Digital Commons Network^™

Prediction Of Synthetic Lethal Interactions In Human Cancers Using Multi-View Graph Auto-Encoder, Zhifeng Hao, Di Wu, Yuan Fang, Min Wu, Ruichu Cai, Xiaoli Li

Research Collection School Of Computing and Information Systems

Synthetic lethality (SL) is a very important concept for the development of targeted anticancer drugs. However, experimental methods for SL detection often suffer from various issues like high cost and low consistency across cell lines. Hence, computational methods for predicting novel SLs have recently emerged as complements for wet-lab experiments. In addition, SL data can be represented as a graph where nodes are genes and edges are the SL interactions. It is thus motivated to design advanced graph-based machine learning algorithms for SL prediction. In this paper, we propose a novel SL prediction method using Multi-view Graph Auto-Encoder (SLMGAE). We …

Development Of A Correction For Defensiveness In The Minnesota Multiphasic Personality Inventory-Second Edition-Restructured Form (Mmpi-2-Rf) Profiles Of Adult Male Sex Offenders, Katie Marie Glauner

Theses and Dissertations

Clinical and forensic psychologists often evaluate sex offenders to determine the level of risk they pose to the community and identify their treatment needs to reduce the risk of future recidivism. Personality assessments are administered in sex offender evaluations to aid in answering these referral questions, while also providing information regarding the evaluees’ response style to the test and descriptions of their personality functioning. The Minnesota Multiphasic Personality Inventory (MMPI) and its revisions have been the most widely used personality assessments in sex offender evaluations, with previous research demonstrating that sex offenders often respond defensively to the test by minimizing …

Biblical Hermeneutical Principles Dealing With Race, Racism And Social Justice Issues, Jiří Moskala

Faculty Publications

Many modern problems arise from the misinterpretation of the Bible, unfortunately. One of my best Church History teachers Amadeo Molnár at the Protestant Faculty in Prague told us: “The history of the Christian Church is the history of the interpretation of the Bible.” At first, I doubted this statement’s truth, but after some reflections, I understood. Divisions were created and wars were fought because of certain dogmas, and millions were tortured, killed, or enslaved due to specific ideologies and wrong belief systems by believers. So many atrocities were committed in the name of God!

Low Temperature Antioxidant Activity Qtl Associate With Genomic Regions Involved In Physiological Cold Stress Tolerance Responses In Rice (Oryza Sativa L.), Huy Phan, Michael Schläppi

Biological Sciences Faculty Research and Publications

Boosting cold stress tolerance in crop plants can minimize stress-mediated yield losses. Asian rice (Oryza sativa L.), one of the most consumed cereal crops, originated from subtropical regions and is generally sensitive to low temperature environments. Within the two subspecies of rice, JAPONICA, and INDICA, the cold tolerance potential of its accessions is highly variable and depends on their genetic background. Yet, cold stress tolerance response mechanisms are complex and not well understood. This study utilized 370 accessions from the Rice Diversity Panel 1 (RDP1) to investigate and correlate four cold stress tolerance response phenotypes: membrane damage, …

Cognitive Barriers To Covid-19 Vaccine Uptake Among Older Adults, Jonathan L. Chia, Andree Hartanto

Research Collection School of Social Sciences

The COVID-19 pandemic has resulted in tremendous loss of life. As of late-July 2021, there have been more than 191 million confirmed cases and over 4.1 million deaths recorded (1). Although most nations have developed some competency in COVID-19 containment (2–4), there are new challenges. The continual spread of COVID-19 has resulted in new variants (5–7). These new variants are posited to have a significantly higher transmissibility (8–10), with higher fatality rates (11, 12).

Alterations To The Brain Following Traumatic Brain Injury, Jacqueline Mader

Honors Projects

Traumatic brain injuries (TBIs) have been labeled as a modern-day epidemic, increasing exponentially with the advancement of technology and society. Gaining a better understanding of the cognitive paths, including the chemical and electrical signals of the brain, neural correlates, and possible interventions for TBI patients allows for the best possible outcome for every patient, and allows for the further advancement of care. By revising and reassessing the ways in which TBIs are categorized and described the prognosis for recovery paints a more realistic view for each individual patient case. The symptoms and impairments that may occur post-injury can be monitored …

Converging Technologies: Targeting The Hallmarks Of Cancer Using Ultrasound And Microbubbles, Janith Wanigasekara, Andressa Maria Aguiar De Carvalho, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin

Articles

Various complex biological effects occur when ultrasonic compression waves travel through biological material. The myriad of biological outcomes instigated by ultrasound are evident when viewed through the lens of the hallmarks of cancer. Herein, we summarise the therapeutic potential of ultrasound, enhanced by microbubbles, for the treatment of cancer.

Holly Creek Formation Of The Trinity Group, Southwest Arkansas, Usa, Celina A. Suarez, Joseph Frederickson, Richard L. Cifelli, Jeffrey G. Pittman, Randall L. Nydam, Rebecca K. Hunt-Foster, Kirsty Morgan

Geosciences Faculty Publications and Presentations

We present a previously discovered but undescribed late Early Cretaceous vertebrate fauna from the Holly Creek Formation of the Trinity Group in Arkansas. The site from the ancient Gulf Coast is dominated by semi-aquatic forms and preserves a diverse aquatic, semi-aquatic, and terrestrial fauna. Fishes include fresh- to brackish-water chondrichthyans and a variety of actinopterygians, including semionotids, an amiid, and a new pycnodontiform, Anomoeodus caddoi sp. nov. Semi-aquatic taxa include lissamphibians, the solemydid turtle Naomichelys, a trionychid turtle, and coelognathosuchian crocodyliforms. Among terrestrial forms are several members of Dinosauria and one or more squamates, one of which, Sciroseps pawhuskai …

The Content Of Our Character, Teneille Brown

Penn State Law Review (2003 - Present)

No abstract provided.

Of Blood Transfusions And Feeding Tubes: Anorexia-Nervosa And Consent, Samuel Director

Jepson School of Leadership Studies articles, book chapters and other publications

Individuals suffering from anorexia nervosa experience dysmorphic perceptions of their body and desire to act on these perceptions by refusing food. In some cases, anorexics want to refuse food to the point of death. This paper explores the following question: If an anorexic, A, wants to refuse food when the food would either be lifesaving or prevent serious bodily harm, can A's refusal be valid? It is shown that there is compelling reason to think that anorexics can validly refuse food, even in these extreme circumstances.

The Holistic Self-Care Learning Experience Of Rn-To-Bsn Students: A Phenomenological Study Of Meaning And Value, Elaina C. Mahlan

Doctor of Education (Ed.D)

The health of the nursing workforce is a critical aspect of high-quality health care and community health promotion, but extensive research indicates that too many nurses neglect selfcare and suffer negative health outcomes. While nursing education must provide self-care learning experiences to improve the health of nurses, the value and influence of a learning experience must be interpreted from the learner’s point of view. The purpose of this phenomenological study was to elicit the personal value that RN-to-BSN students ascribed to a self-care learning experience within a holistic nursing course at a public university. The holistic nursing paradigm offers a …

The Burkholderia Cenocepacia Type Vi Secretion System Effector Teca Is A Virulence Factor In Mouse Models Of Lung Infection, Nicole A. Loeven, Andrew I. Perault, Peggy A. Cotter, Craig A. Hodges, Joseph D. Schwartzman, Thomas H. Hampton, James B. Bliska

Dartmouth Scholarship

Burkholderia cenocepacia is a member of the Burkholderia cepacia complex (Bcc), a group of bacteria with members responsible for causing lung infections in cystic fibrosis (CF) patients. The most severe outcome of Bcc infection in CF patients is cepacia syndrome, a disease characterized by necrotizing pneumonia with bacteremia and sepsis. B. cenocepacia is strongly associated with cepacia syndrome, making it one of the most virulent members of the Bcc. Mechanisms underlying the pathogenesis of B. cenocepacia in lung infections and cepacia syndrome remain to be uncovered. B. cenocepacia is primarily an intracellular pathogen and encodes the type VI secretion system …

Model Systems To Study The Chronic, Polymicrobial Infections In Cystic Fibrosis: Current Approaches And Exploring Future Directions, George A. O’Toole, Aurélie Crabbé, Rolf Kümmerli, John J. Lipuma, Jennifer M. Bomberger, Jane C. Davies, Dominique Limoli, Vanessa V. Phelan, James B. Bliska, William H. Depas, Lars E. Dietrich, Thomas H. Hampton, Ryan Hunter, Cezar M. Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A. Cramer, Joanna B. Goldberg, Freya Harrison, Deborah A. Hogan

Dartmouth Scholarship

A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 351 investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to …

First-In-Human Study In Cancer Patients Establishing The Feasibility Of Oxygen Measurements In Tumors Using Electron Paramagnetic Resonance With The Oxychip, Philip E. Schaner, Benjamin B. Williams, Eunice Y. Chen, Jason R. Pettus, Wilson A. Schreiber, Maciej M. Kmiec, Lesley A. Jarvis, David A. Pastel, Rebecca A. Zuurbier, Roberta M. Diflorio-Alexander, Joseph A. Paydarfar, Benoit J. Gosselin, Richard J. Barth, Kari M. Rosenkranz, Sergey V. Petryakov, Huagang Hou, Dan Tse, Alexandre Pletnev, Ann Barry Flood, Victoria A. Wood

Dartmouth Scholarship

Objective: The overall objective of this clinical study was to validate an implantable oxygen sensor, called the ‘OxyChip’, as a clinically feasible technology that would allow individualized tumor-oxygen assessments in cancer patients prior to and during hypoxia-modification interventions such as hyperoxygen breathing. Methods: Patients with any solid tumor at ≤3-cm depth from the skin-surface scheduled to undergo surgical resection (with or without neoadjuvant therapy) were considered eligible for the study. The OxyChip was implanted in the tumor and subsequently removed during standard-of-care surgery. Partial pressure of oxygen (pO2) at the implant location was assessed using electron paramagnetic resonance (EPR) oximetry. …

Hindlimb Suspension In Wistar Rats: Sex-Based Differences In Muscle Response, Marie Mortreux, Megan E. Rosa-Caldwell, Ian D. Stiehl, Dong Min Sung, Nicholas T. Thomas, Christopher S. Fry, Seward B. Rutkove

Dartmouth Scholarship

Ground-based animal models have been used extensively to understand the effects of microgravity on various physiological systems. Among them, hindlimb suspension (HLS), developed in 1979 in rats, remains the gold-standard and allows researchers to study the consequences of total unloading of the hind limbs while inducing a cephalic fluid shift. While this model has already brought valuable insights to space biology, few studies have directly compared functional decrements in the muscles of males and females during HLS. We exposed 28 adult Wistar rats (14 males and 14 females) to 14 days of HLS or normal loading (NL) to better assess …

Sparsity-Based Recovery Of Three-Dimensional Photoacoustic Images From Compressed Single-Shot Optical Detection, Dylan Green, Anne Gelb, Geoffrey P. Luke

Dartmouth Scholarship

Photoacoustic (PA) imaging combines optical excitation with ultrasonic detection to achieve high-resolution imaging of biological samples. A high-energy pulsed laser is often used for imaging at multi-centimeter depths in tissue. These lasers typically have a low pulse repetition rate, so to acquire images in real-time, only one pulse of the laser can be used per image. This single pulse necessitates the use of many individual detectors and receive electronics to adequately record the resulting acoustic waves and form an image. Such requirements make many PA imaging systems both costly and complex. This investigation proposes and models a method of volumetric …

Enhanced Expression Of Microrna-1273g-3p Contributes To Alzheimer’S Disease Pathogenesis By Regulating The Expression Of Mitochondrial Genes, So Hee Kim, Kyu Yeong Choi, Yega Park, Catriona Mclean, Jiyu Park, Jung Hoon Lee, Kyung Hwa Lee, Byeong C. Kim, Yun Hyun Huh, Kun Ho Lee, Woo Keun Song

Dartmouth Scholarship

Alzheimer’s disease (AD) is the most common form of dementia in the elderly population, but its underlying cause has not been fully elucidated. Recent studies have shown that microRNAs (miRNAs) play important roles in regulating the expression levels of genes associated with AD development. In this study, we analyzed miRNAs in plasma and cerebrospinal fluid (CSF) from AD patients and cognitively normal (including amyloid positive) individuals. miR-1273g-3p was identified as an AD-associated miRNA and found to be elevated in the CSF of early-stage AD patients. The overexpression of miR-1273g-3p enhanced amyloid beta (Aβ) production by inducing oxidative stress and mitochondrial …

Me-Em Enewsbrief, September 2021, Department Of Mechanical Engineering-Engineering Mechanics, Michigan Technological University

Department of Mechanical and Aerospace Engineering eNewsBrief

No abstract provided.

Real-World Assessment Of Asthma Specialist Visits Among U.S. Patients With Severe Asthma., Jessica F Most, Christopher S Ambrose, Yen Chung, James L Kreindler, Aimee Near, Stephen Brunton, Yao Cao, Huan Huang, Xiaohui Zhao

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

BACKGROUND: U.S. guidelines recommend that patients with severe asthma be referred to specialists (allergists/immunologists or pulmonologists) for systematic assessment or comanagement; however, contemporary, real-world data on the frequency and impact of specialist care among U.S. severe asthma patients are lacking.

OBJECTIVES: To quantify the frequency of asthma specialist visits among U.S. patients with severe asthma, identify patient demographic and clinical characteristics associated with specialist visits and describe health outcomes following specialist care.

METHODS: Severe asthma patients aged 6 years or older were identified between January 1, 2015, and December 31, 2017, in the IQVIA PharMetrics® Plus database of commercially insured …

How Analogizing Socio-Legal Responses To Organ Transplantation Can Further The Legalization Of Reproductive Genetic Innovation, Myrisha S. Lewis

Faculty Publications

The Nobel Foundation emphasized the significance of genetic innovation to society, science, and medicine by awarding the 2020 Nobel Prize in Chemistry to “the CRISPR/Cas9 genetic scissors.” This Article focuses on “reproductive genetic innovation,” a term that includes cytoplasmic transfer, mitochondrial transfer, and germline or heritable gene editing techniques that are all categorized as “experimental” in the United States. These techniques all use in vitro fertilization, a legal and widely available practice. Yet reproductive genetic innovation has resulted in controversy and numerous barriers including a recurring federal budget rider, threats of federal enforcement action, and the unavailability of federal funding. …

Land Use As A Predictor Of Water Hyacinth (Eichhornia Crassipes) Presence On The Entebbe Coast Of Lake Victoria, Uganda, Zachary Hoffman

Independent Study Project (ISP) Collection

Lake Victoria is shared amongst Tanzania, Kenya, and Uganda and has tremendous ecological, economical, and cultural significance. Within the lake system, there are several problems, including the proliferation of an invasive weed, water hyacinth (Eichhornia crassipes). Therefore, this study aims to assess several factors that may correlate with water hyacinth proliferation. The specific objectives are (1) to identify possible correlations of water hyacinth density and land use around Entebbe, Uganda, and (2) to identify annual trends in water hyacinth coverage, to better inform policy and conservation efforts. Entebbe has a coastline of six land cover types: flooded vegetation, trees, grasses, …

Bird Diversity In The Ecuadorian Chocó: A Proposal For Avitourism In Villaflora And Manduriacu Reserve, Elizabeth Kroger

Independent Study Project (ISP) Collection

Ecuador is rich in avifauna, and the Chocó bioregion of Northwestern Ecuador is a hotspot for bird endemism and diversity. However, many rare and beautiful species are threatened by human activities such as logging and mining. It is essential that communities are able to find alternative solutions that bring economic benefits and improve public health. Avitourism is an economically beneficial and environmentally friendly solution. This study examined avifaunal biodiversity in Villaflora and Manduriacu Reserve, a small town in the cloud forest of the Chocó region. Point counts on pre-existing trails were used to assess bird communities as well as search …

Effective Implementation Of Blended Learning, Carla Macumber

Master's Theses & Capstone Projects

This literature review depicts the current reality of blended learning in schools and the systems that will need to transform in order to fully implement technology into the daily school experience. Since technology is an integral part of society, schools are tasked with how to create and implement curriculums that include aspects of online learning. Moving from traditional education to a new blended learning approach brings about challenges for both teachers and administrators. Teachers must learn to understand new technologies and how to utilize them to teach with 21st Century skills in mind. Administrators need to lead districts through new …

Race-Based Remedies In Criminal Law, Ion Meyn

William & Mary Law Review

This Article evaluates the constitutional feasibility of using race-based remedies to address racial disparities in the criminal system. Compared to white communities, communities of color are over-policed and over-incarcerated. Criminal system stakeholders recognize that these conditions undermine perceptions of legitimacy critical to ensuring public safety. As jurisdictions assiduously attempt race-neutral fixes, they also acknowledge the shortcomings of such interventions. Nevertheless, jurisdictions dismiss the feasibility of deploying more effective race-conscious strategies due to the shadow of a constitutional challenge. The apprehension is understandable. Debates around affirmative action in higher education and government contracting reveal fierce hostility toward race-based remedies.

This Article, …

"Maryland Appeals Court Rejects Bio Mother’S Attempt To Prevent Transgender Teen Daughter From Getting Change Of Name And Gender Designation", Arthur S. Leonard

Other Publications

No abstract provided.

Have We No Shame? A Moral Exemplar Account Of Atonement, Meghan D. Page, Allison Krile Thornton

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Flowcharts Improve Periodontal Diagnosis By Dental And Dental Hygiene Students, Karo Parsegian, Srinivas Ayilavarapu, Tulsi Patel, Harold A Henson, Nikola Angelov

Faculty, Staff and Student Publications

BACKGROUND: In 2017, the American Academy of Periodontology and the European Federation of Periodontology updated the classification of periodontal and peri-implant diseases and conditions. The goal of the present crossover study was to develop straightforward, illustrative flowcharts and determine their impact on the accuracy and speed of diagnosing periodontal conditions by predoctoral dental students (DS) and dental hygiene students (DHS).

METHODS: Two flowcharts (a decision-tree flowchart and one based on the periodontal disease/condition entity) were developed using updated diagnostic determinants proposed by the 2017 classification. A total of 26 second-, third-, and fourth-year DS (DS2, DS3, and DS4, respectively) and …

The Lawyer: Fall 2021, Seattle University School Of Law

Lawyer

No abstract provided.

The Impact Of The Covid-19 Pandemic On People With Rheumatic And Musculoskeletal Diseases: Insights From Patient-Generated Data On Social Media, Katja Reuter, Atul Deodhar, Souzi Makri, Michael Zimmer, Francis Berenbaum, Elena Nikiphorou

Computer Science Faculty Research and Publications

Objectives

During the COVID-19 pandemic, much communication occurred online, through social media. This study aimed to provide patient perspective data on how the COVID-19 pandemic impacted people with rheumatic and musculoskeletal diseases (RMDs), using Twitter-based patient-generated health data (PGHD).

Methods

A convenience sample of Twitter messages in English posted by people with RMDs was extracted between 1 March and 12 July 2020 and examined using thematic analysis. Included were Twitter messages that mentioned keywords and hashtags related to both COVID-19 (or SARS-CoV-2) and select RMDs. The RMDs monitored included inflammatory-driven (joint) conditions (ankylosing spondylitis, RA, PsA, lupus/SLE and gout).

Results …

Re-Evaluating Standards Of Human Subjects Protection For Sensitive Health Data In Social Media Networks, Kar-Hai Chu, Jason Colditz, Jaime Sidani, Michael Zimmer, Brian Primack

Computer Science Faculty Research and Publications

This study addresses ethical questions about conducting health science research using network data from social media platforms. We provide examples of ethically problematic areas related to participant consent, expectation of privacy, and social media networks. Further, to illustrate how researchers can maintain ethical integrity while leveraging social media networks, we describe a study that demonstrates the ability to use social media to identify individuals affected by cancer. We discuss best practices and ethical guidelines for studying social media network data, including data collection, analysis, and reporting.