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2021

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Role Of Vascular Endothelial Growth Factor Receptor 2 Pathway Due To Preeclampsia: A Review, Firdous Ali Jan 2021

Role Of Vascular Endothelial Growth Factor Receptor 2 Pathway Due To Preeclampsia: A Review, Firdous Ali

Williams Honors College, Honors Research Projects

Preeclampsia is a pregnancy complication that is characterized mainly by hypertension in the mother. The exact pathogenesis of preeclampsia is unknown, although the disease is attributed to a number of factors such as angiogenic factor levels and endothelial dysfunction. Presently, the control program for the disease involves the delivery of the fetus and the placenta. There is a need to develop novel therapies that would control preeclampsia from the moment it is diagnosed to minimize the effects on the mother and child. VEGF is a protein involved in the pathogenesis of the condition. The defect in one of its receptors, …

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Design And Implementation Of Fully Integrated Cmos On-Chip Bandpass Filter With Wideband High-Gain Low Noise Amplifier, Yu Wang Jan 2021

Design And Implementation Of Fully Integrated Cmos On-Chip Bandpass Filter With Wideband High-Gain Low Noise Amplifier, Yu Wang

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Current trends of fully integrated CMOS on-chip bandpass filter are classified into 1) the component level (i.e., active inductor, Q-enhanced passive inductor, negative resistance cancellation), and 2) the circuit level (i.e., adding transmission zeros on stopband, applying the zigzag technique for fewer inductors, superposition of different resonators). The demand for monolithic designs for portable devices attracts market interest in a fully integrated CMOS on-chip bandpass filter. Optimized minimal inductors (OMI) bandpass filter is a good platform for use in both active and passive bandpass filters, mainly because 1) it provides good stopband rejection for high interface attenuation, and 2) the …

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Ascertaining The Relationship Between Traditional Masculinity Ideology And Personal Growth Initiative In College Students, Christopher J. Ha Jan 2021

Ascertaining The Relationship Between Traditional Masculinity Ideology And Personal Growth Initiative In College Students, Christopher J. Ha

Williams Honors College, Honors Research Projects

The emerging psychological field of men and masculinities is credited with the development and validation of an array of instruments to assess masculinity-related constructs, with many emanating from the gender role strain paradigm (GRSP; Levant & Powell, 2017; Levant & Richmond, 2007, 2016; Pleck, 1981, 1995). However, there is little research that employs a positive psychology framework while considering the potential positive aspects of masculinity. The majority of literature utilizing these measures focus on the pathological effects of masculinity. The goal of this study was to explore the relationship between traditional masculinity ideology (TMI) and personal growth initiative (PGI) in …

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Enzymatic Post-Translational Halogenation For Adding Functionality To Biomaterials, Alexander L. Compean Jan 2021

Enzymatic Post-Translational Halogenation For Adding Functionality To Biomaterials, Alexander L. Compean

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Silk fibroin from the silkworm, Bombyx mori, is a unique biomaterial that has been extensively studied for a variety of applications due to its promising properties such as controllable self-assembly, robust mechanical properties, and biological compatibility. Previously, there have been numerous methods describing the chemical modification of silk fibroin that utilize synthetic or enzymatic means that do not use halogens as a means of functionalization. Herein, a halogenation strategy is presented to modify silk fibroin with the aim of developing a novel functional material through the carbon-halogen (C-X) bond. Modification with NaX (X = Cl, Br, and I) salts, hydrogen …

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Sample Mislabeling Detection And Correction In Bioinformatics Experimental Data, Soon Jye Kho Jan 2021

Sample Mislabeling Detection And Correction In Bioinformatics Experimental Data, Soon Jye Kho

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Sample mislabeling or incorrect annotation has been a long-standing problem in biomedical research and contributes to irreproducible results and invalid conclusions. These problems are especially prevalent in multi-omics studies in which a large set of biological samples are characterized by multiple types of omics platforms at different times or different labs. While multi-omics studies have demonstrated tremendous value in understanding disease biology and improving patient outcomes, the complexity of these studies may increase opportunities for human error. Fortunately, the interrelated nature of the data collected in multi-omics studies can be exploited to facilitate the identification and, in some cases, correction …

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Synthesis Of Novel Porphyrin Derived Molecules For The Study Of Self Assembly And Photophysical Properties, Alex Nguyen Jan 2021

Synthesis Of Novel Porphyrin Derived Molecules For The Study Of Self Assembly And Photophysical Properties, Alex Nguyen

Williams Honors College, Honors Research Projects

The photochemical capabilities of self-assembling porphyrins holds the potential to eliminate the use of fossil fuels. Porphyrins have the ability to absorb solar energy to excite its electrons within the highly conjugated π system of the porphyrin ring. The excited electron can then be donated thus creating a charge separated state between the porphyrin donor and the electron acceptor. With self-assembly of porphyrin monomers into a supramolecular structure, this charge separated state can be emphasized and prolonged so the energy potential generated can be harvested. Here, the synthesis of porphyrin derivatives substituted with biologically found molecules is described. The lysine …

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North American Freshwater Snails As Paleoecologic Proxies In Crystal Lake, Medway, Ohio, Jaclyn R. Manker Jan 2021

North American Freshwater Snails As Paleoecologic Proxies In Crystal Lake, Medway, Ohio, Jaclyn R. Manker

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This study combines various paleoecological proxies found within a sediment core extracted from Crystal Lake, Medway, Ohio in order to assess the lake’s sensitivity to past climate changes and how that may have affected lake water levels. Crystal Lake is a natural kettle lake formed at the end of the Wisconsin glaciation. It is now surrounded by approximately 500 residential homes and is privately owned by the HOA of Crystal Lake. A sediment core was extracted from Crystal Lake in 2007 and has been carbon dated to 18000 years before present, indicating that it contains a complete sedimentary history from …

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An Investigation On The Effect Of The Chain Length Of Glutamic Acid Oligomers On The Nucleation, Precipitate Growth, And Phase Transformation Of Amorphous Calcium Phosphate To Crystalline Hydroxyapatite, Emma Harmon Jan 2021

An Investigation On The Effect Of The Chain Length Of Glutamic Acid Oligomers On The Nucleation, Precipitate Growth, And Phase Transformation Of Amorphous Calcium Phosphate To Crystalline Hydroxyapatite, Emma Harmon

Williams Honors College, Honors Research Projects

This project aims to analyze the effect that the chain length of oligo0glutamic acid sequences has on the nucleation, growth, and phase transformation of amorphous calcium phosphate to crystalline hydroxyapatite. As cited in the formal proposal, hydroxyapatite is the main mineral in bone and dentin and it is of particular interest as a biomaterial. Mineralization is required for much of its structural and protective functioning, however the timing of mineralization is also important for proper growth and development. The presence of glutamic acid containing protein residues impacts the mineralization patterns of hydroxyapatite and this study aims to determine exactly what …

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Natural User Interface Based American Sign Language Tutoring Program, Bryce J. Allen Jan 2021

Natural User Interface Based American Sign Language Tutoring Program, Bryce J. Allen

Williams Honors College, Honors Research Projects

The COVID-19 pandemic has exposed a substantial shortcoming in the modern American educational system: there is a sufficient need for our educators to be trained in the practices required to provide an educational experience for their students that is as effective as in-person instruction. There exist already systems of online instruction for various academic subjects, such as math and the sciences. In the subject of linguistic studies, educational programs have been developed to evaluate student proficiency in both the written and spoken forms of the language in which they are studying. However, there exist few programs that can effectively provide …

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The Evolution Of Technology, Kelly Cooper Jan 2021

The Evolution Of Technology, Kelly Cooper

Williams Honors College, Honors Research Projects

As per outlined by Dr. Quinn, this literature review will be a comprehensive review paper including an overview of current and previous research done in the field of Memetics. This will further include sifting through literature to hone in on a specific, new area of memetics Dr. Weeks is focused on, the evolutionary change of abiotic factors through purchasing. This is to be completed with the help of the library worshops designed to teach the skills necessary to undergo a literature review of this size. I will also participate in weekly reading groups to discuss papers and work closely with …

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Microsatellites And Their Association With Break Induced Replication, French J. Damewood Iv Jan 2021

Microsatellites And Their Association With Break Induced Replication, French J. Damewood Iv

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To study microsatellites instability and their repair pathways a dual fluorescent (DF2) and selectable (ganciclovir sensitive/ thymidine kinase (TK) expressing) cell system was assayed using replication fork stalling agents hydroxyurea and telomestatin. These cell lines carried ectopically integrated microsatellites derived from the Dystrophia Myotonica Protein Kinase (DMPK) gene ((CTG)102 microsatellite), or an 88 bp polypurine/ polypyrimidine (Pu/Py) repeat from the PKD-1 locus, inserted into a FLP recombinase target site. These microsatellites form non-B DNA structures in -vivo and in-vitro causing replication fork stalling and double strand breaks. DF2 myc (CTG)102 -TK cells treated with hydroxyurea were assayed for mutagenesis of …

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Augmenting Structure/Function Relationship Analysis With Deep Learning For The Classification Of Psychoactive Drug Activity At Class A G Protein-Coupled Receptors, Hannah Willow Shows Jan 2021

Augmenting Structure/Function Relationship Analysis With Deep Learning For The Classification Of Psychoactive Drug Activity At Class A G Protein-Coupled Receptors, Hannah Willow Shows

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G protein-coupled receptors (GPCRs) initiate intracellular signaling pathways via interaction with external stimuli. [1-5] Despite sharing similar structure and cellular mechanism, GPCRs participate in a uniquely broad range of physiological functions. [6] Due to the size and functional diversity of the GPCR family, these receptors are a major focus for pharmacological applications. [1,7] Current state-of-the-art pharmacology and toxicology research strategies rely on computational methods to efficiently design highly selective, low toxicity compounds. [9], [10] GPCR-targeting therapeutics are associated with low selectivity resulting in increased risk of adverse effects and toxicity. Psychoactive drugs that are active at Class A GPCRs used …

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Il-10 And Tgf-Beta Increase Connexin-43 Expression And Membrane Potential Of Hl-1 Cardiomyocytes Coupled With Raw 264.7 Macrophages, Cora B. Cox Jan 2021

Il-10 And Tgf-Beta Increase Connexin-43 Expression And Membrane Potential Of Hl-1 Cardiomyocytes Coupled With Raw 264.7 Macrophages, Cora B. Cox

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Cardiomyocytes and macrophages have been found to interact via connexin-43 hemichannels. The role of connexin-43, however, is not fully understood. This study shows that these interactions aid in increasing the membrane potential of cardiomyocytes allowing contraction of the cells. HL-1 cardiomyocytes and RAW 264.7 macrophages in coculture increased expression of connexin-43 compared to cardiomyocytes alone. Co-cultures also increased the fluorescence of Di-8-ANEPPS potentiometric dye indicating an increase in cardiomyocyte membrane potential. Treatment with IL-10 and TGF-beta further increased connexin-43 expression and membrane potential. Treatment with SOCS3 inhibited the effects of TGF-beta and IL-10 while having no effect on its own. …

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Investigating Streptococcus Pneumoniae And Adenovirus Co-Infections Of Lung Epithelial Cells, Mark Nicholas Calabro Jan 2021

Investigating Streptococcus Pneumoniae And Adenovirus Co-Infections Of Lung Epithelial Cells, Mark Nicholas Calabro

Browse all Theses and Dissertations

Co-infection is common among viruses and bacteria in the human respiratory system. Adenovirus (AdV) and Streptococcus pneumoniae are clinically relevant respiratory pathogens that cause morbidity and mortality in a variety of patient populations with the highest morbidity occurring among immunocompromised individuals, but also prevalent in infants and the elderly. Acute respiratory distress syndrome may become severe in healthy individuals when co-infection with S. pneumoniae and AdV occurs due to synergistic effects of the pathogens on the host. I hypothesized that S. pneumoniae infection decreases AdV transduction of airway epithelia. To test this hypothesis, we utilized the polarized immortalized airway epithelial …

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The Regulation Of Small Gtpase Rac1 Phosphorylation, Activation And Subcellular Localization By Δnp63Α, Amjad Ahmed Aljagthmi Jan 2021

The Regulation Of Small Gtpase Rac1 Phosphorylation, Activation And Subcellular Localization By Δnp63Α, Amjad Ahmed Aljagthmi

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ΔNp63α, a member of the p53 family of transcription factors, plays a critical role in normal development and human disease. Loss of ΔNp63α expression is associated with increased cancer invasiveness and metastasis. The small GTPase Rac1 is a master regulator of cell motility, and increased Rac1 activity upregulates cell invasion in multiple human cancers. Increased cancer cell invasion associated with ΔNp63α knockdown and Rac1 activation suggests a novel mechanism by which ΔNp63α regulates tumor invasiveness through Rac1. Accordingly, we sought to delineate the effects of ΔNp63α on Rac1 phosphorylation, activation and subcellular localization. We identified a novel ΔNp63α/miR-320a/PKCᵧ signaling pathway …

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Glacial Deposits, Vol. 46, 2021, Department Of Geography, Geology, And The Environment Jan 2021

Glacial Deposits, Vol. 46, 2021, Department Of Geography, Geology, And The Environment

Glacial Deposits

Newsletter of the Department of Geography, Geology, and the Environment

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The Compass, Summer 2021 Jan 2021

The Compass, Summer 2021

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

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Working With Multilingual Student Writers, Purdue Writing Lab Jan 2021

Working With Multilingual Student Writers, Purdue Writing Lab

Purdue Writing Lab/Purdue OWL Creative Materials

Reading and assessing the writing of multilingual students can be a unique challenge for college faculty. This guide offers strategies for how to read, assess, and provide feedback on the work of multilingual student writers, and it contextualizes these strategies in current Second Language Studies research. Sections of the guide address contexts of multilingual writing, common concerns about multilingual writers, and methods for supporting writers and for addressing errors.

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Elementary School Counselors' Experiences Working With Children Who Self-Harm, Maegan Tatum Jan 2021

Elementary School Counselors' Experiences Working With Children Who Self-Harm, Maegan Tatum

Electronic Theses and Dissertations

Elementary-aged children struggle with low self-esteem, are often impulsive, and struggle to develop appropriate coping skills. As such, many children have begun to experiment with self-harm. Because children spend a great deal of time in school, school counselors are often the first to know that a student has self-harmed. Although school counselors have extensive experience working with students who self-harm, most school counselors indicate a need for more training and implementation of school district policies regarding self-harm. Additionally, current literature focuses on the experiences of middle and high school counselors because self-harm and NSSI are primarily noted in adolescents. In …

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Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe Jan 2021

Computational Modeling Of Non-Active Functional States Of The Cannabinoid Receptor 1 And Its Ligands, Ayooluwa Olufunmi Aderibigbe

Electronic Theses and Dissertations

The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor that is implicated in a variety of physiological processes, such as energy homeostasis, appetite regulation, cognition and motor control, and mood regulation. CB1 is widely distributed throughout the body, but is mainly expressed in the brain. Molecules that reduce CB1 signaling exhibit anti-obesity properties due to their effect in reducing appetite and body weight gain. However, the consequence of reducing CB1 signaling in the CNS includes adverse neuropsychiatric effects such as depression and suicidal ideation. Two methods of scientific interest for developing CB1 antagonists as anti-obesity drugs are …

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Stratigraphy And Geochemistry Of Paleocene-Aged Bauxites From North Mississippi, Timothy Brendan Clark Jan 2021

Stratigraphy And Geochemistry Of Paleocene-Aged Bauxites From North Mississippi, Timothy Brendan Clark

Electronic Theses and Dissertations

Bauxite is a heavily-mined aluminum ore that forms through the relative depletion of silica to aluminum. In North Mississippi, bauxite occurring within the Upper Midway and Lower Wilcox groups has been the subject of study for over a century. Despite the abundance and duration of research, controversy surrounds the subjects of bauxite genesis and economic value. The last detailed study of North Mississippi bauxite was in the 1980’s, so the goal of this project is to apply newly available technologies and modern hypotheses on bauxite formation to refine and obtain new data. Fieldwork observations yielded pisoliths, horizonation, and possible rhizoliths, …

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The Meat Of The Gothic: Animality And Social Justice In United States Fiction And Film Of The Twenty-First Century, Amber Hodge Jan 2021

The Meat Of The Gothic: Animality And Social Justice In United States Fiction And Film Of The Twenty-First Century, Amber Hodge

Electronic Theses and Dissertations

The Meat of the Gothic: Animality and Social Justice in United States Fiction and Film of the Twenty-First Century— situates twenty-first century US gothic narratives in relation to animal studies, even as it illuminates how these narratives interrogate the effects of historic and ongoing global systems of human oppression: slavery, imperialism, and capitalism. Instead of reacting to bias by asserting a claim to a humanity perpetually imbricated in divisions of class, race, and gender, present-day authors and filmmakers create characters who form communities that include nonhuman actors as a means of generating empowerment and critique. My approach to these narratives …

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How Do Prey Capture And Simulated Fire Affect Growth And Nutrient Limitation In A Carnivorous Pitcher Plant, Sarracenia Alata?, Jalen Christopher Holloway Jan 2021

How Do Prey Capture And Simulated Fire Affect Growth And Nutrient Limitation In A Carnivorous Pitcher Plant, Sarracenia Alata?, Jalen Christopher Holloway

Electronic Theses and Dissertations

Carnivorous plants are defined as being able to benefit from the nutrients of prey in the environment, and have at least one trait that either retrieves, ingests, or lures a prey to its traps. The association of carnivorous plants with fire-prone habitats was initially described as a paradox, considering that carnivorous plants are often associated with nutrient-poor soils and fires can increase soil nutrient availability. This apparent paradox assumes, however, that the nutrients that increase in availability following fire are those also provided by prey, which might not be true. In habitats with nitrogen-poor soils, fire has been shown to …

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"And They Took My Milk!", I. Bennett Capers Jan 2021

"And They Took My Milk!", I. Bennett Capers

Faculty Scholarship

No abstract provided.

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Adhesive Bonding Of Copper Prepared By Laser-Interference Near The Interference Structuring Limits, H. Liu, J.A. Weibel, P Geoghegan, A.S. Sabu, E.A. Groll Jan 2021

Adhesive Bonding Of Copper Prepared By Laser-Interference Near The Interference Structuring Limits, H. Liu, J.A. Weibel, P Geoghegan, A.S. Sabu, E.A. Groll

CTRC Research Publications

Adhesive bonding requires adequate surface preparation for ensuring an appropriate joint quality. The interest in adhesive joining has recently expanded to thermal systems having a large number of joints employed for manufacturing and assembly. This study presents surface topology of copper 110 produced by a laser-interference setup that would theoretically yield a periodicity of 1.7 mm, which is near the 1.6-2 mm structuring limit that was estimated based on thermal diffusion length scale for an 8 ns laser pulse. The results show that although the expected periodic interference structuring was not attained, the melt-induced texturing was affected by the laser-interference …

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Comparing Capabilities Of Shewanella Oneidensis Mr-1 And The Microbial Community Of Iron Caves To Reduce Fe(Iii), Aaron Douglas Pham Jan 2021

Comparing Capabilities Of Shewanella Oneidensis Mr-1 And The Microbial Community Of Iron Caves To Reduce Fe(Iii), Aaron Douglas Pham

Williams Honors College, Honors Research Projects

Caves are generally formed by the erosion and/or dissolution of rock and its subsequent removal by water. Iron ore caves (IOCs) form despite being hosted by relatively insoluble and weathering-resistant rock. Due to the discovery of a microbial community behind the walls of these caves, it was hypothesized that these bacteria could be responsible for speleogenesis. Iron ore exists in an oxidized (Fe(III)) state, but reduced (Fe(II)) form is soluble. It was further reasoned that the bacteria might be able to reduce Fe(III) through direct metabolic activity, which uses iron as an electron acceptor. Here we show that cave microorganisms …

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Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis Jan 2021

Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis

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Because magnetic resonance (MR) and positron emission tomography (PET) scanning sessions last long durations, motion blur during scanning constitutes a problem for clinical interpretation. To counteract this, motion-correction algorithms have been developed to reduce smearing between scan slices of MRI, but these algorithms are not commonplace for PET. This feasibility study determined if applying MRI motion-correction algorithms to simultaneously acquired PET data improved PET signal clarity in specific brain regions. Seven subjects received increasing levels of PET tracers while undergoing two separate simultaneous PET/MRI scans. We modified existing fMRI algorithms to apply them to the accompanying PET data. We hypothesized …

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Music And Its Effects On The Brain, Caitlyn Herron Jan 2021

Music And Its Effects On The Brain, Caitlyn Herron

Williams Honors College, Honors Research Projects

This paper will discuss, in short, how music influences our brain, as well as some behavioral and physiological effects as a result. The brain consists of many regions responsible for different cognitive processes, such as learning, memory, recall, speech, and our emotions. It has been found that music helps to facilitate all of these cognitive processes, regardless of its emotional valence or whether the music is active or passive, such as singing or listening to it, respectively. It was discovered that music influences our ability to learn novel concepts related to mathematics, reading, and even language acquisition. It was also …

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Minimally Invasive Repair Of Elongated Chordae Tendineae In The Mitral Valve, Walid Abuhashim, Diana Albaba, Austin Ghiates, Rebecca Leiter, Mary Robakowski Jan 2021

Minimally Invasive Repair Of Elongated Chordae Tendineae In The Mitral Valve, Walid Abuhashim, Diana Albaba, Austin Ghiates, Rebecca Leiter, Mary Robakowski

Williams Honors College, Honors Research Projects

In the United States, about 4 million people have been estimated to suffer from severe mitral valve regurgitation [5]. Due to the high risks involved, about half of those patients are ineligible for surgery to repair the valve, because of their poor health [6]. Elongation of the chordae tendineae has been found to be one of the significant causes of regurgitation. To address this, the team has developed a device called “Chord Fastener”, which will restore proper function to the valve via shortening of the chordae tendineae [1]. Via this shortening mechanism, the device will reduce mitral valve regurgitation and …

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The Course Scheduling Problem With Room Considerations, Lijian Xiao Jan 2021

The Course Scheduling Problem With Room Considerations, Lijian Xiao

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The course scheduling problem (CSP), more commonly referred to as the university timetabling problem, belongs to the larger family of general scheduling problems, where the aim is to assign students, faculties, exams, or lectures to a limited number of rooms over time in accordance under real-world constraints. Such problems are known to be NP-complete and have been the subject of study for the optimization society for many decades. This research extends the classical CSP to the CSP with Room Considerations (CSP-R) by incorporating two room-related considerations; cohort-to-room preference and topic-to-room preference. While the former refers to students in each cohort …

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