Digital Commons Network^™

Wall-Induced Translation Of A Rotating Particle In A Shear-Thinning Fluid, Ye Chen, Ebru Demir, Wei Gao, Yuan-Nan Young, On Shun Pak

Mechanical Engineering

Particle–wall interactions have broad biological and technological applications. In particular, some artificial microswimmers capitalize on their translation–rotation coupling near a wall to generate directed propulsion. Emerging biomedical applications of these microswimmers in complex biological fluids prompt questions on the impact of non-Newtonian rheology on their propulsion. In this work, we report some intriguing effects of shear-thinning rheology, a ubiquitous non-Newtonian behaviour of biological fluids, on the translation–rotation coupling of a particle near a wall. One particularly interesting feature revealed here is that the wall-induced translation by rotation can occur in a direction opposite to what might be intuitively expected for …

Characterizing Long Covid: Deep Phenotype Of A Complex Condition, Rachel R. Deer, Madeline A. Rock, Nicole Vasilevsky, Leigh Carmody, Halie Rando, Alfred J. Anzalone, Marc D. Basson, Tellen D. Bennett, Timothy Bergquist, Eilis A. Boudreau, Carolyn T. Bramante, James Brian Byrd, Tiffany J. Callahan, Lauren E. Chan, Haitao Chu, Christopher G. Chute, Ben D. Coleman, Hannah E. Davis, Joel Gagnier, Casey S. Greene, Ramakanth Kavuluru

Institute for Biomedical Informatics Faculty Publications

BACKGROUND: Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 (PASC or "long COVID"), but they are difficult to integrate because of heterogeneous methods and the lack of a standard for denoting the many phenotypic manifestations. Patient-led studies are of particular importance for understanding the natural history of COVID-19, but integration is hampered because they often use different terms to describe the same symptom or condition. This significant disparity in patient versus clinical characterization motivated the proposed ontological approach to specifying manifestations, which will improve capture and integration of future long COVID studies.

METHODS: The Human Phenotype Ontology …

Phylogenomics Of Alligator Lizards Elucidate Diversification Patterns Across The Mexican Transition Zone And Support The Recognition Of A New Genus, Christopher Blair, Robert W. Bryson Jr, Uri O. García-Vázquez, Adrián Nieto-Montes De Oca, David Lazcano, John E. Mccormack, John Klicka

Publications and Research

Genomic data continue to advance our understanding of species limits and biogeographic patterns. However, there is still no consensus regarding appropriate methods of phylogenomic analysis that make the best use of these heterogeneous data sets. In this study, we used thousands of ultraconserved element (UCE) loci from alligator lizards in the genus Gerrhonotus to compare and contrast species trees inferred using multiple contemporary methods and provide a time frame for biological diversification across the Mexican Transition Zone (MTZ). Concatenated maximum likelihood (ML) and Bayesian analyses provided highly congruent results, with differences limited to poorly supported nodes. Similar topologies were inferred …

Protein Kinase Sgk2 Is Induced By The Β3 Adrenergic Receptor-Camp-Pka-Pgc-1Α/Nt-Pgc-1Α Axis But Dispensable For Brown/Beige Adipose Tissue Thermogenesis, Chul Hong Park, Jiyoung Moon, Minsung Park, Helia Cheng, Jisu Lee, Ji Suk Chang

Division of Basic Science Faculty Publications

Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes remains unraveled. Here, we examined the regulation and role of Sgk2 in brown/beige adipose tissue thermogenesis. We found that transcriptional coactivators PGC-1α and NT-PGC-1α activated by the β3 adrenergic receptor-cAMP-PKA pathway are recruited to the Sgk2 promoter, triggering Sgk2 transcription in response to cold. SGK2 elevation was closely associated with increased serine/threonine phosphorylation of proteins carrying the consensus RxRxxS/T phosphorylation site. However, despite cold-dependent …

Landomycins As Glutathione-Depleting Agents And Natural Fluorescent Probes For Cellular Michael Adduct-Dependent Quinone Metabolism, Alessio Terenzi, Mery La Franca, Sushilla Van Schoonhoven, Rostyslav Panchuk, Álvaro Martínez, Petra Heffeter, Redding Gober, Christine Pirker, Petra Vician, Christian R. Kowol, Rostyslav Stoika, Luca Salassa, Jürgen Rohr, Walter Berger

Pharmaceutical Sciences Faculty Publications

Landomycins are angucyclines with promising antineoplastic activity produced by Streptomyces bacteria. The aglycone landomycinone is the distinctive core, while the oligosaccharide chain differs within derivatives. Herein, we report that landomycins spontaneously form Michael adducts with biothiols, including reduced cysteine and glutathione, both cell-free or intracellularly involving the benz[a]anthraquinone moiety of landomycinone. While landomycins generally do not display emissive properties, the respective Michael adducts exerted intense blue fluorescence in a glycosidic chain-dependent manner. This allowed label-free tracking of the short-lived nature of the mono-SH-adduct followed by oxygen-dependent evolution with addition of another SH-group. Accordingly, hypoxia distinctly stabilized the fluorescent mono-adduct. While …

Nuscon: A Community-Driven Platform For Quantitative Evaluation Of Nonuniform Sampling In Nmr, Yulia Pustovalova, Frank Delaglio, D. Levi Craft, Haribabu Arthanari, Ad Bax, Martin Billeter, Mark J. Bostock, Hesam Dashti, D. Flemming Hansen, Sven G. Hyberts, Bruce A. Johnson, Krzysztof Kazimierczuk, Hengfa Lu, Mark Maciejewski, Tomas M. Miljenović, Mehdi Mobli, Daniel Nietlispach, Vladislav Orekhov, Robert Powers, Xiaobo Qu, Scott Anthony Robson, David Rovnyak, Gerhard Wagner, Jinfa Ying, Matthew Zambrello, Jeffrey C. Hoch, David L. Donoho, Adam D. Schuyler

Department of Chemistry: Faculty Publications

Although the concepts of nonuniform sampling (NUS) and non-Fourier spectral reconstruction in multidimensional NMR began to emerge 4 decades ago (Bodenhausen and Ernst, 1981; Barna and Laue, 1987), it is only relatively recently that NUS has become more commonplace. Advantages of NUS include the ability to tailor experiments to reduce data collection time and to improve spectral quality, whether through detection of closely spaced peaks (i.e., “resolution”) or peaks of weak intensity (i.e., “sensitivity”). Wider adoption of these methods is the result of improvements in computational performance, a growing abundance and flexibility of software, support from NMR spectrometer vendors, and …

Glomerular Disease In Temporal Association With Sars-Cov-2 Vaccination: A Series Of 29 Cases, Tiffany N. Caza, Clarissa A. Cassol, Nidia Messias, Andrew Hannoudi, Randy S. Haun, Patrick D. Walker, Rebecca M. May, Regan M. Seipp, Elizabeth J. Betchick, Hassan Amin, Mandolin S. Ziadie, Michael Haderlie, Joy Eduwu-Okwuwa, Irina Vancea, Melvin Seek, Essam B. Elashi, Ganesh Shenoy, Sayeed Khalillullah, Jesse A. Flaxenburg, John Brandt, Matthew J. Diamond, Adam Frome, Eugene H. Kim, Gregory Schlessinger, Erlandas Ulozas, Janice L. Weatherspoon, Ethan Thomas Hoerschgen, Steven L. Fabian, Sung Yong Bae, Bilal Iqbal, Kanwalijit K. Chouhan, Zeina Karam, James T. Henry, Christopher P. Larsen

Pediatrics Research and Scholarship

Background: Immune responses to vaccination are a known trigger for a new onset of glomerular disease or disease flare in susceptible individuals. Mass immunization against SARS-CoV-2 in the COVID-19 pandemic provides a unique opportunity to study vaccination-associated autoimmune kidney diseases. In the recent literature, there are several patient reports demonstrating a temporal association of SARS-CoV-2 immunization and kidney diseases.

Methods: Here, we present a series of 29 cases of biopsy-proven glomerular disease in patients recently vaccinated against SARS-CoV-2 and identified patients who developed a new onset of IgA nephropathy, minimal change disease, membranous nephropathy, ANCA-associated GN, collapsing glomerulopathy, or diffuse …

Investigation Of The Feasibility Of Ventricular Delivery Of Resveratrol To The Microelectrode Tissue Interface, Youjoung Kim, Evon S. Ereifej, William E. Schwartzman, Seth M. Meade, Keying Chen, Jacob M. Rayyan, He Feng, Varoon Aluri, Natalie N. Mueller, Raman Bhambra, Sahaj Bhambra, Dawn M. Taylor, Jeffrey R. Capadona

Faculty Scholarship

(1) Background: Intracortical microelectrodes (IMEs) are essential to basic brain research and clinical brain–machine interfacing applications. However, the foreign body response to IMEs results in chronic inflammation and an increase in levels of reactive oxygen and nitrogen species (ROS/RNS). The current study builds on our previous work, by testing a new delivery method of a promising antioxidant as a means of extending intracortical microelectrodes performance. While resveratrol has shown efficacy in improving tissue response, chronic delivery has proven difficult because of its low solubility in water and low bioavailability due to extensive first pass metabolism. (2) Methods: Investigation of an …

Neuroblastoma Among Omani Children: Clinical Characteristics And Survival Outcome From A Dedicated Centre, Abeer Al-Battashi, Ameera Al-Rahbi, Adbulhakeem Al-Rawahi, Mohammed Mamdouh, Ibrahim Al-Ghaithi, Fatma A. Ramadhan

Sultan Qaboos University Medical Journal

Objectives: A limited number of publications from the Middle East have focused on neuroblastoma, a common childhood malignancy. This study describes the clinical characteristics and survival outcome of Omani children with neuroblastoma treated at the National Oncology Centre, Oman, between 2010 and 2017. Methods: From January 2010 to December 2017, data on Omani children aged less than 13 years with neuroblastoma were retrospectively collected. Survival data were statistically correlated with known prognostic factors, including age, stage of disease, MYCN profile and presence of metastasis. Results: A total of 56 Omani children were included. in this study. The male to female …

Estimate Of The Homa-Ir Cut-Off Value Identifying Subjects At Risk Of Insulin Resistance Using A Machine Learning Approach, Abdelhamid Abdesselam, Hamza Zidoum, Fahd Zadjali, Rachid Hedjam, Aliya Al-Ansari, Riad Bayoumi, Said Al-Yahyaee, Mohammed Hassan, Sulayma Albarwani

Sultan Qaboos University Medical Journal

Objectives: This study describes an unsupervised machine learning approach used to estimate the homeostatic model assessment-insulin resistance (HOMA-IR) cut-off for identifying subjects at risk of IR in a given ethnic group based on the clinical data of a representative sample. Methods: The approach was applied to analyse the clinical data of individuals with Arab ancestors, which was obtained from a family study conducted in Nizwa, Oman, between January 2000 and December 2004. First, HOMA-IR-correlated variables were identified to which a clustering algorithm was applied. Two clusters having the smallest overlap in their HOMA-IR values were retrieved. These clusters represented the …

Nursing Students’ Perceived Disaster Preparedness And Response: Pilot Study In Oman, Joy K. Kamanyire, Ronald Wesonga, Susan Achora, Leodoro L. Labrague, Anju Malik, Sultan Alshaqsi, Jamila As Alhabsi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to assess the perceived level of disaster preparedness and response among nursing students in Oman, as the country is disaster prone and experiences disasters every three to five years. Methods: A descriptive cross-sectional pilot study was conducted from May to June 2019 using a stratified cluster sampling method among nursing students recruited from two government nursing colleges in Muscat, Oman. The Disaster Preparedness Evaluation Tool and Disaster Response Self-Efficacy Scale were used to assess the knowledge, skill, disaster management and self-efficacy in handling disasters. Results: A total of 51 students participated in this study. Most students …

“I Finally Marginalized Myself From The Mainstream”: An Autoethnography Study Of Chinese International Student’S Development Of Intercultural Communicative Competence, Yuqi Lin, Hongzhi Zhang

The Qualitative Report

In the higher education market, the cross-border flow of international students has become increasingly apparent. For Australia, China has been a major student source and most of these students have been enrolled in the higher education sector. Such a phenomenon has rendered the innovation of higher education management necessary, and its socio-cultural influence has attracted attention from the Australian government. This study suggests that international students’ intercultural communicative competence (ICC) deficits could influence their self-perceptions thus compromising their ability to communicate with peers. Using a qualitative research approach, the study explores the extent to which China’s College English influences Chinese …

The Aboveground And Belowground Growth Characteristics Of Juvenile Conifers In The Southwestern United States, N. L. Pirtel, R. M. Hubbard, J. B. Bradford, T. E. Kolb, M. E. Litvak, Scott Abella, S. L. Porter, Matthew Petrie

Life Sciences Faculty Research

Juvenile tree survival will play an important role in the persistence of coniferous forests and woodlands in the southwestern United States (SWUS). Vulnerability to climatic and environmental stress declines as trees grow, such that larger, more deeply rooted juveniles are less likely to experience mortality. It is unclear how juvenile conifers partition the aboveground and belowground components of early growth, if growth differs between species and ecosystem types, and what environmental factors influence juvenile carbon allocation above- or belowground. We developed a novel data set for four juvenile conifer groups (junipers, piñon pines, ponderosa pines, firs; 1121 juveniles sampled, 221 …

Egfr Transactivates Ron To Drive Oncogenic Crosstalk, Carolina Franco Nitta, Ellen W. Green, Elton D. Jhamba, Justine M. Keth, Iraís Ortiz-Caraveo, Rachel M. Grattan, David J. Schodt, Aubrey C. Gibson, Ashwani Rajput, Keith A. Lidke, Bridget S. Wilson, Mara P. Steinkamp, Diane S. Lidke

Pathology Research and Scholarship

Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical and mutational studies to ask how EGFR and RON communicate. EGF stimulation promotes EGFR-dependent phosphorylation of RON, but ligand stimulation of RON does not trigger EGFR phosphorylation - arguing that crosstalk is unidirectional. Nanoscale imaging reveals association of EGFR and RON in common plasma membrane microdomains. Two-color single particle tracking captured formation of complexes between RON and EGF-bound EGFR. Our …

Binational Reflections On Pathways To Groundwater Security In The Mexico–United States Borderlands, Rosario Sanchez, José Agustin Breña-Naranjo, Alfonso Rivera, Randall T. Hanson, Antonio Hernández-Espriú, Rick J. Hogeboom, Anita Milman, Jude A. Benavides, Adrian Pedrozo-Acuña, Julio Cesar Soriano-Monzalvo

School of Earth, Environmental, & Marine Sciences Faculty Publications

Shared groundwater resources between Mexico and the United States are facing unprecedented stressors. We reflect on how to improve water security for groundwater systems in the border region. Our reflection begins with the state of groundwater knowledge, and the challenges groundwater resources face from a physical, societal and institutional perspective. We conclude that the extent of ongoing cooperation frameworks, joint and remaining research efforts, from which alternative strategies can emerge, still need to be developed. The way forward offers a variety of cooperation models as the future offers rather complex, shared and multidisciplinary water challenges to the Mexico–US borderlands.

Low Carbohydrate Diets In Cancer Therapeutics: Current Evidence, Rupesh Kotecha, Adeel Kaiser

All Publications

No abstract provided.

Growing-And-Giving Mindset Intervention In Early Childhood Education: A Collaborative Action Research, Fumiko Masaki

The Qualitative Report

In childhood education, a behaviorist approach (a mixture of praise and punishment) has been used for student target behaviors; however, the results have not been consistent. This study investigated how a constructivist approach would work in the same setting. The participant was a four-year-old student who showed target behaviors with negative attention-seeking and avoidance of self-regulation; three teachers and the author worked with him on collaborative action research. We treated him using the behaviorist approach in the first cycle of intervention. It seemed to work on the surface but was not helping him become autonomously self-regulated; his surroundings learned to …

Two Models Of Coteaching From University Teaching Staff: Phenomenographic Research, Jesus Pinzón-Ulloa, Mariana Tafur Arciniegas Dr, Irma A. Flores H.

The Qualitative Report

The literature of coteaching in the post-secondary landscape encompasses a wide array of different conceptions. Having multiple meanings of coteaching in higher education may pose some challenges for effectively implementing and researching this collaborative model. We should have a clear picture of the qualitatively different ways in which educators who co-teach in post-secondary settings understand this practice. Aiming to offer one of the first contributions to this effort, we analyzed the experiences of 16 university coteaching practitioners from a top university in Bogotá, Colombia. The sample participants´ interviews were analyzed using a phenomenographic methodology (Marton, 1981), which seeks to capture …

Source, Sea And Sink—A Holistic Approach To Understanding Plastic Pollution In The Southern Caribbean, Winnie Courtene-Jones, Taylor Maddalene, Molly K. James, Natalie S. Smith, Kathryn Youngblood, Jenna R. Jambeck, Sally Earthrowl, Denise Delvalle-Borrero, Emily Penn, Richard C. Thompson

School of Biological and Marine Sciences

Marine plastics are considered to be a major threat to the sustainable use of marine and coastal resources of the Caribbean, on which the region relies heavily for tourism and fishing. To date, little work has quantified plastics within the Caribbean marine environment or examined their potential sources. This study aimed to address this by holistically integrating marine (surface water, subsurface water and sediment) and terrestrial sampling and Lagrangian particle tracking to examine the potential origins, flows and quantities of plastics within the Southern Caribbean. Terrestrial litter and the microplastics identified in marine samples may arise from the maritime and …

Optimise: Ms Study Protocol: A Pragmatic, Prospective Observational Study To Address The Need For, And Challenges With, Real World Pharmacovigilance In Multiple Sclerosis, Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Ana Cavey, Stewart Webb, Cheryl Hemingway, Jeremy Hobart, Nikos Evangelou, Neil Scolding, David Rog, Richard Nicholas, Monica Marta, Camilla Blain, Carolyn Anne Young, Helen L. Ford, Paul M. Matthews

Peninsula Medical School

IntroductionThe power of ‘real world’ data to improve our understanding of the clinical aspects of multiple sclerosis (MS) is starting to be realised. Disease modifying therapy (DMT) use across the UK is driven by national prescribing guidelines. As such, the UK provides an ideal country in which to gather MS outcomes data. A rigorously conducted observational study with a focus on pharmacovigilance has the potential to provide important data to inform clinicians and patients while testing the reliability of estimates from pivotal trials when applied to patients in the UK.Methods and analysisThe primary aim of this study is to characterise …

Hematopoiesis Under Telomere Attrition At The Single-Cell Resolution, Natthakan Thongon, Feiyang Ma, Andrea Santoni, Matteo Marchesini, Elena Fiorini, Ashley Rose, Vera Adema, Irene Ganan-Gomez, Emma M Groarke, Fernanda Gutierrez-Rodrigues, Shuaitong Chen, Pamela Lockyer, Sarah Schneider, Carlos Bueso-Ramos, Guillermo Montalban-Bravo, Caleb A Class, Kelly A Soltysiak, Matteo Pellegrini, Ergun Sahin, Alison A Bertuch, Courtney D Dinardo, Guillermo Garcia-Manero, Neal S Young, Karen Dwyer, Simona Colla

Faculty, Staff and Students Publications

The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to redefine the transcriptional and epigenetic landscape of mouse and human hematopoietic stem cells under telomere attrition, as induced by pathogenic germline variants in telomerase complex genes. Here, we show that telomere attrition maintains hematopoietic stem cells under persistent metabolic activation and differentiation towards the megakaryocytic lineage through the cell-intrinsic upregulation of the innate immune signaling response, which directly compromises hematopoietic stem cells' self-renewal capabilities and eventually leads to their exhaustion. …

Large-Scale Dna Demethylation Occurs In Proliferating Ovarian Granulosa Cells During Mouse Follicular Development, Tomoko Kawai, Joanne S Richards, Masayuki Shimada

Faculty, Staff and Students Publications

During ovarian follicular development, granulosa cells proliferate and progressively differentiate to support oocyte maturation and ovulation. To determine the underlying links between proliferation and differentiation in granulosa cells, we determined changes in 1) the expression of genes regulating DNA methylation and 2) DNA methylation patterns, histone acetylation levels and genomic DNA structure. In response to equine chorionic gonadotropin (eCG), granulosa cell proliferation increased, DNA methyltransferase (DNMT1) significantly decreased and Tet methylcytosine dioxygenase 2 (TET2) significantly increased in S-phase granulosa cells. Comprehensive MeDIP-seq analyses documented that eCG treatment decreased methylation of promoter regions in approximately 40% of the genes in granulosa …

Intracranial Mesenchymal Tumors With Fet-Creb Fusion Are Composed Of At Least Two Epigenetic Subgroups Distinct From Meningioma And Extracranial Sarcomas, Emily A. Sloan, Rohit Gupta, Christian Koelsche, Jason Chiang, Javier E. Villanueva-Meyer, Sanda Alexandrescu, Jennifer E. Eschbacher, Wesley Wang, Manuela Mafra, Nasir Ud Din

Department of Pathology and Laboratory Medicine

Intracranial mesenchymal tumor, FET-CREB fusion-positive' occurs primarily in children and young adults and has previously been termed intracranial angiomatoid fibrous histiocytoma (AFH) or intracranial myxoid mesenchymal tumor (IMMT). Here we performed genome-wide DNA methylation array profiling of 20 primary intracranial mesenchymal tumors with FET-CREB fusion to further study their ontology. These tumors resolved into two distinct epigenetic subgroups that were both divergent from all other analyzed intracranial neoplasms and soft tissue sarcomas, including meningioma, clear cell sarcoma of soft tissue (CCS), and AFH of extracranial soft tissue. The first subgroup (Group A, 16 tumors) clustered nearest to but independent of …

Upregulated Type I Interferon Responses In Asymptomatic Covid-19 Infection Are Associated With Improved Clinical Outcome, Kiran I. Masood, Maliha Yameen, Javeria Ashraf, Saba Shahid, Syed Faisal Mahmood, Asghar Nasir, Nosheen Nasir, Bushra Jamil, Najia Karim Ghanchi, Iffat Khanum, Safina Abdul Razzak, Akber Kanji, Rabia Hussain, Martin E. Rottenberg, Zahra Hasan

Department of Pathology and Laboratory Medicine

Understanding key host protective mechanisms against SARS-CoV-2 infection can help improve treatment modalities for COVID-19. We used a blood transcriptome approach to study biomarkers associated with differing severity of COVID-19, comparing severe and mild Symptomatic disease with Asymptomatic COVID-19 and uninfected Controls. There was suppression of antigen presentation but upregulation of inflammatory and viral mRNA translation associated pathways in Symptomatic as compared with Asymptomatic cases. In severe COVID-19, CD177 a neutrophil marker, was upregulated while interferon stimulated genes (ISGs) were downregulated. Asymptomatic COVID-19 cases displayed upregulation of ISGs and humoral response genes with downregulation of ICAM3 and TLR8. Compared across …

Subcutaneous Cladribine To Treat Multiple Sclerosis: Experience In 208 Patients, Kimberley Allen-Philbey, Trane S De, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy Macdougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S. Constantinescu, Catherine Dalton, Rachel A. Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Eli Silber, Stewart Webb, Benjamin P. Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, Klaus Schmierer

Peninsula Medical School

Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up included adverse events, relapses, expanded disability status scale (EDSS), 9-hole-peg and Timed-25-foot-walking tests, no-evidence-of-disease-activity (NEDA), no-evidence-of-progression-or-active-disease (NEPAD), MRI, cerebrospinal fluid (CSF) neurofilament light chain (NfL), and lymphocyte counts. Results: In all, 208 patients received at least one course of …

Nutritive Quality Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, Antonio João Lourenço, V. B. G. Alcantara, Maria T. Colozza

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the nutritive quality of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in full sunlight. The results showed a significant increase in protein content and a significant decrease in NDF and cellulose contents as tree density increased. Comparing the values obtained under shading conditions …

Production And Mineral Composition Of Tropical Grasses Sown Under A Pine Plantation, D. Gutmanis, V. B. G. Alcantara, Maria T. Colozza, Antonio João Lourenço

IGC Proceedings (1977-2023)

A trial was conducted in Brazil to evaluate the performance of 6 tropical grasses: tanzania (Panicum maximum cv. Tanzania), green-panic (P. maximum var. Trichoglume), aruana (P. maximum cv. Aruana), brizanta (Brachiaria brizantha), humidicola (B. humidicola) and tifton-85 (Cynodon dactylon cv. Tifton 85), planted under two different densities of pines (Pinus elliottis): 200 and 400 stems/ha, as well as in the full sunlight. The results showed that the dry matter yield decreased as shading increased. The grasses tanzania and brizanta were the most tolerant to shading. Although N concentration increased with …

Dry Matter Production And Nutritive Value Of Alfalfa (Medicago Sativa L.) And Orchardgrass (Dactylis Glomerata L.) Under Different Light Regimes, A. C. Varella, P. L. Peri, R. J. Lucas, D. J. Moot, D. L. Mcneil

IGC Proceedings (1977-2023)

Spring and summer alfalfa dry matter and nitrogen production rates were greater than orchardgrass in open pasture and under three shade levels. Ten years old Pinus radiata allowed 60% light transmissivity. The addition of artificial shade resulted in 45% and 25% transmissivity. Orchardgrass pastures were nitrogen deficient and water stressed. In contrast, alfalfa was not stressed and it was more light responsive than orchardgrass. Differences in nutritive value were relatively small between species and between light regimes. Sheep liveweight gain on alfalfa was greater than on orchardgrass. Orchardgrass demonstrated shade tolerance, but alfalfa was more productive even at 25% transmissivity. …

Different Methods Of Artificial Shade For Agro-Silvipastoral Research, A. C. Varella, D. J. Moot, R. J. Lucas, D. L. Mcneil, P. L. Peri, K. M. Pollock

IGC Proceedings (1977-2023)

Artificial shading sources are used to simulate silvipastoral light environments and study the effect of shade on pasture. Different sources of shade may not imitate normal forest light environment. An experiment was conducted to examine the light environment and effect on pasture yield components of two artificial shading materials. Alfalfa (Medicago sativa L.) pasture was submitted to three light regimes: full sunlight (100% transmissivity); black shade cloth (40%) and wooden slats (45%).

The pattern of light exposure for plants differed under slats and shade cloth, but light intensity and quality were similar. Alfalfa dry matter (DM) yield and leaf …

Knowledge Management And Innovation: A Critical Literature Review, Muhammad Arif Dr., Miguel Baptista Nunes Prof., Saima Kanwal

Library Philosophy and Practice (e-journal)

This study aims at establishing the state-of-the-art link between knowledge management (KM) and innovation. For this purpose, the study critically reviewed research published in KM and innovation domain over the last ten years. A systematic search strategy was employed to retrieve relevant empirical studies from the Web of Science. Thereafter, the authors applied a critical review strategy to analyse and synthesise the findings of the selected studies. The study’s findings disclose that research in the recent past increased exponentially in KM-innovation domain. In terms of impact, KM contributes to different types of innovation associated with organisational processes, products and services. …