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Understanding The Effect Of Climate And Hydrometeorological Extremes On Natural And Human-Induced Hydrosystems, Jeongwoo Hwang

Dissertations and Theses

The contemporary hydrosystems of the United States involve a complex combination of natural and modified basins in the presence of changing climate and anthropogenic impacts. An enhanced understanding of the interdependence between climate forcings, human-induced interventions, and water balance in both natural and modified basins are essential for developing reliable and resilient hydrosystems and for better water resources management. In response, this dissertation focuses on investigating the hydroclimatology of natural and modified basins across the contiguous United States. It has three research objectives: (1) to explain flow alterations due to anthropogenic activities, especially dam operations, in modified basins and understand …

Investigating The Effect Of Electrolyte Concentration And Charging Protocol On Materials Utilization In Rechargeable Zinc Manganese Dioxide Batteries, Snehal H. Kolhekar

Dissertations and Theses

Achieving a highly cyclable, high energy density battery with MnO₂ cathodes encounters many obstacles. Chief among these is the inability of the widely-used γ-MnO₂ polymorph to retain its structural integrity when cycled to near full one-electron discharge capacity, which is about 280mAh/g for commercially available electrolytic manganese dioxide (EMD). In this one-electron range, discharge occurs by proton insertion producing Mn⁺³ which then reverts to γ-MnO₂ on charging. In the first part of the thesis, we investigate the root cause of failure of MnO₂ cathodes under deep cycling in the one-electron discharge range and establish a …

Development Of A Biaxial Testing System For Research Of Soft Tissue Biomechanics Using Laboratory Models, Tariq Shameen

Dissertations and Theses

The rupture of the cap tissue layer of a fibroatheroma in human coronary vessels is considered the key event leading to the formation of a thrombus and myocardial infarction, resulting in more than half a million deaths in the US every year. In this study, we are interested in investigating the biomechanics of different elastomer materials that can be used as laboratory models to replicate coronary arteries’ ultimate tensile stress (0.2 - 2.08 MPa). To this end, we developed a biomechanical testing system that allows us to characterize the material properties of small samples with high accuracy and precision. We …

Medical Knowledge As A Recalcitrant Epistemological System: An Application Of Standpoint Epistemology In The Analysis Of Marginalization Within U.S Healthcare, Abby Deshazo

CMC Senior Theses

Research on healthcare disparities outside the field of epistemology tend to miss the true origins of oppressions imposed on marginalized individuals by the U.S healthcare system. This happens because of the false belief that these oppressions are reducible to social or political oppressions. By employing the perspective of a standpoint epistemologist, we can better identify the origins of these oppressions and subsequently consider more appropriate solutions. The standpoint epistemologist’s perspective (1) provides an intuitive case for the role individuals’ schemas play in the evaluation of what healthcare professionals know; (2) situates medical knowledge within epistemology, leading us to …

The Duality Of Gnome, Koss Klobucher

CMC Senior Theses

Koss Klobucher's senior thesis, The Duality of Gnome, is a six-part collection of short stories written, edited, and compiled under the mentorship of James Morrison. Themes include death, absurdity, the afterlife, and love.

Sleep Consistency And Its Relation To Inflammation: Identifying The Role Of Emotional Regulation, Caitlyn Louzado

CMC Senior Theses

Sleep duration, quality, and consistency are associated with well-being and productivity. College students struggle to achieve the right balance of sleep and research demonstrates how this has severe repercussions on their physical health academic performance. The effects of sleep consistency interact with emotional regulation (ER). This observational study investigates the relationship between all three sleep characteristics and inflammation, while exploring the mediating and moderating role of ER. Participants included 138 undergraduate students (Females= 81 Males= 57). ER and sleep quality were measured through self-reported questionnaires and inflammation through blood spot analysis. Sleep consistency and duration were assessed using an Acti-Watch. …

Agro-Environmental Approaches To The Moderation Of Outmigration From Northeast Thailand, Megan Perron

CMC Senior Theses

Thailand’s increasing migration rates out of the country’s poorest region over the past few decades have resulted in a range of issues for both migrants and relatives of the migrants who choose to remain at home. A combination of rapid urban growth in Bangkok and a declining agricultural sector in the Northeast, driven by climate change and unsustainable farming practices, is driving rural-to-urban migration that subjects them to harsh working conditions and social marginalization. To attract migration back to Isaan, the implementation of Climate-Smart Agriculture in the near term and eventually, Regenerative Agriculture, will likely build climate resilience in the …

Arguments For The Abolition Of Gender, Antonio Pineda

CMC Senior Theses

Throughout the process of writing this thesis, I have struggled with whether or not to use the term “gender abolition.” In one sense, the term itself initially piqued my interest in the topic. I remember the first time I heard of gender abolition, I had an immediate intuitive resistance. I thought it was another manifestation of the disconnect that exists between academia and society at large. However, my feelings quickly changed when the concept was explained to me in my sophomore year philosophy seminar. My incredulousness transformed to excitement when I realized gender abolition was actually simply the full realization …

Multifractional Brownian Motion And Its Applications To Factor Analysis On Consumer Confidence Index, Christopher Box

CMC Senior Theses

This thesis aims at introducing a new way to model time series objects in statistics using multifractional processes. It provides a detailed review of Brownian motion, fractional Brownian motion and extends the above 2 models to multifractional processes. To demonstrate a successful application to the real world, we perform pattern analysis on consumer confidence and household spending behavior. The analysis is conducted through investigating the local Holder regularity of the consumer confidence index and household expenditure. In the analysis, we first model consumer confidence index and household expenditure with a multifractional stochastic processes. We then use the index, pointwise Holder …

Postpartum Depression Rates In Latine Birthing Parents During The Covid-19 Pandemic: A Closer Look At Cultural Protective Factors And Acculturation, Perla Barajas

CMC Senior Theses

In the Latine community, the prioritization of social or familial support (familism) serves as a cultural protective factor that has typically guarded against unfavorable health outcomes. However, during the COVID-19 pandemic, social interactions and familial support were substantially limited. A vulnerable population during this pandemic was Latine birthing parents because previous studies have shown that perception of social support directly impacts postpartum depression (PPD) in this group. This study will use data from the Pregnancy Risk Assessment Monitoring System to compare PPD rates for Latine birthing parents from before the COVID-19 pandemic to the PPD rates during the pandemic. Moreover, …

A Proposal To Develop And Pilot-Test The Effects Of A Culturally Adapted Stigma Intervention For Latinos, Sandy Ahumada

CMC Senior Theses

The bulk of research examining barriers to mental health services (MHS) for Latinos focuses on financial obstacles such as socioeconomic status and insurance coverage. Unfortunately, less work has been done on cultural barriers such as stigma. The purpose of this proposed study is to develop and pilot-test a culturally adapted contact intervention for Latinos that reduces stigma and increases help-seeking intentions. This study will test the differential efficacy of utilizing psychoeducation with the newly developed interpersonal contact intervention (PIC) as opposed to psychoeducation (P) only. Participants (n=324) will fill out pre- (T1), post- (T2), and 1-week follow-up (T3) …

Assessing The Significance Of Substrate Color And Temperature On Balanus Glandula Growth And Survivorship, Nhi Phan

CMC Senior Theses

The body temperatures of intertidal species are strongly dependent on the temperature of their external environment. This study sought to understand the impact of a substrate’s color and subsequent temperature on Balanus glandula in order to predict the potential effects of warming temperatures from climate change on intertidal species. Barnacles were allowed to settle and grow on three differently colored plates and were photographically monitored over the course of eleven weeks. Settlement and survivorship were recorded on-site, while growth was tracked utilizing digital imaging software. It was hypothesized that barnacles on peach plates would perform the best since the ambient …

Climate Change In Fiction: The Evolution And Challenges Of Environmental Apocalyptic Literature, Lauren Gode

CMC Senior Theses

This thesis examines the several aspects and variations of environmental apocalyptic literature, and its potential ability to mobilize action against the imminent threat of global climate change. It delves into the intersection between climate research and fiction, as well as the rhetorical techniques used in works such as The Death of Grass by John Christopher, The Drowned World by J.G. Ballard, Oryx and Crake by Margaret Atwood, and The Road by Cormac McCarthy, and covers the complementarity between climate fiction and works of non-fiction such as The Great Derangement by Amitav Ghosh. Finally, this thesis will assess the effectiveness of …

The Motherhood Wage Penalty: New Evidence On Long-Run Effects And Group Heterogeneity, Vera Kratz

CMC Senior Theses

This paper seeks to establish the magnitude of the long-run motherhood wage penalty. Using data from the 1997 National Longitudinal Survey of Youth, I examine the difference between the real hourly wages of mothers and non-mothers in the long run. By comparing mothers to not-yet-mothers as well as never-mothers, I am able to better isolate the true wage penalty mothers face. My findings indicate that 21 to 25 years after the birth of their first child, mothers face a 31.75 percentage point wage penalty compared to non-mothers. In addition, I examine differences in the wage penalties of mothers by marital …

More Than A Myth: The Benefits Of Incorporating Holistic Healing Methods From Native American And Mexican Cultures To Approach Opioid Use Disorder (Oud) Treatment, Juliana Favela

CMC Senior Theses

Opioid Use Disorder (OUD) is a substance use disorder that characterizes a dependence on and an addiction to opioids. Opioids attack the prefrontal cortex, the dopaminergic reward system, and the hypothalamic-pituitary-adrenal (HPA) axis which is responsible for the body’s stress response. Opioids constantly shift one’s “set point” to the point where normal actions that cause joy and excitement no longer cause those feelings, resulting in craving and dependence. The opioid epidemic is currently ravaging the United States and has disproportionately affected Native American populations specifically in the rural areas (Tipps, et.al, 2018). The current methods for addressing OUD include medicine …

Environmental Controls On The Spatial Distribution Of Greenfin Darters And Biodiversity In The Blue Ridge Mountains, Dri Tattersfield

CMC Senior Theses

Disproportionate concentrations of biodiversity in mountains worldwide suggest linkages between geologic processes and biodiversity that are not yet well understood. The Tennessee River Basin in the Blue Ridge Mountains of the southeastern U.S. is a global hotspot for freshwater fish biodiversity. To investigate drivers of biodiversity in the Tennessee River Basin, and explore links to geologic processes, I study the Greenfin Darter (Nothonotus chlorobranchius), a small fish endemic to the upper Tennessee River Basin. I use generalized linear models (GLMs) to evaluate the influence of topography, lithology, climate and land use on the distribution of the Greenfin Darter, …

Using Nmr Spectroscopy And Computational Chemistry To Confirm The Structure Of Novel Antibiotic Nocamycin O, Stephanie Lewis

CMC Senior Theses

In recent years, many medically promising antibiotics have been discovered in nature, especially in insect-microbe symbioses. One of the better-studied examples of this kind of defensive relationship is that of fungus-growing ants and the antibiotic-producing Actinobacteria. These bacteria produce several defensive chemicals with myriad uses, including one antibiotic that inhibits the growth of several bacterial strains, including other Actinobacteria. This antibiotic (known as nocamycin O) is a promising candidate for medicinal use due to its similarities to bacterial RNA polymerase inhibitors tirandamycin and streptolydigin, which inhibit several human pathogens. The determination of the structure of nocamycin O will be an …

Understanding The Epigenetic Role Of 8-Oxoguanine And Ogg1 In Non-Small Cell Lung Cancer, Kyrellos Ibrahim

CMC Senior Theses

Oxidative damage to the genome can form 8-oxoguanine (oxoG), a premutagenic lesion suggested to play an epigenetic role in the regulation of various cellular pathways. Alongside oxoG in this regulation is the 8-oxoguanine DNA glycosylase (OGG1), which primarily functions to repair oxoG damage via base excision repair, but is also implicated in recruiting NFκB and impacting gene expression associated with cancer growth. This proposal aims to build genome-wide maps of oxoG occupancy, and indirectly OGG1 localization, in healthy lung cells and in non-small cell lung cancer adenocarcinoma cells in order to identify regulatory regions in the genome at which oxoG …

Viability Of Physiologically Timed Relaxation Interventions In Children With Asd, Nicholas Mendez

CMC Senior Theses

Autism Spectrum Disorder (ASD) is an increasingly common developmental disorder that changes how people experience the world and affects individuals’ social interactions and often leads to many adverse behaviors. Current literature dictates that a primary contributor to these adverse behaviors is that those with ASD have difficulty determining their own emotional states and determining the physiological signals that their body sends them. A study by Dr. Sarabadani et al. determined that it was possible to monitor the physiology of an individual with ASD and correlate certain signals to emotions, such as stress. These findings indicate the feasibility of establishing a …

In Between, Not Really Anywhere: Narratives Of Half Asian-Half White Young Adults Navigating A Monoracial Society, Lena Proctor

CMC Senior Theses

This senior thesis examines half Asian-half white biracial identity development among young adults. While previous literature explores how this group identifies, this study examines why individuals racially identify in the way they do. Over the course of two months, in a series of 10 in-depth, open-ended interviews with half Asian-half white young adults, the paper asks the two questions: 1. How do half Asian-half white individuals develop their racial identity?, and 2. How do half Asian-half white individuals make sense of their biracial identity in a monoracial world?. Through the analysis of the data, I conclude that in racial identity …

Will There Be Changes In Sexually Differentiated Behaviors In Mice Manipulated For The Sry Gene As They Mature Into Adultood?, Subin Joo

CMC Senior Theses

Sexually differentiated behavior has been shown to be affected by both genes and hormones. The discovery of the SRY gene, which codes for the development of testes, lead to the development of the Four Core Genotypes model of mice, and the separation of sex chromosomes and its resulting gonadal hormones. Using the FCG model, this study aims to look at the development of sexually differentiated behavior in mice, and track how it changes throughout their life. FCG mice will be divided into individual and social housing, and repeated experiments carried out to test their reaction to both intact female and …

Community-Based Disaster Risk Management And Covid-19: How Local Ngos In Latin America Adapted To The Pandemic, Emily Pugh

CMC Senior Theses

The global COVID-19 pandemic posed new challenges for communities across Latin America: lack of access to potable water and food, loss of jobs and lack of access to technology now needed for children to attend school. By interviewing different leaders of NGOs throughout the continent, I was able to find out how local NGOs were adapting their typical activities to help their communities face these new and worsening challenges. While the NGOs in this study do not primarily focus on disaster relief, each adapted their initiatives to deal with the current needs of the community they serve. Some were able …

Los Indetectables: An Examination Of Oral Histories Of Hiv+, Undetectable Gay Latino Men During Covid-19 And U=U (Undetectable = Untransmittable) Era, Angel Ornelas

CMC Senior Theses

Since the early 1990s, antiretroviral medications have made it possible to reduce viral loads of HIV/AIDS to the point of undetectability to standard blood tests. Individuals living with such low quantities of the virus have reframed our social understanding of the HIV-AIDS epidemic by redefining HIV infection as a chronic, manageable disease and challenging current public health definitions of safe-sex activity for homosexual men. HIV infection is no longer a death sentence, but it remains a life sentence requiring constant medication adherence and treatment, major changes to lifestyle habits, and a modification in sexual performances. This thesis sheds new light …

Understanding Place-Based Immigration: The Proposal, Its Popularity, And Its Prospects, Mohamad Moslimani

CMC Senior Theses

The idea to create a new class of place-based visas is gaining traction in policy circles. These visas, known in some instances as “heartland visas” and as part of a class of immigration reform called “place-based immigration” (PBI), are designed to give state and local governments the ability to sponsor immigrants to live and work in their local communities. The proposal has gained traction among a variety of candidates for federal office and local immigration policy stakeholders. The reason for this support is the proposal’s ability to address a grave issue facing numerous communities across the U.S.—and its ability to …

'Awakening The Sleeping Giant': Re-Indigenization Principles For Transforming Biodiversity Conservation In Canada And Beyond, M’S-It No’Kmaq, Albert Marshall, Karen F. Beazley, Jessica Hum, Shalan Joudry, Anastasia Papadopoulos, Sherry Pictou, Janet Rabesca, Lisa Young, Melanie Zurba

Articles, Book Chapters, & Popular Press

Precipitous declines in biodiversity threaten planetary boundaries, requiring transformative changes to conservation. Colonial systems have decimated species and ecosystems and dispossessed Indigenous Peoples of their rights, territories, and livelihoods. Despite these challenges, Indigenous governed lands retain a large proportion of biodiversity-rich landscapes. Indigenous Peoples have stewarded the land in ways that support people and nature in respectful relationship. Biodiversity conservation and resurgence of Indigenous autonomies are mutually compatible aims. To work towards these aims requires significant transformation in conservation and re-Indigenization. Key to both are systems that value people and nature in all their diversity and relationships. This paper introduces …

Transparency Of Regulatory Data Across The European Medicines Agency, Health Canada, And Us Food And Drug Administration, Alexander C. Egilman, Amy Kapczynski, Margaret E. Mccarthy, Anita T. Luxkaranayagam, Christopher J. Morten, Matthew Herder, Joshua D. Wallach, Joseph S. Ross

Articles, Book Chapters, & Popular Press

Based on an analysis of relevant laws and policies, regulator data portals, and information requests, we find that clinical data, including clinical study reports, submitted to the European Medicines Agency and Health Canada to support approval of medicines are routinely made publicly available.

From Sandbox To Pandemic: Agile Reform Of Canadian Drug Regulation, Ipek Eren Vural, Matthew Herder, Janice E. Graham

Articles, Book Chapters, & Popular Press

Public health urgency for emerging COVID-19 treatments and vaccines challenges regulators worldwide to ensure safety and efficacy while expediting approval. In Canada, legislative amendments by 2019 Om- nibus Bill C-97 created a new "agile" licensing framework known as the "Advanced Therapeutic Pathway" (ATPathway) and modernized the regulation of clinical trials of drugs, vaccines, and medical devices. Bill C-97′s amendments are worthy of attention in Canada and globally, as health product regulation bends to COVID-19. The amendments follow reforms elsewhere to accommodate health product innovation, how- ever, the Canadian ATPathway is broader and more flexible than its counterparts in other jurisdictions. …

Exploring The Food And Drug Administration’S Review And Approval Of Entresto (Sacubitril/Valsartan), Ashley Eadie, Keith Brunt, Matthew Herder

Articles, Book Chapters, & Popular Press

Federal regulatory agencies such as the United States Food and Drug Administration review pharmacological evidence to ensure the safety and efficacy of new and repurposed pharmaceuticals prior to market approval. The discussions, disagreements and procedural decisions contained within such reviews offer unique insight into a pharmaceutical's strengths, weaknesses and opportunities, yet are often overlooked as a significant source of pharmacological information for research and development. To highlight the value of such resources, we present a case study on Entresto, a first-in-class angiotensin receptor-neprilysin inhibitor for the treatment of heart failure with reduced ejection fraction, and explore the regulatory rationale underlying …

In The Name Of Public Health: Misoprostol And The New Criminalization Of Abortion In Brazil, Mariana Prandini Assis, Joanna Erdman

Articles, Book Chapters, & Popular Press

This article explores the criminal regulation of misoprostol as a controlled drug in Brazil as a new form of abortion criminalization. A qualitative analysis of Brazilian case law shows how the courts use a public health rhetoric of unsafe abortion to criminalize the distribution of misoprostol in the informal sector. Rather than an invention of the local bench, this judicial rhetoric reflects global public health discourse and policy on unsafe abortion and the double life of misoprostol as both an essential medicine and a controlled drug. In contrast to previous studies, the article shows that abortion criminalization is not the …

On The Joint Role Of Non-Hispanic Black Race/Ethnicity And Weight Status In Predicting Postmenopausal Weight Gain, Christopher N Ford, Shine Chang, Alexis C Wood, Joann E Manson, David O Garcia, Helena Laroche, Chloe E Bird, Mara Z Vitolins

Children’s Nutrition Research Center Staff Publications

Objectives: To determine how baseline weight status contributes to differences in postmenopausal weight gain among non-Hispanic Blacks (NHBs) and non-Hispanic Whites (NHWs).

Methods: Data were included from 70,750 NHW and NHB postmenopausal women from the Women's Health Initiative Observational Study (WHI OS). Body Mass Index (BMI) at baseline was used to classify women as having normal weight, overweight, obese class I, obese class II or obese class III. Cox proportional hazards was used to estimate the hazard of a 10% or more increase in weight from baseline.

Results: In both crude and adjusted models, NHBs were more likely to experience …