Digital Commons Network^™

Plan B: Pregnancy In The Age Of Ivf, Gabriella D. Campen

Student Works

No abstract provided.

Fostering Agentic Engagement: Working Toward Empowerment And Equity Through Pedagogical Partnership, Alison Cook-Sather, Samantha Allard, Elena Marcovici, Bill Reynolds

International Journal for the Scholarship of Teaching & Learning

An established body of research details the faculty role in promoting student engagement. Newer scholarship on agentic engagement foregrounds student-initiated engagement in classroom learning. Our SoTL project explored how participating in student-faculty pedagogical partnerships supported two undergraduate students in expanding agentic engagement to encompass student empowerment and equity both within and beyond the classroom. We draw on the students’ autoethnographic accounts of three interrelated experiences: (1) joining a pedagogical partnership program as pedagogical consultants and developing confidence in, capacity for, and commitment to supporting student and faculty learning; (2) carrying that confidence, capacity, and commitment into the courses in which …

A Foray Into The Interval Timing Capabilities Of Tufted Capuchin Monkeys (Cebus [Sapajus] Apella), Gryff Griffin

Honors Theses

Time is a critical part of life and timing on the range from milliseconds to minutes has proven to be critical for several behaviors such as foraging and movement. While the exact neurological structures of interval timing are currently undefined, several studies have been completed comparing the interval timing capabilities of humans and nonhuman primates. However, these studies have unanimously utilized members of Macaca, which limits the abilities for researchers to make apt comparisons between humans and all nonhuman primates. This study sought to investigate whether tufted capuchins (Cebus [Sapajus] apella) have the capability to measure time …

Self-Representation Of Filipino Teachers And Korean Learners Of English In Online Classes, Leonardo Munalim, Betty Tuttle, Cecilia Genuino

PASAA

With an exhaustive survey of published studies, we found that no attempts have been made to analyze classroom talks between Filipino teachers and Korean students of English in online ESL classes. The reason may be attributed to the arduous labor of transcribing and analyzing the data both macro- and microscopically. This lacuna may have provided teachers and students a poor understanding of the features of talk of both interlocutors in an online modality. For this study, we looked at the way Filipino teachers and Korean students of English represented themselves using the first-person pronoun “I” (1PP) through the lens of …

2021 Georgia Southern Football Full Media Guide, Georgia Southern University

Men's Football Records

• Football 2021 Media Guide

Predicting Hpv Vaccination Coverage Rates Using Indicators Of Health Department Clinic Access: A Case Study With South Carolina And Georgia, Ashley A. White

MUSC Theses and Dissertations

Since its introduction in 2006, the human papilloma virus (HPV) vaccine has made substantial developments. The use of the vaccine was expanded to include males. The completion dose series was decreased from three to two shots, if started before the age of 15. The cost of the vaccine is fully covered by private insurance and public programs for various ages ranging from 9 to 26 years old1. With these improvements the HPV vaccine has the capability to safely and significantly prevent and reduce many cancers that cause the deaths of women and men across the United 1,2. Therefore, the underuse …

Prevention Of The Oncogenic Effects Of Lifestyle-Associated Advanced Glycation End-Products (Ages) Via Regular Physical Activity, Bradley A. Krisanits

MUSC Theses and Dissertations

Interrelated lifestyle factors such as a sedentary habit, obesity and diets consisting of highly processed, high protein and fat containing foods, contribute to the accumulation of reactive metabolites known as advanced glycation end-products (AGEs). AGE pathogenic effects are mediated through modification of protein function, genetic fidelity, stress responses, and aberrant cellular signaling. For the first time, this study examined the effects of dietary AGE consumption on cancer progression in vivo and assessed physical activity (PA) as a potential intervention to reduce dietary AGE mediated effects. Given the links between lifestyle and AGEs, we propose that a diet high in AGEs …

The Impacts Of External Patient Variables On Gene Expression Profiles Of Lung Adenocarcinomas, Michael Madsen

CMC Senior Theses

The search for improvements to detection and treatment of cancers is a paramount goal for all of medicine. The most important step for oncological research is to expand the knowledge base of the genetic characteristics and abnormalities that give rise to cancer. In our present day, one of the most pressing and deadly forms of cancer is that of the lung, with lung adenocarcinomas being the most prevalent variation of the disease. Improving our cancer genomic insight can provide the seedings for improved cancer detection, novel cancer treatment, and serve as a guide for avenues to explore with future oncological …

Party Registration Deadlines And Hidden Partisanship: An Individual Analysis, Matthew Thornburg

Commonwealth Review of Political Science

Many voters in states with party affiliation identify with or lean towards one political party but are not registered with it. This sort of “hidden partisanship” may be intentional be it may also result from a combination of changes in a voter’s party identification and the electoral institutions in place. In many states it is difficult to change party registration due to early deadlines intended to prevent crossover voting. Using individual-level survey data, I find that hidden partisanship in a state increases, the further in advance of the primary the deadline to change party affiliation is. This deadline affects primary …

Exploration Of The Use Of Palladium And Nickel To Catalyze Enolate Cross-Coupling And The Enantioselective Mizoroki-Heck Reaction., Mary Elizabeth Sexton (Charlton)

Bryn Mawr College Dissertations and Theses

Palladium catalysis is a common synthetic tool utilized by organic chemists to create carbon-carbon bonds. We utilized palladium to catalyze the γ-arylation of α, β-unsaturated ketones, and esters. This work expands on palladium-catalyzed α-arylation chemistry and extends it to the vinylogous variation at the γ-position. We report the regioselective synthesis of mono-γ-arylated 7-methoxy-4-methylcoumarin. We also report efforts towards applying our reaction conditions to other α,β-unsaturated ketones and esters to expand the scope of our reaction conditions.

In addition, we utilized palladium to catalyze the enantioselective asymmetric intramolecular Mizoroki-Heck reaction to produce potentially bioactive phenanthridinone analogs. We achieve this through the …

Novel Computational Methods For Cancer Genomics Data Analysis, Jinpeng Liu

Theses and Dissertations--Computer Science

Cancer is a genetic disease responsible for one in eight deaths worldwide. The advancement of next-generation sequencing (NGS) technology has revolutionized the cancer research, allowing comprehensively profiling the cancer genome at great resolution. Large-scale cancer genomics research has sparked the needs for efficient and accurate Bioinformatics methods to analyze the data. The research presented in this dissertation focuses on three areas in cancer genomics: cancer somatic mutation detection; cancer driver genes identification and transcriptome profiling on single-cell level.

NGS data analysis involves a series of complicated data transformation that convert raw sequencing data to the information that is interpretable by …

The Functionally Relevant Role Of Sdrna-19b And Sdrna-24 In Prostate Cancer, Addison A. Barchie

Honors Theses

In recent studies small nucleolar RNAs (snoRNA) have been shown to be processed into smaller microRNA-like fragments known as sno-derived RNA (sdRNA). We recently identified 9 snoRNAs that contribute to prostate malignancy using The Cancer Genome Atlas (TCGA) patient prostate tumor next-generation sequencing datasets. These snoRNA were found to be processed into sdRNAs, heavily misexpressed in prostate cancer cell types 8140 and 8550, and shown to function by binding Ago proteins in order to impact mRNA translation. SdRNA-19b and sdRNA-24 in particular stood out as having significant differential expression in prostate cancer vs. control tissue. Interestingly, the targets for sdRNA-19b …

The Role Of Inflammasome In Vascular Remodeling Following Injury, Ted Amadi

Honors Theses

The purpose of the project presented in this thesis is to assess the contribution of inflammasome activation in mediating vascular wall remodeling that occurs following carotid artery injury due to decreased blood flow. To examine this, we used a mouse model of carotid artery ligation in mice lacking the expression of a key mediator of the inflammasome signaling pathway. Following ligation, we completed a histological assessment to compare the degree of the neointima formation and expression of inflammasome related proteins in both injured and the non-injured contralateral carotid artery in both wild-type (WT) and Caspase 1 knockout mice (Cas1 -/-).

Determination Of Pollutant Load Reductions To Three Mile Creek As A Result Of The Implementation Of Storm Water Bio-Infiltration Basins On The Usa Campus, Jordan E. Blackmon

Honors Theses

Three Mile Creek has been identified as an impaired urban stream and is now a priority for cleanup for both the City of Mobile and the Alabama Department of Environmental Management. Methods to better manage storm water runoff on the USA campus have begun, with a goal to reduce sediment and nutrient inputs to Three Mile Creek. Both sediment and nutrient inputs to Three Mile Creek disrupt habitat and lower dissolved oxygen concentrations, which are detrimental to overall stream health. Low Impact Development strategies are an innovative way to use nature-like, green-infrastructures to minimize storm water runoff quantity and improve …

Comparative Analysis Of Computationally Accelerated Ngs Alignment, Ada Chaeli Van Der Zijp-Tan

Honors Theses

The Smith-Waterman algorithm is the basis of most current sequence alignment technology, which can be used to identify similarities between sequences for cancer detection and treatment because it provides researchers with potential targets for early diagnosis and personalized treatment. The growing number of DNA and RNA sequences available to analyze necessitates faster alignment processes than are possible with current iterations of the Smith-Waterman (S-W) algorithm. This project aimed to identify the most effective and efficient methods for accelerating the S-W algorithm by investigating recent advances in sequence alignment. Out of a total of 22 articles considered in this project, 17 …

Utilizing Acoustic Levitation To Determine Ionic Liquid Effects On Enthalpy Of Polymerization, Davina V. Ho

Honors Theses

Ionic liquids (ILs) are emerging as an eco-friendlier alternative to traditional organic compounds. The hope with ILs in this project is to incorporate them with resins used in 3D printing to act as plasticizers which will in turn help prolong the life of the printed object. A common issue with plasticizers like phthalate in particular is they can leach out of plastics due to their vapor pressure which leads to decreased performance and can also pose a health risk being released into its surroundings or atmosphere. A major benefit of incorporating ILs in with resins comes from their low volatility …

Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway

Honors Theses

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that primarily affects women. The etiology is not known yet, but genetics and environmental factors trigger the disease. These epigenetic changes modify gene expression and contribute to the development of the disease. It is known that T cells from patients with lupus overexpress genes that may contribute to the onset and progression of the disease. Dr. Gorelik has shown that OGT (O-linked N-acetyl-Glucosamine Transferase), which is an X-linked gene, is overexpressed in women with SLE. OGT adds b-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of proteins. …

Characterization Of Bpa Sensitive Strains In C. Elegans, Giulianna I. Escobar

Honors Theses

Bisphenol A (BPA) has been present in our environment since 1891 when it was first synthesized by Aleksandr Dianin. BPA has since been a topic of interest due to the possibility of diseases associated in human consumption of the chemical. Interestingly, Caenorhabditiselegans, commonly known as C.eleganshave shown to be able to tolerate the chemical. Thisorganism is an advantageous model organism for research since they are simple organisms to study, cheap, produce a large brood size, and have a short life cycle. Previously a forward genetic screen was done to isolate 2000 healthy strains in order to determine which strains showed …

Community Opioid Overdose Prevention And Naloxone Distribution Programs: An Evidence-To-Practice Review, Madison M. Hauge, Kathryn C. Downs, Zachary K. Winkelmann

Clinical Practice in Athletic Training

According to the Centers for Disease Control and Prevention, 100 people die of drug overdose in the United States every day. This frighteningly high mortality rate has created the need for community-based opioid overdose prevention programs (OOPPs). Currently, there are more than 188 community-run programs operating in the United States. These programs teach individuals how to distribute naloxone and respond properly to a drug overdose situation. This guiding systematic review depicts the current literature available on OOPPs and their effectiveness. The authors performed an article search to discover the most relevant and recent articles, which were graded using a quality …

Ruthenium-Centred Btp Glycoclusters As Inhibitors For Pseudomonas Aeruginosa Biofilm Formation, Ciaran O'Reilly, Salvador Blasco, Bina Parekh, Helen Collins, Gordon Cooke, Thorfinnur Gunnlaugsson, Joseph P. Byrne

Articles

No abstract provided.

Fabrication And Qualitative Analysis Of An Optical Fibre Efpi-Based Temperature Sensor, Fintan Mcguinness, Aidan Clooney, Mohamed Oubaha, Dinesh Babu Duraibabu, M. Mahmood Ali, Gerald Kilkelly, Emma Tobin, Gabriel Leen

Articles

The following presents a comparison of an extrinsic Fabry–Perot interferometer (EFPI)- based temperature sensor, constructed using a novel diaphragm manufacturing technique, with a reference all-glass EFPI temperature sensor. The novel diaphragm was manufactured using polyvinyl alcohol (PVA). The novel sensor fabrication involved fusing a single-mode fibre (SMF) to a length of fused quartz capillary, which has an inner diameter of 132 µm and a 220 µm outer diameter. The capillary was subsequently polished until the distal face of the capillary extended approximately 60 µm beyond that of the single mode fibre. Upon completion of polishing, the assembly is immersed in …

Fabrication And Characterization Of Agarwood Extract-Loaded Nanocapsules And Evaluation Of Their Toxicity And Anti-Inflammatory Activity On Raw 264.7 Cells And In Zebrafish Embryos, Eman Ramadan, Manar A. Eissa, Noha Badawi

Pharmacy

Aquilaria malaccensis has been traditionally used to treat several medical disorders including inflammation. However, the traditional claims of this plant as an anti-inflammatory agent has not been substantially evaluated using modern scientific techniques. The main objective of this study was to evaluate the anti-inflammatory effect of Aquilaria malacensis leaf extract (ALEX-M) and potentiate its activity through nano-encapsulation. The extract-loaded nanocapsules were fabricated using water-in-oil-in-water (w/o/w) emulsion method and characterized via multiple techniques including DLS, TEM, FTIR, and TGA. The toxicity and the anti-inflammatory activity of ALEX-M and the extract-loaded nanocapsules (ALEX-M-PNCs) were evaluated in-vitro on RAW 264.7 macrophages …

Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease, Eman Ramadan, Marwa M. Safar

Pharmacy

Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs people's lives tremendously. The development of innovative treatment modalities for PD is a significant unmet medical need. The critical function of glucagon-like peptide-1 (GLP-1) in neurodegenerative diseases has raised impetus in investigating the repositioning of a dipeptidyl peptidase IV inhibitor, alogliptin (ALO), as an effective treatment for PD. As a result, the focus of this research was to assess the effect of ALO in a rat rotenone (ROT) model of PD. For 21 days, ROT (1.5 mg/kg) was delivered subcutaneously every other day. ALO (30 mg/kg/day), delivered by gavage for …

'Induction Of Apoptosis, Cytotoxicity And Radiosensitization By Novel 3,4-Dihydroquinazolinone Derivatives, Eman Ramadan, Amira Khalil

Pharmacy

Twenty new quinazolinone derivatives bearing a piperonyl moiety were designed and synthesized. The structures of the target compounds were in agreement with the microanalytical and spectral data. Compounds 4-10, 13, 14 and 17-27 were screened for their cytotoxic activity against HepG-2 and MCF-7 cancer cell lines. The target compounds showed IC₅₀ in the range of 2.46-36.85 µM and 3.87-88.93 µM for HepG-2 and MCF-7, respectively. The promising compounds 7, 19, 26 and 27 were selected to measure their EGFR inhibitory activity. The IC₅₀ values of the promising compounds were in the range of 146.9-1032.7 nM for EGFR in …

Chloroquine Ameliorates Bone Loss Induced By D-Galactose In Male Rats Via Inhibition Of Erk Associated Osteoclastogenesis And Antioxidant Effect., Marwa Safar

Pharmacy

No abstract provided.

Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease., Marwa Safar

Pharmacy

No abstract provided.

Sansevieria: An Evaluation Of Potential Cytotoxic Activity In Reference To Metabolomic And Molecular Docking Studies, Amgad Albohy

Pharmacy

Sansevieria trifasciata Prain. and Sansevieria suffruticosa N.E.Br. were selected to evaluate their cytotoxic activity against colon (CACO2), lung (A-549) and liver (HepG-2) carcinoma cell lines. Results indicated that S. suffruticosa N.E.Br. showed a significant cytotoxic effect on CACO2 with IC50= 30.9 ± 0.72 μg/ml. Evaluating the phenolic and flavonoid contents, S. suffruticosa N.E.Br. has higher total phenolic and flavonoid contents than S. trifasciata Prain. The phenolic content was estimated using HPLC detecting the presence of apigenin-7-glucoside and cinnamic acid only in S. suffruticosa N.E.Br. with p-hydroxybenzoic acid and p-coumaric acid being the major compounds. While, catechin and kaempferol are the …

Neuroprotective Repositioning And Anti-Tau Effect Of Carvedilol On Rotenone Induced Neurotoxicity In Rats: Insig& In Vivo Anti-Parkinson’S Disease Studyhts From An Insilico, Amgad Albohy, Rana Kamal, Esther Menze, Hebatalla I. Ahmed, Samar S. Azab

Pharmacy

Current treatments for Parkinson’s Disease (PD) only provide symptomatic relief; however, they don’t delay the disease progression, hence new treatment options should be considered. Carvedilol is a nonselective β & α1 blocker with additional effects as an antioxidant, anti-inflammatory and neuro protective properties. In this research, an insilico study was conducted to primarily evaluate carvedilol as an anti-parkinsonian and anti-tau protein target. PASS prediction was performed followed by a docking study of carvedilol. Carvedilol yielded promising results and forward guided this study onto its in vivo evaluation. The in vivo study aimed to assess the neuro-protective effects of carvedilol in …

Proactive Management Of Acute Oedema Following Hand And Minor Burn Injury, Dale O. Edwick

Theses

Burn injury is a unique trauma. The inflammatory process initiated with burn injury adversely influences all of the Starling equation variables, resulting in increased transvascular fluid filtration, so that oedema as a product of burn injury is more readily formed than in other forms of trauma. Localised wound oedema forms due to minor burn injury, with increasing systemic oedema associated with increased size of burn. It is now recognised that a marked inflammatory and immune response is created with non-severe burn injury, indicating a systemic component with all burns. The effect of oedema formation on the course of the burn …

Extraction Of Cellulose Nanofibers From Empty Palm Fruit Bunches Via Mechanical Defibrillation, Zi-Qian Tan, Takaomi Kobayashi, Duangdao Aht-Ong

Journal of Metals, Materials and Minerals

In recent years, there has been an increasing interest in finding alternative material to replace fossil-oil based product due to the environmental concern. Lignocellulosic biomass has emerged as the promising candidate due to its low-cost and sustainability. The objective of this work was to prepare cellulose nanofibers (CNFs) from empty palm fruit bunches (EPFB), which are the waste originating from palm oil industry. Cellulose fibers were first extracted from EPFB by chemical treatment, followed by mechanical disintegration using high-pressure homogenization. Fiber concentration and defibrillation time during mechanical treatment were studied to investigate their effects on the properties of produced nanofibers. …