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Effect Of Histone H4 Tail On Nucleosome Stability And Internucleosomal Interactions, Tommy Stormberg, Sridhar Vemulapalli, Shaun Filliaux, Yuri L. Lyubchenko

Journal Articles: Pharmaceutical Sciences

Chromatin structure is dictated by nucleosome assembly and internucleosomal interactions. The tight wrapping of nucleosomes inhibits gene expression, but modifications to histone tails modulate chromatin structure, allowing for proper genetic function. The histone H4 tail is thought to play a large role in regulating chromatin structure. Here we investigated the structure of nucleosomes assembled with a tail-truncated H4 histone using Atomic Force Microscopy. We assembled tail-truncated H4 nucleosomes on DNA templates allowing for the assembly of mononucleosomes or dinucleosomes. Mononucleosomes assembled on nonspecific DNA led to decreased DNA wrapping efficiency. This effect is less pronounced for nucleosomes assembled on positioning …

Patient-Derived Induced Pluripotent Stem Cell Models For Phenotypic Screening In The Neuronal Ceroid Lipofuscinoses, Ahmed Morsy, Angelica V. Carmona, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Batten disease or neuronal ceroid lipofuscinosis (NCL) is a group of rare, fatal, inherited neurodegenerative lysosomal storage disorders. Numerous genes (CLN1-CLN8, CLN10-CLN14) were identified in which mutations can lead to NCL; however, the underlying pathophysiology remains elusive. Despite this, the NCLs share some of the same features and symptoms but vary in respect to severity and onset of symptoms by age. Some common symptoms include the progressive loss of vision, mental and motor deterioration, epileptic seizures, premature death, and in the rare adult-onset, dementia. Currently, all forms of NCL are fatal, and no curative treatments are available. Induced pluripotent stem …

Differential Diagnosis Of Abnormal Muscle Gross Anatomy Of A Male Cadaver, Audrey V. Broffman, Carley R. Carpenter

Undergraduate Theses, Professional Papers, and Capstone Artifacts

The ability of healthcare providers to carefully consider all presentations of illness and injury, draw upon research and knowledge to develop a list of potential diagnoses, and further investigate systems expected to be impacted by these diagnoses, is crucial for accurate identification of a condition and subsequent treatment plans to improve the welfare of patients. In order to determine a possible cause for unusual anatomic changes in multiple regions of the male cadaver used in the University of Montana’s Anatomy and Physiology lab, we performed a differential diagnosis.This research is exempt from IRB approval because the individual is no longer …

Unshackling Plea Bargaining From Racial Bias, Elayne E. Greenberg

Journal of Criminal Law and Criminology

“History, despite its wrenching pain, cannot be unlived, [but] if faced with courage, need not be lived again.”

Dr. Maya Angelou

When an African American male defendant tries to plea bargain an equitable justice outcome, he finds that the deep-rooted racial bias that casts African American men as dangerous, criminal and animalistic, compromises his justice rights. Plea bargaining has become the preferred process used to secure convictions for upwards of 97 percent of cases because of its efficiency. This efficiency, however, comes at a cost. The structure and process of plea bargaining makes it more likely that the historical racial …

Blue Light And Adult Sleep Outcomes, Andrew Caddas

Undergraduate Distinction Papers

This study investigated the effects blue light from self-luminous devices has on adult sleeping patterns. We investigated sleep quality and duration qualitatively with a randomized, double-blind, cross-over, placebo-controlled design with a wash-out period. Participants wore blue light blocking lenses or placebo lenses whenever they were using a self-luminous device throughout each day for one week. Each morning, participants filled out a survey to report their number of hours slept, time to fall asleep, and amount of time spent on self-luminous devices. Participants took the Pittsburgh Insomnia Rating Scale (PIRS) at the end of the one week trial (See Appendix A). …

Bulletin Of Yale University School Of Nursing 2021-2022, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 117, Number 15

September 5, 2021

The Utility Of A Maximum Entropy Species Distribution Model For Ixodes Scapularis In Predicting The Public Health Risk Of Lyme Disease In Ontario, Canada, Holly Alexandra Burrows

Public Health Theses

Introduction: Lyme disease is an emerging public health threat in Ontario, Canada due to the range expansion of the tick vector, Ixodes scapularis. Tick abundance and density are important predictors of human Lyme disease risk and are typically measured using active tick surveillance (dragging). New cost-effective tools are needed to augment current surveillance activities.Objective: The objective of this study was to evaluate the ability of a Maximum entropy species distribution model to predict I. scapularis density and abundance in three regions of Ontario – Ottawa, Kingston, and southern Ontario – in order to determine its utility in predicting the public …

Too Fast, Too Furious: Slaughterhouse Line Speeds In The Era Of Covid-19, Zoe Novic

Public Health Theses

Since 1998, the United States Department of Agriculture (USDA) has allowed meat companies to increase slaughter line speeds in order to increase production of meat and poultry. The USDA grants approvals known as “line speed waivers” that bypass the requirements of current speed and inspection regulations. During the Covid-19 pandemic, slaughterhouses became epicenters of Covid-19 outbreaks, which called into question safety regulations established at these facilities. The USDA continued to grant line speed waivers despite evidence that faster line speeds result in increased worker injuries, animal welfare violations, environmental protection violations, food safety violations, and higher risk of Covid-19.

In …

A Prescription For America's Prescriptions, Haley Gintis

Emory International Law Review

The issue of prescription drug costs has dominated the U.S. political discussion, both at the federal and local levels, as the amount individuals must pay to receive the medicines they need continues to increase. In this context, the debate over how best to determine a reasonable drug price and which existing drugs should be subject to such prices has spurred multiple legislation proposals. However, the implementation of a reasonable price mandate to control the cost of prescription drugs is not a novel idea. The U.K, India, and Germany have all established reasonable drug price schemes. This Comment examines why past …

A Comparative Analysis Of The Treatment Of Transgender Prisoners: What The United States Can Learn From Canada And The United Kingdom, Stephanie Saran Rudolph

Emory International Law Review

The treatment of transgender people while incarcerated is an issue that was catapulted into the national spotlight in 2019 when the Ninth Circuit Court of Appeals ruled in favor of providing a transgender inmate gender confirmation surgery. This decision created a circuit split within the United States regarding the medically necessary treatment a state is legally required to provide an inmate with gender dysphoria. This Comment examines the legal and policy approaches of the United Kingdom and Canada to inform the current circuit split and provide suggestions for improvements that could be made in the United States. Through exploration and …

Modeling Long-Term Intentions And Narratives In Autonomous Agents, C. Kronsted, Z. Neemeh, S. Kugele, S. Franklin

CCRG Papers

No abstract provided.

Learning In Lida, S. Kugele, S. Franklin

CCRG Papers

No abstract provided.

2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition By Organometallic Vanadium Complexes: A Potential New Paradigm For Studying Cns Degeneration, David C. Platt, Jonathan Rink, Kamaljit Braich, Craig C. Mclauchlan, Marjorie A. Jones

Faculty Publications – Chemistry

The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely. Recently, there has been renewed interest in the study of this enzyme due to studies that suggest that CNPase plays a role in the mediation of cellular inflammatory responses in renal and nervous system tissues. Also, this enzyme, found in oligodendrocytes of the nervous system, has been reported to participate in significant regulatory changes associated with age which may be involved in age-related CNS degeneration. Consequently, development of CNPase inhibitors is of interest and …

Subsumption Reduces Dataset Dimensionality Without Decreasing Performance Of A Machine Learning Classifier, Donald C. Wunsch, Daniel B. Hier

Chemistry Faculty Research & Creative Works

When Features in a High Dimension Dataset Are Organized Hierarchically, There is an Inherent Opportunity to Reduce Dimensionality. Since More Specific Concepts Are Subsumed by More General Concepts, Subsumption Can Be Applied Successively to Reduce Dimensionality. We Tested Whether Sub-Sumption Could Reduce the Dimensionality of a Disease Dataset Without Impairing Classification Accuracy. We Started with a Dataset that Had 168 Neurological Patients, 14 Diagnoses, and 293 Unique Features. We Applied Subsumption Repeatedly to Create Eight Successively Smaller Datasets, Ranging from 293 Dimensions in the Largest Dataset to 11 Dimensions in the Smallest Dataset. We Tested a MLP Classifier on All …

A Deep Learning Model To Predict Traumatic Brain Injury Severity And Outcome From Mr Images, Dacosta Yeboah, Hung Nguyen, Daniel B. Hier, Gayla R. Olbricht, Tayo Obafemi-Ajayi

Chemistry Faculty Research & Creative Works

For Many Neurological Disorders, Including Traumatic Brain Injury (TBI), Neuroimaging Information Plays a Crucial Role Determining Diagnosis and Prognosis. TBI is a Heterogeneous Disorder that Can Result in Lasting Physical, Emotional and Cognitive Impairments. Magnetic Resonance Imaging (MRI) is a Non-Invasive Technique that Uses Radio Waves to Reveal Fine Details of Brain Anatomy and Pathology. Although MRIs Are Interpreted by Radiologists, Advances Are Being Made in the Use of Deep Learning for MRI Interpretation. This Work Evaluates a Deep Learning Model based on a Residual Learning Convolutional Neural Network that Predicts TBI Severity from MR Images. the Model Achieved a …

Icwa’S Irony, Marcia A. Yablon-Zug

Faculty Publications

The Indian Child Welfare Act (ICWA) is a federal statute that protects Indian children by keeping them connected to their families and culture. The Act’s provisions include support for family reunification, kinship care preferences, cultural competency considerations and community involvement. These provisions parallel national child welfare policies. Nevertheless, the Act is relentlessly attacked as a law that singles out Indian children for unique and harmful treatment. This is untrue but, ironically, it will be if challenges to the ICWA are successful. To prevent this from occurring, the defense of the Act needs to change. For too long, this defense has …

The Bounds Of Energy Law, Shelley Welton

Faculty Publications

U.S. energy law was born of fossil fuels. Consequently, our energy law has long centered on the material and legal puzzles that bringing fossil fuels to market presents. Eliminating these same carbon-producing energy sources, however, has emerged as perhaps the most pressing material transformation needed in the twenty-first century—and one that energy law scholarship has rightfully embraced. Yet in our admirable quest to aid in this transformation, energy law scholars are largely writing into the field bequeathed to us, proposing changes that tweak, but do not fundamentally challenge, last century’s tools for managing the extraction, transport, and delivery of fossil …

Analysis Of Geotagging Behavior: Do Geotagged Users Represent The Twitter Population?, Amir Karami, R. R. Kadari, L. Panati, H. Bheemreddy, B. Bozorgi

Faculty Publications

Twitter’s APIs are now the main data source for social media researchers. A large number of studies have utilized Twitter data for diverse research interests. Twitter users can share their precise real-time location, and Twitter APIs can provide this information as longitude and latitude. These geotagged Twitter data can help to study human activities and movements for different applications. Compared to the mostly small-scale data samples in different domains, such as social science, collecting geotagged data offers large samples. There is a fundamental question whether geotagged users can represent non-geotagged users. While some studies have investigated the question from different …

Feedback Control Of Fed-Batch Cultures Using Raman Spectroscopy For Metabolite Estimation, Brian Hadley

Master's Theses and Capstones

The monitoring and control of mammalian cell culture processes are critical for the safe and cost-effective development of biotherapeutics in drug development. Current control using off line sampling is infrequent and can miss important metabolic shifts which can impact product quality and consistency. Raman spectroscopy can provide in-line monitoring of multiple metabolites and critical process parameters to allow automation and process improvements. In this research a generic model was developed for monitoring multiple cell lines with a platform Chinese hamster ovary (CHO) cell process. Parameter estimation was then used for the implementation of feedback control. Two nutrient feeds were added …

An Interview With Michael Barresi, Michael J.F. Barresi, Alex Eve

Biological Sciences: Faculty Publications

Michael Barresi is Professor of Biological Sciences at Smith College, Northampton, MA, USA, where he uses the zebrafish to understand central nervous system development. Michael is also Program Director of the ‘Student Scientists’ outreach project and has made significant contributions to teaching developmental biology, including being co-author and illustrator of the textbook Developmental Biology, producing developmental documentaries and starting the Online Developmental Teaching Forums. He was awarded the 2021 Viktor Hamburger Outstanding Educator Prize from the Society of Developmental Biology (SDB). We caught up with Michael over Teams to hear more about his career and love of learning.

2021 Faculty Summer Seminar - From Facts To Truth To Wisdom With Thomas Aquinas, Center For Catholic Studies, Seton Hall University

Center for Catholic Studies Faculty Seminars and Core Curriculum Seminars

Michael Ambrosio - From Aquinas to Lonergan and Finnis: The Study and Teaching of Natural Law p.7

Xue-Ming Bao - Understanding Fact, Truth, and Wisdom During the COVID-19 Pandemic Through Lonergan and Aquinas p.16

Andrea Bartoli - From Facts to Truth to Wisdom with St. Thomas Aquinas p.19

Beth Bloom - A Monk and His Cat p.22

Margaret Brady-Amoon - Reflections on From Facts to Truth to Wisdom with St. Thomas Aquinas and Counseling Psychology p.25

Josephine Devito - Evidence Based Practice in Nursing p.28

Anthony Haynor - Can Aquinas Speak to Human Scientists Today? p.31

Jamie Marner - From …

The Role Of Vocal Hostility On Mood: Initial Development Of An Alternative Stress Paradigm, Jaquoy Sowell, Jennifer Gray, Christa C. Christ

University of South Carolina Upstate Student Research Journal

Maltreatment, such as physical or emotional abuse, can alter one’s later emotional regularity and responses to stimuli. To be able to study the effect of maltreatment on later stimuli response, appropriate laboratory paradigms need to be available, which is not currently true. The purpose of the study was to investigate the effect of vocal hostility stimuli on mood change as preliminary steps toward the creation of a laboratory paradigm. Participants were recruited from a regional university in southeast United States and asked to react to recorded audio with a hostile tone. Study 1 found that participants’ mood did not differ …

Agricultural Service Disparities Between White And Non-White Farmers Provided By The Federal Extension Service During The Jim Crow Era, José Leonel Ramírez Solís, Ben Montgomery

University of South Carolina Upstate Student Research Journal

The Federal Extension Service (FES) of the United States Department of Agriculture (USDA) was segregated during the Jim Crow era. FES farm agents provided agricultural education and outreach; they answered questions in office, hosted meetings, and made farm visits. Agents also ran 4-H, which educated youth about agriculture through camps, and demonstrated farming activities carried out by participants. This study investigated whether segregation of services led to disparities between white and non-white (mostly African American) farm operators and families among four South Carolina regions. We compared the level of service provided to white and non-white operators and youth based on …

Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …

Comparison Of Greater Occipital Nerve And Greater Occipital Nerve + Supraorbital Nerveblock Effect In Chronic Medication Overuse Headache, Nermi̇n Tepe, Oktay Faysal Tertemi̇z

Turkish Journal of Medical Sciences

Background /aim: In this study, we aimed to compare the efficacy of greater occipital nerve (GON) block alone and GON combined with supraorbital nerve (SON) block in the treatment of medication overuse headache (MOH). Material and methods: 82 patients were divided into two groups: 41 patients were administered bilateral GON block while the other 41 patients GON + SON block. Nerve blocks were administered every 10 days for a total of 5 sessions. After each administration and 20 days after the last injection, information on pre and post treatment numerical rating scale (NRS) score, number of painful days, analgesic intake, …

Clinical And Molecular Findings In 37 Turkish Patients With Isolated Methylmalonic Acidemia, Berna Şeker Yilmaz, Deni̇z Kör, Fatma Derya Bulut, Sebi̇le Kilavuz, Serdar Ceylaner, Hali̇se Nesli̇han Önenli̇ Mungan

Turkish Journal of Medical Sciences

Background/aim: Isolated methylmalonic acidemia (MMA) is caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase (mut0 or mut- enzymatic subtype), a defect of its cofactor adenosyl-cobalamin (cblA, cblB, or cblD-MMA), or deficiency of the enzyme methylmalonyl-CoA epimerase. While onset of the disease ranges from the neonatal period to adulthood, most cases present with lethargy, vomiting and ketoacidosis in the early infancy. Major secondary complications are; growth failure, developmental delay, interstitial nephritis with progressive renal failure, basal ganglia injury and cardiomyopathy. We aimed to demonstrate clinical and molecular findings based on long-term follow up in our patient cohort. Materials …

Pancreas And Kidney Changes In Type 2 Diabetes Patients: The Role Of Diffusion-Weightedimaging, Mehmet Hamdi̇ Şahan, Adnan Özdemi̇r, Neşe Asal, Mi̇race Yasemi̇n Karadeni̇z Bi̇lgi̇li̇, Adi̇l Doğan, Aşkin Güngüneş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic patients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex- and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was …

Effects Of Intraoperative Blood Loss During Liver Resection On Patients? Outcome: A Singlecenter Experience, Muhammed Seli̇m Bodur, Kadi̇r Tomas, Serdar Topaloğlu, Şükrü Oğuz, Hakan Küçükaslan, Davut Dohman, Erdem Karabulut, Adnan Çalik

Turkish Journal of Medical Sciences

Background/aim: Operative bleeding is one of the major determinants of outcome in liver surgery. This study aimed to describe the impact of intraoperative blood loss on the postoperative course of liver resection (LR). Materials and methods: The data of 257 patients who were treated with LR between January 2007 and October 2018 were retrospectively analyzed. LRs were performed via intermittent portal triad clamping (PTC) under low central venous pressure. Results: LRs were performed for 67.7% of patients with a malignant disease and 32.3% of patients with a benign disease. Major LR was performed in 89 patients (34.6%). The mean PTC …

The Effects Of Water Immersion And Epidural Analgesia On Cellular Immune Response,Neuroendocrine, And Oxidative Markers, Özlem Uzunlar, Ümi̇t Yasemi̇n Sert Di̇nç, Nezaket Kadioğlu, Tuba Çandar, Yaprak Üstün

Turkish Journal of Medical Sciences

Background/aim: Water immersion and epidural analgesia are the most preferred pain relief methods during the labor process. Adverse effects related to these methods, impact on the labor, and perception of pain is well studied in the literature. We aimed to investigate the cord blood level of copeptin, total serum oxidant (TOS), antioxidant (TAS), interleukin (IL)-1, IL-6, and oxytocin after the labor with water immersion, epidural analgesia, and vaginal birth without pain relief. Materials and methods: The study was conducted with 102 healthy pregnant women admitted to the obstetric delivery unit for noncomplicated term birth. Copeptin, oxytocin, TAS, TOS, IL-1, and …

Genistein Suppresses The Inflammation And Gsk-3 Pathway In An Animal Model Ofspontaneous Ovarian Cancer, Füsun Erten, Engi̇n Yeni̇ce, Cemal Orhan, Beşi̇r Er, Pinar Demi̇rel Öner, Patrick Brice Defo Deeh, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg …