Digital Commons Network^™

Defining The Innate Immune Responses For Sars-Cov-2-Human Macrophage Interactions, Mai M. Abdelmoaty, Pravin Yeapuri, Jatin Machhi, Katherine E. Olson, Farah Shahjin, Vikas Kumar, You Zhou, Jingjing Liang, Kabita Pandey, Arpan Acharya, Siddappa N. Byrareddy, R. Lee Mosley, Howard E. Gendelman

Nebraska Center for Biotechnology: Faculty and Staff Publications

Host innate immune response follows severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and it is the driver of the acute respiratory distress syndrome (ARDS) amongst other inflammatory end-organ morbidities. Such life-threatening coronavirus disease 2019 (COVID-19) is heralded by virus-induced activation of mononuclear phagocytes (MPs; monocytes, macrophages, and dendritic cells). MPs play substantial roles in aberrant immune secretory activities affecting profound systemic inflammation and end-organ malfunctions. All follow the presence of persistent viral components and virions without evidence of viral replication. To elucidate SARS-CoV- 2-MP interactions we investigated transcriptomic and proteomic profiles of human monocyte-derived macrophages. While expression of the …

The Roles Of Growth Mindset And Rational Beliefs As Personal Resources On Employees’ Job Performance And Work Engagement : Applying The Job Demands-Resources Model In The Greater Bay Area, Nuoxun Lin

Lingnan Theses (MPhil & PhD)

The purpose of the thesis is to investigate certain kinds of personal resources, especially growth mindset and rational beliefs, that could equip employees who work and live in the Greater Bay Area (GBA) to enhance their job performance to face a competitive and everchanging workplace.

The current research consists of three studies: Study 1 (N = 801, 61.5% female) was a cross-sectional survey which examined the structural validity and relationships between growth mindset, rational beliefs, work engagement, and job performance in the motivational path of the JD-R model. We collected data from Hong Kong and mainland China. Study 2 (N …

A Guide For Authors And Readers Of The American Society For Nutrition Journals On The Proper Use Of P Values And Strategies That Promote Transparency And Improve Research Reproducibility, John D Sorkin, Mark Manary, Paul A M Smeets, Amanda J Macfarlane, Arne Astrup, Ronald L Prigeon, Beth B Hogans, Jack Odle, Teresa A Davis, Katherine L Tucker, Christopher P Duggan, Deirdre K Tobias

Children’s Nutrition Research Center Staff Publications

Two questions regarding the scientific literature have become grist for public discussion: 1) what place should P values have in reporting the results of studies? 2) How should the perceived difficulty in replicating the results reported in published studies be addressed? We consider these questions to be 2 sides of the same coin; failing to address them can lead to an incomplete or incorrect message being sent to the reader. If P values (which are derived from the estimate of the effect size and a measure of the precision of the estimate of the effect) are used improperly, for example …

Clinically Translatable Approaches Of Inhibiting Tgf-Β To Target Cancer Stem Cells In Tnbc, Andrew Sulaiman, Sarah Mcgarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod

Student Publications

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that disproportionally accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. In this review, we highlight the complexity of the transforming growth factor-beta family (TGF-β) pathway and discuss how the dysregulation of the TGF-β pathway promotes oncogenic attributes in TNBC, which negatively affects patient prognosis. Moreover, we discuss recent findings highlighting TGF-β inhibition as a potent method to target mesenchymal (CD44+/CD24-) and epithelial (ALDHhigh) cancer stem cell (CSC) populations. CSCs are associated with tumorigenesis, metastasis, relapse, resistance, and diminished patient prognosis; …

Role Of Enhancers In Development And Diseases, Shailendra S Maurya

Open Access Publications

Enhancers are cis-regulatory elements containing short DNA sequences that serve as binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of genes critical for lineage determination. The activity of enhancer elements is believed to be determined by transcription factor binding, thus determining the cell state identity during development. Precise spatio-temporal control of the transcriptome during lineage specification requires the coordinated binding of lineage-specific transcription factors to enhancers. Thus, enhancers are the primary determinants of cell identity. Numerous studies have explored the role and mechanism of enhancers during development and disease, and various basic questions related to the functions and …

Clinically Translatable Approaches Of Inhibiting Tgf-Β To Target Cancer Stem Cells In Tnbc., Andrew Sulaiman, Sarah Mcgarry, Sai Charan Chilumula, Rohith Kandunuri, Vishak Vinod

Manuscripts, Articles, Book Chapters and Other Papers

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that disproportionally accounts for the majority of breast cancer-related deaths due to the lack of specific targets for effective treatments. In this review, we highlight the complexity of the transforming growth factor-beta family (TGF-β) pathway and discuss how the dysregulation of the TGF-β pathway promotes oncogenic attributes in TNBC, which negatively affects patient prognosis. Moreover, we discuss recent findings highlighting TGF-β inhibition as a potent method to target mesenchymal (CD44+/CD24-) and epithelial (ALDHhigh) cancer stem cell (CSC) populations. CSCs are associated with tumorigenesis, metastasis, relapse, resistance, and diminished patient prognosis; …

Chimes: October 4, 2021, Calvin University

Chimes

Waking up from a nightmare, CTC finally performs "A Midsummer Night's Dream" by Ezra Craker

Short-staffed dining halls are still searching for employees by Lauren Vanden Bosch

Ready to UnLearn: CISD to host 22nd annual UnLearn Week by Jocelyn Nunez-Colon

Dual enrollment, language immersion programs bridge gap between campus and local schools by Hadassa Ribeiro

Hungary semester first off-campus program to return by Abigail Ham

Pop Scholars: Smart-dumb comedy born from a smart-dumb education by Isaiah Tenhuisen

Code red: Calvin community speaks on sustainability, responsibility by Timothy Lin

Friday Night Soccer fosters community in spite of unofficial status this year …

The Nature Of Middle-Earth (2021) By J.R.R. Tolkien, Edited By Carl F. Hostetter, Douglas C. Kane

Journal of Tolkien Research

Book review, by Douglas C. Kane, of The Nature of Middle-earth (2021), by J.R.R. Tolkien, edited by Carl F. Hostetter

Feature Engineering Vs Feature Selection Vs Hyperparameter Optimization In The Spotify Song Popularity Dataset, Alan Cueva Mora, Brendan Tierney

Conference Papers

Research in Featuring Engineering has been part of the data pre-processing phase of machine learning projects for many years. It can be challenging for new people working with machine learning to understand its importance along with various approaches to find an optimized model. This work uses the Spotify Song Popularity dataset to compare and evaluate Feature Engineering, Feature Selection and Hyperparameter Optimization. The result of this work will demonstrate Feature Engineering has a greater effect on model efficiency when compared to the alternative approaches.

Near-Field Imaging Of Plasmonic Nanopatch Antennas With Integrated Semiconductor Quantum Dots, Vasudevan Iyer, Yoong Sheng Phang, Andrew Butler, Jiyang Chen, Brian Lerner, Christos Argyropoulos, Thang Hoang, Benjamin Lawrie

Department of Electrical and Computer Engineering: Faculty Publications

Plasmonic nanopatch antennas that incorporate dielectric gaps hundreds of picometers to several nanometers thick have drawn increasing attention over the past decade because they confine electromagnetic fields to grossly sub-diffraction-limited volumes. Substantial control over the optical properties of excitons and color centers confined within these plasmonic cavities has already been demonstrated with far-field optical spectroscopies, but near-field optical spectroscopies are essential for an improved understanding of the plasmon–emitter interaction at the nanoscale. Here, we characterize the intensity and phase-resolved plasmonic response of isolated nanopatch antennas by cathodoluminescence microscopy. Furthermore, we explore the distinction between optical and electron beam spectroscopies of …

Preoperative Assessment And Management Of Cardiovascular Risk In Patients Undergoing Non-Cardiac Surgery: Implementing A Systematic Stepwise Approach During The Covid-19 Pandemic Era, Eduardo Bossone, Filippo Cademartiri, Hani Alsergani, Salvatore Chianese, Rahul Mehta, Valentina Capone, Carlo Ruotolo, Imran H. Tarrar, Antonio Frangiosa, Olga Vriz, Vincenzo Maffei, Roberto Annunziata, Domenico Galzerano, Brigida Ranieri, Chiara Sepe, Andrea Salzano, Rosangela Cocchia, Massimo Majolo, Giuseppe Russo, Giuseppe Longo, Mario Muto, Paolo Fedelini, Ciro Esposito, Alessandro Perrella, Gianluca Guggino, Eliana Raiola, Mara Catalano, Maurizio De Palma, Luigia Romano, Gaetano Romano, Ciro Coppola, Ciro Mauro, Rajendra H. Mehta

Hospital Medicine Articles

Major adverse cardiac events, defined as death or myocardial infarction, are common causes of perioperative mortality and major morbidity in patients undergoing non-cardiac surgery. Reduction of perioperative cardiovascular risk in relation to non-cardiac surgery requires a stepwise patient evaluation that integrates clinical risk factors, functional status and the estimated stress of the planned surgical procedure. Major guidelines on preoperative cardiovascular risk assessment recommend to establish, firstly, the risk of surgery per se (low, moderate, high) and the related timing (elective vs. urgent/emergent), evaluate the presence of unstable cardiac conditions or a recent coronary revascularization (percutaneous coronary intervention or coronary artery …

Molecular Characterization Of Western Corn Rootworm Pyrethroid Resistance, Dariane Souza, Blair D. Siegfried, Lance Meinke, Nicholas J. Miller

Department of Entomology: Faculty Publications

Background: Western corn rootworm (WCR) pyrethroid resistance has been confirmed in the western US Corn Belt. Toxicological and biochemical studies indicated that multiple mechanisms of resistance might be involved in the resistance trait, such as enhanced metabolism and/or kdr target-site mutation(s) in the voltage-gated sodium channels. To characterize the mechanisms of WCR pyrethroid resistance at the molecular level, pairwise comparisons were made between RNA-Seq data collected from pyrethroid-resistant and -susceptible WCR populations. Gene expression levels and sodium channel sequences were evaluated.

Results: Seven transcripts exhibited significantly different expression (q ≤ 0.05) when comparing field-collected pyrethroidresistant (R-Field) and -susceptible (S-Field) WCR …

Assessing Q&A Trends In Scholarly Communications: A Quantitative Study Of Researchgate, Subhajit Panda, Simran Kaur, Heenam Gakhar, Pooja Kumari, Rupak Chakravarty Prof

Library Philosophy and Practice (e-journal)

The purpose of the study is to explore and analyse the disciplinary question and answer (Q&A) trends prevailing in the scientific social network (SCN)/scientific collaborative network (SCN) also known as an academic social network (ASN), ResearchGate (RG) and to examine the subject wise status of Q&A, content sharing trends of Q & A on RG and statistical analysis of various tests. The present study adopted a quantitative research design (Correlational as well as explanatory) to pursue the research questions and objectives for conducting the study. The data was collected from the research gate (RG) platform and 35 subjects were selected …

Wearing Makeup At Work: Negotiating Grooming Standards In The Workplace (A Roundtable Discussion For Curious Employees), Irena Djukic

Dalhousie Journal of Legal Studies

Wearing makeup is a common grooming practice both in one’s personal and professional life. Yet, in the workplace, gender-specific grooming policies that enforce women to wear makeup present difficult questions as to what employees may expect from their employer and generally, their work environment. Imposing makeup as a grooming standard and requirement for women has various implications for both employees and employers in the workplace. This article aims to explore whether an employer can require their female employees to wear makeup at work. Several themes are discussed to analyze how makeup is a grooming standard and requirement in the workplace. …

Elixir And Toxicology: A Community In Development, Marvin Martens, Rob Stierum, Emma L Schymanski, Chris T Evelo, Reza Aalizadeh, Hristo Aladjov, Kasia Arturi, Karine Audouze, Pavel Babica, Karel Berka, Jos Bessems, Ludek Blaha, Evan E Bolton, Montserrat Cases, Dimitrios Ε Damalas, Kirtan Dave, Marco Dilger, Thomas Exner, Daan P Geerke, Roland Grafström, Alasdair Gray, John M Hancock, Henner Hollert, Nina Jeliazkova, Danyel Jennen, Fabien Jourdan, Pascal Kahlem, Jana Klanova, Jos Kleinjans, Todor Kondic, Boï Kone, Iseult Lynch, Uko Maran, Sergio Martinez Cuesta, Hervé Ménager, Steffen Neumann, Penny Nymark, Herbert Oberacher, Noelia Ramirez, Sylvie Remy, Philippe Rocca-Serra, Reza M Salek, Brett Sallach, Susanna-Assunta Sansone, Ferran Sanz, Haralambos Sarimveis, Sirarat Sarntivijai, Tobias Schulze, Jaroslav Slobodnik, Ola Spjuth, Jonathan Tedds, Nikolaos Thomaidis, Ralf J M Weber, Gerard J P Van Westen, Craig E Wheelock, Antony J Williams, Hilda Witters, Barbara Zdrazil, Anže Županič, Egon L Willighagen

Faculty, Staff and Student Publications

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditionally, toxicology has strong links with other fields such as biology, chemistry, pharmacology and medicine. With the rise of synthetic and new engineered materials, alongside ongoing prioritisation needs in chemical risk assessment for existing chemicals, early predictive evaluations are becoming of utmost importance to both scientific and regulatory purposes. ELIXIR is an intergovernmental organisation that brings together life science resources from across Europe. To coordinate the …

A Case Report Of A Patient On Therapeutic Warfarin Who Died Of Covid-19 Infection With A Sudden Rise In D-Dimer, Reita N. Agarwal, Hersheth Aggarwal, Ashmit Verma, Manish Tripathi

School of Medicine Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has disrupted social and economic life globally. The global pandemic COVID-19 caused by this novel SARS-CoV-2 shows variable clinical manifestations, complicated further by cytokine storm, co-infections, and coagulopathy, leading to severe cases and death. Thrombotic complications arise due to complex and unique interplay between coronaviruses and host cells, inflammatory response, and the coagulation system. Heparin and derivatives are World Health Organization (WHO) recommended anticoagulants for moderate and severe Corona Virus Disease 19 (COVID-19), that can also inhibit viral adhesion to the cell membrane by interfering with heparan sulfate-dependent binding to angiotensin-converting enzyme …

Erythrodermic Psoriasis Exacerbated By Bupropion, Michael Foss, Timothy A. Nyckowski, William Steffes

GME Publications

Erythroderma is a rare, potentially life-threatening presentation of psoriasis that can be triggered by medication reactions. Bupropion is indicated for major depressive disorder (Wellbutrin®, GlaxoSmithKline, Research Triangle Park, NC), smoking cessation (Zyban®, GlaxoSmithKline, Research Triangle Park, NC), and weight loss (when in formulation with naltrexone ER; Contrave®, Orixegen Therapeutics, La Jolla, CA). Bupropion can exacerbate psoriasis, however, this is an under-recognized side effect of the medication, particularly in the United States. We report a case of bupropion-induced erythrodermic psoriasis in a 62-year-old female who was prescribed the medication for depression. Due to the common comorbidities of depression, obesity, and tobacco …

Application Of Near Infrared Reflectance Spectroscopy (Nirs) To Forage Evaluation In Uruguay, D. Cozzolino, Y. Acosta, J. Garcia

IGC Proceedings (1977-2023)

Near infrared reflectance spectroscopy (NIRS) were used to assess the chemical composition of a wide range of forages. Nearly five hundred herbage samples covering a wide range of temperate pastures species and mixtures, previously analysed by conventional wet chemistry were scanned in reflectance with a NIRS 6500 (NIRSystems, Silver Spring, USA). The coefficients of determination in calibration (R² ) and the errors in cross validation (SECV) were 0.98 (5.8), 0.94 (22.2), 0.97 (5.6), 0.94 (6.9) and 0.89 (19.7) for crude protein, in vitro organic matter digestibility, dry matter, ash and acid detergent fiber, in g kg ^–1 on a …

Seasonal Variation Of Brachiaria Spp. Quality In The Pantanal Of Mato Grosso Do Sul, Brazil, S. M. A. Crispim, E. L. Cardoso, F. Fernandes

IGC Proceedings (1977-2023)

This study aims to evaluate the dry matter yield and the crude protein (CP) of Brachiaria decumbens and Brachiaria humidicola and soil covering by these species, considering stand lasting age and hydrologic cycle periods in the Pantanal, from November 1996 to November 1997. Dry matter yield presented differences between hydrologic cycle periods and age, and their interactions. B. decumbens and B. humidicola over 10 years comparison yielded the largest amount of dry matter yield, observed in February. B. humidicola growth rate was slower than B. decumbens. Pastures stand ages did not cause differences in crude protein, but differences have …

Continuous Digestibility Assessment Of Tropical Grasses, A. Chudy, T. Schmidt, A. Glatzle

IGC Proceedings (1977-2023)

The feed value for cattle of three tropical grasses, Gatton (Panicum maximum cv. Gatton), Estrella (Cynodon plectostachyus) and Tifton-85 (Cynodon sp. cv. Tifton-85) was investigated during the growing period, using the method of “continuous digestibility estimation”. Results indicate that feed value is hardly influenced by the growth stage from the 90th day on. Common European in-vitro feed evaluation procedures are not to be recommended for tropical grasses as they presented consistently lower values than did in-vivo measurements.

Prediction Of Intake Of Hay Differing In Species And Maturity By Goats, S. W. Coleman, S. P. Hart, T. Sahlu

IGC Proceedings (1977-2023)

Eight species of forage, a cool-season perennial (Festuca arundinacea) and annual grass (Triticum aestivum), four warm-season perennial grasses (Bothriochloa caucasica, B. ischaemum, Cynodon dactylon, and Tripsacum dactyloides), a warm season annual (Digitaria sanguinalis) and a perennial legume (Medicago sativa), were cut at two or three maturities to provide a wide array of quality difference (n=20). Twenty wether goats (Capra hicus) were fed the hays in four different trials using an incomplete block so that each hay was fed to four different goats. Alfalfa produced the highest DM, …

Climatic Factors, Acid Detergent Fiber, Neutral Detergent Fiber And Crude Protein Contents In Digitgrass, C. S. Chen, S. M. Wang, Y. K. Chang

IGC Proceedings (1977-2023)

Digitgrass (Digitaria Xumifolia) was treated according to a set of programmed harvest cycles to study the impact of climatic factors on the quality of the grass. It is found that seasonal changes have greater effect on the quality of the grass than does the length of the harvest cycle. The highest correlation coefficient (0.81) between the ADF content and accumulated temperature is attained when the base temperature is set to 15.5 , while the highest correlation coefficient (0.88) between CP and is attained at a base temperature of 15.0 . The determination coefficient of regression (R² ) …

أسباب حدوث الاكتساب، ملاحظات حول تعلم اللغة العربية, يوسف باش

Dirassat

Reasons for Acquisition: Notes on Learning Arabic

The research deals with the issue of acquisition and learning theory from multiple angles such as linguistics, philosophy, psychology, biology, issues of acquisition and instinct, characteristics of acquisition in modern theories, and generative grammar.

Influences Of Gender And Sex-Stereotyping Of Middle School Student's Perception And Selection Of Musical Instruments: A Review Of The Literature, Mark J. Walker

Visions of Research in Music Education

Gender stereotypes continue to persist at all levels regarding male and female participation in music. Indeed, stereotypes are evident at the elementary and middle school levels when children choose a musical instrument for study in beginning band or orchestra. Research has shown sex-stereotyping of instruments to exist, often unconsciously, in both males and females. Usually, trombones, drums, tubas are viewed as being overtly masculine instruments while the flute, clarinet, and oboe are viewed as being overtly feminine instruments. These masculine and feminine characteristics that are placed on these instruments are often transferred to the individual who plays them. These stereotypes …

Influences Of Gender And Sex-Stereotyping Of Middle School Student's Perception And Selection Of Musical Instruments: A Review Of The Literature, Mark J. Walker

Visions of Research in Music Education

Gender stereotypes continue to persist at all levels regarding male and female participation in music. Indeed, stereotypes are evident at the elementary and middle school levels when children choose a musical instrument for study in beginning band or orchestra. Research has shown sex-stereotyping of instruments to exist, often unconsciously, in both males and females. Usually, trombones, drums, tubas are viewed as being overtly masculine instruments while the flute, clarinet, and oboe are viewed as being overtly feminine instruments. These masculine and feminine characteristics that are placed on these instruments are often transferred to the individual who plays them. These stereotypes …

Effect Of Level Of Surface Spoilage On The Nutritive Value Of Maize Silage Diets, K. K. Bolsen, L. A. Whitlock, G. L. Huck, M. K. Siefers, T. E. Schmidt, R. V. Pope, M. E. Uriarte

IGC Proceedings (1977-2023)

This study determined the effect of surface spoilage in the diet on feed intake and nutrient digestibilities using growing steers fed whole-plant maize silage-based diets. A bunker silo, 0.9 m in depth, and a 2.7 m diameter AgBag were filled with alternating loads of chopped forage. After 90 days, the bunker was sealed with a sheet of polyethylene, and this silage was designated “spoiled”. The silage in the AgBag was designated “normal”. The four diets contained 90% silage and 10% supplement (dry matter basis), and the proportions of silage in the diets were A) 100% normal, B) 75% normal: 25% …

Selenium And Sulphur Concentrations In Primary Growths Of Different Plant Communities, W. Opitz Von Boberfeld

IGC Proceedings (1977-2023)

The factorised evaluated data of seven different grassland swards and two harvest dates of primary growths led to following results: Regarding the concentrations of selenium and sulphur, a selenium antagonist, and the N/S ratio, there were no significant plant community x harvest date, plant community x year, and harvest date x year interactions. The selenium concentrations, which never met the requirements of ruminants, were the highest in young herbage of a Bromion racemosi community reaching 49 µg kg^-1 DM. The average of all swards and treatments was 33 µg kg^-1 DM of selenium. Apparently, repeated application of selenate-bearing …

Canopy Characteristics, Ingestive Behaviour And Herbage Intake In Cultivated Tropical Grasslands, Lynn E. Sollenberger, J. C. Burns

IGC Proceedings (1977-2023)

Compared to temperate systems, there have been few detailed assessments of canopy characteristics and associated grazing behavior in planted tropical grasslands. Reasons include the large number of forage species used in warm climates, the diversity of their morphology, research priorities emphasizing germplasm evaluation and management, and limited resources. This review describes canopy attributes of C₄ grass pastures, highlights the most important relationships between grazing behavior and these canopy characteristics, and discusses the implications of canopy characteristics and grazing behavior for long-term intake and animal performance. It is suggested that the largest differences in canopy characteristics between tropical and temperate …

Foraging Behaviour And Intake In Temperate Cultivated Grasslands, S. Prache, J. L. Peyraud

IGC Proceedings (1977-2023)

In temperate areas, grazing provides a large part of the nutrient requirements of ruminants and may be an important form of land use. In Europe, grassland occupies some 150 million hectares, and grazing provides about 60 to 75% of the nutrient requirements of cattle (Wilkins and Vidrih 2000). From the end of the 80’s, agricultural surpluses in Europe have led to production quotas and increased interest in more extensive systems. At the beginning of the 90’s, the emergence of the notion of sustainable agriculture combining economic, social (concerns in dereliction of less-favoured rural areas), and environmental issues (pollution, loss of …

2021 Annual Dinner Program, The O'Callahan Society, College Of The Holy Cross

O'Callahan Society Annual Dinner Program

The O'Callahan Society resumes the tradition of an annual dinner after a two-year hiatus. This year's speaker is R. Peter Kimener ’67, a leader in business and a Silver Star recipient for his actions in the Vietnam War

This year we salute those who have served since 9/11/01 and mark the 80th anniversary of the NROTC Program on the Holy Cross campus.