Digital Commons Network^™

Dynamic Phenotypic Switching And Group Behavior Help Non-Small Cell Lung Cancer Cells Evade Chemotherapy, Arin Nam, Atish Mohanty, Supriyo Bhattacharya, Sourabh Kotnala, Srisairam Achuthan, Kishore Hari, Saumya Srivastava, Linlin Guo, Anusha Nathan, Rishov Chatterjee, Maneesh Jain, Mohd W. Nasser, Surinder K. Batra, Govindan Rangarajan, Erminia Massarelli, Herbert Levine, Mohit Kumar Jolly, Prakash Kulkarni, Ravi Salgia

Journal Articles: Biochemistry & Molecular Biology

Drug resistance, a major challenge in cancer therapy, is typically attributed to mutations and genetic heterogeneity. Emerging evidence suggests that dynamic cellular interactions and group behavior also contribute to drug resistance. However, the underlying mechanisms remain poorly understood. Here, we present a new mathematical approach with game theoretical underpinnings that we developed to model real-time growth data of non-small cell lung cancer (NSCLC) cells and discern patterns in response to treatment with cisplatin. We show that the cisplatin-sensitive and cisplatin-tolerant NSCLC cells, when co-cultured in the absence or presence of the drug, display dynamic group behavior strategies. Tolerant cells exhibit …

Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff

Undergraduate Honors Theses

Annual Lyme disease cases continue to rise in the U.S. making it the most reported vector-borne illness in the country. The pathogen (Borrelia burgdorferi) and primary vector (Ixodes scapularis; blacklegged tick) dynamics of Lyme disease are complicated by the multitude of vertebrate hosts and varying environmental factors, making models an ideal tool for exploring disease dynamics in a time- and cost-effective way. In the current study, LYMESIM 2.0, a mechanistic model, was used to explore the effectiveness of three commonly used tick control methods: habitat-targeted acaricide (spraying), rodent-targeted acaricide (bait boxes), and white-tailed deer targeted acaricide (4-poster …

Methodology For C-Glycosylation And Synthesis Of Probes For The Detection Of Cysteine Containing Proteins, Elizabeth Ward

Undergraduate Honors Theses

Throughout my research I have been able to expand my knowledge and gain experience in organic chemistry by working on projects related to biochemistry and hydrocarbons. The projects I have worked on were:

• Project 1: C-glycosylation through photo irradiation with reductive halide atom transfer
• Project 2: Synthesis of rhodamine and biotin probes for the detection of cysteine containing proteins
• Project 3: Literature review on: Fluorescent probes for cysteine containing proteins

Lehigh Valley Topper Cancer Institute: 2021 Statistical Report, Lehigh Valley Health Network

Lehigh Valley Topper Cancer Institute

No abstract provided.

Prioritizing Preparation: Ensuring Access To Health Care Through Hospitals’ Stockpiling Of Personal Protective Equipment, Briana D. Long

Wyoming Law Review

No abstract provided.

Developing New Faculty Voice And Agency Through Trustful, Overlapping, Faculty-Faculty And Student-Faculty Conversations, Alison Cook-Sather, Emily Hong, Tamarah Moss, Adam Williamson

Education Program Faculty Research and Scholarship

Faculty-faculty conversations and student-faculty conversations typically unfold as separate forms of faculty learning. We present an approach to new faculty development through which faculty-faculty conversations in pedagogy seminars overlap with student-faculty conversations in pedagogical partnerships. Writing as three new faculty members and one academic developer in a bi-college consortium, we review scholarship on building trustful conversation in faculty development; present the overlapping forms of faculty-faculty and student-faculty conversation that constitute our approach; share how the three new faculty members developed voice and agency in their pedagogical practices; and note both challenges and other versions of this approach.

Late-Stage Product Development And Approvals By Biotechnology Companies After Initial Public Offering, 1997-2016, Laura M. M. Mcnamee, Ekaterina Galkina Cleary, Sunyi Zhang, Usama Salim, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

Purpose: This work describes the late-stage product portfolios of the biotechnology companies that completed initial public offerings (IPOs) from 1997 to 2016. We asked whether these emerging companies continue to develop innovative, biologic products and produce the innovation promised by the early biotechnology industry.

Methods: We identified therapeutic products that reached Phase III development from 1997 to 2016, the characteristics of the products, the dates of the initiation of Phase III and product approval, proxy indicators of the innovativeness of each product, and the contribution of each biotechnology company. Companies were characterized by IPO window and clinical status of the …

Water Quality Engineering And Wastewater Treatment, Yung-Tse Hung, Hamidi Abdul Aziz, Issam A. Al-Khatib, Rehab O. Abdel Rahman, Mario Gr Cora-Hernandez

Civil and Environmental Engineering Faculty Publications

No abstract provided.

Deep-Pelagic Research In The Gulf Of Mexico: Ten Years And Counting…, Tracey Sutton

Marine & Environmental Sciences Faculty Articles

No abstract provided.

Asbury Theological Seminary Academic Catalog : 2021-2022, Asbury Theological Seminary

Academic Catalogs

No abstract provided.

Lynn Margulis And Boris Kozo-Polyansky: How The Symbiogenesis Was Translated From Russian, Victor Fet

Biological Sciences Faculty Research

This contribution details the complex history of the early work by Boris Kozo-Polyansky (1924) that became available in English translation 86 years after it was published in Russian. The great American naturalist Lynn Margulis—whose serial endosymbiosis theory was presciently predated by Kozo-Polyansky by four decades—was instrumental in organizing this resurrection and ‘horizontal transfer’ of knowledge, forgotten by that time even in Russia.

Trademarks In Conversation: Assessing Genericism After Booking.Com, Laura A. Heymann

Cardozo Arts & Entertainment Law Journal

It is a fundamental principle of U.S. trademark law that to serve as a trademark, a word or phrase must "indicate the source" of the goods or services with which it is associated and, conversely, that a term that is understood to be the common name of a good or service is "generic" and cannot be protected as a trademark. Yet it still seems difficult to determine exactly what each concept means, particularly when the actual "source" of any goods or services might be opaque to consumers.

In part, this difficulty comes from the fact that status as a trademark …

Smoking And Early-Onset Basal Cell Carcinoma, Zhaopei Liu

Public Health Theses

Background – Smoking has been identified as a risk factor for many cancers. While many studies have investigated the association between smoking and basal cell carcinoma (BCC), the results have been inconsistent, and no study has evaluated this association among a young population.

Methods – Early-onset BCC cases (n=374) and controls with minor benign skin conditions (n=384) under age 40 were identified through Yale Dermatopathology. Participants over 18 years old were asked whether they ever smoked (defined as ever smoked at least 100 cigarettes) during an in-person interview. Those who responded affirmatively were then asked about their smoking history. We …

Discrimination In Modern Labor Markets: A Field Experiment, Taekmin Nam

Economics Honors Papers

With the growing prominence of big data and algorithms in the hiring process, it seems only apt to systematically identify the effect that these changes are having on labor markets. In this paper, I seek to take the first step in filling this void by systematically analyze the effect of big data and algorithms on discrimination in the hiring process. I conduct a correspondence study adapted to the new job application process to see how big data and algorithms are affecting discrimination in the hiring process.

Introduction And Invitation (Chapter One Of Generating Tact And Flow For Effective Teaching And Learning), Susanna M. Steeg Thornhill, Ken Badley

Faculty Publications - College of Education

Extract: "This book is for teachers, written by teachers, about the magic days. The days when things go so well you imagine that although teaching is a severely underpaid gig, you loved your work so much you might consider teaching for free. Maybe your most challenging students joined you on the learning journey in a new way, or a slightly under-planned lesson went much better than you anticipated, generating clear direction for the following week. Maybe things took a completely unexpected turn, and a teachable moment turned into a power hour fueled by excited and engaged students. These are the …

Implementing Connectivity Conservation In Canada, Christopher J. Lemieux, Aerin L. Jacob, Paul A. Gray

Geography and Environmental Studies Faculty Publications

No abstract provided.

Perceptions Of Scientists Held By Us Students Can Be Broadened Through Inclusive Classroom Interventions, Sarah L. Sheffield, Meghan L. Cook, Victor J. Ricchezza, Guizella A. Rocabado, Fenda A. Akiwumi

School of Geosciences Faculty and Staff Publications

More diverse representation in undergraduate classrooms may be an important step towards turning science, technology, engineering, and mathematics (STEM) disciplines into more inclusive communities. In the United States of America, the individuals whose work is discussed in typical introductory science courses collectively do not represent the diversity of students’ identities in the classroom and further reinforce existing stereotypes of scientists as male, white, and aged. Here we report on the implementation of a semester-long intervention in an introductory-level geoscience course at the University of South Florida, USA. We introduced students to individuals with marginalized identities who are either scientists or …

Levels Of Interpersonal Trust Across Different Types Of Environment: The Micro-Macro Interplay Between Relational Distance And Human Ecology, Yiming Jing, Huajian Cai, Michael Harris Bond, Yang Li, Adam W. Stivers, Qianbao Tan

Psychology Faculty Scholarship

Social and behavioral scientists have long investigated the relationship between interpersonal trust and features of the environment. However, it remains unclear how the microenvironment of relational distance (i.e., social proximity between 2 persons) interacts with the macroenvironment of human ecology (i.e., social and natural environments) to predict people’s levels of trusting other persons. In this research, we tackled this puzzle using diverse methodologies (e.g., meta-analysis, experiment, and multilevel analysis) and large, cultural-group samples. Four studies found that, across many countries (e.g., 77 countries in Study 3) and regions within a country (e.g., 28 Chinese provinces in Study 4), members of …

Ecological System And Psychosocial Well-Being Of Myanmar Migrant Workers During The Covid-19 Pandemic "A Case Of Mahachai", Susan Moe Kyaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The complex interactions in each ecological setting influence the psychosocial well-being of a person. Migrant workers’ well-being is highly influenced by their working conditions, security, and social relationship. They encounter not only work-related stress, and discrimination, but are also caused by socio-economic changes during the global crisis such as the Covid-19 outbreak. Prior to the COVID-19 outbreak in Thailand, Mahachai has been a place of many studies and research as it hosts thousands of migrant workers, and its major seafood production, fishery, metal, and other factories in its area. It draws the attention of migration scholars, policymakers, and researchers to …

Cholesterol-Lowering And Probiotic Properties Of Selected Lactic Acid Bacteria, Engkarat Kingkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ninety strains of lactic acid bacteria (LAB) isolated from fermented foods and bark of Tamarindus indica were screening cholesterol-lowering effects, selected and identified based on the phenotypic, chemotaxonomic characteristics and 16S rRNA gene sequence analysis. They were identified as Companilactobacillus farciminis (5 strains), C. formosensis (10 strains), C. futsaii (6 strains), C. pabuli (4 strains), Enterococcus thailandicus (2 strains), Lactiplantibacillus argentoratensis (3 strains), Lactiplantibacillus pentosus (10 strains), Lactiplantibacillus plantarum subsp. plantarum (17 strains), Lactococcus lactis subsp. lactis (2 strains), Lentilactobacillus buchneri (8 strains), Limosilactobacillus fermentum (2 strains), P. pentosaceus (12 strains) and each of En. durans, En. hirae, En. lactis, …

Louisiana Agriculture Winter, 2021, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Clinical Commissioning Of Intensity-Modulated Proton Therapy Systems: Report Of Aapm Task Group 185, Jonathan B. Farr, Michael F. Moyers, Chris E. Allgower, Martin Bues, Wen Chien Hsi, Hosang Jin, Dimitris N. Mihailidis, Hsiao Ming Lu, Wayne D. Newhauser, Narayan Sahoo, Roelf Slopsema, Daniel Yeung, X. Ronald Zhu

Faculty Publications

Proton therapy is an expanding radiotherapy modality in the United States and worldwide. With the number of proton therapy centers treating patients increasing, so does the need for consistent, high-quality clinical commissioning practices. Clinical commissioning encompasses the entire proton therapy system's multiple components, including the treatment delivery system, the patient positioning system, and the image-guided radiotherapy components. Also included in the commissioning process are the x-ray computed tomography scanner calibration for proton stopping power, the radiotherapy treatment planning system, and corresponding portions of the treatment management system. This commissioning report focuses exclusively on intensity-modulated scanning systems, presenting details of how …

Beyond The Boundaries Of Childhood: African American Children In The Antebellum North, Anna Mae Duane

Civil War Book Review

"Crystal Lynn Webster’s new book, Beyond the Boundaries of Childhood, asks how gradual emancipation in Northern States assigned Black children spaces outside the boundaries of Victorian childhood. Webster also reveals the ways in which Black children were harmed when they were included in reformers’ ideals about childhood, as white reformers felt that Black children’s vulnerability required separation from their families."

Slavery, Fatherhood, And Paternal Duty In African American Communities Over The Long Nineteenth Century., Kathleen Kennedy

Civil War Book Review

"Overall, Hilde has written a convincing book that adds depth and complexity to the existing literature on enslaved masculinity . . . It thus encourages us to think about the complexities of enslaved men’s experiences and inner life as historians of women have done for enslaved women. Furthermore, the work is accessible as Hilde keeps the stories of enslaved people at the center of her work while deftly framing those stories within a narrative that emphasizes the interrelationships between gender and race in shaping social categories such as fatherhood."

Global Sex Disparity Of Covid-19: A Descriptive Review Of Sex Hormones And Consideration For The Potential Therapeutic Use Of Hormone Replacement Therapy In Older Adults, S C. Okpechi, J T. Fong, S S. Gill, J C. Harman, S C. Okpechi, Q C. Chukwurah, I O. Onor, S K. Alahari

Faculty Publications

The 2019-2020 SARS-related coronavirus-2 (SARS-CoV-2) pandemic has brought unprecedented challenges to healthcare sectors around the world. As of November 2020, there have been over 64 million confirmed cases and approaching 2 million deaths globally. Despite the large number of positive cases, there are very limited established standards of care and therapeutic options available. To date, there is still no Food and Drug Administration (FDA) approved vaccine for COVID-19, although there are several options in various clinical trial stages. Herein, we have performed a global review evaluating the roles of age and sex on COVID-19 hospitalizations, ICU admissions, deaths in hospitals, …

Bats And Humans During Thesars-Cov-2outbreak: The Case Of Bat-Coronaviruses From Mexico, P Colunga-Salas, G Hernandez-Canchola

Faculty Publications

The novelSARS-CoV-2coronavirus has attracted attention due to the high number of human cases around the world. It has been proposed that this virus originated in bats, possibly transmitted to humans by an intermediate host, making bats a group of great interest during this outbreak. Almost 10% of the world's bat species inhabit Mexico, and 14 previous novel CoVs have been recorded in Mexican bats. However, the phylogenetic relationships between these viruses and the novel coronavirus are unknown. The aim of this communication was therefore to describe the phylogenetic relationships between Mexican bat-CoVs andSARS-CoV-2. We showed that Mexican bat-CoVs sequences are …

The Interplay Between Environmental Exposures And Covid-19 Risks In The Health Of Children, P D. Sly, B A. Trottier, C M. Bulka, S A. Cormier, P D. Sly, R C. Fry, K W. Kim, S Kleeberger, P Kumar, P J. Landrigan, K L. Carlsen, A Pascale, F Polack, M Ruchirawat, H J. Zar, W A. Suk

Faculty Publications

Background: An unusual feature of SARS-Cov-2 infection and the COVID-19 pandemic is that children are less severely affected than adults. This is especially paradoxical given the epidemiological links between poor air quality and increased COVID-19 severity in adults and that children are generally more vulnerable than adults to the adverse consequences of air pollution. Objectives: To identify gaps in knowledge about the factors that protect children from severe SARS-Cov-2 infection even in the face of air pollution, and to develop a transdisciplinary research strategy to address these gaps. Methods: An international group of researchers interested in children's environmental health was …

Btk/Itk Dual Inhibitors: Modulating Immunopathology And Lymphopenia For Covid-19 Therapy, M C. Mcgee, A August, W S. Huang

Faculty Publications

Bruton's tyrosine kinase (BTK) signaling is involved in innate immune responses and regulates the production of proinflammatory cytokines that can contribute to COVID-19 immunopathology. Clinical trials with BTK inhibitors in COVID-19 treatment have been proposed, and previous studies have attempted to investigate the therapeutic effects of ibrutinib and underlying mechanisms in treating viral pneumonia. These attempts, however, did not consider potential off target effect of BTK inhibitors on T cell differentiation, function, and survival, which may be beneficial in treatment for COVID-19. Here, we summarize the current knowledge of BTK/IL-2-inducible T-cell kinase (ITK) signaling in immunopathology and lymphopenia and discuss …

Everything You Wanted To Know About Space Radiation But Were Afraid To Ask, Jeffery Chancellor, Craig Nowadly, Jacqueline Williams, Serena Aunon-Chancellor, Megan Chesal, Jayme Looper, Wayne Newhauser

Faculty Publications

The space radiation environment is a complex combination of fast-moving ions derived from all atomic species found in the periodic table. The energy spectrum of each ion species varies widely but is prominently in the range of 400–600 MeV/n. The large dynamic range in ion energy is difficult to simulate in ground-based radiobiology experiments. Most ground-based irradiations with mono-energetic beams of a single one ion species are delivered at comparatively high dose rates. In some cases, sequences of such beams are delivered with various ion species and energies to crudely approximate the complex space radiation environment. This approximation may cause …

An Environmental History Of The Civil War, Matthew Stith

Civil War Book Review

In this"effort to rediscover and recast the war in the same natural prism through which the war’s original actors viewed and experienced it 160 years ago" Browning and Silver "give a level of agency to the natural environment as it pertained to humans and their actions" in the great conflagration.