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2021

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Health Risk Assessment Of Toxic Metals In Commonly Consumed Salad Leafy Vegetables In Bangkok, Zin Htoo Hlyan Jan 2021

Health Risk Assessment Of Toxic Metals In Commonly Consumed Salad Leafy Vegetables In Bangkok, Zin Htoo Hlyan

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this study were 1) to investigate concentrations of toxic metals including As, Cd, and Pb in the commonly consumed salad leafy vegetables which were sold in Bangkok, and 2) to assess potential human health risks of As, Cd, and Pb exposure via salad leafy vegetables consumption. A total of 120 samples were randomly collected from local fresh markets in Bangkok. The total concentrations of toxic metals were determined by an inductively coupled plasma mass spectroscopy (ICP-MS). Total concentrations of As, Cd and Pb in coral lettuce (CL), red coral (RC) and green oak (GO) for soil cultivation …

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Spray Dried Asiatic Acid-Palm Oil Nanoemulsion With Improved Characteristics And Antihypertensive Effect Study In Rat Model Of Hypertension, Aditya Trias Pradana Jan 2021

Spray Dried Asiatic Acid-Palm Oil Nanoemulsion With Improved Characteristics And Antihypertensive Effect Study In Rat Model Of Hypertension, Aditya Trias Pradana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hypertension is a risk factor for premature death worldwide.It is characterized by an increase in blood pressure, so it needs therapy to regulate it and keep the value normal. Asiatic acid (AA) and palm oil (PO) were alternative antihypertensive agents that were promising to be developed. Both were natural compounds obtained from the Centella asiatica and Elaesis guineensis plants. However, low solubility, low absorption, rapid metabolism, low bioavailability and high oxidation were the limitation for both of them as an active compounds. Thus, a combination of nanoemulsion formulation and drying with a spray dryer was necessary to improve the physicochemical …

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Assessments Of Chromium Pollution In Surface Sediment Of The Inner Gulf Of Thailand, Patcha Leelakun Jan 2021

Assessments Of Chromium Pollution In Surface Sediment Of The Inner Gulf Of Thailand, Patcha Leelakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The inner Gulf of Thailand is an important marine resource for economic and social developments of Thailand. Moreover, the inner Gulf of Thailand is a diverse of biological coastal ecosystem, which is make an equilibrium marine environment. On the other hand, this area is due mainly to a variety of pollutant sources from the surface runoff, particularly major large rivers including the Mae Klong, the Tha Chin, the Chao Phraya and the Bangpakong Rivers. As a result, chromium contamination can occur in the inner Gulf of Thailand and ultimately become a serious environmental issue in Thailand. Therefore, the surface sediments …

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Evaluation Of Cadmium Bioaccumulations In Pak Choi Grown By Hydroponics System, Piyachet Jinsart Jan 2021

Evaluation Of Cadmium Bioaccumulations In Pak Choi Grown By Hydroponics System, Piyachet Jinsart

Chulalongkorn University Theses and Dissertations (Chula ETD)

Cadmium is one of the most harmful heavy metals reported to contaminate the food chain and pose a high risk for health, including non-carcinogenic and carcinogenic effects. High levels of cadmium contamination due to industrial effluent discharge have been reported to affect plant growth and productivity, which could be used as a bio-indicator for cadmium bioaccumulation in plants. The utilization of cadmium-contaminated water for vegetable production has been known to increase the health risk for human consumption. Moreover, pH level was known as a factor affecting cadmium solubility and cadmium uptake by plants. However, there is still unknown about critical …

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Influence Of Seasonal Variations On Contamination Level And Ecological Risk Of Heavy Metals In The Surface Sediments Of The Inner Gulf Of Thailand, Phuttiphat Lapat-Atiwat Jan 2021

Influence Of Seasonal Variations On Contamination Level And Ecological Risk Of Heavy Metals In The Surface Sediments Of The Inner Gulf Of Thailand, Phuttiphat Lapat-Atiwat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Inner Gulf of Thailand is a marine resource that provides ecological and economic value. Meanwhile, its can be acted like pollutions sink, especially heavy metals. After that, the extensions of industrialization, agriculturalization, and urbanization can degenerate to the inner Gulf environment quality. Therefore, this thesis was aimed to study the spatial distribution and seasonal variation of heavy metal concentration (Cd, Pb, Cu, Co, Ni, Mn and Zn) in surface sediment including the Mae Klong, the Tha Chin, the Chao Phraya and the Bangpakong River estuaries. Moreover, the contamination status and ecological risk were also evaluated. The results shown the …

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Investigation Of Copper And Zinc Contaminations In Bioponic Systems Using Chicken Manure Fertilizer, Satja Aksorn Jan 2021

Investigation Of Copper And Zinc Contaminations In Bioponic Systems Using Chicken Manure Fertilizer, Satja Aksorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

The bioponic system is a system that utilizes biological waste as a nutrient-rich source such as chicken manure fertilizer for plant growth integrated with aquaponic. At present, chicken manure fertilizer is contaminated with Cu and Zn may have the potential health effects through vegetable consumption. The objective of this study was to evaluate nitrogen transformation, nitrogen recovery, and plant growth in chicken manure-based bioponics at Cu (50–150 mg/kg) and Zn (200–600 mg/kg) supplementation and investigate the effects of Cu and Zn supplementations on plant bioaccumulation, root microbial community, and dietary health risk. Cu and Zn concentrations were analyzed using inductively …

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Ecological Risk Assessment Of Microplastics And Heavy Metals In Central Industrial Wastewater Treatment Plant, Thamonwan Phuprasert Jan 2021

Ecological Risk Assessment Of Microplastics And Heavy Metals In Central Industrial Wastewater Treatment Plant, Thamonwan Phuprasert

Chulalongkorn University Theses and Dissertations (Chula ETD)

Microplastics become a big concern in environment. Their small particle size can absorb a variety of pollutants from the nearby environment when discharged into the environment, especially heavy metals. Central industrial wastewater treatment plant (WWTP) is an important source of microplastics in the environment. In this study, wastewater and sludge were collected from two industrial estates in Thailand. Wastewater was collected from 4 points i.e., influent, post grit chamber, post aeration tank, and post sedimentation tank while sludge was collected from sludge storage. Concentration of microplastics, heavy metals and heavy metals on microplastics were examined to evaluate ecological risk assessment. …

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Queering The Migrant Experience: Gay Filipino Workers’ Performance Of Gender And Sexual Identities In Bangkok, Hans Kevin Madanguit Jan 2021

Queering The Migrant Experience: Gay Filipino Workers’ Performance Of Gender And Sexual Identities In Bangkok, Hans Kevin Madanguit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Philippine migration scholarship heavily focuses on heteronormative issues that depict the migrant workers as heterosexuals. Due to this trend, there is a scarcity of studies on overseas Filipino workers who identify as part of the Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+) Community. Hence, this qualitative research focuses on eleven documented Filipino workers in Thailand who are males assigned at birth and identify as gay homosexuals. Individual informal interviews were employed to investigate how they practice their non-normative gender and sexuality, given their multiple yet intersectional social identities in a country with vibrant queer cultures. It also probes the …

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Development Of Novel Point-Of-Care-Testing For Oxalate Detection In Urine Based On Oxalate-Binding Ligands, Naruerat Joybumrung Jan 2021

Development Of Novel Point-Of-Care-Testing For Oxalate Detection In Urine Based On Oxalate-Binding Ligands, Naruerat Joybumrung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Kidney stone disease is the third most common urinary tract disease worldwide that is more prevalent in the tropics. In Thailand, the highest stone prevalence up to 17% is reported in the Northeast. The disease is highly recurrent with a recurrence rate of about 50% within 5-10 years. The most common type of kidney stones is calcium oxalate (CaOx), and an increased urinary oxalate excretion is an important risk factor. Most of kidney stone patients have a hyperoxaluria condition (urinary oxalate >40 mg/day or >0.46 mmol/day). Therefore, urinary oxalate measurement has been widely used for estimating the risk of CaOx …

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Epigenetic Regulation Of Reactive Oxygen Species-Induced Tumor Progression In Hepatocellular Carcinoma, Suchittra Phoyen Jan 2021

Epigenetic Regulation Of Reactive Oxygen Species-Induced Tumor Progression In Hepatocellular Carcinoma, Suchittra Phoyen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oxidative stress is a consequence of an imbalance of antioxidants and reactive species. The most common form of reactive species is derived from oxygen, called reactive oxygen species (ROS). ROS involve in pathogenesis of several diseases including cancers. Cancer genesis and progression are contributed through both genetic and epigenetic mechanisms. Histone modification, a post-translational modification at histone tails, is one of the epigenetic mechanisms known to participate in carcinogenesis and tumor progression. Although the ROS-induced histone modification alteration has been demonstrated in some cancers, the change in histone methylation and gene expression by ROS in hepatocellular carcinoma (HCC) is scarcely …

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Integrative Transcriptomic Analysis And Validation Of Non-Coding Rna In Liver Cancers, Varunya Virushkul Jan 2021

Integrative Transcriptomic Analysis And Validation Of Non-Coding Rna In Liver Cancers, Varunya Virushkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are the most common and cause cancer-related deaths. Due to the lack of sensitivity and specificity of conventional markers, such as AFP, CA19-9 and CEA. Thus, this study aimed to identify miRNAs as a diagnostic biomarker for HCC and iCCA. First, in discovery set, RNA sequencing and small RNA sequencing data of 992 HCC and adjacent tissues and 116 iCCA and adjacent tissues were downloaded from the GEO database. After that, the lncRNA-miRNA-mRNA network was constructed and analyzed for the differential expression of lncRNA (DElncRNA), miRNA (DEmiRNA), and mRNA (DEmRNA). Then, the significant …

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Development Of A Human Viable Heavy Chain Antibody Against The Alpha Folate Receptor As A Molecule For Targeted Application By Phage Display Technology, Nattihda Parakasikron Jan 2021

Development Of A Human Viable Heavy Chain Antibody Against The Alpha Folate Receptor As A Molecule For Targeted Application By Phage Display Technology, Nattihda Parakasikron

Chulalongkorn University Theses and Dissertations (Chula ETD)

Alpha folate receptor (FRα) is currently under investigation as a target for the treatment of patients with non-small-cell lung cancer (NSCLC), since it is highly expressed in tumor cells but is largely absent in normal tissue. In this study, a novel human variable domain of a heavy-chain (VH) antibody fragment specific to FRα was enriched and selected by phage bio-planning. The positive phage clone (3A102 VH) is specifically bound to FRα and also cross-reacted with FRβ, as tested by ELISA. Clone 3A102 VH was then successfully expressed as a soluble protein in an E. coli shuffle strain. The obtained soluble …

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A Comparative Study Of Gut Microbiota In The Healthy Elderly And The Elderly With Colorectal Cancer, Nutta Iadsee Jan 2021

A Comparative Study Of Gut Microbiota In The Healthy Elderly And The Elderly With Colorectal Cancer, Nutta Iadsee

Chulalongkorn University Theses and Dissertations (Chula ETD)

Colorectal cancer is one of the third most common cancer worldwide. Dysbiosis of the human gut microbiota has been linked to sporadic colorectal cancer (CRC). This study aimed to compare the gut microbiota profile of a total of 80 Thai volunteers, who were above 50 years old, among 25 CRC patients, 33 adenoma patients, and 22 healthy controls (HC). The 16S rRNA sequencing was utilized to characterize the gut microbiome in both mucosal tissue and stool samples. Moreover, absolute quantitative PCR (qPCR) assay was conducted to quantify six CRC-associated bacteria including Fusobacterium nucleatum (FN), Parvimonas micra (PM), colibactin positive strains …

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The Effect Of Xylitol And Erythritol In The Presence Of Sucrose On Single And Mixed-Species Biofilm Of Early Colonizer And Cariogenic Streptococci, Panadda Yuapibanrak Jan 2021

The Effect Of Xylitol And Erythritol In The Presence Of Sucrose On Single And Mixed-Species Biofilm Of Early Colonizer And Cariogenic Streptococci, Panadda Yuapibanrak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries is caused by multiple factors. An essential factor is sucrose. Dental caries is the result of an imbalance between early colonizers and cariogenic bacteria in biofilms. Sugar alcohols, xylitol and erythritol, become more popular because they do not cause cavities and are also effective at preventing caries. In everyday life, however, sucrose consumption is unavoidable. Thus, the aim of this study was to investigate the effect of xylitol and erythritol in the presence of sucrose on single- and mixed-species biofilm of early colonizers and cariogenic bacteria. Bacteria were cultured in broth containing 1% sucrose compared to broth containing …

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Comparative Response Of Dendritic Cells To Pathogenic And Non-Pathogenic Leptospira Spp., Pratomporn Krangvichian Jan 2021

Comparative Response Of Dendritic Cells To Pathogenic And Non-Pathogenic Leptospira Spp., Pratomporn Krangvichian

Chulalongkorn University Theses and Dissertations (Chula ETD)

Leptospirosis is a zoonotic disease caused by pathogenic Leptospira species, which consist of three groups and contain 4 subclades: pathogenic strains (P1), intermediate strains (P2), and non-pathogenic strains (S1 and S2). Infection of pathogenic leptospires occurs through contact with contaminated environments. Then, leptospires present in the bloodstream disseminate to target organs. Nowadays, the knowledge of the immune response to pathogenic and non-pathogenic leptospires during early infection is still limited. Due to the limitation of a susceptible host, immunological reagents for hamsters and strains of mice are limited and not available. Dendritic cells are the first cells to encounter leptospires found …

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Designing An Extracorporeal Plasma Filtration Column With Specific Binding To Dengue Virions, Sasiwimon Thonghong Jan 2021

Designing An Extracorporeal Plasma Filtration Column With Specific Binding To Dengue Virions, Sasiwimon Thonghong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue infection is one of the major public health concerns and no specific treatment is currently available. An extracorporeal system is one of the alternative treatment in severe dengue patients with impending shock. However, the commercial immunoadsorption devices were size-exclusive, non-selective designed for multipurpose thus not specific for dengue syndrome. This study focuses on establishing the flavivirus-specific (4G2) antibody entrapped into the alginate bead. Results showed that the viral titer reduced more than 90 % after 3 h running on a simulated circuit quantified by reverse transcription qPCR and plaque titration assay. The experiments were repeated with two biological replicates …

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Endotoxemia From Nsaids-Induced Gut-Leakage Enhanced Lupus Characteristics In Fc Gamma Receptor Iib Deficient Lupus Mice, Thansita Bhunyakarnjanarat Jan 2021

Endotoxemia From Nsaids-Induced Gut-Leakage Enhanced Lupus Characteristics In Fc Gamma Receptor Iib Deficient Lupus Mice, Thansita Bhunyakarnjanarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

High dose of non-steroidal anti-inflammatory drugs (NSAIDs), the common analgesia, might induce lupus activity through NSAIDs-induced gastrointestinal permeability defect (gut leakage) that causes endotoxemia. Indomethacin (25 mg/day) was orally administered for 7 days in 24-week-old Fc gamma receptor IIb deficient (FcgRIIb-/-) mice, an asymptomatic lupus model, and age-matched wild-type (WT) mice. The severity of indomethacin-induced enteropathy in FcgRIIb-/- mice was higher than WT mice as demonstrated by intestinal injury (histology, immune-deposition and intestinal cytokines), gut leakage (FITC-dextran assay and endotoxemia) and serum cytokines. In addition, higher responses against endotoxemia in indomethacin-administered FcgRIIb-/- mice was also supported by the prominent responses …

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Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen Jan 2021

Impact Of Bacterial Dna In Severity Of Sepsis, Warerat Kaewduangduen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacterial sepsis can be caused by intestinal damage, leading to the passage of viable bacteria and their components into the circulatory system. Bacterial-free DNA in the blood during sepsis can be derived from bacterial death and intestinal translocation of free DNA in the gut contents. The presence of bacterial DNA in combination with lipopolysaccharide (LPS) can lead to more serious outcomes of sepsis. To explore the impact of bacterial-free DNA in sepsis, animal and macrophage experiments were performed. Firstly, the appearance of bacterial-free DNA and bacteriome in the blood was presented in mice with cecal ligation and puncture sepsis. Secondly, …

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Dosimetric Comparison Of Rapidplan And Manually Optimized Plans For Hippocampus Avoidance Whole Brain Radiation Therapy, Laksamon Phimolasawakun Jan 2021

Dosimetric Comparison Of Rapidplan And Manually Optimized Plans For Hippocampus Avoidance Whole Brain Radiation Therapy, Laksamon Phimolasawakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, whole-brain radiation therapy (WBRT) is a good method to cure brain metastases. However, it has been noted that whole-brain radiation therapy could be a cause to neurological toxicity which could damage the hippocampus that is an important part of forming long-term memories. The HA-WBRT is a complicated plan depending on planner skills, the researcher would like to simplify this problem using knowledge-based planning called RapidPlan. The objective of this study was to compare the dosimetric difference of RapidPlan and manually optimized plans for the treatment of HA-WBRT. The RapidPlan model was created for HA-WBRT. The PTV and OARs constraints …

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Hepatic Lesion Detectability On Dual Energy Computed Tomography Imaging : Phantom Study, Hataipat Jantawong Jan 2021

Hepatic Lesion Detectability On Dual Energy Computed Tomography Imaging : Phantom Study, Hataipat Jantawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study is to determine the hepatic lesion detectability in abdomen from various phantom sizes by dual-energy computed tomography (DECT) imaging and to investigate the factors affecting the detectability of hepatic lesion in abdomen by dual-energy CT in phantom study. The anthropomorphic liver with nodule inserted phantom with extension rings simulating the small, medium, and large patients were scanned under DECT acquisitions by varying three kVp combinations (80/-,90/-, and 100/Sn150-kVp). The series of 40-,50-,60-, and 70-keV VMI were generated from DECT data set. All images were used to assess the task-based image quality; task transfer function (TTF), …

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Dosimetric Impact Of Interplay Effects Instereotactic Body Radiation Therapy (Sbrt) Lung Cancer, Vanida Poolnapol Jan 2021

Dosimetric Impact Of Interplay Effects Instereotactic Body Radiation Therapy (Sbrt) Lung Cancer, Vanida Poolnapol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Lung cancer patient breathing induced interplay effects in the volumetric modulated arc therapy (VMAT) together with stereotactic body radiation therapy (SBRT), which lead to non-uniform doses within the target volume and unwanted dose to the surrounding tissues. The purpose of this study was to investigate the dosimetric impact of interplay effects in 6 MV FFF of photon beams for lung cancer and to calculate the novel interplay effects factor (IEF) for VMAT-SBRT lung cancer. This study performed the static and dynamic measurements using two dimensions (2D) robotic platform and diode array for 3D-conformal radiation therapy (3D-CRT) plans, while using three …

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Identification Of Shared Neoantigens In Brca1-Related Breast Cancer, Lucksica Ruangapirom Jan 2021

Identification Of Shared Neoantigens In Brca1-Related Breast Cancer, Lucksica Ruangapirom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Personalized neoantigen-based cancer vaccine has been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and brings about delay in treatment. Using off-the-shelf cancer vaccine by targeting shared neoantigen may circumvent these problems. We identified BRCA1-mutated breast cancer as a candidate for shared neoantigens because of its clinical aggressiveness and its genotypic and phenotypic similarities suggesting common somatic mutational events within the group. Therefore, we hypothesized that shared-neoantigen may be identified among BRCA1-related breast cancer and may be used as targets for shared neoantigen vaccine. For analyses, we obtained genome sequencing data of …

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Identification Of Snp Barcode For Classify Carbapenem-Resistant Enterobacteriaceae (Cre) And Non-Cre Using Nanopore Sequencing, Nicha Sangpiromapichai Jan 2021

Identification Of Snp Barcode For Classify Carbapenem-Resistant Enterobacteriaceae (Cre) And Non-Cre Using Nanopore Sequencing, Nicha Sangpiromapichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The continuous increase of carbapenem-resistant Enterobacteriaceae (CRE) prevalence has been a serious problem for public health worldwide. In the previous study, 25% of 3864 Klebsiella pneumoniae isolates were carbapenem-resistant. One of the most important risks of bacterial drug resistance is the improper use of antibiotics. The routine antimicrobial-susceptibility test requires overnight and has a turnaround time of approximately 2–3 days which delays the proper antibiotics. This study aims to develop a technique to classify CRE and non-CRE by SNP barcode. Method: Forty Klebsiella pneumoniae (KP) clinical isolates were collected from 2020–2021 at King Chulalongkorn Memorial Hospital. Twenty samples were …

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Study Of G6pd Deficiency With Clinical And Hematological Correlation In Newborn Infants, Thanaporn Pimpakan Jan 2021

Study Of G6pd Deficiency With Clinical And Hematological Correlation In Newborn Infants, Thanaporn Pimpakan

Chulalongkorn University Theses and Dissertations (Chula ETD)

G6PD deficiency is the most common enzymatic aberration, affecting more than a million people worldwide. If severe cases at birth are not diagnosed and treated promptly, they can develop into cerebral jaundice and hyperbilirubinemia. Hyperbilirubinemia is caused by an imbalance between increased bilirubin production and ineffective excretion of bilirubin. This can result in the neurotoxicity of bilirubin, kernicterus, and fatal mental retardation. Besides, It has been speculated that the presence of a high number of reticulocytes in newborns interferes with the diagnosis of G6PD deficiency since reticulocytes contain higher amounts of G6PD enzyme than mature erythrocytes. Therefore, the purposes of …

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Tuning The Wettability Of Metal Surface With Electrodeposited Porous Copper And Graphene Coatings, Husam Eltigani Jan 2021

Tuning The Wettability Of Metal Surface With Electrodeposited Porous Copper And Graphene Coatings, Husam Eltigani

Chulalongkorn University Theses and Dissertations (Chula ETD)

Electrodeposition of porous copper is an interesting type of coating that is emerging for various applications. However, the understanding of the relationships between copper surface wettability control and electrodeposition parameters and post-electrodeposition storage conditions is quite limited. Furthermore, it is worthwhile to explore how nanomaterials such as graphene would interact with porous copper to provide surface wettability modifications. This work therefore aims to develop a framework for the relationship of copper and graphene deposition processes, storage conditions, and the wetting behavior of copper surfaces. The research work performed in this study is divided into 2 parts: (i) effects of plating …

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The Effects Of A Recurrent Stroke Prevention Program On Blood Pressure, Low Density Lipoprotein Cholesterol, And Blood Glucose Among Patients With First Ischemic Stroke, Orapin Jullmusi Jan 2021

The Effects Of A Recurrent Stroke Prevention Program On Blood Pressure, Low Density Lipoprotein Cholesterol, And Blood Glucose Among Patients With First Ischemic Stroke, Orapin Jullmusi

Chulalongkorn University Theses and Dissertations (Chula ETD)

This cluster randomized control trial research with control group and repeated measure. The objectives of this study were to explore the effect of a recurrent stroke prevention program on blood pressure, low density lipoprotein cholesterol, and blood glucose among patients with first ischemic stroke. The participants were the patients who have been diagnosed with first ischemic stroke. They were recruited from two stroke units from two tertiary hospitals in public health region 2, Thailand. Sixty participants were randomly recruited and divided into experimental group (n=30) and control group (n=30). The participants in the experimental group received the recurrent stroke prevention …

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Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong Jan 2021

Effect Of Different Placement Methods On Voids Formationin Class Ii Cavity Restored With Bulk-Fill Resin Composite, Parinthorn Siyoputhawong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to evaluate void formation by micro-computed tomography in two-surface Class II cavities restored with two bulk-fill resin composites using different placement methods. Standardized Class II cavities were prepared in forty intact human maxillary first premolar teeth. The teeth were randomly divided into four groups and restored with (n=10): 1) one bulk placement with hand instrument; 2) two-bulk placement with hand instrument; 3) one bulk placement with injectable dispenser; 4) one bulk placement with injectable dispenser and sonic-activated handpiece. Percentage of void formation in the entire restoration was evaluated. Welch's ANOVA and Games-Howell post hoc …

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Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook Jan 2021

Factors Influencing The Dentist’S Decision To Propose A Tooth Autotransplantation In The Faculty Of Dentistry, Chulalongkorn University, Thunchanok Sinprasurdsook

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: To study factors which influence a dentist’s decision to propose the Tooth Autotransplantation (AT). Material and methods: A cross-sectional study was conducted among 99 dentists between January and March 2021. A questionnaire comprised demographic characteristics, unprimed scenario, primed scenario, reasoning behind decisions, experience, and knowledge of AT. Data were analyzed using the Chi-square test, McNemar’s test, and multiple logistic regression. Results: The respondents comprised 73 females and 26 males with a mean age of 30.84 ± 6.238 years. In the unprimed scenario, there were significant associations between fields of expertise, experience, knowledge of current indications, outcomes, and the benefits …

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Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin Jan 2021

Role Of Extracellular Adenosine Triphosphate (Eatp) On Immunomodulatory Function Of Human Periodontal Ligament Cells, Maythwe Kyawsoewin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Adenosine triphosphate, a nucleotide that acts as an important extracellular messenger, is released into the extracellular environment during various physiologic and pathological conditions. Human periodontal ligament cells (hPDLCs) can release adenosine triphosphate into the extracellular environment in response to mechanical stress. Extracellular adenosine triphosphate (eATP) plays role in both inflammation and osteogenic differentiation processes. eATP also participates in immunosuppressive action on immune cells. However, the role of eATP on the immunomodulatory function of hPDLCs is still unclear. This study aims to investigate the effects of eATP on the immunomodulatory function of hPDLCs and the participation of specific purinergic P2 …

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Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi Jan 2021

Anti-Inflammatory And Regeneration Properties Of Iloprost On Inflamed Human Dental Pulp Cells Model: An In Vitro Study, Rahman Wahyudi

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the clinical situation, pulp exposure can happen during caries removal procedures. Inflammation can occur on the pulp of the exposed area because of infiltration of bacteria from caries or as a result of pulp reaction to caries removal drilling. When the pulp was exposed during the caries removal procedure, traditional methods to preserve the pulp such as pulp capping and pulpotomy were performed. The ideal treatment outcome of the pulp exposure is to regain the primary structure of tubular dentin as well as maintain the vitality and healthiness of the dental pulp Thus, good dental materials or drugs used …

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