Digital Commons Network^™

The Manifestation Of Inner-Gender Oppression In Margaret Atwood’S The Handmaid’S Tale As Results From Intentional Patriarchal Power Structures, Aliyah Browning

Capstone Showcase

Margaret Atwood’s The Handmaid’s Tale has long been studied for its cautionary warnings about sexist ideologies that exist between men and women; seldom has it been so closely analyzed for instances of inner gender oppression. Inner-gender oppression, which this thesis seeks to define and highlight through the novel’s context, offers artificial forms of power to those in oppressed classes, enough to attract women themselves to participate in the indoctrination and policing of their own sex. This essay highlights the ways in which Atwood’s dystopian society parallels sexist beliefs held by societies past and present.

Disney Princess Films And Their Effects On Gender And Body Image Through The Social Learning Theory, Jessica Yakubovsky

Capstone Showcase

Many of us grew up watching Disney Films and throughout the last decade and prior, the Walt Disney Company has created a variety of characters whom we grew up alongside. As we watched these films we found ourselves within the characters and learned things through them. This thesis paper aims to analyze Disney Princess Films and their profound effects on Gender and Body image through the theoretical perspective of the Social Learning theory. I will analyze Classic Disney princesses such as Snow White and Cinderella, and modern princesses such as Mulan(1998) and Merida (2011). My critical analysis indicates that Disney …

Chloroplast Genome Evolution In The Klebsormidiophyceae And Streptofilum, Sarah Glass

Theses and Dissertations

The Klebsormidiophyceae are a class of green microalgae found globally in both freshwater and terrestrial habitats. Morphology-based classification schemes of this class have been shown to be insufficient, particularly due to the simple morphology of these algae, the tendency of morphology to vary in culture versus in field conditions, and rampant morphological homoplasy. Molecular studies revealing cryptic diversity have renewed interest in this group. We sequenced the complete chloroplast genomes of taxa in the Klebsormidiophyceae representing the known taxonomic breadth of this class, as well as the chloroplast genomes of three strains of Streptofilum, a recently discovered algal lineage …

How The Amino Acid L-Serine Provides Neuroprotection Against L-Bmaa Induced Alzheimer’S Disease, Joseph Cimino

Capstone Showcase

More than 6 million people in America are living with Alzheimer’s Disease (AD) and there are currently no cures or treatments. It is time to move on from the ꞵ-amyloid hypothesis and broaden AD research. New research is suggesting that dietary exposure to a cyanobacterial toxin known as L-BMAA is causing neurodegenerative diseases such as AD, Amyotrophic lateral sclerosis (ALS), and Parkinson’s Disease. L-BMAA is misincorporated during protein folding, in place of the proper amino acid, L-Serine. It has been shown that the naturally occurring amino acid, L-Serine, can provide neuroprotection against L-BMAA, but the mechanism by which L-Serine infers …

Therapeutical Studies Of The Disrupted Cftr Gene In Affected Sheep And Rabbit Models Produced By Genome Editor Crispr/Cas9, Nicole Teberio

Capstone Showcase

Cystic Fibrosis (CF) is a life-threatening, autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Patients with CF have a decreased lifespan due to complications with lung infections/disease, decreased airway function, and persistent cough with phlegm. Over the past few decades, scientists have contributed to CF research by using animal models to understand the pathology of the disease. The models selected have similar pathogenesis to humans, so they are key insights for understanding the effects of CFTR gene malfunctions. More recently, animal models, such as CRISPR generated sheep and rabbits used in the two current …

#Aminext: The Link Between European Colonization And Gender-Based Violence In Contemporary South Africa, Jenna Meredith Pagel

Capstone Showcase

Alarmingly, the female murder rate in South Africa is five times the global average (BBC News 2019). According to data from 2017 and 2018, a woman is murdered every four hours in South Africa (Wilkinson 2019). More than 30 women were killed by their spouses in August 2019, and at least 137 sexual offenses are committed per day in South Africa (Francke 2019).

For this thesis, and in order to understand why South Africa has some of the highest rates of violence against women in the world, I consult a number of scholars who conclude that the overall issue of …

Experiential Learning In Soil Science: Evaluating Soil Quality In South Wollo, Ethiopia, Melissa Allen, Martha Mamo, Shimelis Beyene, Teshome Regassa, Gandura O. Abagandura, Solomon Abreha, Anthony James Mucia, Tsegaye Tadesse

National Drought Mitigation Center: Faculty Publications

This study abroad program provided an opportunity to enhance the international experience and research skills of University of Nebraska-Lincoln (UNL) students within a multidisciplinary team’s research-education goal on improving food security in Ethiopia. The experiential study component of the project included preparatory sessions during the Fall 2015 Semester at the UNL followed by a four- to five-week fieldwork experience in Ethiopia. Teams from the UNL and an Ethiopian university participated in survey data collection and field soil evaluations from farms in the Gerado area of South Wollo, Ethiopia. Having students interact with farmers increased student self-confidence and enhanced their leadership …

The Rise And Fall Of Wiñaymarka: Rethinking Cultural And Environmental Interactions In The Southern Basin Of Lake Titicaca, Maria C. Bruno, José M. Capriles, Christine A. Hastorf, Sherilyn C. Fritz, D. Marie Weide, Alejandra I. Domic, Paul A. Baker

Department of Earth and Atmospheric Sciences: Faculty Publications

Investigations of how past human societies managed during times of major climate change can inform our understanding of potential human responses to ongoing environmental change. In this study, we evaluate the impact of environmental variation on human communities over the last four millennia in the southern Lake Titicaca basin of the Andes, known as Lake Wiñaymarka. Refined paleoenvironmental reconstructions from new diatom-based reconstructions of lake level together with archaeological evidence of animal and plant resource use from sites on the Taraco Peninsula, Bolivia, reveal frequent climate and lake-level changes within major cultural phases. We posit that climate fluctuations alone do …

The Evaluation Of The Role Of Research Administrators In The Biomedical Research Grant Lifecycle And How Public Universities’ Policies Are Designed To Protect Funding, Megan Eder

MPA/MPP/MPFM Capstone Projects

There was a time in the not-so-distant past, where a simple infection had the opportunity to send an individual to an early grave. With advancements in biomedical research, medical professionals can treat simple infections as well as more complicated illnesses. Medical research has come a long way, but there is still a need for research in order to find, treat, and advance cures for illness and disease. Last year, during the COVID-19 pandemic, the entire world was waiting for researchers to create a vaccine to help slow the spread and get the world back to operating at a normal capacity. …

Lactate Promotes Macrophage Hmgb1 Lactylation, Acetylation, And Exosomal Release In Polymicrobial Sepsis, Kun Yang, Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, Fei Tu, P. S. Gill, Tuanzhu Ha, Li Liu, David L. Williams, Chuanfu Li

ETSU Faculty Works

High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and acetylation in macrophages during polymicrobial sepsis. We found that macrophages can uptake extracellular lactate via monocarboxylate transporters (MCTs) to promote HMGB1 lactylation via a p300/CBP-dependent mechanism. We also observed that lactate stimulates HMGB1 acetylation by Hippo/YAP-mediated suppression of deacetylase SIRT1 and β-arrestin2-mediated recruitment of acetylases p300/CBP to the nucleus via G protein-coupled receptor 81 (GPR81). …

Kdm6a Lysine Demethylase Directs Epigenetic Polarity Of Mdscs During Murine Sepsis, Isatou Bah, Tuqa Alkhateeb, Dima Youssef, Zhi Q. Yao, Charles E. Mccall, Mohamed El Gazzar

ETSU Faculty Works

Sepsis-induced myeloid-derived suppressor cells (MDSCs) increase mortality risk. We previously identified that long non-coding RNA Hotairm1 supports myeloid precursor shifts to Gr1+CD11b+ MDSCs during mouse sepsis. A major unanswered question is what molecular processes control Hotairm1 expression. In this study, we found by a genetic deletion that a specific PU.1-binding site is indispensable in controlling Hotairm1 transcription. We then identified H3K4me3 and H3K27me3 at the PU.1 site on the Hotairm1 promoter. Controlling an epigenetic switch of Hotairm1 transcription by PU.1 was histone KDM6A demethylase for H3K27me3 that derepressed its transcription with possible contributions from Ezh2 methyltransferase for H3K27me3. KDM6A knockdown …

Applying Latent Class Analysis On Cancer Registry Data To Identify And Compare Health Disparity Profiles In Colorectal Cancer Surgical Treatment Delay, Francisco A. M. Ishino, Emmanuel A. Odame, Kevin Villalobos, Martin Whiteside, Hadii Mamudu, Faustine Williams

ETSU Faculty Works

Context: Colorectal cancer (CRC) surgical treatment delay (TD) has been associated with mortality and morbidity; however, disparities by TD profiles are unknown. Objectives: This study aimed to identify CRC patient profiles of surgical TD while accounting for differences in sociodemographic, health insurance, and geographic characteristics. Design: We used latent class analysis (LCA) on 2005-2015 Tennessee Cancer Registry data of CRC patients and observed indicators that included sex/gender, age at diagnosis, marital status (single/married/divorced/widowed), race (White/Black/other), health insurance type, and geographic residence (non-Appalachian/Appalachian). Setting: The state of Tennessee in the United States that included both Appalachian and non-Appalachian counties. Participants: Adult …

Selective Oxidative Stress Induces Dual Damage To Telomeres And Mitochondria In Human T Cells, Ling Wang, Zeyuan Lu, Juan Zhao, Madison Schank, Dechao Cao, Xindi Dang, Lam N. Nguyen, Lam N. Nguyen, Sushant Khanal, Jinyu Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress-mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells—the major effectors of host adaptive immunity against infection and malignancy—is poorly understood due to the pleiotropic effects of ROS. Here we employed a novel chemoptogenetic tool that selectively produces a single oxygen (1O2) only at telomeres or mitochondria in Jurkat T cells. We found that targeted 1O2 production at telomeres triggered not only telomeric DNA damage but also mitochondrial dysfunction, resulting in …

Competing Visions: A History Of California, Robert W. Cherny, Gretchen Lemke-Santangelo, Richard Griswold De Castillo

SMC Open Access Books

No abstract provided.

Covid-19 And Comparative Corporate Governance, Martin Gelter, Julia M. Puaschunder

Faculty Scholarship

With the pandemic caused by the novel coronavirus SARS-CoV-2 raging around the world, many countries’ economies are at a crucial juncture. The COVID-19 external shock to the economy has the potential to affect corporate governance profoundly. This Article explores its possible impact on comparative corporate governance. For an economy to operate successfully, a society must first find a politically sustainable social equilibrium. In many countries, historical crises—such as the Great Depression and World War II—have resulted in a reconfiguration of corporate governance institutions that set the course for generations. While it is not yet clear whether COVID-19 will have a …

Compensation For Environmental Damage: Progressively Casting A Wider Net, But What’S The Catch?, M P Ram Mohan, Els R. Kini

Vanderbilt Journal of Transnational Law

In the case Certain Activities Carried Out by Nicaragua in the Border Area (Costa Rica v. Nicaragua)–-Compensation Owed by The Republic of Nicaragua to The Republic of Costa Rica (the Costa Rica case), the International Court of Justice (ICJ) had to ascertain the compensation amount due by Nicaragua for the environmental damage it had caused to Costa Rica. This was the first time the ICJ was asked to weigh in and settle an environmental damage compensation claim between two states. After a concise introduction in Part I, this Article will first review the distinction between state responsibility for wrongful acts …

Losing Yourself: Cults, Greeks, And Sociological Theories Of Self And Identity, Emma Morgan

Honors Program Theses

This thesis is theoretical in nature. It is an exploration of sociological theory using cults and greek life as case studies for examining the construction of the self in the context of powerful social groups.

Aurobindo Ghose’S Early Approaches To Hindu-Muslim Relations (1906-1909), Edward Ulrich

Journal of Hindu-Christian Studies

No abstract provided.

The Green Gītā: Connecting Ontology, Soteriology, And Environmental Ethics, Supratik Sen

Journal of Hindu-Christian Studies

No abstract provided.

Undergraduate Catalog, Georgia Southern University

Undergraduate & Graduate Catalogs

No abstract provided.

Molecular Basis Of Arrested Liver Stage Development Of The Gamma Irradiated Plasmodium Yoelii Sporozoite, George A. Ndeta, J. M. Porter-Kelly

Health & Biomedical Sciences Faculty Publications

Worldwide, about 270 million people are diagnosed with malaria annually and about a million deaths occur from this disease mostly in children and pregnant women in Africa. Despite enormous effort and resources directed towards malaria control and eradication, problems of resistance to chloroquine by the malaria parasite and resistance to insecticide by the mosquito vector have only contributed to worsening of the spread of the disease. These problems have led to the search for alternate and efficacious mode of treatments with one being vaccine. Previously, sporozoites isolated from mosquitoes exposed to 12,000 rads of radiation from a 137Cesium source and …

Horn Fly (Diptera: Muscidae) - Biology, Management, And Future Research Directions, Gary Brewer, Dave J. Boxler, Luisa D. Domingues, Rebecca T. Trout Fryxell, Chris Holderman, Kelly M. Loftin, Erika Machtinger, Brandon Smythe, Justin L. Talley, Wes Watson

Department of Entomology: Faculty Publications

The horn fly, Haematobia irritans irritans (L.), is one of the most important external parasites of cattle in North America and elsewhere. Horn fly adults have an intimate association with cattle, their primary host. With their often-high numbers and by feeding up to 38 times per day per fly, horn flies stress cattle. The resulting productivity loss is valued at more than 2.3 billion USD in the United States. Insecticides are commonly used to mitigate direct injury from feeding and indirect injury from disease transmission. This paper discusses horn fly biology, distribution, and management. Emphasis is on promising new approaches …

Pyrethroid Exposure Reduces Growth And Development Of Monarch Butterfly (Lepidoptera: Nymphalidae) Caterpillars, Annie Krueger, Kathryn J. Hanford, Thomas Weissling, Ana M. Vélez, Troy D. Anderson

Department of Entomology: Faculty Publications

Insecticide exposure has been identified as a contributing stressor to the decline in the North American monarch butterfly Danaus plexippus L. (Lepidoptera: Nymphalidae) population. Monarch toxicity data are currently limited and available data focuses on lethal endpoints. This study examined the 72-h toxicity of two pyrethroid insecticides, bifenthrin and β-cyfluthrin, and their effects on growth and diet consumption. The toxicity of bifenthrin to caterpillars was lower than β-cyfluthrin after 72 h. Survival was the most sensitive endpoint for bifenthrin, but diet consumption and caterpillar growth were significantly reduced at sublethal levels of β-cyfluthrin. Using AgDRIFT spray drift assessment, the aerial …

Depressive Disorders And Substance Abuse Screening In Pediatric Primary Care Using Phq-A And Crafft Screening Tools, Lemuel M. Gitari

Doctor of Nursing Practice Projects

No abstract provided.

Cost Of Co-Infection In Peromyscus Leucopus Mice, Ananya Sagar

Scripps Senior Theses

Abstract

Co-infections occur frequently across humans & wildlife, and can have effects on host health. Despite the prevalence of microparasite-helminth co-infections, majority of the research focuses either on singular infections or on concurrent infections in a laboratory setting. This fails to take into account the interspecific interactions between the multiple parasites and the host in natural settings. The interactions could be direct by resource competition, or indirect via the host immune system. In our research, we studied the relationship between nematodes and coccidia in their host, Peromyscus leucopus mice, at the Mountain Lake Biological Station, Virginia. We further evaluated the …

Grounds For A New Normal: Integration Of Telenephrology In Rural Communities, Carolyn J. Mattson

Doctor of Nursing Practice Projects

Patients with kidney disease represent a group of people who are known to have comorbidities, high costs of care, decreased quality of life, and invasive interventions. In rural communities of Western Washington State, many nephrology patients experience factors evidenced to impede access to quality and timely management of their disease, compounding the risk for poor outcomes. Telenephrology is a novel modality of service delivery with the potential to make care more efficient, cost-effective, flexible, and accessible. The author created this project to develop a telenephrology program plan and evaluation for rural settings in Western Washington, informed by relevant epidemiology, pathophysiology, …

Reducing Weight Bias: Creating An Anti-Weight Stigma Educational Simulation For Nurse Practitioner Students, Andrea A. Eickelmann

Doctor of Nursing Practice Projects

Background: Large-bodied people make up the majority of the American population, but healthcare providers are rarely taught specific techniques and strategies for management of their care and medical spaces are designed with furniture and equipment that does not accommodate large bodies. This alienation has resulted in a measurable detriment to the population’s mortality and morbidity, such increased mortality of 60% from experiencing weight stigma and over 50% high combined cancer death rates as compared to the rates of those with normal BMIs (Sutinet al., 2015; Calle et al., 2003).

Objective: This project will examine the evidence about weight stigma, efficacy …

The Utility Of A Bumble Bee (Bombus Spp. [Hymenoptera: Apidae]) Brood Test For Evaluating The Effects Of Pesticides, Annie Krueger, Tara M. Early, Randy J. Ripperger, Ana R. Cabrera, Daniel R. Schmehl

Department of Entomology: Faculty Publications

Risk assessment for chemicals in the United States relies upon the honey bee (Apis meliffera L. [Hymenoptera: Apidae]) as a surrogate for other bee species. There is uncertainty in extrapolating honey bee toxicity data to bumble bees due to differences in life history strategies, food consumption, and nest structure. Here we evaluated the design of a queenless bumble bee microcolony test that could be considered for generating larval toxicity data. Three microcolony studies were conducted with Bombus impatiens to evaluate the effects of exposure to 1) diflubenzuron in pollen, 2) dimethoate in pollen, and 3) dimethoate in sucrose. Immature drone …

Toxicological Analysis Of Stilbenes Against The Fall Armyworm, Spodoptera Frugiperda, Sarah E. Mccomic, Leslie C. Rault, Troy D. Anderson, Daniel R. Swale

Department of Entomology: Faculty Publications

The fall armyworm (FAW), Spodoptera frugiperda, is a global pest of multiple economically important row crops and the development of resistance to commercially available insecticidal classes has inhibited FAW control. Thus, there is a need to identify chemical scaffolds that can provide inspiration for the development of novel insecticides for FAW management. This study aimed to assess the sensitivity of central neurons and susceptibility of FAW to chloride channel modulators to establish a platform for repurposing existing insecticides or designing new chemicals capable of controlling FAW. Potency of select chloride channel modulators were initially studied against FAW central neuron …

Technological Advances To Address Current Issues In Entomology: 2020 Student Debates, Lina Bernaola, Molly Darlington, Kadie Britt, Patricia Prade, Morgan Roth, Adrian Pekarcik, Michelle Boone, Dylan Ricke, Anh Tran, Joanie King, Kelly Carruthers, Morgan Thompson, John J. Ternest, Sarah E. Anderson, Scott W. Gula, Kayleigh C. Hauri, Jacob R. Pecenka, Sajjan Grover, Heena Puri, Surabhi Gupta Vakil

Department of Entomology: Faculty Publications

The 2020 Student Debates of the Entomological Society of America (ESA) were live-streamed during the Virtual Annual Meeting to debate current, prominent entomological issues of interest to members. The Student Debates Subcommittee of the National ESA Student Affairs Committee coordinated the student efforts throughout the year and hosted the live event. This year, four unbiased introductory speakers provided background for each debate topic while four multi-university teams were each assigned a debate topic under the theme ‘Technological Advances to Address Current Issues in Entomology’. The two debate topics selected were as follows: 1) What is the best taxonomic approach to …