-2023)

Variability in rainfall is the single greatest cause of variation in forage production for a given site. Current climate scenarios predict future annual rainfall to decrease at some geographic regions. The intensity of future rainfall is also predicted to increase at other regions, with the expectation of greater variability in soil moisture. The adaptation of forage species to drought is an issue that is likely to remain with us into the future.

Precise definitions are critical to water relations work, and imprecise use of terms has complicated comparisons of some studies on plant response to drought. Drought is a purely …

Spittlebugs: Bioecology, Host Plant Resistance And Advances In Ipm, José R. Valério, C. Cardona, D. C. Peck, G. Sotelo

IGC Proceedings (1977-2023)

Several species and genera of spittlebugs (Homoptera: Cercopidae) are economic pests of grasses in tropical America. These insects compete with grazing animals by reducing forage availability and quality. They may cause serious losses on millions of hectares of improved pastures based on cultivars of several species of Brachiaria (signal grasses). Except for the cultivar Marandu, most of the available commercial cultivars of Brachiaria are susceptible to spittlebugs. In spite of their economic importance, much research need to be done yet. Such insect-plant system encompasses a diverse group of spittlebug species, a diverse group of forage grass species, which are under …

Representing Africa In The ‘Coming To America’ Films, Samuel K. Bonsu, Delphine Godefroit-Winkel

Markets, Globalization & Development Review

Through an interpretive analysis of the two Eddie Murphy films "Coming to America" (CTA) and "Coming 2 America", spaced nearly 30 years apart, this review essay underscores the persistence of Orientalist Othering of Africa. The negative images of Africa that are so engrained in people have been facilitated in significant part by a strategic, but perhaps unconscious, effort to socialize audiences into an identity construction process that casts Africans as inferior. Despite attempts at favorable depictions of Africa, these processes continue to play out.

Grassland Plant Diseases: Management And Control, S. Chakraborty

IGC Proceedings (1977-2023)

Grasslands cover 40% of the earth’s surface and support animal-based industries; maintain soil cover, watersheds and biodiversity; sequester atmospheric carbon for storage in the soil; and provide tourism and leisure income. Diseases continue to decrease herbage and seed yield and reduce nutritive value and palatability of grasslands to impact on animal health and productivity but realistic data on loss are hard to find. Although principles of disease management remain the same, strategies used in crop protection can not be directly applied to grasslands due to differences in heterogeneity, population size, density and spatial distribution and population continuity. Low per hectare …

Soil Carbon And Nitrogen Dynamics After Pasture Installation In The Amazon Region, C. C. Cerri, M. Bernoux, C. E. P. Cerri

IGC Proceedings (1977-2023)

The objective of this paper is to present the soil carbon (C) and nitrogen (N) dynamics in a chronosequence made of a forest and pastures of different ages established in a Oxisol in the Western Brazilian Amazon Basin. The results of soil Carbon and Nitrogen stocks and gases fluxes were discussed. Stable ¹³C isotopic technique was used to calculate for a determinate age of pasture installation, the proportion of soil C remaining from the forest system and the proportion of soil C introduced by the grasses of the pasture system. The C lost from the original pool under the …

Micronutrients In Grassland Production, U. C. Gupta, F. A. Monteiro, J. C. Werner

IGC Proceedings (1977-2023)

Micronutrients, also known as trace minerals, which chiefly include boron (B), molybdenum (Mo), copper (Cu), zinc (Zn), manganese (Mn) and iron (Fe), are required in extremely small quantities by crops and livestock. Their name, however, is not meant to imply their role is minor. Their lack, e.g., can cause serious crop production problems in forages and health disorders in livestock. This presentation includes the response of forage legumes and grasses to micronutrients, their deficiency and sufficiency levels in forages and their sufficiency levels in livestock. Forage legumes are more responsive to micronutrients, particularly B and Mo, than grasses. There are …

Pasture Seed Production Technology In Brazil, Ronaldo Pereira De Andrade

IGC Proceedings (1977-2023)

Efficient and low cost production systems, which rely on the use of cultivated pastures, are the basis of beef and milk production in Brazil. The success of these pasture-based systems would not be possible without the support of an aggressive and dynamic pasture seed production sector to supply the internal demand, which is estimated to be around 90000 tons per year. The market is dominated by grass species and among them, Brachiaria. brizantha cv. Marandu accounts for more than 80% of the total seed volume in the market. Seed production systems in Brazil vary from highly specialized to opportunistic accordingly …

Judgement Bias In Miniature Donkeys: Conditioning Factors And Personality Links, Maria Pinto, Francisco Javier Navas González, Camie Heleski, Amy Mclean

Animal and Food Sciences Faculty Publications

Expectation-related bias may configure individuals’ perception of their surrounding environment and of the elements present in it. This study aimed to determine the repercussions of environmental (weather elements) or subject-inherent factors (sex, age, or personality features) on judgment bias. A cognitive bias test was performed in eight Miniature jennies and four jacks. Test comprised habituation, training and testing phases during which subjects were trained on how to complete the test and scored based on their latency to approach an ambiguous stimulus. A questionnaire evaluating eleven personality features was parallelly completed by three caretakers, five operators and two care assistants to …

Dark Side Of Cancer Therapy: Cancer Treatment-Induced Cardiopulmonary Inflammation, Fibrosis, And Immune Modulation, Boopathi Ettickan, Chellappagounder Thangavel

Department of Dermatology and Cutaneous Biology Faculty Papers

Advancements in cancer therapy increased the cancer free survival rates and reduced the malignant related deaths. Therapeutic options for patients with thoracic cancers include surgical intervention and the application of chemotherapy with ionizing radiation. Despite these advances, cancer therapy-related cardiopulmonary dysfunction (CTRCPD) is one of the most undesirable side effects of cancer therapy and leads to limitations to cancer treatment. Chemoradiation therapy or immunotherapy promote acute and chronic cardiopulmonary damage by inducing reactive oxygen species, DNA damage, inflammation, fibrosis, deregulation of cellular immunity, cardiopulmonary failure, and non-malignant related deaths among cancer-free patients who received cancer therapy. CTRCPD is a complex …

Effects Of Ecg Data Length On Heart Rate Variability Among Young Healthy Adults, En-Fan Chou, Michelle Khine, Thurmon Lockhart, Rahul Soangra

Physical Therapy Faculty Articles and Research

The relationship between the robustness of HRV derived by linear and nonlinear methods to the required minimum data lengths has yet to be well understood. The normal electrocardiography (ECG) data of 14 healthy volunteers were applied to 34 HRV measures using various data lengths, and compared with the most prolonged (2000 R peaks or 750 s) by using the Mann–Whitney U test, to determine the 0.05 level of significance. We found that SDNN, RMSSD, pNN50, normalized LF, the ratio of LF and HF, and SD1 of the Poincaré plot could be adequately computed by small data size (60–100 R peaks). …