Digital Commons Network^™

Quantitative Super-Resolution Microscopy, Andrew Barentine

Yale Graduate School of Arts and Sciences Dissertations

The diffraction limit fundamentally restricts the achievable resolution of conventional microscopes, however it can be circumvented if only a subset of fluorophores within a given diffraction-limited volume are simultaneously emitting. Such super-resolution methods routinely achieve tens of nanometer resolution in whole (if not living) cells. However, being relatively young, these techniques still struggle with providing robust, quantitative, and statistically powerful data in a routine manner. Accurate quantification of subcellular features requires an estimate of the achieved spatial resolution, but traditional methods of measuring it do not cope well with these techniques. Effects subject to biological variability additionally require increased population …

Freeman Honors Newsletter, Fall 2021 Issue, Texas Southern University, Thomas F. Freeman Honors College

Honor's College Newsletters

Fall 2021 Newsletter

2022 Western Australian Crop Sowing Guide, B. Shackley, B. Paynter, J. Bucat, M. Seymour, S. Power

Bulletins 4000 -

Welcome to the 2022 edition of the Crop Sowing Guide for WA, which introduces 27 new variety releases: three wheat, nine barley (three recently accredited for malt and six currently under malt evaluation), twelve canola, two field pea and a lentil.

The Crop Sowing Guide for WA has been compiled by officers in the Department of Primary Industries and Regional Development. It provides information to support variety decisions for each of the major crops for the upcoming season.

In this edition, lupin agzones have been reduced from 8 agzones to 6 so that all varieties for each of the major …

Sulcation Of The Intraparietal Sulcus Is Related To Symbolic But Not Non-Symbolic Number Skills, M. Roell, A. Cachia, A. A. Matejko, O. Houdé, D. Ansari, G. Borst

Paediatrics Publications

Understanding the constraints, including biological ones, that may influence mathematical development is of great importance because math ability is a key predictor of career success, income and even psychological well-being. While research in developmental cognitive neuroscience of mathematics has extensively studied the key functional regions for processing numbers, particularly the horizontal segment of intraparietal sulcus (HIPS), few studies have investigated the effects of early cerebral constraints on later mathematical abilities. In this pre-registered study, we investigated whether variability of the sulcal pattern of the HIPS, a qualitative feature of the brain determined in-utero and not affected by brain maturation and …

Dynamic Interplay Of Two Molecular Switches Enabled By The Mek1/2–Erk1/2 And Il-6–Stat3 Signaling Axes Controls Epithelial Cell Migration In Response To Growth Factors, Lyugao Qin, Xuan Cao, Tomonori Kaneko, Courtney Voss, Xuguang Liu, Guoping Wang, Shawn S.C. Li

Paediatrics Publications

Cell migration is an essential physiological process, and aberrant migration of epithelial cells underlies many pathological conditions. However, the molecular mechanisms governing cell migration are not fully understood. We report here that growth factor–induced epithelial cell migration is critically dependent on the crosstalk of two molecular switches, namely phosphorylation switch (P-switch) and transcriptional switch (T-switch). P-switch refers to dynamic interactions of deleted in liver cancer 1 (DLC1) and PI3K with tensin-3 (TNS3), phosphatase and tensin homolog (PTEN), C-terminal tension, and vav guanine nucleotide exchange factor 2 (VAV2) that are dictated by mitogen-activated protein kinase kinase 1/2–extracellular signal–regulated protein kinase 1/2–dependent …

Feminine Hygiene Kits For Girls/Women Worldwide, Deseret Lauree Lazarte

IPS/BAS 495 Undergraduate Capstone Projects

Through research and personal experience I found that there is a disparity for girls and women throughout the world when it comes to a natural occurrence for females, called menstruation. For the sake of brevity, I will use the general term “girls” though I mean to include women, also. In many countries girls don’t understand this monthly feminine process and don’t have the proper equipment to use. In many countries girls are taught wives’ tales on why women menstruate. Because of this they perpetuate the falsehoods to their girls and this leads to insecurities and shame. They also do not …

Cardiovascular Health Intervention In Firefighters, Kyle T. Manuel

Selected Honors Theses

As each year passes, a fatal cardiovascular event continues to be the leading cause of death among on-duty firefighters. Risk factors for a fatal cardiovascular event and cardiovascular health disease (CVD) are obesity, sleep deprivation, weight gain, lack of exercise, unhealthy diet, etc. The research in this thesis lays out the poor association between cardiovascular health and firefighters. Interventional programs that aim to improve the cardiovascular health of firefighters must be implemented universally to all fire departments by the International Association of Firefighters. Pertinent information collected on the cardiovascular health of surveyed firefighters of Hernando County was paradoxical. While most …

A Safety Net: Early Assessment Of Multiple Social Determinants Of Health Risk Factors In The Pediatric Inpatient Population, Emily Caroline Brister

Doctoral Projects

A lack of protocol for screening of social determinants of health (SDH), specifically for pediatric patients, despite national endorsement, is setting a basis for increased rates of negative health outcomes that can follow individuals into adulthood. The PRAPARE tool, or the Protocol for Responding to and Assessing Patients’ Assets, Risks, and Experiences, is a guided national effort to assist healthcare centers in the collection of the necessary social data required to care for patients and act upon their social determinants of health (The National Association of Community Health Centers [NACHC], 2019). This project acted to identify if the early assessment …

Usft Digital Scholarship Services Annual Report: Fy 2020-2021, Digital Scholarship Services

Digital Commons @ USF Publications

This is the annual report for FY 2020-2021, the fifth full year of Digital Scholarship Services (DSS).

Alumni Journal - Volume 92, Number 3, Loma Linda University School Of Medicine

Alumni Journal, School of Medicine

Editorials
2 | From the Editor
4 | From the President
6 | From the Dean

News
8 | Alumni News + This and That
11 | APC 2022 Preview
12 | School of Medicine News
14 | Students
16 | Department Reports: Physical Medicine & Rehabilitation and Cardiology

The New Hospital
20 | Campus Transformation
22 | By the Numbers
24 | Historical Snapshot: LLUH Emergency Department

Features
27 | Mission Stories: Connecting the Disconnected
28 | Chad: Staci Davenport '14
30 | Sierra Leone: James Fernando '16
32 | Angola: Annelisa Olson '04
34 | Guam: Michael Robinson …

Uncovering The Model Minority Narrative: A Case Study On Asian American Students In High-Achieving Schools, Joanne Choi

NERA Conference Proceedings 2021

Asian American students in high-achieving secondary schools often have unique cultural experiences, perspectives, and challenges due to the perpetuation of the “Model Minority” conceptualization coined by sociologist William Peterson. Guided by the theoretical frameworks of Critical Race Theory and Culturally Responsive Teaching from the existing literature by theorists such as Ladson-Billings, Gay, and Paris, my research attempts to devise potential methods for secondary educators to make their classrooms more culturally responsive, address Asian American students' deficits or educational challenges, and eliminate harmful biases.

Research Opportunity For Freshmen And Sophomores, Katie E. Crump, Julie Torruellas Garcia, Emily Schmitt

Trick to the Treat of Internships and Research

No abstract provided.

How To Actually Get An Internship, Zachary Lawrence

Trick to the Treat of Internships and Research

No abstract provided.

Telescribe Scribeamerica - Undergraduate Research Halmos College Of Arts And Sciences, Tanya Mariah

Trick to the Treat of Internships and Research

No abstract provided.

Summer Internship Program In Biomedical Research (Sip), Snigdha Marivada

Trick to the Treat of Internships and Research

No abstract provided.

Crest Project: Protein Modeling Internship, Emily Schmitt Lavin, Lyla Abbas, Arthur Sikora, Pujita Julakanti, Feza Abbas, Sanjana Likki, Matthew Hunt, Carol Manikkuttiyil, Christo Manikkuttiyil, Carolina Alzamora

Trick to the Treat of Internships and Research

No abstract provided.

Unm Medicine Fall 2021, University Of New Mexico, Health Sciences Center, School Of Medicine

School of Medicine Alumni Magazine

No abstract provided.

Unm Medicine, The University Of New Mexico School Of Medicine Alumni Magazine, Fall 2020, Ashley Salazar, Bridgette Wagner Jones, Alexandria Sanchez, Elizabeth Sandlin, David A. Andrade, Supreetha Gubbala, Tenisha Marques, Ruth Morgan, Paige R. Penland, Michael E. Richards, C Nathaniel Roybal, Maggie Schold, Michele W. Sequeria, Jett Loe, Raymond Mares, José Rodriguez, Alan Stone

School of Medicine Alumni Magazine

No abstract provided.

Trauma-Informed Grief Counseling With Older Bipoc Individuals, Jillian M. Blueford, Charmayne R. Adams

Adultspan Journal

No abstract provided.

Using Experimentally Calibrated Regularized Stokeslets To Assess Bacterial Flagellar Motility Near A Surface, Orrin Shindell, Hoa Nguyen, Nicholas Coltharp, Frank G. Healy, B. Rodenborn

Physics and Astronomy Faculty Research

The presence of a nearby boundary is likely to be important in the life cycle and evolution of motile flagellate bacteria. This has led many authors to employ numerical simulations to model near-surface bacterial motion and compute hydrodynamic boundary effects. A common choice has been the method of images for regularized Stokeslets (MIRS); however, the method requires discretization sizes and regularization parameters that are not specified by any theory. To determine appropriate regularization parameters for given discretization choices in MIRS, we conducted dynamically similar macroscopic experiments and fit the simulations to the data. In the experiments, we measured the torque …

Ant 130: Introduction To Biological Anthropology Syllabus (Fall 2021), Britney Kyle

Open Course Materials

This is a science course on human evolution exploring what makes our species unique, strange, and wonderful. We will first learn the biological mechanisms underlying evolution and natural selection. Next, we will look at modern primate variation today (including humans) and learn how to use primates as models to help us learn about the behavior, environments, and lifeways of extinct species. Third, we will interpret data from the human fossil record to understand where, how, when, and in what way modern humans evolved. Finally, we will examine specific modern human traits through this evolutionary lens to build arguments for how …

Ant130: Introduction To Biological Anthropology (Fall 2021), Marian Hamilton

Open Course Materials

This is a science course on human evolution exploring what makes our species unique, strange, and wonderful. We will first learn the biological mechanisms underlying evolution and natural selection. Next, we will look at modern primate variation today (including humans) and learn how to use primates as models to help us learn about the behavior, environments, and lifeways of extinct species. Third, we will interpret data from the human fossil record to understand where, how, when, and in what way modern humans evolved. Finally, we will examine specific modern human traits through this evolutionary lens to build arguments for how …

The College Student Study Playlist: A Comparison Of Genres, John C. Pokhan

Selected Honors Theses

Music has played a significant role in the lives of students. Various genres of music have been studied to determine their specific effects on human behavior. Christian Praise and Worship music is a normal piece of service, whether it is in the chapel and or the church. Wolfgang Amadeus Mozart is a renowned classical music composer whose music has been shown to have positive effects in improving concentration. A student’s emotions are critical when it comes to studying. When a student is studying, they need to concentrate and work on their assignment with confidence, inspiration, and excitement while managing their …

Novel Phosphatidylserine-Binding Molecule Enhances Antitumor T-Cell Responses By Targeting Immunosuppressive Exosomes In Human Tumor Microenvironments., Maulasri Bhatta, Gautam N Shenoy, Jenni L Loyall, Brian D Gray, Meghana Bapardekar, Alexis Conway, Hans Minderman, Raymond J Kelleher, Beatriz M Carreno, Gerald Linette, Leonard D. Shultz, Kunle Odunsi, Sathy V Balu-Iyer, Koon Yan Pak, Richard B Bankert

Faculty Research 2021

BACKGROUND: The human tumor microenvironment (TME) is a complex and dynamic milieu of diverse acellular and cellular components, creating an immunosuppressive environment, which contributes to tumor progression. We have previously shown that phosphatidylserine (PS) expressed on the surface of exosomes isolated from human TMEs is causally linked to T-cell immunosuppression, representing a potential immunotherapeutic target. In this study, we investigated the effect of ExoBlock, a novel PS-binding molecule, on T-cell responses in the TME.

METHODS: We designed and synthesized a new compound, (ZnDPA)

RESULTS: ExoBlock was able to bind PS with high avidity and was found to consistently and significantly …

Testing The Role Of Wfs1 In Calcium Regulation In Drosophila Cells, Briana Scott, Alyandra Lee

Fall Showcase for Research and Creative Inquiry

The purpose of the project is to knock out the Wfs1 gene in Drosophila (fruit fly) cells and test the hypothesis that this gene is involved in regulating intracellular calcium levels. To test this hypothesis, the gene will first be knocked out using CRISPR-Cas9 molecular tools that are readily available in Dr. Shanle's lab. This will effectively inactivate the Wsf1 gene in cells. To do this, we will transfect Drosophila cells with CRISPR-Cas9 targeting the gene. Next, we will confirm that the gene is mutated using genomic DNA purification, polymerase chain reaction, and sequencing. Finally, we will treat cells with …

Analysis Of Oxycontin Addiction And Recovery From Both A Physical And Psychological Lens, Meagan Munley, Carrie Flickinger

Fall Showcase for Research and Creative Inquiry

We will investigate the physical impacts both short and long term effects of of substance use. In doing so we will frame an argument for the substance's addictive properties as it relates to both its physically addictive and sociological addictive properties. In doing, so a stronger understanding of how an individual can move through the stages of substance use, to abuse, and finally addiction will be reviewed. We will then address current treatment strategies for the substance and how they address or fail to address both the physical and sociological impacts of its use.

Risk Assessment Of Blackbird Mine, Tinsae Alem

Fall Showcase for Research and Creative Inquiry

The risk assessment process involves identifying and characterizing hazards, determining dose-response relationships, and assessing possible exposures to toxins in order to inform risk management. The goal of this project was to complete the steps of a risk assessment and develop a perspective on risk management. Data collected from publicly available databases, scholarly articles, and targeted sources were used to perform a risk assessment for Blackbird Mine. Social, economic, political, and/or legal perspectives were considered when determining the best risk management approaches.

Risk Assessment Of Blackbird Mine, Eli Caldwell

Fall Showcase for Research and Creative Inquiry

The risk assessment process involves identifying and characterizing hazards, determining dose-response relationships, and assessing possible exposures to toxins in order to inform risk management. The goal of this project was to complete the steps of a risk assessment and develop a perspective on risk management. Data collected from publicly available databases, scholarly articles, and targeted sources were used to perform a risk assessment for Blackbird Mine. Social, economic, political, and/or legal perspectives were considered when determining the best risk management approaches.

Risk Assessment Of Pcb Exposure From Mvp In Southwest, Va, Elizabeth Garri

Fall Showcase for Research and Creative Inquiry

The risk assessment process involves identifying and characterizing hazards, determining dose-response relationships, and assessing possible exposures to toxins in order to inform risk management. The goal of this project was to complete the steps of a risk assessment and develop a perspective on risk management. Data collected from publicly available databases, scholarly articles, and targeted sources were used to perform a risk assessment for PCB exposure from MVP in Southwest Virginia. Social, economic, political, and/or legal perspectives were considered when determining the best risk management approaches.

Risk Assessment Of Anaconda Copper Mine, Kelly Jarratt

Fall Showcase for Research and Creative Inquiry

The risk assessment process involves identifying and characterizing hazards, determining dose-response relationships, and assessing possible exposures to toxins in order to inform risk management. The goal of this project was to complete the steps of a risk assessment and develop a perspective on risk management. Data collected from publicly available databases, scholarly articles, and targeted sources were used to perform a risk assessment for Anaconda Copper Mine. Social, economic, political, and/or legal perspectives were considered when determining the best risk management approaches.