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2021

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The Energy Transition And Mining: Reconciling The Growth Of Renewable Energy With The Need For New Mineral Development, Alexandra B. Klass, Allison J. Mitchell Jan 2021

The Energy Transition And Mining: Reconciling The Growth Of Renewable Energy With The Need For New Mineral Development, Alexandra B. Klass, Allison J. Mitchell

Articles

Under the Paris Agreement, the global governmental signatories embraced the goal to hold global average temperature increase to “well below 2°C above pre-industrial levels” while “pursuing efforts to limit the temperature increase to 1.5°C above pre-industrial levels.” Almost every country in the world signed on to the Paris Agreement, adopting the prevailing science that anthropocentric greenhouse gas emissions would result in rising global temperatures and catastrophic damages from climate change in the absence of immediate action. In pursuit of this goal, the signatories agreed that all member countries would work together to bring greenhouse gas emissions to zero within the …


Rhetorical Body Work: Professional Embodiment In Health Provider Education And The Technical Writing Classroom, Lillian Campbell Jan 2021

Rhetorical Body Work: Professional Embodiment In Health Provider Education And The Technical Writing Classroom, Lillian Campbell

English Faculty Research and Publications

This article introduces “rhetorical body work” as a framework for understanding professional embodiment in health provider education and technical and professional communication (TPC) pedagogy. Using the case study of clinical nursing simulations and drawing on sociological theory, I provide a detailed analysis of three components of rhetorical body work as they manifest in three simulation scenarios: physical, emotional, and discursive. I conclude by considering the implications of these findings for the embodied teaching of TPC.


Diasporic Dreams: Law, Whiteness, And The Asian American Identity, Nicholas Loh Jan 2021

Diasporic Dreams: Law, Whiteness, And The Asian American Identity, Nicholas Loh

Fordham Urban Law Journal

No abstract provided.


Essential Or Disposable?: Healthcare Workers' Right To Refuse Hazardous Work, Christa Coryea Jan 2021

Essential Or Disposable?: Healthcare Workers' Right To Refuse Hazardous Work, Christa Coryea

Fordham Urban Law Journal

No abstract provided.


Advancing Applied Research In Conservation Criminology Through The Evaluation Of Corruption Prevention, Enhancing Compliance, And Reducing Recidivism, Jessica S. Kahler, Joseph W. Rivera, Zachary T. Steele, Pilar Morales-Giner, Christian J. Rivera, Carol F. Ahossin, Ashpreet Kaur, Diane J. Episcopio-Sturgeon Jan 2021

Advancing Applied Research In Conservation Criminology Through The Evaluation Of Corruption Prevention, Enhancing Compliance, And Reducing Recidivism, Jessica S. Kahler, Joseph W. Rivera, Zachary T. Steele, Pilar Morales-Giner, Christian J. Rivera, Carol F. Ahossin, Ashpreet Kaur, Diane J. Episcopio-Sturgeon

Biological Sciences Faculty Publications

Concomitant with an increase in the global illegal wildlife trade has been a substantial increase in research within traditional conservation-based sciences and conservation and green criminology. While the integration of criminological theories and methods into the wildlife conservation context has advanced our understanding of and practical responses to illegal wildlife trade, there remain discrepancies between the number of empirical vs. conceptual studies and a disproportionate focus on a few select theories, geographical contexts, and taxonomic groups. We present three understudied or novel applications of criminology and criminal justice research within the fields of fisheries, forestry, and wildlife conservation. First, we …


Microsphere Photolithography Patterned Nanohole Array On An Optical Fiber, Ibrahem Jasim, Jiayu Liu, Chen Zhu, Muhammad Roman, Jie Huang, Edward Kinzel, Mahmoud Almasri Jan 2021

Microsphere Photolithography Patterned Nanohole Array On An Optical Fiber, Ibrahem Jasim, Jiayu Liu, Chen Zhu, Muhammad Roman, Jie Huang, Edward Kinzel, Mahmoud Almasri

Electrical and Computer Engineering Faculty Research & Creative Works

Microsphere Photolithography (MPL) is a nanopatterning technique that utilizes a self-assembled monolayer of microspheres as an optical element to focus incident radiation inside a layer of photoresist. The microspheres produces a sub-diffraction limited photonic-jet on the opposite side of each microsphere from the illumination. When combined with pattern transfer techniques such as etching/lift-off, MPL provides a versatile, low-cost fabrication method for producing hexagonal close-packed metasurfaces. This article investigates the MPL process for creating refractive index (RI) sensors on the cleaved tips of optical fiber. The resonant wavelength of metal elements on the surface is dependent on the local dielectric environment …


Data-Driven Identification Of Governing Partial Differential Equations For The Transmission Line Systems, Yanming Zhang, Lijun Jiang Jan 2021

Data-Driven Identification Of Governing Partial Differential Equations For The Transmission Line Systems, Yanming Zhang, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

Discovering governing equations for transmission line is essential for the study on its properties, especially when the nonlinearity is introduced in a transmission line system. In this paper, we propose a novel data-driven approach for deriving the governing partial differential equations based on the spatial-temporal samples of current and voltage in the transmission line system. The proposed method is based on the ridge regression algorithm to determine the active spatial differential terms from the candidate library that includes nonlinear functions, in which the time and spatial derivatives are estimated by using polynomial interpolation. Three examples, including uniform and nonuniform transmission …


Development And Characterization Of Nb₃N/Al₂0₃ Superconducting Multilayers For Particle Accelerators, Chris Sundahl, Junki Makita, Paul B. Welander, Yi-Feng Su, Fumitake Kametani, Lin Xie, Huimin Zhang, Lian Li, Alex Gurevich, Chang-Beom Eom Jan 2021

Development And Characterization Of Nb₃N/Al₂0₃ Superconducting Multilayers For Particle Accelerators, Chris Sundahl, Junki Makita, Paul B. Welander, Yi-Feng Su, Fumitake Kametani, Lin Xie, Huimin Zhang, Lian Li, Alex Gurevich, Chang-Beom Eom

Physics Faculty Publications

Superconducting radio-frequency (SRF) resonator cavities provide extremely high quality factors > 1010 at 1-2 GHz and 2 K in large linear accelerators of high-energy particles. The maximum accelerating field of SRF cavities is limited by penetration of vortices into the superconductor. Present state-of-the-art Nb cavities can withstand up to 50 MV/m accelerating gradients and magnetic fields of 200-240 mT which destroy the low-dissipative Meissner state. Achieving higher accelerating gradients requires superconductors with higher thermodynamic critical fields, of which Nb3Sn has emerged as a leading material for the next generation accelerators. To overcome the problem of low vortex penetration …


Electroosmotic Flow Of Viscoelastic Fluid Through A Constriction Microchannel, Jianyu Ji, Shizhi Qian, Zhaohui Liu Jan 2021

Electroosmotic Flow Of Viscoelastic Fluid Through A Constriction Microchannel, Jianyu Ji, Shizhi Qian, Zhaohui Liu

Mechanical & Aerospace Engineering Faculty Publications

Electroosmotic flow (EOF) has been widely used in various biochemical microfluidic applications, many of which use viscoelastic non-Newtonian fluid. This study numerically investigates the EOF of viscoelastic fluid through a 10:1 constriction microfluidic channel connecting two reservoirs on either side. The flow is modelled by the Oldroyd-B (OB) model coupled with the Poisson–Boltzmann model. EOF of polyacrylamide (PAA) solution is studied as a function of the PAA concentration and the applied electric field. In contrast to steady EOF of Newtonian fluid, the EOF of PAA solution becomes unstable when the applied electric field (PAA concentration) exceeds a critical value for …


Mechanism For The Unfolding Of The Top7 Protein In Steered Molecular Dynamics Simulations As Revealed By Mutual Information Analysis, Ognjen Perišić, Willy Wriggers Jan 2021

Mechanism For The Unfolding Of The Top7 Protein In Steered Molecular Dynamics Simulations As Revealed By Mutual Information Analysis, Ognjen Perišić, Willy Wriggers

Mechanical & Aerospace Engineering Faculty Publications

We employed mutual information (MI) analysis to detect motions affecting the mechanical resistance of the human-engineered protein Top7. The results are based on the MI analysis of pair contact correlations measured in steered molecular dynamics (SMD) trajectories and their statistical dependence on global unfolding. This study is the first application of the MI analysis to SMD forced unfolding, and we furnish specific SMD recommendations for the utility of parameters and options in the TimeScapes package. The MI analysis provided a global overview of the effect of perturbation on the stability of the protein. We also employed a more conventional trajectory …


A Phewas Model Of Autism Spectrum Disorder, John Matta, Daniel Dobrino, Swade Howard, Dacosta Yeboah, Jonathan Kopel, Yasser El-Manzalawy, Tayo Obafemi-Ajayi Jan 2021

A Phewas Model Of Autism Spectrum Disorder, John Matta, Daniel Dobrino, Swade Howard, Dacosta Yeboah, Jonathan Kopel, Yasser El-Manzalawy, Tayo Obafemi-Ajayi

Electrical and Computer Engineering Faculty Research & Creative Works

Children with Autism Spectrum Disorder (ASD) exhibit a wide diversity in type, number, and severity of social deficits as well as communicative and cognitive difficulties. It is a challenge to categorize the phenotypes of a particular ASD patient with their unique genetic variants. There is a need for a better understanding of the connections between genotype information and the phenotypes to sort out the heterogeneity of ASD. In this study, single nucleotide polymorphism (SNP) and phenotype data obtained from a simplex ASD sample are combined using a PheWAS-inspired approach to construct a phenotype-phenotype network. The network is clustered, yielding groups …


0864: Douglass High School Reunion Committee Records, 1924-1996, Marshall University Special Collections Jan 2021

0864: Douglass High School Reunion Committee Records, 1924-1996, Marshall University Special Collections

Guides to Manuscript Collections

The collection is divided into three series:

Series 1: Reunion Planning and Alumni Materials – This series includes materials related to the planning and execution of Douglass High School reunions as planned by Douglass High School Foundation Incorporated and materials distributed to alumni outside of reunions. Materials include subcommittee and officer reports, alumni newsletters, and financial and organizational documents. Most materials date between 1988 and 1996.

Series 2: Clippings and Ephemera – This series includes assorted clippings and ephemera related to Douglass High School history, alumni, and Black Huntingtonians more broadly. Most materials are mounted on cardstock, seemingly for presentation …


College Of Natural Sciences 2021 Year-End Publication, College Of Natural Sciences Jan 2021

College Of Natural Sciences 2021 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Welcome, Table of Contents
Page 3 Our Departments: Highlights From 2021
Page 4 Overview of the College
Page 5 Overview of Bold & Blue
Pages 6, 7 Announcing the First Endowed Professorship in the College of Natural Sciences
Page 8 Spooky Science, Astronomy Outreach, SDSU Chemistry Research Features on Journal Cover
Page 9 Students Win Business Plan Competition With Aims to Improve Shelf Life of Produce, Summer Researchers
Page 10 NIH Grant Helps Unravel Rare Inflammatory Genetic Disorders, International Excellence in South Dakota
Page 11 The Next Frontier of Science Education: Virtual Reality, SDSU Researchers Uncover how Cancer …


Polycystic Kidney Disease: An Examination And Review Of Disease Type, Presentation, Treatment, And Prognosis, Zoey Mann Jan 2021

Polycystic Kidney Disease: An Examination And Review Of Disease Type, Presentation, Treatment, And Prognosis, Zoey Mann

Biology and Microbiology Graduate Students Plan B Research Projects

Polycystic Kidney Disease (PKD) is a ciliopathy that primarily presents as renal cysts. Inherited as either a dominant (ADPKD) or recessive (ARPKD) mutation, PKD is one of the most commonly inherited kidney diseases. ADPKD is caused by the inheritance of a mutation in either PKD1 or PKD2, which code for the polycystin-1 and -2 proteins, respectively. The less severe form of PKD, ADPKD is typically adult-onset, with the possibility of extremely late-stage presentation. In addition to renal cysts, hepatic and pancreatic cysts are common, as well as other non-cystic symptoms including headache and hypertension. ARPKD is caused by the inheritance …


Guillain-Barre Syndrome: A Review Of Current Diagnostic Tools, Treatments, And Research, Kaitlyn Hespen Jan 2021

Guillain-Barre Syndrome: A Review Of Current Diagnostic Tools, Treatments, And Research, Kaitlyn Hespen

Biology and Microbiology Graduate Students Plan B Research Projects

Guillain-Barre Syndrome is a rare post-infection inflammatory disorder. It is caused by the cross-reactivity of antibodies produced from a recent infection which then attack the gangliosides of the peripheral nervous system. Guillain-Barre syndrome includes multiple subtypes which are categorized based on both disease course and symptoms, which include length of progression phase, pain, and cranial nerve involvement. This paper will serve as a review of diagnostic tools and treatment options used for Guillain-Barre syndrome patients. It will also discuss recent research on these topics as well as studies on viral outbreaks which may be linked to Guillain-Barre syndrome. These will …


Current And Future Perspectives In The Treatment Of Fracture Nonunions, Zebadiah Nelson Jan 2021

Current And Future Perspectives In The Treatment Of Fracture Nonunions, Zebadiah Nelson

Biology and Microbiology Graduate Students Plan B Research Projects

Fracture nonunions comprise one of the serious clinical complications in orthopedics. Fracture nonunions result when the time to union is greater than 6 to 9 months. It is estimated that approximately 5% to 10% of all fractures progress to fracture nonunion due to a host of complicating patient variables and risk factors. New scoring systems have emerged which help in directing the treatment strategies. Fracture nonunion management should be directed toward maintaining the diamond concept which introduces osteogenic cells lines, an osteoconductive scaffold for those cells to grow, as well as the necessary growth factors, and a stable mechanical microenvironment. …


Association Between Colorectal Cancer Prevalence And Patients Age, Race And Sex, Arsiema Fisuh Jan 2021

Association Between Colorectal Cancer Prevalence And Patients Age, Race And Sex, Arsiema Fisuh

Biology and Microbiology Graduate Students Plan B Research Projects

Colorectal cancer is one of the top leading causes of cancer deaths affecting people of different ages, sex and races disproportionately. The American Cancer society researchers have studied that lack of physical activities, smoking, consumption of red meat, and heavy alcohol use to be high risk factors for developing colorectal cancer in addition to genetic inheritances. Previous research studies have shown that disparities in cancer screening, socioeconomic status and others impacts on colorectal cancer prevalence and death. The objective of this project is to review the existing literature to better understand the disparities in colorectal cancer prevalence and deaths in …


The Importance Of Care Coordination Of Patients With Multimorbidity: An Evaluation Of The Patient-Centered Medical Home Model, Mary Boksa Jan 2021

The Importance Of Care Coordination Of Patients With Multimorbidity: An Evaluation Of The Patient-Centered Medical Home Model, Mary Boksa

Biology and Microbiology Graduate Students Plan B Research Projects

The rise in multimorbidity among various patient populations has made fragmentation of care an increasingly common issue due to the need for specialized care of each chronic condition and complexity of treatment plans. Implementation of care coordination intervention models has been identified as an essential component in combating this fragmented nature of our current health care system. This is done by providing an organized model of care and improving communication between all parties involved in care and treatment plans. This literature review will begin with a brief discussion on the importance of care coordination and components needed for implementation and …


The Relationship Between Land Use Change And Disease Prevalence, Allison Bjornstad Jan 2021

The Relationship Between Land Use Change And Disease Prevalence, Allison Bjornstad

Biology and Microbiology Graduate Students Plan B Research Projects

Zoonotic disease outbreaks are becoming more novel and are increasing in frequency. This increase can be partially attributed to land use changes including deforestation, urbanization, and cultivation. Land use change alters disease prevalence by causing an increase in contact rates between disease hosts and humans. Land use changes also alter species compositions in the area to contain more competent disease hosts. Each pathogen can react to these changes in different ways. The specific reactions that each pathogen has to land use changes should be further researched so proper mitigation steps can be taken. Once the effects of land use change …


Evolution Of Three Streambanks Before And After Stabilization And Record Flooding, Matthew Russell, Aaron R. Mittelstet, Tiffany Messer, Jesse T. Korus, R.M. Joeckel Jan 2021

Evolution Of Three Streambanks Before And After Stabilization And Record Flooding, Matthew Russell, Aaron R. Mittelstet, Tiffany Messer, Jesse T. Korus, R.M. Joeckel

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Stabilization projects are increasingly used to mitigate the effects of anthropogenic streambank erosion, yet the effectiveness of stabilization has been insufficiently measured. Sound monitoring practices inform adjustments in implementation and maintenance, which improve engineered effectiveness. Thus, the objectives of this study were to: 1) measure streambank migration from in three reaches stabilized with wooden jetties following a major flooding event, and 2) quantify deposition around the jetties between pre-flood and post-flood. Streambank deposition was measured in 2019 with a River Surveyor and Global Positioning System (GPS). Bank erosion rates in Reaches 1, 2 and 3 were 0.41, 0.96 and 0.07 …


Journal Of Sociology And Social Welfare Vol. 48, No. 3 Jan 2021

Journal Of Sociology And Social Welfare Vol. 48, No. 3

The Journal of Sociology & Social Welfare

No abstract provided.


Phage Antibiotic Antagonism Of Escherichia Coli B And T4 Phage, Mikaela Griechen, Miranda Griechen, Tyler Mueller Jan 2021

Phage Antibiotic Antagonism Of Escherichia Coli B And T4 Phage, Mikaela Griechen, Miranda Griechen, Tyler Mueller

Student Academic Conference

Antibiotic resistance has resulted in researchers finding new methods for treating diseases caused by pathogenic bacteria. Antibiotic resistance forms due to the presence of plasmids and mutations in the bacterial genome. Phage Antibiotic synergy has been reported when exposing bacteria to phages in previous studies. Bacterial immune mechanisms, specifically those that aid against bacteriophages, have been exploited by researchers as a potential treatment for infection and diseases. These mechanism includes Superinfection (Sie), Abortive infection, surface modification, etc. Escherichia coli B is a bacteria that contains an outer membrane with receptors, porins, lipopolysaccharides, and other surface molecules that aid in defense …


Undergraduate Bulletin, 2021-2022, Minnesota State University Moorhead Jan 2021

Undergraduate Bulletin, 2021-2022, Minnesota State University Moorhead

Undergraduate Bulletins (Catalogs)

No abstract provided.


Graduation Bulletin, 2021-2022, Minnesota State University Moorhead Jan 2021

Graduation Bulletin, 2021-2022, Minnesota State University Moorhead

Graduate Bulletins (Catalogs)

No abstract provided.


Density Data For Lake Ontario Benthic Invertebrate Assemblages From 1964 To 2018, Lyubov E. Burlakova, Alexander Karatayev, Allison R. Hrycik, Susan Daniel, Knut Mehler, Lars G. Rudstam, James M. Watkins, Ronald Dermott, Jill Sharold, Ashley K. Elgin, Thomas F. Nalepa, Elizabeth K. Hinchey, Stephen J. Lozano Jan 2021

Density Data For Lake Ontario Benthic Invertebrate Assemblages From 1964 To 2018, Lyubov E. Burlakova, Alexander Karatayev, Allison R. Hrycik, Susan Daniel, Knut Mehler, Lars G. Rudstam, James M. Watkins, Ronald Dermott, Jill Sharold, Ashley K. Elgin, Thomas F. Nalepa, Elizabeth K. Hinchey, Stephen J. Lozano

Great Lakes Center Faculty Publications

Benthic invertebrates are important trophic links in aquatic food webs and serve as useful bioindicators of environmental conditions because their responses integrate the effects of both water and sediment qualities. However, long-term data sets for benthic invertebrate assemblages across broad geographic areas are rare and, even if collected, historic data sets are often not readily accessible. This data set provides densities of benthic macroinvertebrates for all taxa collected during lake-wide surveys in Lake Ontario, a Laurentian Great Lake, from 1964 to 2018. This information resulted from surveys funded by the governments of the United States and Canada to investigate the …


A Repeated Triple Lysine Motif Anchors Complexes Containing Bone Sialoprotein And The Type Xi Collagen A1 Chain Involved In Bone Mineralization, Jeff P. Gorski, Nichole T. Franz, Daniel Pernoud, Andrew Keightley, David R. Eyre, Julia Thom Oxford Jan 2021

A Repeated Triple Lysine Motif Anchors Complexes Containing Bone Sialoprotein And The Type Xi Collagen A1 Chain Involved In Bone Mineralization, Jeff P. Gorski, Nichole T. Franz, Daniel Pernoud, Andrew Keightley, David R. Eyre, Julia Thom Oxford

Biology Faculty Publications and Presentations

While details remain unclear, initiation of woven bone mineralization is believed to be mediated by collagen and potentially nucleated by bone sialoprotein (BSP). Interestingly, our recent publication showed that BSP and type XI collagen form complexes in mineralizing osteoblastic cultures. To learn more, we examined the protein composition of extracellular sites of de novo hydroxyapatite deposition which were enriched in BSP and Col11a1 containing an alternatively spliced “6b” exonal sequence. An alternate splice variant “6a” sequence was not similarly co-localized. BSP and Col11a1 co-purify upon ion-exchange chromatography or immunoprecipitation. Binding of the Col11a1 “6b” exonal sequence to bone sialoprotein was …


Monitoring Tropical Forest Succession At Landscape Scales Despite Uncertainty In Landsat Time Series, T. Trevor Caughlin, Cristina Barber, Gregory P. Asner, Nancy F. Glenn, Stephanie A. Bohlaman, Chris H. Wilson Jan 2021

Monitoring Tropical Forest Succession At Landscape Scales Despite Uncertainty In Landsat Time Series, T. Trevor Caughlin, Cristina Barber, Gregory P. Asner, Nancy F. Glenn, Stephanie A. Bohlaman, Chris H. Wilson

Biology Faculty Publications and Presentations

Forecasting rates of forest succession at landscape scales will aid global efforts to restore tree cover to millions of hectares of degraded land. While optical satellite remote sensing can detect regional land cover change, quantifying forest structural change is challenging. We developed a state-space modeling framework that applies Landsat satellite data to estimate variability in rates of natural regeneration between sites in a tropical landscape. Our models work by disentangling measurement error in Landsat-derived spectral reflectance from process error related to successional variability.We applied our modeling framework to rank rates of forest succession between 10 naturally regenerating sites in Southwestern …


Preservice Elementary Teachers’ Identity Development In Learning To Teach Science: A Multi-Site Case Study, Deepika Menon, Saiqa Azam Jan 2021

Preservice Elementary Teachers’ Identity Development In Learning To Teach Science: A Multi-Site Case Study, Deepika Menon, Saiqa Azam

Department of Teaching, Learning, and Teacher Education: Faculty Publications

The purpose of this qualitative study was to investigate preservice elementary teachers’ science teacher identity development during their participation in the field-based science methods course and a year after. Grounded within the Feiman-Nemser’s thematic framework of learning to teach, this study utilized a case study approach aimed to examine the experiences that contributed to formation of science teacher identities of two participants uniquely positioned in the teacher education programs at the two sites, USA and Canada. Data collected over a year included science autobiographies, reflective journals, interviews, classroom observations, and artifacts. The analysis of the data revealed that experiences and …


Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke Jan 2021

Investigation Into The Source Of Contamination Of Surface Waters Flowing Through The Wright State University Woods, Nnadozie Kennedy Okeke

Browse all Theses and Dissertations

This investigative research was carried out with the purpose of determining the source of contaminants present in the surface waters flowing through the Wright State University woods. Five sample sites going from upstream to downstream namely; Inflow to Nutter Center Pond (INNCP), Nutter Center Pond (NCP), Outfall 21 (OTF 21), Burley, and Outfall 15 (OTF 15), were sampled over a time period spanning from June 2020 to January 2021. Samples collected were analyzed for Escherichia coli (E. coli) using 3M™ Petrifilm™ E. coli/Coliform Count (EC) plates, select anions (Phosphate PO43-, Nitrate NO3-, Sulfate SO42-, Fluoride F- and Chloride Cl-) using …


Als-Induced Excitability Changes In Individual Motorneurons And The Spinal Motorneuron Network In Sod1-G93a Mice At Symptom Onset, Christiana S.I. Draper Jan 2021

Als-Induced Excitability Changes In Individual Motorneurons And The Spinal Motorneuron Network In Sod1-G93a Mice At Symptom Onset, Christiana S.I. Draper

Browse all Theses and Dissertations

Amyotrophic lateral sclerosis (ALS) is the most common motorneuron (MN) disease in adulthood. ALS is hallmarked by the progressive loss of MNs in the brain, brainstem, and spinal cord. Many hypotheses to explain the pathogenesis of ALS have been explored, but the exact mechanisms underlying the development of this disease remain unknown. However, abnormalities in MN excitability and glutamate excitotoxicity are the most widely studied. For decades, researchers have examined MN excitability in ALS, but the current literature is inconsistent, showing evidence of hyperexcitability, hypoexcitability, or no change in excitability of MNs in ALS. Many of these studies also focus …