Digital Commons Network^™

A Prospective Observational Study Of Antihemophilic Factor (Recombinant) Prophylaxis Related To Physical Activity Levels In Patients With Hemophilia A In The United States (Space), Barbara A. Konkle, Doris V. Quon, Leslie Raffini, Michael Recht, Vlad C. Radulescu, Shannon L. Carpenter, Amy L. Dunn, Mei Lu, Maureen Watt

Pediatrics Faculty Publications

Introduction: High collision-risk physical activity can increase bleeding risk in people with hemophilia A, as can increasing the time between factor VIII (FVIII) administration and physical activity. FVIII prophylaxis may be tailored to planned activities to prevent activity-related bleeding.

Aim: To explore the relationship between physical activity levels, FVIII infusion timing, and occurrence of bleeding in patients with severe/moderately severe hemophilia A without FVIII inhibitors receiving antihemophilic factor (recombinant) (rAHF; ADVATE^®; Baxalta US Inc., a Takeda company, Lexington, MA, USA).

Methods: SPACE was a 6-month, prospective, multicenter, observational outcomes study (NCT02190149). Enrolled patients received an eDiary application and …

Garnet & Black Fall 2021, University Of South Carolina, Office Of Student Media

Garnet & Black Magazine

No abstract provided.

Whalesong 2021-10-14 (V.41 No.6), Mike Flunker, Margaret Everson, Kenedy Williams, Lucas Stewart, Sierra Lissick, Becky Iverson, Sam Kito Iii, Mary Glaves

Whalesong

No abstract provided.

Ahdc1 Missense Mutations In Xia-Gibbs Syndrome, Michael M. Khayat, Jianhong Hu, Yunyun Jiang, He Li, Varuna Chander, Moez Dawood, Adam W. Hansen, Shoudong Li, Jennifer Friedman, Laura A. Cross, Emilia K. Bijlsma, Claudia A L Ruivenkamp, Francis H. Sansbury, Jeffrey W. Innis, Jessica Omark O'Shea, Qingchang Meng, Jill A. Rosenfeld, Kirsty Mcwalter, Michael F. Wangler, James R. Lupski, Jennifer E. Posey, David Murdock, Richard A. Gibbs

Manuscripts, Articles, Book Chapters and Other Papers

Xia-Gibbs syndrome (XGS; MIM: 615829) is a phenotypically heterogeneous neurodevelopmental disorder (NDD) caused by newly arising mutations in the AT-Hook DNA-Binding Motif-Containing 1 (AHDC1) gene that are predicted to lead to truncated AHDC1 protein synthesis. More than 270 individuals have been diagnosed with XGS worldwide. Despite the absence of an independent assay for AHDC1 protein function to corroborate potential functional consequences of rare variant genetic findings, there are also reports of individuals with XGS-like trait manifestations who have de novo missense AHDC1 mutations and who have been provided a molecular diagnosis of the disorder. To investigate a potential …

A Prospective Observational Study Of Antihemophilic Factor (Recombinant) Prophylaxis Related To Physical Activity Levels In Patients With Hemophilia A In The United States (Space)., Barbara A. Konkle, Doris V. Quon, Leslie Raffini, Michael Recht, Vlad C. Radulescu, Shannon L. Carpenter, Amy L. Dunn, Mei Lu, Maureen Watt

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: High collision-risk physical activity can increase bleeding risk in people with hemophilia A, as can increasing the time between factor VIII (FVIII) administration and physical activity. FVIII prophylaxis may be tailored to planned activities to prevent activity-related bleeding.

Aim: To explore the relationship between physical activity levels, FVIII infusion timing, and occurrence of bleeding in patients with severe/moderately severe hemophilia A without FVIII inhibitors receiving antihemophilic factor (recombinant) (rAHF; ADVATE®; Baxalta US Inc., a Takeda company, Lexington, MA, USA).

Methods: SPACE was a 6-month, prospective, multicenter, observational outcomes study (NCT02190149). Enrolled patients received an eDiary application and …

Untargeted Metabolomic Analysis Of Human Milk From Mothers Of Preterm Infants, Lila S Nolan, Angela N Lewis, Qingqing Gong, James J Sollome, Olivia N Dewitt, Robert D Williams, Misty Good

2020-Current year OA Pubs

The application of metabolomics in neonatology offers an approach to investigate the complex relationship between nutrition and infant health. Characterization of the metabolome of human milk enables an investigation into nutrients that affect the neonatal metabolism and identification of dietary interventions for infants at risk of diseases such as necrotizing enterocolitis (NEC). In this study, we aimed to identify differences in the metabolome of breast milk of 48 mothers with preterm infants with NEC and non-NEC healthy controls. A minimum significant difference was observed in the human milk metabolome between the mothers of infants with NEC and mothers of healthy …

Irreproducibility In Searches Of Scientific Literature: A Comparative Analysis, Gábor Pozsgai, Gábor L. Lövei, Liette Vasseur, Geoff Gurr, Péter Batáry, János Korponai, Nick A. Littlewood, Jian Liu, Arnold Móra, John J. Obrycki, Olivia Reynolds, Jenni A. Stockan, Heather Vanvolkenburg, Jie Zhang, Wenwu Zhou, Minsheng You

Entomology Faculty Publications

1. Repeatability is the cornerstone of science, and it is particularly important for systematic reviews. However, little is known on how researchers’ choice of database, and search platform influence the repeatability of systematic reviews. Here, we aim to unveil how the computer environment and the location where the search was initiated from influence hit results.
2. We present a comparative analysis of time-synchronized searches at different institutional locations in the world and evaluate the consistency of hits obtained within each of the search terms using different search platforms.
3. We revealed a large variation among search platforms and showed that PubMed and Scopus …

Role Of Gut Microbiome In Covid-19: An Insight Into Pathogenesis And Therapeutic Potential, Ikram Hussain, Gabriel Liu Yuan Cher, Muhammad Abbas Abid, Muhammad Bilal Abid

Department of Pathology and Laboratory Medicine

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulted in an unprecedented global crisis. Although primarily a respiratory illness, dysregulated immune responses may lead to multi-organ dysfunction. Prior data showed that the resident microbial communities of gastrointestinal and respiratory tracts act as modulators of local and systemic inflammatory activity (the gut-lung axis). Evolving evidence now signals an alteration in the gut microbiome, brought upon either by cytokines from the infected respiratory tract or from direct infection of the gut, or both. Dysbiosis leads to a "leaky gut". The intestinal permeability then allows access to …

Rapid Analysis Of Adp-Ribosylation Dynamics And Site-Specificity Using Tlc-Maldi, Sean R. Wallace, Leila Y. Chihab, Miles Yamasaki, Braden T. Yoshinaga

Chemistry and Biochemistry

Poly(ADP-ribose) polymerases, PARPs, transfer ADP-ribose onto target proteins from nicotinamide adenine dinucleotide (NAD+). Current mass spectrometric analytical methods require proteolysis of target proteins, limiting the study of dynamic ADP-ribosylation on contiguous proteins. Herein, we present a matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) method that facilitates multisite analysis of ADP-ribosylation. We observe divergent ADP-ribosylation dynamics for the catalytic domains of PARPs 14 and 15, with PARP15 modifying more sites on itself (+3–4 ADP-ribose) than the closely related PARP14 protein (+1–2 ADP-ribose)─despite similar numbers of potential modification sites. We identify, for the first time, a minimal peptide fragment (18 amino-acids) that is preferentially …

Tardive Dyskinesia In Older Persons Taking Antipsychotics, Leslie Citrome, Stuart H Isaacson, Danielle Larson, Daniel Kremens

Department of Neurology Faculty Papers

Tardive dyskinesia (TD) is a hyperkinetic movement disorder caused by the use of dopamine receptor-blocking agents (DRBAs), a category of medications that includes first-and second-generation antipsychotics (APs) and agents such as metoclopramide that are used for the treatment of nausea and gastrointestinal dysmotility. While TD can affect people of all ages, older age is associated with increased risk of TD and also with the emergence of TD occurring after shorter treatment durations and lower dosages of DRBAs. TD is characterized by involuntary movements that include the face, limbs, and trunk, and is associated with increased comorbidities, social stigmatization, and impaired …

Global Gene Expression Analysis Of Systemic Sclerosis Myofibroblasts Demonstrates A Marked Increase In The Expression Of Multiple Nbpf Genes, Giuseppina Abignano, Heidi Hermes, Sonsoles Piera-Velazquez, Sankar Addya, Francesco Del Galdo, Sergio A. Jimenez

Kimmel Cancer Center Faculty Papers

Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described. The purpose of this study was to identify transcriptome differences between SSc myofibroblasts and non-myofibroblastic cells. Alpha smooth muscle actin (α-SMA) expressing myofibroblasts and α-SMA negative cells were isolated employing laser capture microdissection from dermal cell cultures from four patients with diffuse SSc of recent onset. Total mRNA was extracted from both cell populations, amplified and analyzed employing microarrays. Results for specific genes were validated by Western blots …

Gaufinia, A New Stonefly Genus (Plecoptera: Chloroperlidae), With The Description Of Six New Species From Western North America, Bill P. Stark, Richard W. Baumann

Monographs of the Western North American Naturalist

Gaufinia is proposed as a new genus for the Sweltsa lamba (Needham and Claassen 1925) species group, and 5 current and 6 new species are recognized based primarily on scanning electron microscopy of the male epiproct. Males of the new genus are distinguished from all other Chloroperlidae by the presence of a distinctive leaf-like aedeagal lamella. A preliminary key for males of the 11 currently recognized species is presented to assist in identification.


Se propone Gaufinia como un nuevo género del grupo de especies Sweltsa lamba (Needham y Claassen 1925) y se reconocen 5 especies actuales y 6 nuevas basándose …

End Matter, Vol. 13

Monographs of the Western North American Naturalist

No abstract provided.

A Selective Antibiotic For Lyme Disease, Nadja Leimer, Xiaoqian Wu, Yu Imai, Madeleine Morrissette, Norman Pitt, Quentin Favre-Godal, Akira Iinishi, Samta Jain, Mariaelena Caboni, Inga V Leus, Vincent Bonifay, Samantha Niles, Rachel Bargabos, Meghan Ghiglieri, Rachel Corsetti, Megan Krumpoch, Gabriel Fox, Sangkeun Son, Dorota Klepacki, Yury S Polikanov, Cecily A Freliech, Julie E Mccarthy, Diane G Edmondson, Steven J Norris, Anthony D'Onofrio, Linden T Hu, Helen I Zgurskaya, Kim Lewis

Faculty, Staff and Student Publications

Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an estimated 500,000 people in the United States alone. The antibiotics currently used to treat Lyme disease are broad spectrum, damage the microbiome, and select for resistance in non-target bacteria. We therefore sought to identify a compound acting selectively against B. burgdorferi. A screen of soil micro-organisms revealed a compound highly selective against spirochetes, including B. burgdorferi. Unexpectedly, this compound was determined to be hygromycin A, a known antimicrobial produced by Streptomyces hygroscopicus. Hygromycin A targets the ribosomes and is taken up by B. burgdorferi, explaining …

Importance Of Woodland Patches As Hibernacula For Gartersnakes In A Prairie River Floodplain Of Central Nebraska, Tony Bridger, Keith Geluso

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Gartersnakes are common inhabitants along prairie rivers in the Great Plains, but little information is known about hibernacula among diverse floodplain habitats. We radio-tracked Common Gartersnakes (Thamnophis sirtalis) and Plains Gartersnakes (Thamnophis radix) to hibernacula on islands in a braided river system subject to frequent environmental changes along the Platte River in central Nebraska. We further examined capture rates of gartersnakes in floodplain woodland patches from June to November to examine seasonal use of this habitat. In early and mid-September, movements of snakes with transmitters were in grasslands. From late September to mid-October, the farthest movements …

Norovirus Protease Structure And Antivirals Development, Boyang Zhao, Liya Hu, Yongcheng Song, Ketki Patil, Sasirekha Ramani, Robert L Atmar, Mary K Estes, B V Venkataram Prasad

Faculty, Staff and Students Publications

Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available. The protease encoded by the HuNoV genome plays a critical role in virus replication by cleaving the polyprotein and is an excellent target for developing small-molecule inhibitors. The current strategy for developing HuNoV protease inhibitors is by targeting the enzyme's active site and designing inhibitors that bind to the substrate-binding pockets located near the active site. However, subtle differential conformational flexibility in response to the different substrates in the polyprotein and structural differences in the active site and …

Vista: October 14, 2021, University Of San Diego

USD Vista (1965-)

No abstract provided.

Kenyon Collegian - October 14, 2021

The Kenyon Collegian

No abstract provided.

Epidemic Conditions With Temporary Link Deactivation On A Network Sir Disease Model, Hannah Scanlon, John Gemmer

Spora: A Journal of Biomathematics

The spread of an infectious disease depends on intrinsic properties of the disease as well as the connectivity and actions of the population. This study investigates the dynamics of an SIR type model which accounts for human tendency to avoid infection while also maintaining preexisting, interpersonal relationships. Specifically, we use a network model in which individuals probabilistically deactivate connections to infected individuals and later reconnect to the same individuals upon recovery. To analyze this network model, a mean field approximation consisting of a system of fourteen ordinary differential equations for the number of nodes and edges is developed. This system …

Influence Of Seasonality And Agricultural Practices On Soil Microbes In Kamishihoro, Japan, Y. Madegwa, Y. Uchida

IGC Proceedings (1977-2023)

Soil microbes are important for maintenance of soil fertility and ecosystem functions. Agricultural practices such as land use, seasonality and fertilizer application effect the soil microbial community structure. However, the effect of these management practices on soil microbes and related functions, especially in one specific region, is still not clear.

Therefore, the study was conducted in Kamishihoro, Japan, to determine effect of land use (cropland, grassland), season (summer, spring) and fertilizer (anaerobic digestate, control) on soil microbial community and functions. Experimental procedure included DNA extraction, quantification, purification, amplification of 16SrRNA (bacterial gene) and Next Generation Sequencing (Ion PGM). Data analysis …

Hydraulic Responses Of Shrubs And Grasses To Fire Frequency And Drought In A Tallgrass Prairie Experiencing Bush Encroachment, K. O’Keefe, R. Keen, E. Tooley, S. Bachle, J. B. Nippert, K. Mcculloh

IGC Proceedings (1977-2023)

The increase in abundance and density of woody plants in herbaceous ecosystems (i.e. bush encroachment) is occurring globally and is driven by reduced fire frequency, climate change, and the utilization of deeper, more reliable soil water by woody plants. Thus, a comprehensive understanding of the physiological processes through which woody and herbaceous plants use water will provide greater insight into the mechanisms of bush encroachment, as well as the trajectory of encroachment in a changing climate. Our objective was to assess how experimental changes in water availability and fire frequency impact belowground water-use traits in Cornus drummondii, the primary …

Fighting Wildfire With Prescribed Fire In The Southern Great Plains, Usa: Liability, Regulatory And Social Factors, Urs P. Kreuter, M. L. Treadwell, C. L. Wonkka, D. Toledo, D. L. Stroman, D. Twidwell

IGC Proceedings (1977-2023)

Elevated fuel loads together with hotter and drier climatic conditions are expected to produce more frequent catastrophic wildfires in rangelands. This has led to calls for more prescribed fire to reduce fuel loads. However, perceptions that prescribed fire presents substantial legal liability risks hinder its use by landowners. Here we present research findings about the perceptions of landowners, county commissioners and district court judges regarding prescribed fire in the Southern Great Plains. The extent of liability incorporated in legal statutes pertaining to prescribed fire can affect the use of this land management tool, and the enactment of burn bans by …

Pre- And Post-Degradation Management Of Rangelands: Implications For Sustainable Management, S. K. Tuffa, A. C. Treydte

IGC Proceedings (1977-2023)

Rangeland degradation directly affects livestock production, resulting in food insecurity and ecological instability. A shift in vegetation from grass to woody plants has severely affected cattle production in Ethiopian rangelands. Those grass species that are perceived by the pastoralists as highly palatable and desirable are currently decreasing in both quality and quantity. A reason for this decline has been claimed to be degradation owing to overgrazing and climate change. While appropriate management of livestock density in rangelands is essential for sustainable production and grassland ecosystem health, the management of dryland ecosystems is mired in controversy due to the complexity of …

Indian Forage Scenario – Region Wise Availability And Deficit, A. K. Roy, Rajiv K. Agrawal, N. R. Bhardwaj, Asim Kumar Misra, S. K. Mahanta

IGC Proceedings (1977-2023)

In India, rapid urbanisation, changing food habit and higher purchasing power have increased the demand for animal based food products.Proper feeding strategies using green nutritious fodderis key to increase livestock production and productivity in economical and sustainable way.Three major sources of fodder are crop residues, cultivated fodder from arable land (irrigated and rainfed) and fodder from common property resources like forests, permanent pastures, grazing lands, cultivated wasteland, fallow lands etc.

Based on the livestock census, we estimated the green and dry fodder availability vis-a-vis demand and emerging deficit/surplus situation. The state wise livestock population for Cattle, Buffaloes, Goat, Sheep, Yak …

Grólind – Sustainable Land Use Based On Ecological Knowledge, B. Marteinsdóttir, E. F. Þórarinsdóttir, G. Halldórsson, J. H. Stefánsson, J. Þórsson, K. Svavarsdóttir, R. Finnsdóttir, S. Jónsdóttir

IGC Proceedings (1977-2023)

The highlands of Iceland play an important role as summer rangelands for sheep. Large areas are badly degraded and the sustainability of this practice has been questioned. To achieve sustainable land management it is necessary both to obtain data on ecosystem changes over time and to ensure that the results are used by land users and policy makers in their management plans.

Currently, the first long-term national vegetation and soil monitoring programme (GróLind) is being developed in Iceland. The programme is based on an agreement between the Icelandic National Associations of Sheep Farmers, the Farmers Association of Iceland, Ministry of …

Grasses And Ruminants That Will Help Save Space Ship Earth, A. M. Craig, L. L. Blythe

IGC Proceedings (1977-2023)

For the last twenty years, it has been known that grasses are capable of extracting toxins from the soil. More recently, it has been shown that microorganisms from ruminants, especially sheep, can biodegrade certain toxins in plants and soil, including munition residues. The combination of these two processes act as an agricultural means to clear toxins and munitions from land has been termed Phyto-Ruminal-Bioremediation by the United States Department of Agriculture (USDA) as illustrated in the discussion below. As an example, plants containing toxins such as pyrrolizidine alkaloids can be cleared from pastures using sheep and their ruminant microorganisms. Use …

Mongolian Rangelands Have A Great Potential For Natural Recovery, Bulgamaa Densambuu, Sumjidmaa Sainnemekh, Brandon T. Bestelmeyer, Budbaatar Ulambayar, Burmaa Dashbal, Erdenetsetseg Baasandai

IGC Proceedings (1977-2023)

Mongolians are aware that rangeland degradation is accelerating due to the combination of unsustainable use and drought events, but the natural recovery of degraded rangeland and timelines for recovery are less well studied. In this paper, we describe the use of “recovery class” concepts in rangeland classification that are being used to evaluate rangeland condition and management impacts across Mongolia. Recovery classes are analogous to degradation classes already used in Mongolia, but are based on ecological site descriptions (ESDs) and provide information about expected recovery rates based on quantitative measurements. While the degradation levels communicate the severity of plant community …

Livestock Corridors Working As Pollinator Refuges And Dispersal Hotspots: Lessons From Spain, P. Manzano, A. García-Fernández, J. Seoane, F. M. Azcárate, J. M. Iriondo, B. Peco

IGC Proceedings (1977-2023)

Habitat fragmentation is one of the greatest threats to biodiversity conservation and ecosystem productivity mediated by direct human impact. Its consequences include genetic depauperation, comprising phenomena such as inbreeding depression or reduction in genetic diversity. While the capacity of wild and domestic herbivores to sustain long-distance seed dispersal has been proven, the impact of herbivore corridors in plant population genetics has not been observed previously.

We conducted this study in the Conquense Drove Road in Spain, where sustained use by livestock over centuries has involved transhumant herds passing twice a year en route to winter and summer pastures. We compared …

Choosy Grazers And Plant Communities – Interactions Between Cattle Breeds And Vegetation In Semi-Natural Pastures, C. M. Pauler, Johannes Isselstein, J. Berard, T. Braunbeck, M. K. Schneider

IGC Proceedings (1977-2023)

It is well recognized that domesticated and wild ruminant grazers have an important impact on the composition of grassland vegetation, mainly by forage selection, trampling and defaecation. However, little is known on the effects of genetic diversity, for example differences among breeds of cattle. Cattle breeds differ in terms of robustness, growth rate, weight and probably also in movement and forage selection behaviour, which all could impact vegetation composition. Our study therefore aimed at identifying breed-specific differences in forage selection and behaviour and its consequences for vegetation. In a controlled experiment on semi-natural pastures in the Swiss Alps, suckler cows …

Germinable Soil Seed Bank Of Bothriochloa Macra Dominated Pasture In South-Eastern Australia, M. L. Mitchell, J. M. Virgona, A. Durling, F. W. Dempsey

IGC Proceedings (1977-2023)

In native pastures, soil seed banks play an important role in conserving the genetic material in a plant population, influencing community structure and providing protection against adverse climatic conditions. One important native grass is Bothrichloa macra (Steud.) S.T.Blake (Red grass, Red-leg grass). This grass is a C₄ indigenous perennial grass that is commonly found in native pastures in the high rainfall zone of south-eastern Australia.

At Tarrawingee, NE Victoria, (36°25´S, 146°31´E) and Wymah, southern NSW, (35°58´S, 147°11´E), Australia, two sites that had Bothriochloa macra as the dominant native grass were sampled. Three hundred cores (50 mm diameter and 50 …