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2021

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Adipose Depot-Specific Effects Of 16 Weeks Of Pioglitazone On In Vivo Adipogenesis In Women With Obesity: A Randomised Controlled Trial, Ursula White, Mark D. Fitch, Robbie A. Beyl, Marc K. Hellerstein, Eric Ravussin Jan 2021

Adipose Depot-Specific Effects Of 16 Weeks Of Pioglitazone On In Vivo Adipogenesis In Women With Obesity: A Randomised Controlled Trial, Ursula White, Mark D. Fitch, Robbie A. Beyl, Marc K. Hellerstein, Eric Ravussin

Clinical Research Faculty Publications

Aims/hypothesis: In vitro and rodent studies suggest that pioglitazone, a thiazolidinedione, can promote adipogenesis in adipose tissue (AT); however, there is a lack of in vivo studies in humans to support these findings. The objectives of this randomised, placebo-controlled, parallel-arm trial were to test if pioglitazone stimulates in vivo adipogenesis in the subcutaneous adipose tissue depots and if these measures were related to metabolic health outcomes in women with obesity. Methods: Forty-one healthy women with obesity (20 black; 21 white; 29 ± 6 years; BMI 32.0 ± 1.7 kg/m2; 44.0 ± 3.6% body fat) were randomised to consume 30 mg/day …

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Effect Of An Office-Based Intervention On Visceral Adipose Tissue: The Workactive-P Randomized Controlled Trial, James L. Dorling, Christoph Höchsmann, Catrine Tudor-Locke, Robbie Beyl, Corby K. Martin Jan 2021

Effect Of An Office-Based Intervention On Visceral Adipose Tissue: The Workactive-P Randomized Controlled Trial, James L. Dorling, Christoph Höchsmann, Catrine Tudor-Locke, Robbie Beyl, Corby K. Martin

Clinical Research Faculty Publications

Office-based activity reduces sedentariness, yet no randomized controlled trials (RCTs) have assessed how such activity influences visceral adipose tissue (VAT). This study examined the effect of an office-based, multicomponent activity intervention on VAT. The WorkACTIVE-P RCT enrolled sedentary office workers (body mass index: 31.4 (standard deviation (SD) 4.4) kg/m2 ) to an intervention (n = 20) or control (n = 20) group. For 3 months, the intervention group received an office-based pedal desk, further to an intervention promoting its use and increased walking. The control group maintained habitual activity. At baseline and follow-up, VAT, cardiometabolic disease risk markers, physical activity, …

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Leucine And Sildenafil Combination Therapy Reduces Body Weight And Metformin Enhances The Effect At Low Dose: A Randomized Controlled Trial, Candida J. Rebello, Michael B. Zemel, Orville Kolterman, Gilbert Alexander Fleming, Frank L. Greenway Jan 2021

Leucine And Sildenafil Combination Therapy Reduces Body Weight And Metformin Enhances The Effect At Low Dose: A Randomized Controlled Trial, Candida J. Rebello, Michael B. Zemel, Orville Kolterman, Gilbert Alexander Fleming, Frank L. Greenway

Clinical Research Faculty Publications

Background:This study evaluated the potential of activating the fuel-sensing enzymes Adenine monophosphate (AMP)-activated protein kinase and the deacetylase sirtuin1, to promote weight loss. We tested the efficacy of a fixed dose combination of the amino acid leucine and 2 well-characterized agents with established safety profiles to modulate energy metabolism and facilitate weight loss.Study Question:Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight?Study Design:We conducted a 24-week randomized controlled trial evaluating the effect on weight loss of leucine 1.1 g and sildenafil 1.0 mg or 4.0 mg, with and without metformin …

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Agronomic And Environmental Performance Of Biochar Amendment In Alluvial Soils Under Subtropical Sugarcane Production, Negar Tafti, Jim Wang, Lewis Gaston, Jong Hwan Park, Meng Wang, Scott Pensky Jan 2021

Agronomic And Environmental Performance Of Biochar Amendment In Alluvial Soils Under Subtropical Sugarcane Production, Negar Tafti, Jim Wang, Lewis Gaston, Jong Hwan Park, Meng Wang, Scott Pensky

Faculty Publications

This study investigated the amendment of sugarcane bagasse biochar (SCBB) on soil fertility, crop yield, and nutrient loss in two different-textured soils under sugarcane (Saccharum spp.) production. Eleven megagrams per hectare of freshly incorporated biochar increased yield of plant cane by 22% in light-texture soil (LS) and 12% in heavy-textured soil (HS). Although the overall yield of the ratoon crop was lower, the biochar treatment produced 20 and 14% higher yields than the control at the LS and HS sites, respectively. Biochar increased soil carbon (Csoil) across LS and HS sites by 15% and decreased the soil C/N ratio by …

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Global Health Risk Factors: Physical Inactivity, Fiona Bull, Regina Guthold, Daniel J. Friedman, Peter Katzmarzyk Jan 2021

Global Health Risk Factors: Physical Inactivity, Fiona Bull, Regina Guthold, Daniel J. Friedman, Peter Katzmarzyk

Population and Public Health Science Faculty Publications

Regular physical activity improves physical and mental health across all ages, and provides many social, environmental, and economic co-benefits. Physical activity includes all forms of active recreation, sports participation, cycling and walking for transportation, as well as activity undertaken at home or for work. Despite well-established benefits, one quarter of adults and three quarters of adolescents are not sufficiently active. The policy and practice of promoting physical activity integrates multidisciplinary knowledge from across clinical and social medicine, exercise science, health psychology, public health, transport, and environmental studies, to improve global health. With increasing recognition of its role in promoting better …

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Sympathetic Innervation Of White Adipose Tissue: To Beige Or Not To Beige?, Heike Münzberg, Elizabeth Floyd, Ji Suk Chang Jan 2021

Sympathetic Innervation Of White Adipose Tissue: To Beige Or Not To Beige?, Heike Münzberg, Elizabeth Floyd, Ji Suk Chang

Division of Basic Science Faculty Publications

Obesity research progresses in understanding neuronal circuits and adipocyte biology to regulate metabolism. However, the interface of neuro-adipocyte interaction is less studied. We summarize the current knowledge of adipose tissue innervation and interaction with adipocytes and emphasize adipocyte transitions from white to brown adipocytes and vice versa. We further highlight emerging concepts for the differential neuronal regulation of brown/beige versus white adipocyte and the interdependence of both for metabolic regulation.

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The Ubiquitin Ligase Siah2 Negatively Regulates Glucocorticoid Receptor Activity And Abundance, Susan J. Burke, Jessica L. Taylor, Heidi M. Batdorf, Robert C. Noland, David H. Burk, Yongmei Yu, Z. Elizabeth Floyd, J. Jason Collier Jan 2021

The Ubiquitin Ligase Siah2 Negatively Regulates Glucocorticoid Receptor Activity And Abundance, Susan J. Burke, Jessica L. Taylor, Heidi M. Batdorf, Robert C. Noland, David H. Burk, Yongmei Yu, Z. Elizabeth Floyd, J. Jason Collier

Division of Basic Science Faculty Publications

Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days. In the present study, we tested the hypothesis that seven-in-absentia mammalian homolog-2 (SIAH2), a ubiquitin ligase that regulates adipogenesis, is important for controlling adipocyte size, inflammation, and the ability of adipose tissue to expand in response to a glucocorticoid challenge. Using mice with global deletion of SIAH2 exposed or not to corticosterone, we found that adipocytes are larger in response to glucocorticoids in the absence of SIAH2. In addition, SIAH2 regulates glucocorticoid receptor (GR) transcriptional activity …

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Bioenergetics Of Islet Preparations In A Pilot Clinical Trial Of Peri-Transplant Hydroxychloroquine For Autologous Islet Transplantation, Ruth E. Mcdowell, Khawla F. Ali, Saloni Lad, Vicente T. San Martin, Rita Bottino, Matthew Walsh, Tyler Stevens, William Wilke, John P. Kirwan, Betul Hatipoglu Jan 2021

Bioenergetics Of Islet Preparations In A Pilot Clinical Trial Of Peri-Transplant Hydroxychloroquine For Autologous Islet Transplantation, Ruth E. Mcdowell, Khawla F. Ali, Saloni Lad, Vicente T. San Martin, Rita Bottino, Matthew Walsh, Tyler Stevens, William Wilke, John P. Kirwan, Betul Hatipoglu

Division of Basic Science Faculty Publications

The inflammatory response is an obstacle to success in both allogeneic and autologous islet transplantation. In autologous islet transplantation (AIT), however, the recipient is also the donor, permitting pretreatment of donor/recipient for a controlled duration prior to transplantation. We sought to exploit this feature of (AIT) by pretreating donor/recipients with chronic pancreatitis undergoing total pancreatectomy and autologous islet transplantation (TPAIT) to test the hypothesis that peri-transplant treatment with the FDA-approved anti-inflammatory hydroxychloroquine (HCQ) improves graft function. In this randomized placebo-controlled pilot clinical study, patients (n = 6) were treated with oral HCQ for 30 days prior to and 90 days …

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Beyond Weight Loss: Current Perspectives On The Impact Of Calorie Restriction On Healthspan And Lifespan, Maryam Kebbe, Joshua R. Sparks, Emily W. Flanagan, Leanne M. Redman Jan 2021

Beyond Weight Loss: Current Perspectives On The Impact Of Calorie Restriction On Healthspan And Lifespan, Maryam Kebbe, Joshua R. Sparks, Emily W. Flanagan, Leanne M. Redman

Clinical Research Faculty Publications

Introduction: Changes to mental, physical, and physiological functions drive the complex processes underlying the variable progression of human aging. Nutritional interventions are one of the most promising non-pharmacological therapeutics to attenuate aging in humans. This narrative review aims to describe the implications of moderate and prolonged calorie restriction (CR) in healthy adults without obesity that occur beyond weight loss. Areas covered: Findings from CR studies, such as the CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) trials, the most rigorous trials to date examining a prolonged 25% CR, are described. The main areas covered include; changes to …

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Combustion By-Products And Their Health Effects: Summary Of The 16th International Congress, Angela Violi, Stephania Cormier, Brian Gullett, Stina Jansson, Slawo Lomnicki, Chloe Luyet, Andreas Mayer, Ralf Zimmermann Jan 2021

Combustion By-Products And Their Health Effects: Summary Of The 16th International Congress, Angela Violi, Stephania Cormier, Brian Gullett, Stina Jansson, Slawo Lomnicki, Chloe Luyet, Andreas Mayer, Ralf Zimmermann

Division of Basic Science Faculty Publications

The 16th International Congress on Combustion By-Products and their Health Effects (PIC2019) was held in Ann Arbor, Michigan, from July 10 to 12, 2019. For the last 28 years, this conference has served as an interdisciplinary platform for the discussion of the formation, environmental fate, health effects, policy, and remediation of combustion by-products. The technical areas for PIC2019 included mobile and stationary sources in urban environments, open fires, in- door air pollution, and halogenated pollutants. The congress was sponsored by the National Institute of Environmental Health Sciences (NIEHS), the U.S. EPA, the School of Public Health at the University of …

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Constrained Learning Of Task-Related And Spatially-Coherent Dictionaries From Task Fmri Data, Sreekrishna Ramakrishnapillai, Harris R. Lieberman, Jennifer C. Rood, Stefan M. Pasiakos, Kori Murray, Preetham Shankapal, Owen T. Carmichael Jan 2021

Constrained Learning Of Task-Related And Spatially-Coherent Dictionaries From Task Fmri Data, Sreekrishna Ramakrishnapillai, Harris R. Lieberman, Jennifer C. Rood, Stefan M. Pasiakos, Kori Murray, Preetham Shankapal, Owen T. Carmichael

Clinical Research Faculty Publications

Dictionary learning and sparse coding techniques overcome limitations of traditional voxel-level analyses of task-based functional magnetic resonance imaging (fMRI) data by identifying broader temporal and spatial patterns of brain activity. However, prior applications of these methods to task-related fMRI data are not simultaneously optimized to find temporal patterns of activity that change in concert with changes in task conditions and spatial patterns that leverage existing neuroscience knowledge. In this study we present a new sparse dictionary learning method that uses prior knowledge of the temporal pattern of task conditions and the locations of brain regions hypothesized to be involved in …

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Estrogen, Brain Structure, And Cognition In Postmenopausal Women, Christina P. Boyle, Cyrus A. Raji, Kirk I. Erickson, Oscar L. Lopez, James T. Becker, H. Michael Gach, Lewis H. Kuller, William Longstreth, Owen T. Carmichael, Brandalyn C. Riedel, Paul M. Thompson Jan 2021

Estrogen, Brain Structure, And Cognition In Postmenopausal Women, Christina P. Boyle, Cyrus A. Raji, Kirk I. Erickson, Oscar L. Lopez, James T. Becker, H. Michael Gach, Lewis H. Kuller, William Longstreth, Owen T. Carmichael, Brandalyn C. Riedel, Paul M. Thompson

Clinical Research Faculty Publications

Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer's disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsistent. Effects of HT may be mediated by estrogen receptors found throughout the brain. Effects may also depend on lifestyle factors, timing of use, and genetic risk. We studied the impact of self-reported HT use on brain volume in 562 elderly women (71–94 years) with mixed cognitive status while adjusting for aforementioned factors. Covariate-adjusted voxelwise linear regression analyses …

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Eat Clean And Safe Food: A Food-Based Dietary Guideline For The Elderly In South Africa, Makenzie Miller, Wilna Oldewage-Theron, Carin Napier Jan 2021

Eat Clean And Safe Food: A Food-Based Dietary Guideline For The Elderly In South Africa, Makenzie Miller, Wilna Oldewage-Theron, Carin Napier

Faculty Publications

As the population of elderly individuals in South Africa (SA) grows, there is a need to promote the continued health of these persons as they progress through the life cycle. Food Based Dietary Guidelines (FBDGs) for the SA elderly were developed to address this need. These thirteen guidelines for the elderly collectively offer a basis of health practices that the elderly can follow to ensure that they are taking the right steps toward maintaining their health. While the guideline ‘Eat clean and safe food’ is not included in the current SA FBDGs, this recommendation is of particular importance to the …

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Food And Beverages Promoting Elderly Health: Six Food-Based Dietary Guidelines To Plan Good Mixed Meals For Elderly South Africans, Sanjoy Saha, Upasana Mukherjee, Makenzie Miller, Li Ling Peng, Carin Napier, Heleen Grobbelaar, Wilna Oldewage-Theron Jan 2021

Food And Beverages Promoting Elderly Health: Six Food-Based Dietary Guidelines To Plan Good Mixed Meals For Elderly South Africans, Sanjoy Saha, Upasana Mukherjee, Makenzie Miller, Li Ling Peng, Carin Napier, Heleen Grobbelaar, Wilna Oldewage-Theron

Faculty Publications

Studies have shown that the elderly are at a higher risk of developing malnutrition due to physiological and pathological changes. Several studies have confirmed that older South Africans have insufficient dietary diversity, resulting in nutritional deficiencies. Furthermore, poor and uninformed dietary choices are associated with the development of several diseases and increased mortality. Following the Elderly Food Based Dietary Guidelines (EFBDGs) related to promoting elderly health could ensure that the elderly have an adequate intake of nutritious foods. This paper provides an overview of six FBDGs relating to promoting health and is based on the South African Food Based Dietary …

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Effects Of Immersion In Fermented Tea Liquid And Steam Treatments On Physicochemical Properties And Ginsenoside Profiles Of Korean Ginseng, Peerarat Doungtip, Kyung Tack Kim, Hee Do Hong, Shin Eun Ju, Jae Woong Choi, Thanyaporn Siriwoharn, Witoon Prinyawiwatkul, Sujinda Sriwattana Jan 2021

Effects Of Immersion In Fermented Tea Liquid And Steam Treatments On Physicochemical Properties And Ginsenoside Profiles Of Korean Ginseng, Peerarat Doungtip, Kyung Tack Kim, Hee Do Hong, Shin Eun Ju, Jae Woong Choi, Thanyaporn Siriwoharn, Witoon Prinyawiwatkul, Sujinda Sriwattana

Faculty Publications

The study was performed to investigate some changes in physicochemical characteristics and ginsenoside profiles of Korean ginseng after being subjected to immersion in fermented tea liquid (FTL) [at a ratio of ginseng powder: FTL; 1:4, 1:6, and 1:8, w/w] and steam treatments (with and/or without steam). The ratio at 1:4 w/w showed the highest yield of bioactive components and was, therefore, selected to evaluate the effects of steam conditions [temperatures (60, 80, and 100°C) and times (1, 2, and 3 hr)]. The sample treated with FTL, regardless of the steam treatment, had darker color and higher antioxidant activity (IC50 for …

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Feedback Stabilization With Discrete Measurements Using Bounds On Fundamental Matrices, Frederic Mazenc, Michael Malisoff Jan 2021

Feedback Stabilization With Discrete Measurements Using Bounds On Fundamental Matrices, Frederic Mazenc, Michael Malisoff

Faculty Publications

We prove a new robust stabilization theorem for systems with time-varying disturbances and sampled measurements, using novel bounds on fundamental matrices for systems with disturbances. Our main tools use properties of positive systems and Metzler matrices. Our numerical example illustrates an advantage of using our method instead of previous methods.

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Mitochondrial Dna Indicates Paraphyletic Relationships Of Disjunct Populations In The Neotoma Mexicana Species Group, Giovani Hernández-Canchola, Livia León-Paniagua, Jacob A. Esselstyn Jan 2021

Mitochondrial Dna Indicates Paraphyletic Relationships Of Disjunct Populations In The Neotoma Mexicana Species Group, Giovani Hernández-Canchola, Livia León-Paniagua, Jacob A. Esselstyn

Faculty Publications

Woodrats (genus Neotoma) comprise 24 species found primarily in the United States and México. The Neotoma mexicana species group reaches its southernmost distribution in the highlands of southern México and Central America. Previous research suggested that N. mexi-cana has a discontinuous distribution, whereas N. ferruginea and N. picta have allopatric distributions around the lowlands of the Isthmus of Tehuantepec. However, these hypotheses were suggested with incomplete subspecific sampling near the isthmus. We used samples of N. m. parvidens from the Sierra Sur de Oaxaca and N. m. tropicalis from the Sierra Norte de Oaxaca to assess their taxonomic affinity. Our …

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Effect Of Hydrological Fluctuation On Nutrient Stoichiometry And Trade-Offs Of Carex Schmidtii, Dongjie Zhang, Qing Qi, Shouzheng Tong, Jim Wang, Mingye Zhang, Guanglei Zhu, Xianguo Lu Jan 2021

Effect Of Hydrological Fluctuation On Nutrient Stoichiometry And Trade-Offs Of Carex Schmidtii, Dongjie Zhang, Qing Qi, Shouzheng Tong, Jim Wang, Mingye Zhang, Guanglei Zhu, Xianguo Lu

Faculty Publications

Nutrient stoichiometry and trade-offs focusing on the mass balance of multiple nutrient elements play important roles in the response mechanism of plants to environmental stresses in wetlands. Nonetheless, little is known about the response dynamics and trade-offs of nutrient elements of wetland plants, especially potassium (K), under hydrological fluctuation conditions. Greenhouse experiments have been undertaken to assess the effects of initial water level (DW), water-level amplitude (AW), lasted time and their interactions on the response processes of nutrient stoichiometry of Carex schmidtii. Plant nutrient trade-offs and limitation were investigated under multiple hydrological fluctuation conditions. Results showed that plant nitrogen (N), …

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Current Pest Status And Management Practices For Systena Frontalis (Coleoptera: Chrysomelidae) In Ornamental Plants In The Eastern United States: An Online Survey, Shimat V. Joseph, Juang Horng Chong, Benjamin Campbell, Brian Kunkel, Danny Lauderdale, Stacey Jones, Stanton Gill, Yan Chen, Peter Schultz, David Held, Frank Hale, Adam Dale, Erfan Vafaie, Will Hudson, Dan Gilrein, Alejandro Del Pozo-Valdivia Jan 2021

Current Pest Status And Management Practices For Systena Frontalis (Coleoptera: Chrysomelidae) In Ornamental Plants In The Eastern United States: An Online Survey, Shimat V. Joseph, Juang Horng Chong, Benjamin Campbell, Brian Kunkel, Danny Lauderdale, Stacey Jones, Stanton Gill, Yan Chen, Peter Schultz, David Held, Frank Hale, Adam Dale, Erfan Vafaie, Will Hudson, Dan Gilrein, Alejandro Del Pozo-Valdivia

Faculty Publications

Systena frontalis (F.) (Coleoptera: Chrysomelidae) is an important pest in ornamental plant nurseries in the United States. Information on current pest status and management practices employed by nurseries, garden centers, and landscape care operations are crucial to developing an effective research and extension program for ornamental crops. An online survey was developed and administered by the research team in 2020 to gather data on pest status and current pest management practices. The questionnaire included three focus areas: 1) participant (location, industry type, or operating area); 2) pest status indicators (incidence, affected crops, and estimated loss); and 3) common pest management …

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Nonlinear Kernels, Dominance, And Envirotyping Data Increase The Accuracy Of Genome-Based Prediction In Multi-Environment Trials, Germano Costa-Neto, Roberto Fritsche-Neto, José Crossa Jan 2021

Nonlinear Kernels, Dominance, And Envirotyping Data Increase The Accuracy Of Genome-Based Prediction In Multi-Environment Trials, Germano Costa-Neto, Roberto Fritsche-Neto, José Crossa

Faculty Publications

Modern whole-genome prediction (WGP) frameworks that focus on multi-environment trials (MET) integrate large-scale genomics, phenomics, and envirotyping data. However, the more complex the statistical model, the longer the computational processing times, which do not always result in accuracy gains. We investigated the use of new kernel methods and modeling structures involving genomics and nongenomic sources of variation in two MET maize data sets. Five WGP models were considered, advancing in complexity from a main-effect additive model (A) to more complex structures, including dominance deviations (D), genotype × environment interaction (AE and DE), and the reaction-norm model using environmental covariables (W) …

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Influence Of Preharvest Management Strategies In Beef Cattle On Growth Performance, Carcass Characteristics, And Meat Quality, Erin Gubbels Jan 2021

Influence Of Preharvest Management Strategies In Beef Cattle On Growth Performance, Carcass Characteristics, And Meat Quality, Erin Gubbels

Electronic Theses and Dissertations

The overall goal of this thesis project was to better understand the influence of preharvest management strategies at critical growth and development periods on beef performance and meat quality. This was accomplished through two primary objectives: 1) to investigate the effects of maternal prepartum dietary energy source during mid- and late-gestation on growth performance, carcass composition, and meat quality of offspring and 2) to compare the influence of two low stress weaning methods with conventional weaning on post-weaning performance and carcass characteristics of steers. For objective 1, Angus-based cows from two sources (n = 129 from South Dakota State University, …

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Study On The Human Gut Bacteria Under Different Ecological Conditions: Antibiotic Perturbation And Dietary Quercetin, Shruti Shashidharan Menon Jan 2021

Study On The Human Gut Bacteria Under Different Ecological Conditions: Antibiotic Perturbation And Dietary Quercetin, Shruti Shashidharan Menon

Electronic Theses and Dissertations

The human intestine encompasses a vast community of microorganisms known as the gut microbiota that play a crucial role in maintaining health. Common perturbations such as changes in the normal diet, antibiotic treatment, and changes in environmental conditions can alter the gut microbiome. This can create dysbiosis in the gut leading to disease conditions. Therefore, it becomes important to determine the forces that influence the gut microbial ecology. In the first study, we focus on antibiotic perturbations on microbial succession and resilience in a synthetic consortium consisting of the most prevalent gut bacteria in humans. In addition, we investigated the …

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Analysis Of Metabolites And Therapeutics For Toxic Inhaled Agent Exposure, Abigail Bemah Donkor Jan 2021

Analysis Of Metabolites And Therapeutics For Toxic Inhaled Agent Exposure, Abigail Bemah Donkor

Electronic Theses and Dissertations

The inhalation of toxic inhaled agents (TIAs) such as methyl isocyanate and cyanide can compromise an individual’s general health due to their extremely toxic nature. Nonetheless, these gases are used extensively in the electronics, chemical, welding, electroplating industries, etc., increasing the risk of exposure to both civilians and industrial workers. It is therefore very crucial to develop analytical methods for TIA metabolites and therapeutic agents. Methyl isocyanate (MIC), an intermediate in the synthesis of carbamate pesticides is a toxic industrial chemical that causes irritation and damage to the eyes, respiratory tracts, and skin. Due to its reactivity with proteins, protein …

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Quantifying The Benefits Of The Expanded Food And Nutrition Education Program (Efnep) Using Biomarkers For Chronic Disease Risk, Richard Acquah-Sarpong Jan 2021

Quantifying The Benefits Of The Expanded Food And Nutrition Education Program (Efnep) Using Biomarkers For Chronic Disease Risk, Richard Acquah-Sarpong

Electronic Theses and Dissertations

The Expanded Food and Nutrition Education Program (EFNEP) is among the major nutrition education programs funded by the United States Department of Agriculture (USDA) with the aim of reducing food insecurity among low-income families. The program reaches about 70,000 adults and youth of low-income families in the US, District of Columbia, and six U.S. territories. Prior studies have used self-reported data, which possesses measurement errors, to estimate the benefits of the program. This can lead to underestimation or overestimation of results. To address this limitation, I use clinically measured objective biomarkers, such as body mass index (BMI), blood sugar level …

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Comparison Of Software Packages For Detecting Differentially Expressed Genes From Single-Sample Rna-Seq Data, Rong Zhou Jan 2021

Comparison Of Software Packages For Detecting Differentially Expressed Genes From Single-Sample Rna-Seq Data, Rong Zhou

Electronic Theses and Dissertations

RNA-sequencing (RNA-seq) has rapidly become the tool in many genome-wide transcriptomic studies. It provides a way to understand the RNA environment of cells in different physiological or pathological states to determine how cells respond to these changes. RNA-seq provides quantitative information about the abundance of different RNA species present in a given sample. If the difference or change observed in the read counts or expression level between two experimental conditions is statistically significant, the gene is declared as differentially expressed. A large number of methods for detecting differentially expressed genes (DEGs) with RNA-seq have been developed, such as the methods …

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Can Robots Get Some Human Rights? A Cross-Disciplinary Discussion, Priya Persaud, Aparna S. Varde, Weitian Wang Jan 2021

Can Robots Get Some Human Rights? A Cross-Disciplinary Discussion, Priya Persaud, Aparna S. Varde, Weitian Wang

Department of Computer Science Faculty Scholarship and Creative Works

An autonomous household robot passed a self-awareness test in 2015, proving that the cognitive capabilities of robots are heading towards those of humans. While this is a milestone in AI, it raises questions about legal implications. If robots are progressively developing cognition, it is important to discuss whether they are entitled to justice pursuant to conventional notions of human rights. This paper offers a comprehensive discussion of this complex question through cross-disciplinary scholarly sources from computer science, ethics, and law. The computer science perspective dissects hardware and software of robots to unveil whether human behavior can be efficiently replicated. The …

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Interdisciplinary Stem Undergraduate Programs And The Effectiveness Of Computing Competencies Within The Curriculum, Katherine G. Herbert, Thomas J. Marlowe, Kees Leune, Robert M. Siegfried, Jeanette Wilmanski Jan 2021

Interdisciplinary Stem Undergraduate Programs And The Effectiveness Of Computing Competencies Within The Curriculum, Katherine G. Herbert, Thomas J. Marlowe, Kees Leune, Robert M. Siegfried, Jeanette Wilmanski

Department of Computer Science Faculty Scholarship and Creative Works

Undergraduate interdisciplinary, multidisciplinary and transdisciplinary computing-related STEM programs are proliferating extensively. Each of these programs requires a robust computing component to be integrated into the curriculum. However, including an introductory, programmingoriented sequence designed for CS majors is not always the best fit for these multifaceted programs. In this work in progress paper, we set out to investigate possibilities and issues for the computing component, focusing on three fields: bioinformatics, data science, and cybersecurity. We explore commonalities and differences, and discuss initial plans to test our hypotheses. In doing so, we consider data organization, data acquisition, and a preliminary survey design.

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Are You There, Law? It's Me, Semen, Anita Bernstein Jan 2021

Are You There, Law? It's Me, Semen, Anita Bernstein

Faculty Scholarship

No abstract provided.

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New Beginnings Jan 2021

New Beginnings

In Case You Missed It

JANUARY 2021

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The Acute Effect Of Magnesium Supplementation On Endothelial Function: A Randomized Cross-Over Pilot Study, Catriona Murphy, Jennifer A. Byrne, Jennifer Keogh, Michelle Headland, Peter M. Clifton Jan 2021

The Acute Effect Of Magnesium Supplementation On Endothelial Function: A Randomized Cross-Over Pilot Study, Catriona Murphy, Jennifer A. Byrne, Jennifer Keogh, Michelle Headland, Peter M. Clifton

Articles

: Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2 ) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men …

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