Digital Commons Network^™

Mitochondrial Metal Homeostasis: A Look Into Iron And Copper Mobilization Within Mitochondria, Jonathan Dietz

Department of Biochemistry: Dissertations, Theses, and Student Research

Cellular iron and copper homeostasis is interdependent with mitochondrial iron and copper homeostasis. Mitochondria must import iron to form iron-sulfur clusters and heme, while it must import copper for usage and storage. These cofactors are incorporated into mitochondrial proteins that support essential functions, including cellular respiration and maintaining redox homeostasis. In turn, mitochondria also provide heme to the cell and enables the biogenesis of cytosolic iron-sulfur cluster containing proteins, while also providing copper when needed. Due to both metals (and their modified species) reactivity, iron and copper are stored and trafficked within the mitochondria carefully. Although these cofactors are crucial …

Cognitive Effects Of Alcohol Use And Sleep Disruption In College Students, Taylor English

Department of Psychology: Dissertations, Theses, and Student Research

Alcohol use and sleep disruption are highly prevalent amongst college students, yet their combined effects on cognitive functioning and subsequent classroom performance have not been fully examined. Alcohol use has been shown to negatively impact cognitive functioning, especially in college students without fully matured brain regions. This has led to decreases in academic functioning and increases in college dropout. Disruptions in sleep functioning can lead to both lapses in attention and an overall decrease in attention, which can negatively impact learning in a classroom environment.

Participants were 96 undergraduate students who were invited to participate based on responses from a …

Moraxella Species Associated With Infectious Bovine Keratoconjunctivitis: Detection, Characterization, And Immunity, Matthew M. Hille

School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research

Infectious bovine keratoconjunctivitis (IBK) represents the most common ocular disease of cattle. Moraxella bovis (M. bovis) is the only bacteria proven to cause IBK under experimental conditions. A closely related bacteria, Moraxella bovoculi (M. bovoculi) is cultured from IBK lesions more frequently than M. bovis, and is suspected to cause IBK, although a causal relationship between M. bovoculi and IBK has not been confirmed experimentally. Two distinct genotypes were recently characterized in M. bovoculi based on whole genome sequencing. Genotype 1 M. bovoculi appears to represent a potential pathogen …

Quantitative Super-Resolution Microscopy To Assess Adhesion Of Neuronal Cells On Single-Layer Graphene Substrates, Silvia Scalisi, Francesca Pennacchietti, Sandeep Keshavan, Nathan D. Derr, Alberto Diaspro, Dario Pisignano, Agnieszka Pierzynska-Mach, Silvia Dante, Francesca Cella Zanacchi

Biological Sciences: Faculty Publications

Single Layer Graphene (SLG) has emerged as a critically important nanomaterial due to its unique optical and electrical properties and has become a potential candidate for biomedical applications, biosensors, and tissue engineering. Due to its intrinsic 2D nature, SLG is an ideal surface for the development of large-area biosensors and, due to its biocompatibility, can be easily exploited as a substrate for cell growth. The cellular response to SLG has been addressed in different studies with high cellular affinity for graphene often detected. Still, little is known about the molecular mechanism that drives/regulates the cellular adhesion and migration on SLG …

Chosen Family, Care, And The Workplace, Deborah Widiss

Articles by Maurer Faculty

Employees often request time off work to care for the medical needs of loved ones who are part of their extended or chosen family. Until recently, most workers would not have had any legal right to take such leave. A rapidly growing number of state laws, however, not only guarantee paid time off for family health needs, but also adopt innovative and expansive definitions of eligible family.

Several provide leave to care for intimate partners without requiring legal formalization of the relationship. Some go further to include any individual who has a relationship with the employee that is “like” or …

Membranes Are Decisive For Maximum Freezing Efficiency Of Bacterial Ice Nucleators, R. Schwidetzky, P. Sudera, A. T. Backes, U. Pöschl, M. Bonn, J. Fröhlich-Nowoisky, Konrad Meister

Faculty, Staff, and Students

Ice-nucleating proteins (INPs) from Pseudomonas syringae are among the most active ice nucleators known, enabling ice formation at temperatures close to the melting point of water. The working mechanisms of INPs remain elusive, but their ice nucleation activity has been proposed to depend on the ability to form large INP aggregates. Here, we provide experimental evidence that INPs alone are not sufficient to achieve maximum freezing efficiency and that intact membranes are critical. Ice nucleation measurements of phospholipids and lipopolysaccharides show that these membrane components are not part of the active nucleation site but rather enable INP assembly. Substantially improved …

Salient Experiences In Student Development: Impact Of An Undergraduate Stem Teacher Preparation Program, Amie S. Sommers, Kelly Gomez Johnson, Paula Jakopovic, Julio Rivera, Neal Grandgenett, John A. Conrad, William E. Tapprich, Christine E. Cutucache

Educational Leadership Faculty Publications

The need for a comprehensive, high-quality pipeline for the development of undergraduate pre-service teachers, especially those that represent a diverse student body, within STEM disciplines is acute. Here, we studied the NoyceSCIENCE program to determine the most impactful experiences offered to undergraduates through the lens of student development theory. We used qualitative coding to analyze data collected from journals (n = 29) written by students of varying backgrounds, and at varying levels within the program (i.e., the Scholar and Intern level) over a 3-year program running period. We observed that faculty mentorship, the ability of undergraduates to mentor others, volunteer …

Salient Experiences In Student Development: Impact Of An Undergraduate Stem Teacher Preparation Program, Amie Sommers, Kelly Gomez Johnson, Paula M. Jakopovic, Julio Rivera, Neal Grandgenett, John A. Conrad, William Tapprich, Christine Cutucache

Teacher Education Faculty Publications

The need for a comprehensive, high-quality pipeline for the development of undergraduate pre-service teachers, especially those that represent a diverse student body, within STEM disciplines is acute. Here, we studied the Noyce SCIENCE program to determine the most impactful experiences offered to undergraduates through the lens of student development theory. We used qualitative coding to analyze data collected from journals written by students of varying backgrounds, and at varying levels within the program (i.e., the Scholar and Intern level) over a 3-year program running period. We observed that faculty mentorship, the ability of undergraduates to mentor others, volunteer experiences, and …

The Echo: November 1, 2021, Taylor University

2021-2022 (Volume 109)

New Taylor president envisions the next chapter — A bird’s eye view: Michael Lindsay’s professional career — Taylor requires COVID-19 vaccination for study abroad — Lutheran Health Network builds hospital in Gas City — Samuel Morris statues renovated, running — Fall Fashion — Eaks serves the DC at quarantine peaks — Marissa Williams: Unification through photography — Scheduling J-terms — Building a relationship with food — Editors explain: Michael Lindsay’s professional career — Grieving shared trauma through unity — Parnassus holds true to their mission — ‘Ted Lasso’ season two crabs up the humor and heart — Taylor soccer players …

Coronavirus, Compulsory Licensing, And Collaboration: Analyzing The 2020 Global Vaccine Response With 20/20 Hindsight, Arjun Padmanabhan

Student Scholarship

In December 2019, COVID-19, a novel strain of the SARS-2 Virus, appeared in Wuhan, China. Within a year, over ninety million people had been infected, and two million had died. Amid all the death and desolation, humanity's ingenuity and willpower emerged in history's greatest vaccine race. The global community sought to find novel ways to protect innovation and intellectual property while still collaborating to roll out a vaccine in record time. Despite the presence of compulsory licensing provisions like 28 U.S.C. § 1498 and the Bayh-Dole Act in the U.S., and the TRIPS Agreement at the international level, the journey …

Vaccine Clinical Trials And Data Infrastructure, Ana Santos Rutschman

Utah Law Review

We find ourselves at a momentous turn in the history of vaccines. The COVID-19 pandemic triggered a quasi-global vaccine race that not only compressed vaccine research and development (R&D) timelines, but also paved the way for the administration of a new type of vaccine technology – mRNA vaccines, which work in substantially different ways from the vaccines in use before the pandemic.

While the process of bringing emerging COVID-19 vaccines to market has taken place in an unusually short timeframe, it was largely predicated on the same scientific and regulatory processes that govern the development, approval and deployment of new …

The Open Covid Pledge: Design, Implementation And Preliminary Assessment Of An Intellectual Property Commons, Jorge L. Contreras

Utah Law Review

Early during the COVID-19 pandemic, a number of widely-publicized incidents gave rise to concerns that holders of patents and other intellectual property (IP) rights could hinder the development, manufacture and distribution of essential medical devices, protective equipment and biomedical products. The global response to these concerns was swift and included the issuance of compulsory licensing orders by several national governments, as well as the proposal of a technology pool by the World Health Organization (WHO). Alongside these efforts, a group of scientific, engineering and legal experts created a lightweight, open framework under which IP holders could voluntarily pledge not to …

Event-Triggered Control Using A Positive Systems Approach, Frédéric Mazenc, Michael Malisoff, Corina Barbalata, Zhong Ping Jiang

Faculty Publications

We provide a new event-triggered control strategy that relies on the notion of positive systems. Our results cover output feedback, and robustness with respect to uncertain dynamics. Our proofs are based on interval observers. Our examples show potential advantages of our approach over earlier event-triggered methods.

Cuts: Scaling Subgraph Isomorphism On Distributed Multi-Gpu Systems Using Trie Based Data Structure, Lizhi Xiang, Arif Khan, Edoardo Serra, Mahantesh Halappanavar, Aravind Sukumaran-Rajam

Computer Science Faculty Publications and Presentations

Subgraph isomorphism is a pattern-matching algorithm widely used in many domains such as chem-informatics, bioinformatics, databases, and social network analysis. It is computationally expensive and is a proven NP-hard problem. The massive parallelism in GPUs is well suited for solving subgraph isomorphism. However, current GPU implementations are far from the achievable performance. Moreover, the enormous memory requirement of current approaches limits the problem size that can be handled. This work analyzes the fundamental challenges associated with processing subgraph isomorphism on GPUs and develops an efficient GPU implementation. We also develop a GPU-friendly trie-based data structure to drastically reduce the intermediate …

Be Inspired By Women In Stem, Nov. 9, Kassidy Taylor

UNH Today Archive

No abstract provided.

Optimization Of Neurite Tracing And Further Characterization Of Human Monocyte-Derived-Neuronal-Like Cells, Alfredo Bellon, Tuna Hasoglu, Mallory Peterson, Katherine Gao, Michael Chen, Elisabeta Blandin, Alonso Cortez-Resendiz, Gary Clawson, Liyi Elliot Hong

Department of Psychiatry and Human Behavior Faculty Papers

Deficits in neuronal structure are consistently associated with neurodevelopmental illnesses such as autism and schizophrenia. Nonetheless, the inability to access neurons from clinical patients has limited the study of early neurostructural changes directly in patients’ cells. This obstacle has been circumvented by differentiating stem cells into neurons, although the most used methodologies are time consuming. Therefore, we recently developed a relatively rapid (~20 days) protocol for transdifferentiating human circulating monocytes into neuronal-like cells. These monocyte-derived-neuronal-like cells (MDNCs) express several genes and proteins considered neuronal markers, such as MAP-2 and PSD-95. In addition, these cells conduct electrical activity. We have also …

Twin Reactor Catalytic Assisted Pyrolysis For Food Court Waste Conversion Into High End Chemicals, Răzvan Nicolae State, Gabriela Ionescu, Mariana Pătrașcu, Adrian Volceanov, Dorin Boldor, Cosmin Mărculescu

Faculty Publications

Waste generation is growing every day and its disposal presents multiple challenges. One particular type of waste consists of food court waste (FCW) from food areas in malls. Its disposal requires many stages, starting with transportation, continuing with sorting and recycling, and ending with landfilling or combustion. Thus, this study managed to convert FCW into valuable products, disposing of it at the same time in an environmentally friendly way. For this ex situ catalytic pyrolysis process, experiments were performed by passing products from pyrolysis performed at 500 °C through HZSM5 or MeHZSM5 catalyst (Me = Co, Mo) kept at 300, …

Ipulse: November 2021, Lynn University

Student Newspapers

Issues:

• November 2021 [Fall Week 7]: Scooters are Making a Comeback; Founders Day in a Flash; The No Fun League Strikes Again; Don't Feed Your Pup Thanksgiving Scraps; Virtual School? No Problem!; Students Protest Book Ban; Founders Day Fashion; Behind the Wheel
• November 2021 [Fall Week 8]: A Routine to Success; A Clean Environment is a Human Right; The Best Thanksgiving Dish; Keep Them Safe; Hidden Gems of South Florida; The Rise of Josh Allen; Posing in Progress; The Fashion Icons of 2021; Passionate to Make a Difference in Children's Lives

Bioart Towards A New Concept Of Identity, Heba Elaziz Elsarraff

Journal of Art, Design and Music

The speed made by science and technology in recent times, especially in biotechnology and genomics, has urged a lot of specialists in several areas, including the sectors of culture and science as well as artists, to respond to those changes. Which brought a significant cultural change changed our traditional understanding of civilization and our coping with it under the scientific and cultural amalgamation, in turn, resulted in changing the concept of art and its philosophy and aesthetics. Accordingly, a need for an artistic formulation has become urgent that could express the impact of technology on restoring the formulation of ideas …

Gaze, Volume 4, Number 12

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Thomas Smith, Joe Calhoun, Joel Tate, Scott Correll, Clifton St. John, Ric Sullivan, John House, Pat Jones. Nashville Correspondent: Jeff Thompson. Production and Graphics: Allen Cook, Charles Overfield, Cecil McLeod. Circulation: Cecil McLeod, Marty Martin, Rick Van Hooser, John Stillwell, Jeff Thompson. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 5, Number 9

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Charlie McMullen, Carole Taylor, Jeff Thompson, Houston Butler, Timothy James, Bob Dumais. Syndicated Features: Dr. Harvey Thompson, MD., Max Angst, Rev. Larry J, Uhrig, Bruce Billings. Nashville Correspondent: Jeff Thompson. Nashville Reporter: Timothy James. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Stilwell. Circulation: Cecil McLeod, Timothy James, Jeff Thompson, John Stilwell, Bob Dumais. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 5, Number 7

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Charlie McMullen, Carole Taylor, Jeff Thompson, Houston Butler, Timothy James, Bob Dumais. Syndicated Features: Dr. Harvey Thompson, MD., Max Angst, Rev. Larry J, Uhrig, Bruce Billings. Nashville Correspondent: Jeff Thompson. Nashville Reporter: Timothy James. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Stilwell. Circulation: Cecil McLeod, Timothy James, Jeff Thompson, John Stilwell, Bob Dumais. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 5, Number 3

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Thomas Smith, Joe Calhoun, Joel Tate, Scott Correll, Clifton St. John, Ric Sullivan, Jim Stanley. Nashville Correspondent: Jeff Thompson. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Sparks. Circulation: Cecil McLeod, John Stilwell, Jeff Thompson. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 5, Number 1

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Thomas Smith, Joe Calhoun, Joel Tate, Scott Correll, Clifton St. John, Ric Sullivan, Jim Stanley. Nashville Correspondent: Jeff Thompson. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Sparks. Circulation: Cecil McLeod, John Stilwell, Jeff Thompson. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 6, Number 6

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Charlie McMullen, Carole Taylor, Bob Dumais. Syndicated Features: Dr. Harvey Thompson, MD., Max Angst, Rev. Larry J. Uhrig, Bruce Billings. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Stilwell. Circulation: Cecil McLeod, John Stilwell, Bob Dumais. National Advertising: Rivendell Marketing.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Gaze, Volume 6, Number 1

Gaze, 1979-1990

Co-Editors: John Stilwell, Allen Cook. Staff Writers: Charlie McMullen, Carole Taylor, Jeff Thompson, Houston Butler, Timothy James, Bob Dumais. Syndicated Features: Dr. Harvey Thompson, MD., Max Angst, Rev. Larry J, Uhrig, Bruce Billings. Nashville Correspondent: Jeff Thompson. Nashville Reporter: Timothy James. Typesetting and Layout: Allen Cook, Cecil McLeod, Bob Dumais, John Stilwell. Circulation: Cecil McLeod, Timothy James, Jeff Thompson, John Stilwell, Bob Dumais. National Advertising: Rivendell Markerting.

Special thanks to Rhodes College and the Paul Barret Jr. Library for providing initial scanning of this collection.

Evaluation Of Placentation And The Role Of The Aryl Hydrocarbon Receptor Pathway In A Rat Model Of Dioxin Exposure., Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F Roby, Carrie A. Vyhlidal, Michael J. Soares

Manuscripts, Articles, Book Chapters and Other Papers

Background: Our environment is replete with chemicals that can affect embryonic and extraembryonic development. Dioxins, such as 2,3,7,8-tetrachlorodibenzo-p" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: 0; font-size: 18.08px; overflow-wrap: normal; word-spacing: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; margin: 0px; padding: 1px 0px; position: relative;">pp-dioxin (TCDD), are compounds affecting development through the aryl hydrocarbon receptor (AHR).

Objectives: The purpose of this investigation was to examine the effects of TCDD exposure on pregnancy and placentation and to evaluate roles for AHR and cytochrome P450 1A1 (CYP1A1) in TCDD action.

Methods: Actions …

Complementary And Alternative Medicine Mind-Body Approaches Used Among Racially And Ethnically Diverse Adolescents, Dora L. Clayton-Jones, Lee Za Ong, Mauricio Garnier-Villarreal, Lori Vick, Rachel Sawdy, Safiya George, Kristin Haglund

College of Nursing Faculty Research and Publications

Purpose

The aim of this paper is to examine complementary and alternative medicine (CAM) use among racially and ethnically diverse adolescents. Greater understanding of CAM use among this group is warranted to better inform health care providers in delivering a culturally relevant health promotion approach.

Design and methods

A secondary data analysis was conducted using the 2012 Child Complementary and Alternative Medicine Supplement of the National Health Interview Survey (CAM-NHIS) data, which was collected from a national sample of adolescents aged 12–17 years. A logistic regression test was employed to investigate the predictors associated with CAM use among racially and …

Down-Regulation Of Cyclin D2 In Amyloid Β Toxicity, Inflammation, And Alzheimer’S Disease, Joanna B. Strosznajder, Grzegorz A. Czapski, Magdalena Cieślik, Emilia Białopiotrowicz, Walter J. Lukiw

School of Medicine Faculty Publications

In the current study, we analyzed the effects of the systemic inflammatory response (SIR) and amyloid β (Aβ) peptide on the expression of genes encoding cyclins and cyclin-dependent kinase (Cdk) in: (i) PC12 cells overexpressing human beta amyloid precursor protein (βAPP), wild-type (APPwt-PC12), or carrying the Swedish mutantion (APPsw-PC12); (ii) the murine hippocampus during SIR; and (iii) Alzheimer’s disease (AD) brain. In APPwtPC12 expression of cyclin D2 (cD2) was exclusively reduced, and in APPsw-PC12 cyclins cD2 and also cA1 were down-regulated, but cA2, cB1, cB2, and cE1 were up-regulated. In the SIR cD2, cB2, cE1 were found to be significantly …

Psychobiology Of Stress And Adolescent Depression (Psy Sad) Study: Protocol Overview For An Fmri-Based Multi-Method Investigation, Stassja Sichko, Theresa Q. Bui, Meghan Vinograd, Grant S. Shields, Krishanu Saha, Suzanne Devkota, Hector A. Olvera-Alvarez, Judith E. Carroll, Steven E. Cole, Michael R. Irwin, George M. Slavich

Psychological Science Faculty Publications and Presentations

Depression is a common, often recurrent disorder that causes substantial disease burden worldwide, and this is especially true for women following the pubertal transition. According to the Social Signal Transduction Theory of Depression, stressors involving social stress and rejection, which frequently precipitate major depressive episodes, induce depressive symptoms in vulnerable individuals in part by altering the activity and connectivity of stress-related neural pathways, and by upregulating components of the immune system involved in inflammation. To test this theory, we recruited adolescent females at high and low risk for depression and assessed their psychological, neural, inflammatory, and genomic responses to a …