Digital Commons Network^™

Helping The Have-Nots: Examining The Relationship Between Rehabilitation Adherence And Self-Efficacy Beliefs In Acl Reconstructed Naia And Ncaa Dii And Diii Female Athletes, Myles Tutin Englis

Theses and Dissertations--Kinesiology and Health Promotion

Anterior cruciate ligament injuries are among the most common and traumatic sport-related injuries, and often negatively impact one’s quality of life during and post-rehabilitation. For many NCAA Division I and professional female athletes, rehabilitation is streamlined with a multidisciplinary team, including sport psychology. For others (e.g., NAIA, NCAA Division II, III athletes) this may not always be the case, as many of these athletic programs may not have the resources to meet the various needs of injured and rehabilitating female student-athletes. In these instances, rehabilitation motivation, adherence, and success may be more dependent on the athletes’ individual resources and personalities, …

Mechanical Deviations And Verbal-Cue Altered Gait In The Femoroacetabular Impingement Syndrome Population, Walter Menke

Theses and Dissertations--Kinesiology and Health Promotion

Femoroacetabular impingement syndrome (FAIS) is an abnormal physical hip morphology that causes functional changes and pain during gait. Mechanical gait differences in this population require further biomechanical investigation to elucidate characteristics unique to this group. Fixed speed gait trials were performed on force plates and analyzed in addition to isokinetic strength testing to find a multitude of biomechanical variables including joint moment, joint power, joint work, and peak joint angle. This work has discovered evidence of muscular deficits at the hip, specifically hip extension, as well as knee joint power contributions to gait when compared to controls. These findings suggest …

Facilitating Analysis Of Toxoplasma Gondii Bradyzoite Metabolic Activity Via Image Processing And Multivariate Logistic Regression For High Throughput Classification Of Mitochondrial Morphologies, Brooke Place

Theses and Dissertations--Biomedical Engineering

Approximately a third of the population worldwide is chronically infected by the parasite Toxoplasma gondii. During chronic infection the parasite resides within tissue cysts as the poorly understood bradyzoite form. Observation of these bradyzoites via microscopic imaging within tissue cyst purified from infected mouse brains has shown metabolic activity with heterogeneous replication potential. With fluorescence microscopy imaging targeting the parasite’s actively respiring mitochondria, the parasite’s metabolic state can be further investigated as the morphology of mitochondria can be associated with specific physiologic states. However, manually classifying mitochondrial morphologies from these images can be tedious and prone to error as …

Leadership Storytelling Of Rural School Superintendents Engaged In Change And Innovation, Tony Barrett

Theses and Dissertations--Education Sciences

This dissertation examined the leadership storytelling uses and practices by rural, public school superintendents in North Georgia who are engaged in change and innovation through agreements with the state in exchange for flexibility waivers from Title 20 of the Georgia Code. This study was the result of the participation of five rural, Appalachian superintendents in semi-structured interviews. Two of the districts were Strategic Waivers School Systems (SWSS) and three of them were Charter Systems. The context of this study was framed by Georgia’s broad flexibility waivers which encourage school districts to promote and pursue innovative approaches in K-12 education. The …

High Performance: Exploratory Study Into The High Performance Model And Qualitative Secondary Analysis Of Elite Sport Management In The United States, Jon Gregory Hill

Theses and Dissertations--Education Sciences

This dissertation examines the area of high performance in elite sport through high performance professionals’ perspectives in the United States Olympic and Paralympic National Governing Bodies. The study’s purpose was to establish a shared meaning of the high performance sport management model by its elements in the athletic arena. Interviews with 16 high performance directors and managers were conducted to establish definitions, backgrounds, and anatomy of high performance in sport: high performance, high performance sport, high performance management, high performance model.

A qualitative secondary analysis was conducted to examine the high performance model in the U.S. and explore the job …

An Examination Of High School Physical Education Teachers Support Of Students’ Physical Activity Self-Efficacy, Ken Murfay

Theses and Dissertations--Education Sciences

Providing students with experiences to increase their confidence (self-efficacy) to be physically active is important because of the many health benefits associated with physical activity (U.S. Department of Health and Human Services [USDHHS], 2020). Several studies have shown that physical activity (PA) tends to decline as students age (Cooper et al., 2015; Metcalf et al., 2015; Troiano et al., 2008) and the largest declines usually occur in adolescence (Sallis, 2000). It is recommended that physical education (PE) serve as an intervention to promote PA and provide students with experiences to increase motor competence and PA knowledge (Weiss, 2013). Interventions within …

Co-Teaching Practices Of General And Special Educators In Secondary Science Classrooms, Samantha Jolene Ringl

Theses and Dissertations--Education Sciences

The purpose of this study was to establish current levels of co-teaching implementation and to explore teachers’ perceptions of co-teaching and co-teacher relationships. This study also examined whether there is a relationship between teachers’ perception of their co-teaching relationship and their perception of co-teaching implementation in their classrooms. Analysis revealed that teachers generally have positive perceptions of their co-teaching partners and relationships, and these perceptions did not significantly differ between science teachers and special educators. However, this study found that teachers are not regularly planning lessons together, sharing the workload in the classroom, or choosing co-teaching models together. This study …

Artificial Intelligence And Soft Computing In Smart Structural Systems, Sajad Javadinasab Hormozabad

Theses and Dissertations--Civil Engineering

Next-generation smart cities are the key feature in the next chapter of human life. Cities that employ innovative and technology-driven solutions to improve the sustainability, resilience, prosperity, and amenity of the community are considered smart cities. Development of smart cities requires fundamental innovations in many technical and technological aspects including those contributing to smart structures. Smart technologies improve the structural performance against natural disasters like earthquakes, hurricanes, tornados, and promote the sustainability of structural systems. Next-generation smart structures encompass a variety of technologies including Structural Control (SC) and Structural Health Monitoring (SHM). SC covers methodologies and technologies that modify the …

Investigating How Timing Of Case Study Presentation On Huntington Disease Influences Construction Of Argument Warrant While Learning The Central Dogma Of Molecular Biology, Katherine A. Sharp

Theses and Dissertations--Education Sciences

A common belief among pre-medical and medical students is that biochemistry is not relevant to practicing medicine. Among topics commonly taught in biochemistry, courses include the Central Dogma of Molecular Biology, which is among the most critical science topics taught to medical students by biochemistry educators. Perceived irrelevance among students may be due to common curricular trends in biochemistry education. Many biochemistry courses are found at Research I (R1) universities that teach biochemistry using traditional lectures with little evidence of supporting learning with real-world applications. Instructors commonly assume that students can make realworld connections independently during lecture courses, but it …

Global Competence And Deeper Learning: Secondary Principals’ Perceptions In An Intermountain District, Lorren Amanda Siebert

Theses and Dissertations--Education Sciences

Education has become increasingly global in recent years. Student and teacher global competence have been studied at length. School administrators’ application of global competencies in their administrative practice has not been explored until recently. Secondary school administrators’ global competencies were investigated under seven tenets. The aim of this study was to examine how secondary principals in one Intermountain school district perceived and implemented global competencies in their current professional practice. Further, this study explored how those global competencies translated into deeper learning educational leadership practices.

A sequential explanatory approach was utilized for this two-phase mixed method study. Quantitative survey data …

Catalyzing Change In Higher Education: Social Capital And Network Leadership In The Competency-Based Education Network, Bruce William Haupt Jr.

Theses and Dissertations--Education Sciences

Collaborative inter-organizational networks can be effective at catalyzing and supporting the generation and diffusion of new models and practices. With shared purpose, structure, and resources, network organizations can facilitate knowledge exchange and the growth of inter-organizational relationships. In this study, I sought to better understand how network organizations influence social capital and the spread of innovative practices. Of particular interest were the roles of national network and sub-national network organizations (sub-networks), and the interactive learning processes of network newcomers. I focused on the diverse array of colleges and universities involved in the Competency-Based Education Network (C-BEN), and their efforts to …

Impact Of Short Meditation On Attentional Performance, Lauren E. Guerriero

Theses and Dissertations--Biology

Meditation describes a large variety of traditions that all include the conscious focus of attention. By maintaining attention, meditators experience both acute and long-term changes in physiology, anatomy, and cognitive performance. The type of performance benefit is believed to depend, at least in part, on the specific type of mental training. What is much less clear in the literature is the impact of a single session of meditation on the brain and how the acute changes could impact performance. Studies in advanced meditators show an increase in neuronal coordination and slowing of neuronal firing across many regions in the brain, …

Uncovering Frontier Mythologies: Memorial Landscapes In Minneapolis, Mn, Corrin Turkowitch

Theses and Dissertations--Geography

This thesis analyzes the relationship between settler colonialism and public memory in B.F. Nelson Park, a downtown park in Minneapolis. My focus is the Pioneer statue, a large granite memorial depicting a frontier family in the middle of the park, which I examine through the lenses of race, gender, power, and violence. Using archival and landscape analysis I examine the historical and present built environment of the park and how it relates to white supremacy. Through interviews of two municipal constituencies, I evaluate how these organizations maintain present narratives of European settlement and in turn uphold the monument. This research …

Southern Alterity In The Global Modernist Novel, 1899-1966, Benjamin J. Wilson

Theses and Dissertations--English

My dissertation examines the portrayal of southern alterity in the global modernist novel. The trope of southern spaces as sites of decay, degeneration, and dissolution proves to be remarkably durable in both fictions set within the domestic U.S. south, as well as those colonial and postcolonial texts associated with the global modernist canon. Novels like Joseph Conrad’s Heart of Darkness and William Faulkner’s Absalom, Absalom! suggest that the alterity of places like the Congo and Haiti are inextricably bound up with racial hierarchies. On the other hand, texts such as Charles W. Chesnutt’s The Marrow of Tradition and Zora Neale …

"To Claim That Greatness For Themselves”: A History Of The Kentucky Horse Park, Emily Elizabeth Libecap

Theses and Dissertations--History

The Kentucky Horse Park describes itself as the world’s only equine theme park. However, the park is not entirely without historical precedent; instead, world’s fairs, amusement parks, and theme parks all form a century-long pedigree chart through which the park can trace its ancestors. The Kentucky Horse Park’s links to these predecessors deepen our understanding of how the park is a reflection of the world around it and the motivations for how and why it was built. From its inception in the late 1960s, to when it opened in 1978, through the present day, the Kentucky Horse Park was and …

The “Case” For Assessments: An Evaluation Of Case End Of Course Assessments And Teacher Motivation, Andrew Lawrence Hauser

Theses and Dissertations--Community & Leadership Development

Curriculum for Agricultural Science Education (CASE) End of Course (EoC) assessments are summative assessments used to evaluate the CASE curriculum. This quantitative study explored the effects teacher motivation has on student performance on CASE EoC assessments. CASE teachers (n= 55) who participated in the study responded to the 28-item CASE End of Course Assessment Teacher Motivation Questionnaire on a 5-point Likert-type scale. The researcher conducted a Pearson r Correlation test to determine a relationship between questionnaire mean values and secondary student assessment data. Results from the study outline frequency of responses, perceived value and expectancy mean values, and correlations …

Living As An Impostor: An Exploration Of The Lived Experiences Among Multiracial Youth In Secondary Agricultural Education, Juliana Danielle Markham

Theses and Dissertations--Community & Leadership Development

The racial demographic of the United States is ever changing, and the increase of multiracial children is substantial. This multiple-case study examined the lived experiences of multiracial youth in secondary agricultural education. This study finds evidence of Impostor Phenomenon among these multiracial students in regard to their races. This study provides insight to advise other educational institutions and organizations on how these multiracial students perceive and are perceived, within agricultural education, how it affects them, and gives recommendations to improve the future experiences of multiracial students within agricultural education.

Acl Injury, A Time Course Study Of Transcriptional Changes, Thomas Carter

Theses and Dissertations--Medical Sciences

ACL tear is a common injury in the United States with a significant cost and time burden during recovery; reconstructive surgery often results in weakened quadricep muscle and higher risk of posttraumatic osteoarthritis. Prior research has highlighted cellular derangements within the quadriceps after ACL injury and reconstruction, but the early molecular effectors of cellular dysfunction remain to be identified. To further understand the molecular effectors of quadriceps dysfunction following ACL injury, this study aims to quantify the timing and magnitude of transcriptional differences between the quadriceps muscle of injured and contralateral non-injured limbs. These data will provide insight into the …

The Role Of Vascular Endothelial Growth Factor In Leukemia Trafficking, Shaw Powell

Theses and Dissertations--Medical Sciences

Vascular endothelial growth factor (VEGF) is a signaling protein involved in inducing and regulating endothelial cell proliferation and function (Duffy et al 2000). VEGF is also involved in cancer progression, as it induces vascular permeability and promotes angiogenesis to tumor laden areas, giving cancer cells critical oxygen and nutrients (Hoeppner et al.,2012. Studies indicate VEGF prevents lymphoblast apoptosis, which may contribute to leukemia formation and enable the proliferation of leukemic cells (Duffy et al 2000). Ongoing research seeks to further examine VEGF in leukemia, using a rag2:GFP-Myc expressing transgenic zebrafish as the animal model of T-cell Acute Lymphoblastic Leukemia (T-ALL). …

S. Gordonii-Produced Hydrogen Peroxide Modulates Mir-663a And Ccl20 Expression In Oral Epithelial Cells, Marshall Houston Maynard

Theses and Dissertations--Medical Sciences

The mechanisms through which a persistent recognition of commensal bacteria by oral epithelial cells (OECs) mitigates an uncontrolled inflammatory response of the oral mucosa remain unknown. CCL20 secretion by OECs in response to pathogenic bacteria is regulated by S. gordonii (Sg)-induced miR-663a; nevertheless, the mechanisms involved in these Sg-modulated responses remain to be elucidated. Since Sg is a hydrogen peroxide (H₂O₂) producer, and H₂O₂ has been shown to stimulate miRNA expression, we hypothesized that H₂O₂ could be involved in Sg-induced miR663a and CCL20 responses. Expression of miR663a …

Application Of Genetic Techniques To Investigate Chlamydia Trachomatis Type Iii Secretion Effector Biology, Gabrielle Keb

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Chlamydia trachomatis is the causative agent of the most reported bacterial sexually transmitted disease in the United States. The establishment of an intracellular niche within mucosal epithelium is sufficient to drive immunopathology and disease sequela. As obligate intracellular bacteria, Chlamydia spp. have evolved numerous mechanisms for establishing an intracellular growth environment. The type III secretion system (T3SS) delivers effector proteins to the host cytosol and is essential for C. trachomatis invasion and development. The effectors TmeA, TmeB, and TarP, are all secreted during C. trachomatis invasion. TarP and TmeA have been associated with manipulation of actin networks and are …

Carnosic Acid Differentially Modulates The Nrf2- Antioxidant Response In Male And Female Mice Following Experimental Traumatic Brain Injury, Jacob A. Dunkerson

Theses and Dissertations--Neuroscience

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Each year, an estimated 2.8 million Americans are diagnosed with a TBI due to falling, motor vehicle collisions, gun violence, and sports related concussions. Although inflicted by a single event, the post-traumatic effects of TBI often develop into a life-long disease. Survivors often experience cognitive decline, memory loss, emotional instability, changes in personality, and physical disabilities. A single TBI, and more-so repetitive TBI's, place an individual at a greater risk of developing chronic neurological disorders, such as dementia or Alzheimer’s disease, earlier in life. …

Examining Human Apoe Genotype And Sex As Modulators Of Respiratory Plasticity In The Presence And Absence Of Spinal Cord Injury, Lydia Ella Strattan

Theses and Dissertations--Neuroscience

There are over 17,000 new spinal cord injuries (SCIs) every year in the Unites States alone. Almost 60% of these injuries occur at the cervical level, potentially leading to loss of function in a variety of sensory and motor systems including upper and lower limbs, respiratory, and autonomics. In addition to the physical and emotional costs, individuals who experience these higher level injuries also face a massive financial burden, incurring over $1 million in expenses during the first year after injury in addition to substantial yearly costs for the rest of their lifetime. A myriad of therapeutic approaches targeting plasticity …

Characterizing The Physiology And Genetics Of Contact Dependent Growth Inhibiton Systems In Burkholderia Species, Alice Elizabeth Oates

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

Contact-dependent growth inhibition (CDI) systems mediate interbacterial competition. The genes encoding these systems are widespread among Gram-negative bacteria, including Burkholderia pathogens. CDI systems of Burkholderia species are composed of two-partner secretion pathway proteins and function to deliver the toxic C-terminus of a polymorphic surface-exposed exoprotein BcpA (Burkholderia CDI protein A) to the cytoplasm of neighboring recipient bacteria upon cell-cell contact. Specific outer and inner membrane proteins facilitate BcpA translocation both out of the donor bacterium and into the recipient cell cytoplasm. Most Burkholderia species-specific CDI translocation factors in recipient cells are unknown. BcpA intoxication functions as a mechanism by …

Dimension Reduction Techniques In Regression, Pei Wang

Theses and Dissertations--Statistics

Because of the advances of modern technology, the size of the collected data nowadays is larger and the structure is more complex. To deal with such kinds of data, sufficient dimension reduction (SDR) and reduced rank (RR) regression are two powerful tools. This dissertation focuses on these two tools and it is composed of three projects. In the first project, we introduce a new SDR method through a novel approach of feature filter to recover the central mean subspace exhaustively along with a method to determine the dimension, two variable selection methods, and extensions to multivariate response and large p …

Interactions Of Post-Pks Enzymes Of The Mithramycin Biosynthetic Pathway, Ryan Wheeler

Theses and Dissertations--Pharmacy

Combinatorial biosynthesis is a powerful tool for generating new, more active drug analogues to combat disease. But in order for combinatorial biosynthesis to be employed to its full potential, a deep understanding of the enzymes that produce the parent molecule must be had. The goals of the work presented in this thesis are to characterize the reaction catalyzed by MtmW, the final enzyme in the mithramycin (MTM) biosynthetic pathway, and to discover the interaction between MtmW and MtmOIV.

MtmW is an aldol-ketoreductase responsible for reducing the most distal carbonyl on the MTM pentyl side chain. It forms an octamer that …

Human Regulatory T Cells Control Inflammation From Effector T Cells In Prediabetes, Rui Liu

Theses and Dissertations--Pharmacy

Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease. A T cell cytokine profile (Th17) from PBMCs can distinguish obese T2D from obese non-diabetes subjects. Individual T cell subsets interact with each other and the diverse subsets jointly determine overall inflammation. Cellular metabolism drives cytokine production of CD4⁺ T cells, and therefore contributes to inflammation in T2D. However, specific changes in metabolism and function of CD4⁺ T cells during the progression from lean healthy to obese and diabetic stages in people have not been clarified.

We hypothesize that human regulatory T cells (Treg) impact metabolism of effector …

Abc Transporters In Glioblastoma: Anticancer Drug Transport And Transporter Regulation At The Blood-Brain Barrier, Julia A. Schulz

Theses and Dissertations--Pharmacy

Glioblastoma is one of the deadliest cancers, with a median survival of only one year. Even after aggressive treatment consisting of surgical resection, radiation, and chemotherapy, most glioblastoma patients suffer from tumor recurrence within 6-9 months. One reason for treatment failure of anticancer drugs is the blood-brain barrier that protects the brain by impeding xenobiotic uptake from the blood. To this end, efflux transporters at the human blood-brain barrier, such as P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2), prevent many compounds, including anticancer drugs, from entering the brain. Thus far, approaches to deliver anticancer drugs across the blood-brain barrier …

Investigation Of The Biosynthesis Of The Nucleoside Antibiotic Sphaerimicin, Jonathan Overbay

Theses and Dissertations--Pharmacy

Antibiotic-resistance has become a widespread problem in the United States and across the globe. Meanwhile, new antibiotics are entering the clinic at an alarmingly low rate. Highly-modified nucleosides, a class of natural products often produced by actinobacteria, target MraY bacterial translocase I. MraY is a clinically unexploited enzyme target that is ubiquitous and essential to peptidoglycan cell wall biosynthesis. The nucleoside antibiotics known vary in efficacy and the functionalities contributing to improved activity is poorly understood. Sphaerimicin, a newly discovered modified nucleoside, has potent inhibitory activity with an IC50 of 13.65 nM against MraY. In general, sphaerimicin is primarily effective …

Examining Childhood Outcomes In Neonatal Abstinence Syndrome, Kailyn Conner

Theses and Dissertations--Pharmacy

Rates of neonatal abstinence syndrome have been rising over the past several years, alongside rising rates of opioid use disorder, propelled by the continuing Opioid Epidemic ravaging the country. Children born withdrawing from opioids they were exposed to in utero have known health complications through the first year of life that have been studied in the current literature. Less is known, however, about the outcomes these children face in childhood. As many of these children are progressing to childhood, there is an urgent need for healthcare system to prepare to handle the health needs of these children; outcomes related to …