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2021

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Comparative Study Of Agrogeophysical Methods For Identifying Soil Pipes, Md Abdus Abdus Samad Jan 2021

Comparative Study Of Agrogeophysical Methods For Identifying Soil Pipes, Md Abdus Abdus Samad

Electronic Theses and Dissertations

Soil erosion is considered the greatest challenge for soil management and agri-food production threatening human habitat and livelihood. Although soil erosion due to surficial processes has been well studied, the role of the subsurface process such as internal soil pipes has often been overlooked. Internal soil pipes directly contribute to total soil loss in agricultural fields that severely threaten agricultural sustainability. Locating, measuring, and mapping internal soil pipes and their networks are vital to assess the total soil loss in agricultural fields. Internal soil pipes are not commonly visible at the surface, and their subsurface networks rarely follow the surface …

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Modeling Rna:Dna Hybrids With Formal Grammars, Natas̆A Jonoska, Nida Obatake, Svetlana Poznanović, Candice Price, Manda Riehl, Mariel Vazquez Jan 2021

Modeling Rna:Dna Hybrids With Formal Grammars, Natas̆A Jonoska, Nida Obatake, Svetlana Poznanović, Candice Price, Manda Riehl, Mariel Vazquez

Mathematics Sciences: Faculty Publications

R-loops are nucleic acid structures consisting of a DNA:RNA hybrid and a DNA single strand. They form naturally during transcription when the nascent RNA hybridizes to the template DNA, forcing the coding DNA strand to wrap around the RNA:DNA duplex. Although formation of R-loops can have deleterious effects on genome integrity, there is evidence of their role as potential regulators of gene expression and DNA repair. Here we initiate an abstract model based on formal grammars to describe RNA:DNA interactions and the formation of R-loops. Separately we use a sliding window approach that accounts for properties of the DNA nucleotide …

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Race-Ing Roe: Reproductive Justice, Racial Justice, And The Battle For Roe V. Wade, Melissa Murray Jan 2021

Race-Ing Roe: Reproductive Justice, Racial Justice, And The Battle For Roe V. Wade, Melissa Murray

Faculty Articles

Amidst a raft of major Supreme Court decisions, a relatively quiet concurrence has planted the seeds for what may precipitate a major transformation in American constitutional law. Writing for himself in Box v. Planned Parenthood, Justice Thomas chided the Court for declining to review a decision invalidating an Indiana law that prohibited abortions undertaken “solely because of the child’s race, sex, diagnosis of Down syndrome, disability, or related characteristics.” Arguing that the challenged law was merely Indiana’s modest attempt to prevent “abortion from becoming a tool of modern-day eugenics,” Justice Thomas proceeded to elaborate a misleading history in which he …

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Delegation Of Powers: A Historical And Functional Analysis, Richard A. Epstein Jan 2021

Delegation Of Powers: A Historical And Functional Analysis, Richard A. Epstein

Faculty Articles

It is important here not to get ahead of oneself, for what is often missing in these elaborate historical debates is a sure sense of why anyone—legislators, judges, lawyers, laypersons, and even scholars—should care about the doctrine in the first place. This Article aims to fill the gap with a functional analysis of the nondelegation doctrine that helps explain where it should have teeth and where it should not. Accordingly, Part I offers a brief account of the evolution of the nondelegation doctrine from a historical—mostly originalist in nature—and doctrinal perspective. Part II develops a simple analytical model to explain …

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Describing The Gut Microbiome Of Amblema Plicata, Lauren Lawson Jan 2021

Describing The Gut Microbiome Of Amblema Plicata, Lauren Lawson

Electronic Theses and Dissertations

Freshwater mussels are important for nutrient cycling and ecosystem health, as they filter feed on their surrounding water column. This form of feeding makes these bivalves especially sensitive to conditions in their environment. Gut microbial communities (microbiomes) have been recognized as important to both host organism and ecosystem health; however, how microbiomes are organized and influenced is still unclear. In this study, the gut microbiomes of 58 individuals of the freshwater mussel Amblema plicata were compared across two river basins, five rivers, and nine sites in the southeastern USA. Planctomycetes, Firmicutes, and Cyanobacteria were the most common phyla within all …

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The Efficacy Of Neurofeedback In The Treatment Of Individuals With Anxiety-Spectrum Disorders: A Meta-Analysis, Gordon Michael Russo Jan 2021

The Efficacy Of Neurofeedback In The Treatment Of Individuals With Anxiety-Spectrum Disorders: A Meta-Analysis, Gordon Michael Russo

Electronic Theses and Dissertations

A number of authors have published articles that assert the efficacy of neurofeedback (NFB) in the treatment of people with anxious symptomatology. Despite this, many insurance companies identify NFB as experimental, which prohibits individuals from utilizing benefits to obtain this therapeutic treatment. In order to examine these discrepancies, the present meta-analyses were conducted and guided by research questions designed to examine the overall effectiveness of NFB, the impact of participant characteristics, and identify the if there is a significant difference in anxiety-spectrum outcomes. Twenty-six trials were divided based on design (14 single group [SG]; 12 between group [BG]) and analyzed …

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Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott Jan 2021

Group Sandtray Therapy With Adult Survivors Of Childhood Sexual Assault: A Single-Case Research Design, Jana Elaine Scott

Electronic Theses and Dissertations

Childhood sexual assault (CSA) is a growing problem in our society. A child who experiences a sexual assault not only deals with the immediate trauma surrounding this event, but also the aftermath of this event as they progress into adulthood. Trauma and sexual trauma is an umbrella term that incorporates all of the various implications of experiencing a negative event. In the instance of trauma, neurobiological implications have been well researched and established. This knowledge highlights the need for counseling techniques to be developed and studied that target those who have experienced CSA. The aim of this single-case research design …

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Enzyme-Initiated Admicellar Polymerization, Elaheh Shakeri Jan 2021

Enzyme-Initiated Admicellar Polymerization, Elaheh Shakeri

Electronic Theses and Dissertations

Admicellar polymerization was developed in the 1980s as an economical method for modifying various surfaces. In admicellar polymerization, a low monomer to initiator (M/I) ratio was traditionally required to overcome this limitation and achieve high polymer conversion when oxygen was present in the headspace and dissolved in the reaction medium. To develop an environmentally friendly, cost-efficient, and feasible deoxygenation and initiation technique, we studied the use of glucose oxidase (GOx) in admicellar polymerization. In this method, GOx acts as the catalyst in the oxidation of ?-D-glucose, while consuming oxygen and generating hydrogen peroxide and D-glucono-?-lactone. There are many advantages of …

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Reducing Disparites In Act Results According To Racial Identity: An Applied Research Study Into The Weact Program In Tinlake High School, Marcus Stewart Jan 2021

Reducing Disparites In Act Results According To Racial Identity: An Applied Research Study Into The Weact Program In Tinlake High School, Marcus Stewart

Electronic Theses and Dissertations

ABSTRACT The ACT provides opportunities for students of various socioeconomic backgrounds, racial identities, and family structures. Throughout the nation, there is a disparity that involves Black students scoring less than White students on the test by a margin of five points. The applied mixed methods research aimed to identify elements to help decrease the gap in student scores. The combined efforts of all the elements, tutorials, boot camps, ACT prep classes, and providing ACT resources in daily instruction formed the WeACT program. The students of Tinlake High School were exposed to this pilot program to assist in their ACT growth. …

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Just Southern Food: Food Justice For The Mississippi Delta, Christian Tabor Owen Jan 2021

Just Southern Food: Food Justice For The Mississippi Delta, Christian Tabor Owen

Electronic Theses and Dissertations

The primary objective of this research is to promote food justice for the Mississippi Delta by investigating facts about the intersections of extreme poverty, food insecurity, and chronic illness in the Mississippi Delta. By exploring relevant literature and highlighting current initiatives, this work looks at the semantics of food justice and related terms, discusses challenges unique to the Mississippi Delta, and broadly characterizes public health models with the greatest potential for food justice advancement in this region. Pivotal to interpreting food justice not only for the Mississippi Delta or the Global South, but for any community, is a clear understanding …

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Type 2 Diabetes Mellitus And Oral Health Problems Cross-Sectional Study, Asmaa Ras, Eman Khalil Jan 2021

Type 2 Diabetes Mellitus And Oral Health Problems Cross-Sectional Study, Asmaa Ras, Eman Khalil

Dentistry

ABSTRACT In Egypt, diabetes mellitus is considered to be a foremost health issue with a major influence on the disease and the rate of death. Diabetes mellitus is a communal disorder having affiliated oral disorders that influence dental care. The purpose of this study was to study the prevalence of oral changes in diabetes type 2 in the Egyptian participants to raise awareness between diabetic patients and dental professionals. Methods: This was a cross-sectional study that was done on 200 patients who were diagnosed with diabetes mellitus type 2 at Diabetes and Endocrinology Clinic in Kasr Al Ainy, Cairo University …

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The Effect Of Egf On Vegf Expression On Submandibular Salivary Gland Of Albino Rats Receiving Doxorubicin, Mohamed Shamel, Mohamed Mansy, Rabab Mubarak Jan 2021

The Effect Of Egf On Vegf Expression On Submandibular Salivary Gland Of Albino Rats Receiving Doxorubicin, Mohamed Shamel, Mohamed Mansy, Rabab Mubarak

Dentistry

Background: Vascular endothelial growth factor (VEGF) has two prominent biological effects of inducing mitogenesis and migration of vascular endothelial cells and to produce permeability on the microvasculature. Epidermal growth factor (EGF), known by its mitogenic activity on different types of cells, could induce the proliferation and differentiation of the epithelial cells and stimulate its regeneration. Doxorubicin (DXR) is a widely used anticancer drug and is one of most commonly used chemotherapeutic drugs, however it may cause some serious complications such as toxicity in various tissues in the body. Aims: The present study aims to investigate the effect of EGF on …

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Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara Jan 2021

Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara

Honors Theses

It is widely known that patients suffer diminished long-term outcomes in the years following secondary infections, infectious diseases that occur during or after treatment of a primary infection such as influenza or COVID-19. One common secondary infection is pneumonia, which has become the most fatal hospital-acquired infection. The bacterium responsible for pneumonia is known as Pseudomonas aeruginosa. The cytotoxic supernatant in these studies was generated from a PA103 strain of Psuedomonas aeruginosa with a type III secretion system that maintains the ability to transfer exoenzymes ExoU and ExoT into target cells during infection. The focus of the following studies was …

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Assessment Of Hypothermia As A Correlate Of Pde4 Inhibitor-Induced Nausea In Mice, Marianna Susan Oditt Jan 2021

Assessment Of Hypothermia As A Correlate Of Pde4 Inhibitor-Induced Nausea In Mice, Marianna Susan Oditt

Honors Theses

Type-4-cAMP-phosphodiesterases (PDE4s) are a group of isoenzymes that hydrolyze the second messenger cyclic adenosine monophosphate (cAMP). PDE4 inhibitors have many therapeutic uses including reducing inflammation, however, they also have side effects like nausea and emesis, which have diminished the clinical utility of PDE4 inhibitors. When administered to mice, PDE4 inhibitors have been shown to cause hypothermia. Given that nausea and emesis in humans are also associated hypothermia, this project served to determine whether PDE4 inhibitor-induced hypothermia may represent a correlate of nausea and/or emesis in mice. To this end, the current literature was screened for articles that explore nausea, emesis …

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Functionalization Of Novel Pp5 Inhibitors, Hope P. Hill Jan 2021

Functionalization Of Novel Pp5 Inhibitors, Hope P. Hill

Honors Theses

The overexpression of protein phosphatase 5 has been correlated to tumor cell reproduction making it a candidate for small molecule drug therapy. Selective and potent inhibition of protein phosphatase 2A (PP2A) enzyme has been previously achieved through the development of the molecule fostriecin with key functionality being a lactone and unsaturated linear chain. The large synthetic overhead of fostriecin has led to exploration of other small molecule inhibitors that could mirror fostriecin’s interaction with the active site in the catalytic domain of PP5. The naturally occurring inhibitor, cantharidin, is functionalized with an epoxy containing eleven carbon chain to optimize binding …

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Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger Jan 2021

Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger

Honors Theses

Current asthma therapies include corticosteroids, long acting β2-adrenergic receptor (β2-AR) agonists paired with corticosteroids, or short-acting β2-AR agonists used in rescue inhalers. Chronic use of β-agonists results in diminished effectiveness, and use of long-acting β-agonists can even exacerbate asthma symptoms; this is partly because anti-inflammatory therapy does not directly address the exaggerated airway narrowing due to excessive shortening of airway smooth muscle (ASM), which is the hallmark of asthma. These observations led our collaborators to investigate other potential asthma therapies – bitter taste agonists. 2 Bitter taste agonists, such as chloroquine, activate a subset of Gq-coupled receptors known as bitter …

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Parametric, Nonparametric, And Semiparametric Linear Regression In Classical And Bayesian Statistical Quality Control, Chelsea L. Jones Jan 2021

Parametric, Nonparametric, And Semiparametric Linear Regression In Classical And Bayesian Statistical Quality Control, Chelsea L. Jones

Theses and Dissertations

Statistical process control (SPC) is used in many fields to understand and monitor desired processes, such as manufacturing, public health, and network traffic. SPC is categorized into two phases; in Phase I historical data is used to inform parameter estimates for a statistical model and Phase II implements this statistical model to monitor a live ongoing process. Within both phases, profile monitoring is a method to understand the functional relationship between response and explanatory variables by estimating and tracking its parameters. In profile monitoring, control charts are often used as graphical tools to visually observe process behaviors. We construct a …

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Injectable Gelatin-Silk Fibroin Composite Hydrogels For In Situ Cell Encapsulation, Ryann D. Boudreau Jan 2021

Injectable Gelatin-Silk Fibroin Composite Hydrogels For In Situ Cell Encapsulation, Ryann D. Boudreau

Honors Theses and Capstones

Hydrogels are widely used tools for tissue engineering and regenerative medicine. Characterized as biofunctional, water-based polymer matrices with tunable mechanical properties, hydrogels have promising but limited applications in biomedical engineering, due to poor and static matrix strength. Here we plan to rectify this issue by introducing a new hydrogel made from a composite of gelatin and silk fibroin crosslinked by microbial transglutaminase (mTG) instantly and beta sheet formation gradually, respectively. This interpenetrating network (IPN) shows enhanced mechanical stiffness and strength compared to gelatin hydrogels, and is capable of encapsulating human cells with high viability demonstrated by the encapsulation of human …

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Cross-Model Parameter Estimation In Epidemiology, Julia R. Fitzgibbons Jan 2021

Cross-Model Parameter Estimation In Epidemiology, Julia R. Fitzgibbons

Honors Theses and Capstones

No abstract provided.

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Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood Jan 2021

Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood

Honors Theses and Capstones

SARS-CoV-2, the etiological agent of the COVID-19 pandemic, has rapidly become a worldwide public health concern. Classified as a betacoronavirus, it is the third human coronavirus (HCoV) to emerge in the 21st century that causes severe disease, alongside SARS-CoV and MERS-CoV. The genome consists of open reading frames encoding accessory proteins and four structural proteins, including the spike protein which is a key determinant of host cell tropism. Mutations within the genome, particularly the spike gene, have been linked in-vitro to increased binding affinity to the human receptor angiotensin-converting enzyme 2 (hACE2), increased fitness in human hosts, and immune evasion. …

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Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp Jan 2021

Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp

Honors Theses and Capstones

Gray seals (Halichoerus grypus) are a common pinniped species in New England coastal waters. Parasitic infection is an important cause of mortality for this species, and lungworm species are frequently implicated in cases of respiratory infection, especially in pups and weanling seals. The most common of these is Otostrongylus circumlitus, a large nematode found in the bronchi and bronchioles of affected seals. The full life cycle is unknown but its presence in lungs and sometimes pulmonary arteries suggests that migration via arterial circulation occurs. Signs and microscopic findings are widely variable; our cases included dyspnea, bloody mucoid …

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Mimicking The Effect Of Prolactin On Stat3/Stat5 Activity In Breast Cancer, Jennifer N. Barbuto, Sarah R. Walker Jan 2021

Mimicking The Effect Of Prolactin On Stat3/Stat5 Activity In Breast Cancer, Jennifer N. Barbuto, Sarah R. Walker

Honors Theses and Capstones

Signal transducers and activators of transcription (STAT) 3 and 5 are commonly constitutively activated in breast cancer. STAT5 can outcompete STAT3 and reduce cell proliferation and metastasis. STAT5 activation is stimulated by prolactin, a natural hormone that can be harmful at high levels. The aim of this study is to identify some possible previously developed drugs that mimic the effect of prolactin and STAT5 without the added risk in MDA-MB231 breast cancer cells. Using the CLUE database query app and STAT5 up- and downregulation signatures, three drugs (X, K, and M) were chosen based on their similarity in signatures to …

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Scottish Marine Renewable Energy: U.S. Approaches For Development Of Wave And Tidal Technologies, Stella Kathryn Fairall Jan 2021

Scottish Marine Renewable Energy: U.S. Approaches For Development Of Wave And Tidal Technologies, Stella Kathryn Fairall

Honors Theses and Capstones

Marine renewable energy, energy harnessed from various ocean resources such as waves, tides, currents, thermal gradients, and marine streams, has incredible potential in the United States. Several European countries have realized the potential of the resource in the North Sea and Atlantic and have created incredibly successful industries already. The United Kingdom, particularly Scotland, is the world leader because of the comprehensive policy, labor force, and markets it has established in order to make MRE a competitive energy source. In the United States, the industry is immature, underfunded, and lacks policy support. In order to establish itself as a world …

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The Rural Church As Community Support For Grandparents Raising Their Grandchildren, William Shane Cassida Jan 2021

The Rural Church As Community Support For Grandparents Raising Their Grandchildren, William Shane Cassida

Doctoral Dissertations and Projects

A growing trend in rural communities located in the Southern Appalachian Mountains, as well as across much of the United States, is the significant increase in the number of grandparents that are being forced to accept the responsibility of raising their grandchildren due to a crisis within the family structure. The US Census Bureau cited in 2016 that over 2.5 million grandparents are helping with the responsibility of raising their grandchildren, and that 7.8 million children live in homes owned by their grandparents. This accounts for almost 10% of all children nationally. There is a current ministry need for churches …

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Effects Of A Suggestion Based Intervention On Human Cooperation In The Stag Hunt Game, Melvin S. Marsh Jan 2021

Effects Of A Suggestion Based Intervention On Human Cooperation In The Stag Hunt Game, Melvin S. Marsh

College of Graduate Studies: Theses & Dissertations

Cooperation has been one of the most foundational aspect of human society and is frequently studied via use of “The Stag Hunt” which has been used to tease out factors which may influence cooperation. The present study is the first study to attempt to influence human cooperation by means of positive imagery. Participants included 33 males and 72 females) who listened to either an a 7-minute audio designed to encourage them to trust others or an audio designed to encourage them to trust themselves. Participants played 40 rounds of the Stag Hunt game. The total number of times the participant …

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"Who's The Man?" Examining The Relationships Between Black Masculinity, Perceived Social Support, And Sexual Behavior In Black Male College Students, James Thomas Jan 2021

"Who's The Man?" Examining The Relationships Between Black Masculinity, Perceived Social Support, And Sexual Behavior In Black Male College Students, James Thomas

College of Graduate Studies: Theses & Dissertations

Introduction: Sexual health disparities in college-aged Black men remains a critical public health issue. Black men are likely to have an earlier sexual debut, acquire sexually transmitted infections (STIs) and HIV at higher rates, and enter fatherhood at earlier ages than their White counterparts. Previous research has identified masculinity and perceived social support as predictors of sexual risk behavior for men in the U.S. However, when exploring masculinity’s influence on sexual behavior, studies that are culturally sensitive to Black men’s experiences and perspectives on manhood are few. The purpose of this study was to explore the relationship between Black masculinity, …

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Assessing Habitat Suitability Of Ribbed Mussels (Geukensia Demissa) In Georgia Salt Marshes By Examining Predicted Mussel Densities And Mussel Population Parameters, William K. Annis Jr Jan 2021

Assessing Habitat Suitability Of Ribbed Mussels (Geukensia Demissa) In Georgia Salt Marshes By Examining Predicted Mussel Densities And Mussel Population Parameters, William K. Annis Jr

College of Graduate Studies: Theses & Dissertations

Geukensia demissa (ribbed mussel) is an ecology important bivalve that has the potential to contribute to salt marsh restoration. Understanding the factors that contribute to the distribution of mussels can help inform managers on choosing locations to optimize the survivorship of mussels in restoration projects. This study sought to model mussel densities across the coast of Georgia and to compare predicted mussel densities with mussel population parameters as means to gauge habitat suitability. Mussel densities were collected through field surveys across a range of salt marshes along the coast of Georgia and were compared with spatial data such as distance …

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Measuring The Success Of A Coastal Sand Dune Restoration On Tybee Island: Plant Growth, Sand Accretion, And Implications For Management, Shannon Matzke Jan 2021

Measuring The Success Of A Coastal Sand Dune Restoration On Tybee Island: Plant Growth, Sand Accretion, And Implications For Management, Shannon Matzke

College of Graduate Studies: Theses & Dissertations

Coastal communities are developing rapidly in the face of increased risks of sea level rise and hurricanes stemming from anthropogenic climate change. In the US, erosion is projected to cost $530 million/year in property loss, but beaches and dune systems can minimize these losses. Dunes are vital to coastal protection, particularly when they are colonized by native plant species that stabilize sand with their root systems and accumulate sand by trapping particles with their stems and leaves. Dune construction can be used as a nature-based solution to climate change, but more studies are needed to fully understand the best practices …

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The Effects Of Habitat Fragmentation On Avian Mobbing Behavior, Jada T. Daniels Jan 2021

The Effects Of Habitat Fragmentation On Avian Mobbing Behavior, Jada T. Daniels

College of Graduate Studies: Theses & Dissertations

Habitat fragmentation has negative effects on bird species diversity, as well as reproductive success of some species. However, there is little comparative information on the effect it may have on bird behavior. For example, small forest fragments are likely to have fewer bird species and individuals. This may limit the success of mobbing as an antipredator behavior because mobbing success depends on recruiting other birds to the group. This possibility has never been tested. The objective of my study is to quantify the effects of forest size on mobbing behavior in forest-dwelling birds. Mobbing behavior was elicited in 100 randomly …

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Exposure Assessment Of Emerging Contaminants: Rapid Screening And Modeling Of Plant Uptake, Majid Bagheri Jan 2021

Exposure Assessment Of Emerging Contaminants: Rapid Screening And Modeling Of Plant Uptake, Majid Bagheri

Doctoral Dissertations

"With the advent of new chemicals and their increasing uses in every aspect of our life, considerable number of emerging contaminants are introduced to environment yearly. Emerging contaminants in forms of pharmaceuticals, detergents, biosolids, and reclaimed wastewater can cross plant roots and translocate to various parts of the plants. Long-term human exposure to emerging contaminants through food consumption is assumed to be a pathway of interest. Thus, uptake and translocation of emerging contaminants in plants are important for the assessment of health risks associated with human exposure to emerging contaminants. To have a better understanding over fate of emerging contaminants …

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