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Articles 31831 - 31860 of 33727
Full-Text Articles in Entire DC Network
Promoting Early-Adolescent Dual Language Learners' Language Use & Reading Skills, Holly Griskell
Promoting Early-Adolescent Dual Language Learners' Language Use & Reading Skills, Holly Griskell
Dissertations
Most studies of Dual Language Learners’ (DLLs’) literacy development focus on the early childhood years. As such, this three-study dissertation sought to advance our knowledge of DLLs’ English language and reading comprehension skills during early adolescence, a developmental stage when many students struggle with reading. Study 1, “Classroom Discussion and Early-Adolescent Dual Language Learners’ Motivation and Reading Comprehension”, considered how features of the classroom language environment promote DLLs’ reading comprehension skills. We examined relations between students’ (N = 413; M age = 11.66-years-old) engagement in high-quality classroom discussions and reading comprehension as a function of their motivation to participate in …
Ethical Health Care In An African Context: Linking Conventional Medicine And Traditional Healing Practices In Igboland, Nigeria., Michael Osondu Okoro
Ethical Health Care In An African Context: Linking Conventional Medicine And Traditional Healing Practices In Igboland, Nigeria., Michael Osondu Okoro
Dissertations
This dissertation argues that in Nigeria’s Igboland, a health care ethic reflective of the Roman Catholic Christian faith must build links between the rightful practices of both conventional Western medicine and traditional Igbo healers. It calls such a health care ethic an “integral health care ethic” in the Nigerian Igbo context.The inspiration for this dissertation comes from the growing respect given to indigenous people and their knowledge by the Roman Catholic Church since the Second Vatican Council and, more specifically, the attention Pope Francis has given to indigenous people in his writings and speeches. For example, in his remarks on …
Ursolic Acid Inhibits Collective Cell Migration And Promotes Jnk-Dependent Lysosomal Associated Cell Death In Gioblastoma Multiforme Cells, Gillian Conway, Diamante Zizyte, Julie Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Orla L. Howe, James Curtin
Ursolic Acid Inhibits Collective Cell Migration And Promotes Jnk-Dependent Lysosomal Associated Cell Death In Gioblastoma Multiforme Cells, Gillian Conway, Diamante Zizyte, Julie Mondala, Zhonglei He, Lorna Lynam, Mathilde Lecourt, Orla L. Howe, James Curtin
Articles
Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling pathways in Glioblastoma multiforme (GBM) and offers a promising starting point in drug discovery; however, understanding the relationship between cell death and migration has yet to be elucidated. UA induces a dose dependent cytotoxic response demonstrated by flow cytometry and biochemical cytotoxicity assays. Inhibitor and fluorescent probe studies demonstrate that UA induces a caspase independent, JNK dependent, mechanism of cell death. Migration studies established that UA inhibits GBM collective cell migration in a time dependent manner that …
Deciphering Property Insurers’ Indemnification Obligations After Disasters, Pandemics And Business Interruption Losses: An Analysis Of State Supreme Courts And Federal Circuits’ Declaratory Judgments, Willy E. Rice
Journal of Business & Technology Law
No abstract provided.
Dramaturgi Sakaiba Dalam Hibridisasi Budaya Minahasa Sulawesi Utara, Tony Tampake, Micchelle Hermanus
Dramaturgi Sakaiba Dalam Hibridisasi Budaya Minahasa Sulawesi Utara, Tony Tampake, Micchelle Hermanus
Paradigma: Jurnal Kajian Budaya
This paper discusses the sakaiba ritual procession in Minahasa which is carried out every year by the Christian community to welcome the New Year. The research was conducted in Taratara village, Tomohon, North Sulawesi. This study focuses on the significance and meaning of the sakaiba ritual procession within the context of the hybridization of contemporary religious culture in Minahasa. By using the theoretical concepts of ritual and dramaturgy, as well as applying the descriptive qualitative methods, this research found that the sakaiba ritual procession is a liminal hinge that allows a peaceful encounter between the ancient Minahasa traditions and the …
Opportunities For Public Comments On Pending Trap/Pot Fishery Regulations To Protect The North Atlantic Right Whale, Catherine Schluter
Opportunities For Public Comments On Pending Trap/Pot Fishery Regulations To Protect The North Atlantic Right Whale, Catherine Schluter
Marine Affairs Institute Staff Publications
No abstract provided.
Small Unmanned Aircraft Systems Acoustic Analysis For Noninvasive Marine Mammal Response: An Exploratory Field Study, David Thirtyacre, Gennifer Brookshire, Sarah Callan, Brittany Arvizu, Patrick Sherman
Small Unmanned Aircraft Systems Acoustic Analysis For Noninvasive Marine Mammal Response: An Exploratory Field Study, David Thirtyacre, Gennifer Brookshire, Sarah Callan, Brittany Arvizu, Patrick Sherman
International Journal of Aviation, Aeronautics, and Aerospace
As in countless other fields of human endeavor, small unmanned aircraft systems (sUAS) have the potential to benefit pinniped (Pinnipedia; e.g., Phocidae [seals], Otariidae [sea lions], and Odobenidae [walruses]) response efforts. The employment of sUAS could give responders a close-up look at animals in distress in order to determine their condition as well as develop a response strategy. However, unlike other subjects that are regularly inspected by sUAS (e.g., croplands and civil infrastructure) pinnipeds may respond to the distinctive sound generated by small, multirotor sUAS. This reaction may include retreating into the water en masse, which could put …
Albatross And Falcon Inspired Bionic Uav: An Aerodynamic Analysis, Bilji C. Mathew, Sagar K. Sahu, Prantik Dutta, Rushi Savale, Muruga Lal Jeyan Jv Dr.
Albatross And Falcon Inspired Bionic Uav: An Aerodynamic Analysis, Bilji C. Mathew, Sagar K. Sahu, Prantik Dutta, Rushi Savale, Muruga Lal Jeyan Jv Dr.
International Journal of Aviation, Aeronautics, and Aerospace
The drone industry yearns for enhanced aerodynamic performance. In order to achieve this feat, researchers and engineers are trying to mimic the natural flyers due to their aerodynamic optimality. One such flyer, the Albatross is an inspiration for many marine drones due to its planform and aerodynamic efficiency. The wing of the plan form is designed and simulated to study its properties. The Bell-Shaped Lift Distribution is incorporated for higher efficiency and elimination of the total downwash produced in case of an Elliptical Lift Distribution. A blended wing body inspired by the Falcon is used for smoother airflow interactions. Furthermore, …
Aerodynamic Characterization Of Bio-Mimicked Pleated Dragonfly Aerofoil, Md Akhtar Khan, Chinmaya Padhy
Aerodynamic Characterization Of Bio-Mimicked Pleated Dragonfly Aerofoil, Md Akhtar Khan, Chinmaya Padhy
International Journal of Aviation, Aeronautics, and Aerospace
The work inspired by the dragonfly wing corrugation positioned at the front wing's radius section lying at 40% of the total wingspan of forewing from the root section. During gliding flight, dragonfly wings presumed to be an ultra-light aerofoil due to its well-defined cross-sectional corrugation. The aerodynamic simulation carried out to understand the aerodynamic performance of a bio-mimetic dragonfly corrugated airfoil at low Reynolds number range of 75000-150000 to explore the potential advantages of pleated airfoils at a varying angle of attack from 0° to 12°. CFD analysis accomplished by using ANSYS Fluent to understand the aerodynamic performance of the …
Using Diffractive Activity To (Re)Configure Parental Choice Of Pre-Compulsory Education, Vicky Bamsey
Using Diffractive Activity To (Re)Configure Parental Choice Of Pre-Compulsory Education, Vicky Bamsey
Plymouth Institute of Education Theses
Prompted by the increasing number of children accessing alternatives to mainstream education, this research project was designed to investigate the activity of parents as they engaged in choosing different forms of education for their four-year-old child. The intention was to highlight the individual and entangled activity of parental choice in the English system of education. Facet methodology facilitated an exploration of the multi-dimensionality of each parent’s lived experience. It allowed for flexibility within the research process that used open interviews to follow the narratives of six sets of parents while they were thinking about and making different educational choices for …
Environmental Controls On The Skeletal Mineralogy Of Marine Calcifiers, Kilian Eichenseer
Environmental Controls On The Skeletal Mineralogy Of Marine Calcifiers, Kilian Eichenseer
School of Geography, Earth and Environmental Sciences Theses
Calcifying organisms secrete skeletons consisting of calcium carbonate (CaCO3). The two principle CaCO3 polymorphs used by marine calcifiers are aragonite and calcite. In the abiotic precipitation of CaCO3, the Mg/Ca ratio and the temperature are established controls of polymorph formation, but the importance of other factors, for example salinity, remains uncertain. The first objective of this thesis was to clarify the role of salinity in abiotic CaCO3 precipitation (Chapter 2). Experiments at salinities of 20, 35 and 50 and a Mg/Ca ratio of 2 resulted in co-precipitation of aragonite and calcite in all experiments, and no significant salinity influence on …
Optimising Oak Woodland Establishment Into Uk Upland Pastures In The Context Of Climate Change; And The Role Of Oak Woodland In Soil Hydrological Recovery For Natural Flood Management, Thomas Murphy
School of Geography, Earth and Environmental Sciences Theses
Increases in the magnitude and extremity of upland (>250-300m a.s.l.) precipitation associated with anthropogenic climate change (ACC) and coinciding with soil compaction leave downstream communities at elevated flood risk. The study examines changes in upland precipitation and the impact of upland ‘Atlantic’ oak (Quercus robur, Quercus petraea) woodland establishment on the recovery of soils for natural flood management (NFM). The soil moisture, livestock grazing and dispersal constraints for potential oak woodland expansion in upland pastures are assessed. The study is located within Dartmoor National Park (DNP) and finds greater increases in precipitation in upland areas than the lowland site, …
Evaluating The Emerging Environmental Risks Of Mycotoxins In Freshwater Ecosystems., Emily Eagles
Evaluating The Emerging Environmental Risks Of Mycotoxins In Freshwater Ecosystems., Emily Eagles
School of Geography, Earth and Environmental Sciences Theses
Deoxynivalenol (DON) and zearalenone (ZON) are two of the prominent mycotoxins which regularly contaminate food, both of these natural toxins are produced by fungi within the Fusarium genus. With the known widespread occurrence of these toxins in cereal crops there has been rising interest into the potential transference into freshwaters. Multiple reports of mycotoxin occurrence in freshwater samples have led to their consideration as natural chemicals of emerging concern, particularly with ZON seen to act in an oestrogenic nature, yet the ecotoxicological data to support analysis of risk to freshwater ecosystems is lacking. The main aim of this work was …
The Holistic Assessment And Care Planning In Partnership (Happi) Study A Mixed Methods Feasibility Study Of A Nurse-Led Intervention For Older People Who Live With Frailty, Helen Lyndon
School of Nursing and Midwifery Theses
Aim. This mixed-methods feasibility study aimed to identify and to develop consensus on the components of a holistic assessment and care planning intervention for frail older people in primary care and to conduct a feasibility cluster randomised, controlled trial with an embedded qualitative study to assess potential trial methods for a definitive trial.Background. Frailty is a serious but not inevitable consequence of ageing that can be managed as a long-tern condition. Frail older people are more at risk to adverse health outcomes than the non-frail, yet many do not receive evidence based management including a comprehensive geriatric assessment (CGA); a …
Across The River: Ferries As A Vehicle For Exploring Riverborderscapes, Eva Mcgrath
Across The River: Ferries As A Vehicle For Exploring Riverborderscapes, Eva Mcgrath
School of Geography, Earth and Environmental Sciences Theses
This thesis uses the concept of the riverborderscape to provide new understandings of watery geographies, borders and landscape. This is a spatial and conceptual term used to explore the space of the river through a holistic approach, focusing upon the materialities, experiences and narratives that shape, emerge within and construct this space. These ideas are applied in relation to three rivers that form an everyday border between places at different scales in the South West of England: the River Tamar (regional), River Torridge (district) and Helford River (parish). Research is situated on and across the river, through the routes of …
Employability As Sustainable Balance Of Stakeholder Expectations - Towards A Model For The Health Professions, Martin Cake, Melinda Bell, Liz Mossop, Caroline F. Mansfield
Employability As Sustainable Balance Of Stakeholder Expectations - Towards A Model For The Health Professions, Martin Cake, Melinda Bell, Liz Mossop, Caroline F. Mansfield
Health Sciences Papers and Journal Articles
The conceptual complexity of employability remains a barrier for its integration into discipline-based curricula. In the health professions, a particular challenge lies in integrating employability with the dominant paradigms of competency and professionalism. In this study, we explore these contextual challenges, and present the rationale and conceptual basis for a potential re-framing of employability within the context of this discipline group. We propose a novel definition and a conceptual model of employability better aligned to the needs of health professions. While employability has proven difficult to define broadly, it is framed around the expectations of both the employer and employee, …
Senegalese Parent, Family, And Community Engagement In Education: An Ubuntu-Inspired Inquiry, Nikysha D. Gilliam
Senegalese Parent, Family, And Community Engagement In Education: An Ubuntu-Inspired Inquiry, Nikysha D. Gilliam
LMU Theses and Dissertations
The relationship between families and schools, and the importance of parents and families to a child’s academic success is well documented internationally. However, the development of frameworks, theories, policies, and programs has not resulted in an increase in parent or family engagement in public schools, nor has it remedied the historical alienation and marginalization of families of color in the United States; positive comprehensive programs in communities of color at the middle and high school levels often seem to be missing. Because of African American families’ cultural connection to countries in Africa resulting from the Atlantic Slave Trade, I used …
Optimization And Assessment Of Phytoplankton Size Class Algorithms For Ocean Color Data On The Northeast U.S. Continental Shelf, Kyle J. Turner, Colleen B. Mouw, Kimberly J.W. Hyde, Ryan Morse, Audrey B. Ciochetto
Optimization And Assessment Of Phytoplankton Size Class Algorithms For Ocean Color Data On The Northeast U.S. Continental Shelf, Kyle J. Turner, Colleen B. Mouw, Kimberly J.W. Hyde, Ryan Morse, Audrey B. Ciochetto
Graduate School of Oceanography Faculty Publications
The size structure of phytoplankton communities influences important ecological and biogeochemical processes, including the transfer of energy through marine food webs. A variety of algorithms have been developed to estimate phytoplankton size classes (PSCs) from satellite ocean color data. However, many of these algorithms were developed for application to the global ocean, and their performance in more productive, optically complex coastal and continental shelf regions warrants evaluation. In this study, several existing PSC models were applied in the Northeast U.S. continental shelf (NES) region and compared with in situ PSC estimates derived from a local HPLC pigment data set. The …
Surviving Heatwaves: Thermal Experience Predicts Life And Death In A Southern Ocean Diatom, Toby Samuels, Tatiana A. Rynearson, Sinéad Collins
Surviving Heatwaves: Thermal Experience Predicts Life And Death In A Southern Ocean Diatom, Toby Samuels, Tatiana A. Rynearson, Sinéad Collins
Graduate School of Oceanography Faculty Publications
Extreme environmental fluctuations such as marine heatwaves (MHWs) can have devastating effects on ecosystem health and functioning through rapid population declines and destabilization of trophic interactions. However, recent studies have highlighted that population tolerance to MHWs is variable, with some populations even benefitting from MHWs. A number of factors can explain variation in responses between populations including their genetic variation, previous thermal experience and the cumulative heatwave intensity (°C d) of the heatwave itself. We disentangle the contributions of these factors on population mortality and post-heatwave growth rates by experimentally simulating heatwaves (7.5 or 9.2°C, for up to 9 days) …
Meta-Analysis Of Primary Producer Amino Acid Δ15N Values And Their Influence On Trophic Position Estimation, Matthew D. Ramirez, Alexi C. Besser, Seth D. Newsome, Kelton Mcmahon
Meta-Analysis Of Primary Producer Amino Acid Δ15N Values And Their Influence On Trophic Position Estimation, Matthew D. Ramirez, Alexi C. Besser, Seth D. Newsome, Kelton Mcmahon
Graduate School of Oceanography Faculty Publications
- Compound-specific stable isotope analysis of individual amino acids (CSIA-AA) has emerged as a transformative approach to estimate consumer trophic positions (TPCSIA) that are internally indexed to primary producer nitrogen isotope baselines. Central to accurate TPCSIA estimation is an understanding of beta (β) values—the differences between trophic and source AA δ15N values in the primary producers at the base of a consumers’ food web. Growing evidence suggests higher taxonomic and tissue-specific β value variability than typically appreciated.
- This meta-analysis fulfills a pressing need to comprehensively evaluate relevant sources of β value variability and its contribution to …
Open Ocean Particle Flux Variability From Surface To Seafloor, B. B. Cael, Kelsey Bisson, Maureen Conte, Manon T. Duret, Christopher L. Follett, Stephanie A. Henson, Makio C. Honda, Morten H. Inversen, David M. Kart, Richard S. Lampitt, Colleen B. Mouw, Frank Muller-Karger, Corinne A. Pebody, Kenneth L. Smith, David Talmy
Open Ocean Particle Flux Variability From Surface To Seafloor, B. B. Cael, Kelsey Bisson, Maureen Conte, Manon T. Duret, Christopher L. Follett, Stephanie A. Henson, Makio C. Honda, Morten H. Inversen, David M. Kart, Richard S. Lampitt, Colleen B. Mouw, Frank Muller-Karger, Corinne A. Pebody, Kenneth L. Smith, David Talmy
Graduate School of Oceanography Faculty Publications
The sinking of carbon fixed via net primary production (NPP) into the ocean interior is an important part of marine biogeochemical cycles. NPP measurements follow a log-normal probability distribution, meaning NPP variations can be simply described by two parameters despite NPP's complexity. By analyzing a global database of open ocean particle fluxes, we show that this log-normal probability distribution propagates into the variations of near-seafloor fluxes of particulate organic carbon (POC), calcium carbonate, and opal. Deep-sea particle fluxes at subtropical and temperate time-series sites follow the same log-normal probability distribution, strongly suggesting the log-normal description is robust and applies on …
Addressing Urgent Questions For Pfas In The 21st Century, Carla Ng, Ian T. Cousins, Jamie C. Dewitt, Juliane Glüge, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Sharyle Patton, Martin Scheringer, Xenia Trier, Zhanyun Wang
Addressing Urgent Questions For Pfas In The 21st Century, Carla Ng, Ian T. Cousins, Jamie C. Dewitt, Juliane Glüge, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Sharyle Patton, Martin Scheringer, Xenia Trier, Zhanyun Wang
Graduate School of Oceanography Faculty Publications
Despite decades of research on per- and polyfluoroalkyl substances (PFAS), fundamental obstacles remain to addressing worldwide contamination by these chemicals and their associated impacts on environmental quality and health. Here, we propose six urgent questions relevant to science, technology, and policy that must be tackled to address the “PFAS problem”: (1) What are the global production volumes of PFAS, and where are PFAS used? (2) Where are the unknown PFAS hotspots in the environment? (3) How can we make measuring PFAS globally accessible? (4) How can we safely manage PFAS-containing waste? (5) How do we understand and describe the health …
Information Requirements Under The Essential-Use Concept: Pfas Case Studies, Juliane Glüge, Rachel London, Ian T. Cousins, Jamie Dewitt, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Carla A. Ng, Sharyle Patton, Xenia Trier, Zhanyun Wang, Martin Scheringer
Information Requirements Under The Essential-Use Concept: Pfas Case Studies, Juliane Glüge, Rachel London, Ian T. Cousins, Jamie Dewitt, Gretta Goldenman, Dorte Herzke, Rainer Lohmann, Mark Miller, Carla A. Ng, Sharyle Patton, Xenia Trier, Zhanyun Wang, Martin Scheringer
Graduate School of Oceanography Faculty Publications
Per- and polyfluoroalkyl substances (PFAS) are a class of substances for which there are widespread concerns about their extreme persistence in combination with toxic effects. It has been argued that PFAS should only be employed in those uses that are necessary for health or safety or are critical for the functioning of society and where no alternatives are available (“essential-use concept”). Implementing the essential-use concept requires a sufficient understanding of the current uses of PFAS and of the availability, suitability, and hazardous properties of alternatives. To illustrate the information requirements under the essential-use concept, we investigate seven different PFAS uses, …
An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, Melissa M. Omand, Bethany D. Jenkins, Heather Mcnair, Tatiana A. Rynearson, Et Al
An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, Melissa M. Omand, Bethany D. Jenkins, Heather Mcnair, Tatiana A. Rynearson, Et Al
Graduate School of Oceanography Faculty Publications
The goal of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign is to develop a predictive understanding of the export, fate, and carbon cycle impacts of global ocean net primary production. To accomplish this goal, observations of export flux pathways, plankton community composition, food web processes, and optical, physical, and biogeochemical (BGC) properties are needed over a range of ecosystem states. Here we introduce the first EXPORTS field deployment to Ocean Station Papa in the Northeast Pacific Ocean during summer of 2018, providing context for other papers in this special collection. The experiment was conducted with …
Differential Patterns Of Connectivity In Western Pacific Hydrothermal Vent Metapopulations: A Comparison Of Biophysical And Genetic Models, Corinna Breusing, Shannon B. Johnson, Satoshi Mitarai, Roxanne A. Beinart, Verena Tunnicliffe
Differential Patterns Of Connectivity In Western Pacific Hydrothermal Vent Metapopulations: A Comparison Of Biophysical And Genetic Models, Corinna Breusing, Shannon B. Johnson, Satoshi Mitarai, Roxanne A. Beinart, Verena Tunnicliffe
Graduate School of Oceanography Faculty Publications
Hydrothermal ecosystems face threats from planned deep-seabed mining activities, despite the fact that patterns of realized connectivity among vent-associated populations and communities are still poorly understood. Since populations of vent endemic species depend on larval dispersal to maintain connectivity and resilience to habitat changes, effective conservation strategies for hydrothermal ecosystems should include assessments of metapopulation dynamics. In this study, we combined population genetic methods with biophysical models to assess strength and direction of gene flow within four species of the genus Alviniconcha (A. boucheti, A. kojimai, A. strummeri and A. hessleri) that …
Deep Learning Of Sea Surface Temperature Patterns To Identify Ocean Extremes, J. Xavier Prochaska, Peter C. Cornillon, David M. Reiman
Deep Learning Of Sea Surface Temperature Patterns To Identify Ocean Extremes, J. Xavier Prochaska, Peter C. Cornillon, David M. Reiman
Graduate School of Oceanography Faculty Publications
We performed an out-of-distribution (OOD) analysis of ∼12,000,000 semi-independent 128 × 128 pixel2 sea surface temperature (SST) regions, which we define as cutouts, from all nighttime granules in the MODIS R2019 Level-2 public dataset to discover the most complex or extreme phenomena at the ocean’s surface. Our algorithm (ULMO) is a probabilistic autoencoder (PAE), which combines two deep learning modules: (1) an autoencoder, trained on ∼150,000 random cutouts from 2010, to represent any input cutout with a 512-dimensional latent vector akin to a (non-linear) Empirical Orthogonal Function (EOF) analysis; and (2) a normalizing flow, which maps the autoencoder’s latent …
A Decade Of Gomri Dispersant Science: Lessons Learned And Recommendations For The Future, Antonietta Quigg, John W. Farrington, Sherryl Gilbert, Steven A. Murawski, Vijay T. John
A Decade Of Gomri Dispersant Science: Lessons Learned And Recommendations For The Future, Antonietta Quigg, John W. Farrington, Sherryl Gilbert, Steven A. Murawski, Vijay T. John
Marine Science Faculty Publications
Dispersants are among a number of options available to oil spill responders. The goals of this technique are to remove oil from surface waters in order to reduce exposure of surface-dwelling organisms, to keep oil slicks from impacting sensitive shorelines, and to protect responders from volatile organic compounds. During the Deepwater Horizon response, unprecedented volumes of dispersants (Corexit 9500 and 9527) were both sprayed on surface slicks from airplanes and applied directly at the wellhead (~1,500 m water depth). A decade of research followed, leading to a deeper understanding of dispersant effectiveness, fate, and effects. These studies resulted in new …
The Northwest Passage In The Arctic : A Brief Assessment Of The Relevant Marine Transportation System And Current Availability Of Search And Rescue Services, Rebecca Sheehan, Dimitrios Dalaklis, Anastasia Christodoulou, Megan Drewniak, Peter Raneri, Angelos Dalaklis
The Northwest Passage In The Arctic : A Brief Assessment Of The Relevant Marine Transportation System And Current Availability Of Search And Rescue Services, Rebecca Sheehan, Dimitrios Dalaklis, Anastasia Christodoulou, Megan Drewniak, Peter Raneri, Angelos Dalaklis
Articles
No abstract provided.
The Role Of Hippo Signalling In Merlin Null Tumours Of The Nervous System, Liyam Laraba
The Role Of Hippo Signalling In Merlin Null Tumours Of The Nervous System, Liyam Laraba
Other Faculty of Health Theses
Meningiomas and schwannomas are mostly benign tumours of the nervous system that currently have no clinically approved treatments apart from surgical resection. The tumour suppressor Moesin-Ezrin-Radixin-Like Protein (Merlin) is deleted in 50-60% and 70% of meningiomas and schwannomas respectively. The Hippo pathway is an evolutionarily conserved pathway that has been shown to control tissue size by contactmediated growth inhibition. Previous studies have shown that there is aberrant nuclear activity of yes-associated protein (YAP) and transcriptional coactivator with PDZbinding motif (TAZ), the co-transcriptional activators of the Hippo pathway in Merlinnull meningioma and schwannoma. Nuclear YAP and TAZ activate transcription, primarily by …
Ionic Dysregulation In White Matter Damage, Christopher Bulman
Ionic Dysregulation In White Matter Damage, Christopher Bulman
Other Faculty of Health Theses
White matter damage can occur in a variety of neurological diseases where it contributes significantly to impairment of brain function. Dysregulation of ion gradients across membranes is a common phenomenon across many diseases and can be damaging due to increased metabolic demand, oedema and activation of destructive enzyme cascades. Breakdown of ionic gradients can occur under many circumstances. For example, loss of energy supply to ion pumps causes disruption early in stroke progression. Activation of ion channels through voltage or ligand gating contributes greatly to complications such as intracellular calcium overload in many diseases. This thesis investigated the contribution of …