Digital Commons Network^™

Christ In The Covenant Curses? Deuteronomy 28 And The Gospel, A. Rahel Wells

Journal of the Adventist Theological Society

Is the Jesus who says to “love your enemies” (Matt 5:44) really the same God who will “take delight in bringing ruin” upon his people (Deut 28:63)? How can Christ be seen in all Scripture when the covenant curses are included? This paper argues that the covenant curses are often misunderstood, and are actually at the center of God’s heart of love, even pointing forward to the Messiah. Many scholars have analyzed and documented different structures within the covenant curses.1 One of the most comprehensive analyses finds numerous smaller chiastic structures within Deut 28, both in the blessings and the …

Looking Toward Brexit's Aftermath: Pharmaceutical Provisions Affecting The Nhs In A Future U.S.-U.K. Bilateral Trade Agreement, Ryan Rainey

Minnesota Journal of International Law, Vols. 28:2 onward (2019-present)

No abstract provided.

Bioenergy And Minigrids For Sustainable Human Development, Andrew Allee

Dartmouth College Ph.D Dissertations

Human-caused climate change and deep disparities in human development imperil a prosperous and just future for our planet and the people who live on it. Transforming our society to mitigate global warming offers an opportunity to rebuild energy systems to the benefit of those who are harmed by global inequality today. I examine this opportunity through the lens of two sustainable energy technologies: bioenergy and miniature electricity grids (minigrids).

Bioenergy requires land to produce biomass and is inextricably connected to the surrounding environment, agricultural livelihoods, and food system. I apply data science tools to study aspects of land use and …

When Therapy Goes Public: Copyright Gatekeepers And Sharing Therapeutic Artifacts On Social Media, Amanda Reid, Pablo Miño

Faculty Publications

No abstract provided.

Applying Model Approaches In Non-Model Systems: A Review And Case Study On Coral Cell Culture, Liza M. Roger, Hannah G. Reich, Evan Lawrence, Shuaifeng Li, Whitney Vizgaudis, Nathan Brenner, Lokender Kumar, Judith Klein-Seetharaman, Jinkyu Yang, Hollie M. Putnam, Nastassja A. Lewinski

Biological Sciences Faculty Publications

Model systems approaches search for commonality in patterns underlying biological diversity and complexity led by common evolutionary paths. The success of the approach does not rest on the species chosen but on the scalability of the model and methods used to develop the model and engage research. Fine-tuning approaches to improve coral cell cultures will provide a robust platform for studying symbiosis breakdown, the calcification mechanism and its disruption, protein interactions, micronutrient transport/exchange, and the toxicity of nanoparticles, among other key biological aspects, with the added advantage of minimizing the ethical conundrum of repeated testing on ecologically threatened organisms. The …

Who Is Bisexual? Perceptions Of Sexual Orientations Under Ambiguity, Megan E. Wilson

Arts & Sciences Graduate Student Theses and Dissertations

How do people determine another individual’s sexual orientation? As sexuality often does not have visible cues, people must often rely on how others identify and behave. However, sexual identity and behavior can often conflict (Pathela et al., 2006; Ross et al., 2003). In Study 1, I examined whether participants perceived individuals to be straight, gay, or bisexual when identity and behavior conflicted (e.g., a man who identifies as “straight” but had sex with other men). Study 2 examined how perceptions were affected by the characteristics of the target and their behavior and Study 3 examined how perception was related to …

Corralling The Chorale, Chelsea Burns, William O'Hara, Marcelle Pierson, Katherine Pukinskis, Peter Smucker, William Van Geest

Journal of Music Theory Pedagogy

No abstract provided.

The Risks For Eating Disorders/Disordered Eating In Refugee & Immigrant Experiences And The Imperative Of Culturally Alert Screening, Chantal A. Bushelle

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Eating Disorders (ED)/Disordered Eating (DE) largely remain outside of global mental health agendas. There are limited data on the epidemiology EDs/DE in refugee and immigrant populations, and there is a paucity of research on refugee and immigrant experiences of EDs/DE. Study of acculturation issues in refugee and immigrant populations have historically missed investigating what role and impact experiences of stress and trauma (e.g., historical, chronic) along with cultural change and transition may have on their food attitudes and eating behaviors. While there has been some study of eating habits within refugee and immigrant populations, the focus is typically on food …

Pragmatic Reconstruction In Jurisprudence: Features Of A Realistic Theory, Brian Z. Tamanaha

Scholarship@WashULaw

A century ago the pragmatists called for reconstruction in philosophy. Philosophy at the time was occupied with conceptual analysis, abstractions, a priori analysis, and the pursuit of necessary, universal truths. Pragmatists argued that philosophy instead should center on the pressing problems of the day, which requires theorists to pay attention to social complexity, variation, change, power, consequences, and other concrete aspects of social life. The parallels between philosophy then and jurisprudence today are striking, as I show, calling for a pragmatism-informed theory of law within contemporary jurisprudence. The realistic theory outlined in this essay focuses on what law does, what …

Migrating Genes: Using Adna And Archaeological Data To Explain Migration In The Casas Grandes Region Of Northern Mexico, Meradeth Snow, Michael T. Searcy

Faculty Publications

Migration as an archaeological topic has addressed huge distances, such as the colonization of the Americas, as well as smaller regions, such as the peopling of specific sites. The use of genetics as a medium to enhance our understanding of population movement can be an asset. There are potential pitfalls, however, such as the misrepresentation of DNA ranging across the landscape without human vectors or motivations. Genetic data must be interpreted through the lens of all available data from the site and surrounding region in order to understand how it its into the potential for human migration. These ideas will …

Anticancer Activities Of Plant Secondary Metabolites: Rice Callus Suspension Culture As A New Paradigm, Wusirika Ramakrishna, Anuradha Kumari, Nafeesa Rahman, Pallavi Mandave

Michigan Tech Publications, Part 1

Plant natural products including alkaloids, polyphenols, terpenoids and flavonoids have been reported to exert anticancer activity by targeting various metabolic pathways. The biological pathways regulated by plant products can serve as novel drug targets. Plant natural compounds or their derivatives used for cancer treatment and some novel plant-based compounds which are used in clinical trials were discussed. Callus suspension culture with secondary metabolites can provide a continuous source of plant pharmaceuticals without time and space limitations. Previous research has shown that rice callus suspension culture can kill >95% cancer cells with no significant effect on the growth of normal cells. …

Machine Learning Applications In Microbial Ecology, Human Microbiome Studies, And Environmental Monitoring, Ryan B. Ghannam, Stephen Techtmann

Michigan Tech Publications, Part 1

Advances in nucleic acid sequencing technology have enabled expansion of our ability to profile microbial diversity. These large datasets of taxonomic and functional diversity are key to better understanding microbial ecology. Machine learning has proven to be a useful approach for analyzing microbial community data and making predictions about outcomes including human and environmental health. Machine learning applied to microbial community profiles has been used to predict disease states in human health, environmental quality and presence of contamination in the environment, and as trace evidence in forensics. Machine learning has appeal as a powerful tool that can provide deep insights …

Radiome: Challenges During The Development Of A Real Time Tool To Support People With Dementia, G Shakeri, S Brewster, S Venkatesh, D Moffat, A Kirke, E Miranda, S Banerjee, A Street, J Fachner, H Odell-Miller

School of Art, Design and Architecture

No abstract provided.

The Impact Of Ocean‐Wave Coupling On The Upper Ocean Circulation During Storm Events, D. Bruciaferri, M. Tonani, H. W. Lewis, J. R. Siddorn, A. Saulter, Sanchez Jm Castillo, N. G. Valiente, D. Conley, P. Sykes, I. Ascione, N. Mcconnell

School of Biological and Marine Sciences

Many human activities rely on accurate knowledge of the sea surface dynamics. This is especially true during storm events, when wave-current interactions might represent a leading order process of the upper ocean. In this study, we assess and analyze the impact of including three wave-dependent processes in the ocean momentum equation of the Met Office North West European Shelf ocean-wave forecasting system on the accuracy of the simulated surface circulation. The analysis is conducted using ocean currents and Stokes drift data produced by different implementations of the coupled forecasting systems to simulate the trajectories of surface (iSphere) and 15 m …

Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

No abstract provided.

Nitrogen Fixation: A Poorly Understood Process Along The Freshwater-Marine Continuum, Amy M. Marcarelli, Robinson W. Fulweiler, J. Thad Scott

Michigan Tech Publications, Part 1

N2 fixation is a major component of the global N cycle and has been extensively studied in open-ocean and terrestrial ecosystems. Yet rates and ecological dynamics remain virtually unknown for the inland and coastal aquatic ecosystems (lakes, wetlands, rivers, streams, and estuaries) that connect terrestrial and marine biomes. This is due to the diversity of these habitats as well as the traditional paradigm that N2 fixation rates were low to nonexistent, and therefore not important, in these ecosystems. We identify three major research themes to advance understanding of aquatic N2 fixation: (1) the biological diversity of diazotrophs and variability of …

Tool Use And Function Knowledge Shape Visual Object Processing, Francois R. Foerster, Jeremy Goslin

School of Psychology

Perceiving the environment automatically informs how we can interact with it through affordance mechanisms. However, it remains unknown how our knowledge about the environment shapes how it is perceived. In this training study, we evaluated whether motor and function knowledge about novel objects affects visual object processing. Forty-three participants associated a usage or function to a novel object in interactive virtual reality while their EEG was recorded. Both usage and function influenced the mu-band (8–12 Hz) rhythms, suggesting that motor and function object information influence motor processing during object recognition. Learning the usage also prevented the reduction of the theta-band …

How Does Familiarity With A Voice Affect Trait Judgements?, Nadine Lavan, Mila Mileva, Carolyn Mcgettigan

School of Psychology

No abstract provided.

The Availability Of Training Opportunities In Personality Disorders In American Psychological Association- And Psychological Clinical Science Accreditation System-Accredited Clinical And Counseling Psychology Doctoral Programs, K. N. Levy, William D. Ellison

Psychology Faculty Research

Personality disorders are relatively common, especially in clinical settings. A number of evidence-based treatments are now available, especially for borderline personality disorder. However, little is known about the relevant training available to doctoral students in clinical and counseling psychology. in the current study, data were extracted from 336 clinical and counseling Ph.D. and Psy.D. programs from the Insider’s Guide to Graduate Programs in Clinical and Counseling Psychology (Norcross & Sayette, 2020), including the number of programs with faculty with specific interests in personality disorders and the number of programs with clinical opportunities related to personality disorders. We found that formal …

Ron Signalling Promotes Therapeutic Resistance In Esr1 Mutant Breast Cancer, Derek Dustin, Shunqiang Li, Et Al

Open Access Publications

BACKGROUND: Oestrogen Receptor 1 (ESR1) mutations are frequently acquired in oestrogen receptor (ER)-positive metastatic breast cancer (MBC) patients who were treated with aromatase inhibitors (AI) in the metastatic setting. Acquired ESR1 mutations are associated with poor prognosis and there is a lack of effective therapies that selectively target these cancers.

METHODS: We performed a proteomic kinome analysis in ESR1 Y537S mutant cells to identify hyperactivated kinases in ESR1 mutant cells. We validated Recepteur d'Origine Nantais (RON) and PI3K hyperactivity through phospho-immunoblot analysis, organoid growth assays, and in an in vivo patient-derived xenograft (PDX) metastatic model.

RESULTS: We demonstrated that RON …

Tlr3 Controls Constitutive Ifn-Β Antiviral Immunity In Human Fibroblasts And Cortical Neurons, Daxing Gao, Michael S Diamond, Et Al

Open Access Publications

Human herpes simplex virus 1 (HSV-1) encephalitis can be caused by inborn errors of the TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity. Deficiencies of the TLR3 pathway impair cell-intrinsic immunity to vesicular stomatitis virus (VSV) and HSV-1 in fibroblasts, and to HSV-1 in cortical but not trigeminal neurons. The underlying molecular mechanism is thought to involve impaired IFN-α/β induction by the TLR3 recognition of dsRNA viral intermediates or by-products. However, we show here that human TLR3 controls constitutive levels of IFNB mRNA and secreted bioactive IFN-β protein, and thereby also controls constitutive mRNA levels for IFN-stimulated genes …

Cd11c+ Cd88+ Cd317+ Myeloid Cells Are Critical Mediators Of Persistent Cns Autoimmunity, Navid Manouchehri, Rehana Z. Hussain, Petra D. Cravens, Ekaterina Esaulova, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Anne H. Cross, Richard Doelger, Nicolas Loof, Todd N. Eagar, Thomas G. Forsthuber, Laurent Calvier, Joachim Herz, Olaf Stüve

Open Access Publications

No abstract provided.

Monitoring The Variation In The Gut Microbiota Of Captive Woolly Monkeys Related To Changes In Diet During A Reintroduction Process, Camilo Quiroga-González, Luis Alberto Chica Cardenas, Mónica Ramírez, Alejandro Reyes, Camila González, Pablo R. Stevenson

Open Access Publications

No abstract provided.

Inflammatory Signaling Sensitizes Piezo1 Mechanotransduction In Articular Chondrocytes As A Pathogenic Feed-Forward Mechanism In Osteoarthritis, Whasil Lee, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. Mcnulty, Yong Chen, Farshid Guilak, Wolfgang B. Liedtke

Open Access Publications

No abstract provided.

Long, Noncoding Rna Dysregulation In Glioblastoma, Patrick A Desouza, Xuan Qu, Hao Chen, Bhuvic Patel, Christopher A Maher, Albert H Kim

Open Access Publications

Transcription occurs across more than 70% of the human genome and more than half of currently annotated genes produce functional noncoding RNAs. Of these transcripts, the majority-long, noncoding RNAs (lncRNAs)-are greater than 200 nucleotides in length and are necessary for various roles in the cell. It is increasingly appreciated that these lncRNAs are relevant in both health and disease states, with the brain expressing the largest number of lncRNAs compared to other organs. Glioblastoma (GBM) is an aggressive, fatal brain tumor that demonstrates remarkable intratumoral heterogeneity, which has made the development of effective therapies challenging. The cooperation between genetic and …

Mechanical Dysfunction Of The Sarcomere Induced By A Pathogenic Mutation In Troponin T Drives Cellular Adaptation, Sarah R. Clippinger, Paige E. Cloonan, Wei Wang, Lina Greenberg, W. Tom Stump, Paweorn Angsutararux, Jeanne M. Nerbonne, Michael J. Greenberg

Open Access Publications

Familial hypertrophic cardiomyopathy (HCM), a leading cause of sudden cardiac death, is primarily caused by mutations in sarcomeric proteins. The pathogenesis of HCM is complex, with functional changes that span scales, from molecules to tissues. This makes it challenging to deconvolve the biophysical molecular defect that drives the disease pathogenesis from downstream changes in cellular function. In this study, we examine an HCM mutation in troponin T, R92Q, for which several models explaining its effects in disease have been put forward. We demonstrate that the primary molecular insult driving disease pathogenesis is mutation-induced alterations in tropomyosin positioning, which causes increased …

Variables Associated With Intravenous Rehydration And Hospitalization In Children With Acute Gastroenteritis: A Secondary Analysis Of 2 Randomized Clinical Trials, Naveen Poonai, Philip Tarr, Et Al

Open Access Publications

Importance: Despite guidelines endorsing oral rehydration therapy, intravenous fluids are commonly administered to children with acute gastroenteritis in high-income countries.

Objective: To identify factors associated with intravenous fluid administration and hospitalization in children with acute gastroenteritis.

Design, Setting, and Participants: This study is a planned secondary analysis of the Pediatric Emergency Research Canada (PERC) and Pediatric Emergency Care Applied Research Network (PECARN) probiotic trials. Participants include children aged 3 to 48 months with 3 or more watery stools in 24 hours between November 5, 2013, and April 7, 2017, for the PERC study and July 8, 2014, and June 23, …

Lysis Of Arterial Thrombi By Perfusion Of N,N'-Diacetyl-L-Cystine (Dinac), Dongjune Kim, Susan M. Shea, David N. Ku

Open Access Publications

The search persists for a safe and effective agent to lyse arterial thrombi in the event of acute heart attacks or strokes due to thrombotic occlusion. The culpable thrombi are composed either primarily of platelets and von Willebrand Factor (VWF), or polymerized fibrin, depending on the mechanism of formation. Current thrombolytics were designed to target red fibrin-rich clots, but may be not be efficacious on white VWF-platelet-rich arterial thrombi. We have developed an in vitro system to study the efficacy of known and proposed thrombolytic agents on white clots formed from whole blood in a stenosis with arterial conditions. The …

Cannabis-Induced Hypodopaminergic Anhedonia And Cognitive Decline In Humans: Embracing Putative Induction Of Dopamine Homeostasis, Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi, Mark S Gold

Open Access Publications

Over years, the regular use of cannabis has substantially increased among young adults, as indicated by the rise in cannabis use disorder (CUD), with an estimated prevalence of 8. 3% in the United States. Research shows that exposure to cannabis is associated with hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and increased addiction severity in young adults. The addiction medicine community is increasing concern because of the high content of delta-9-tetrahydrocannabinol (THC) currently found in oral and vaping cannabis products, the cognitive effects of cannabis may become more pronounced in young …

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning And Predisposes To Oral Antigen Sensitization In Mice, Taeko K Noah, Jee-Boong Lee, Christopher A Brown, Amnah Yamani, Sunil Tomar, Varsha Ganesan, Rodney D Newberry, Gary B Huffnagle, Senad Divanovic, Simon P Hogan

Open Access Publications

Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization. As housing mice at thermoneutrality (Tn) - the temperature of metabolic homeostasis (26-30°C) - has been shown to improve modeling various human diseases involved in inflammation, we tested the impact of Tn housing on an experimental model of food sensitization. Here we demonstrate that WT BALB/c mice housed under standard temperature (18-20°C, Ts) conditions translocated the luminal antigens in the small intestine (SI) across the epithelium