Digital Commons Network^™

A Match Made In Heaven: Exploring Views Of Medicine Students, Pharmacy Interns And Facilitators In An Interprofessional Medicines Pilot Study, Eileen M. Mckinlay, Melanie Brown, Debbie Wallace, Caroline Morris, Amanda Garnett, Ben Gray

Internet Journal of Allied Health Sciences and Practice

Purpose: To date, few interprofessional education initiatives have included just medicine and pharmacy learners. This research sought to explore learners’ and facilitators’ views of an interprofessional education medicines pilot study involving medical students and pharmacy interns. Methods: Qualitative feedback was gathered from the participating learners and a facilitator focus group was undertaken. Results: Medical student and pharmacy intern learners reported enjoying taking part and found the simulation and overall initiative to be authentic. They described learning most about each other’s roles and responsibilities and about teamwork, collaborative management, and collaboration. Some logistical improvements were suggested. The facilitators judged that the …

Closing The Patent Loophole Across Borders, 20 Uic Rev. Intell. Prop. L. 358 (2021), Mattias Rättzén

UIC Review of Intellectual Property Law

No abstract provided.

Immunex V. Sandoz: Drafting Assignments As Licenses To Avoid Obviousness-Type Double Patenting, 20 Uic Rev. Intell. Prop. L. 412 (2021), Michael Mand

UIC Review of Intellectual Property Law

No abstract provided.

Evaluating Potential Effects Of Solar Power Facilities On Wildlife From An Animal Behavior Perspective, Rachel Y. Chock, Barbara Clucas, Elizabeth K. Peterson, Bradley Blackwell, Daniel T. Blumstein, Kathleen Church, Esteban Fernández-Juricic, Gabriel Francescoli, Alison L. Greggor, Paul Kemp, Gabriela M. Pinho, Peter M. Sanzenbacher, Bruce A. Schulte, Pauline Toni

United States Department of Agriculture Wildlife Services: Staff Publications

Solar power is a renewable energy source with great potential to help meet increasing global energy demands and reduce our reliance on fossil fuels. However, research is scarce on how solar facilities affect wildlife. With input from professionals in ecology, conservation, and energy, we conducted a research-prioritization process and identified key questions needed to better understand impacts of solar facilities on wildlife. We focused on animal behavior, which can be used to identify population responses before mortality or other fitness consequences are documented. Behavioral studies can also offer approaches to understand the mechanisms leading to negative interactions (e.g., collision, singeing, …

Temporal And Spatial Blood Feeding Patterns Of Urban Mosquitoes In The San Juan Metropolitan Area, Puerto Rico, Matthew W. Hopken, Limarie J. Reyes-Torres, Nicole Scavo, Antoinette J. Piaggio, Zaid Abdo, Daniel Taylor, James Pierce, Donald A. Yee

United States Department of Agriculture Wildlife Services: Staff Publications

Simple Summary: Understanding the biodiversity of urban ecosystems is critical for management of invasive and pest species, conserving native species, and disease control. Mosquitoes (Culicidae) are ubiquitous and abundant in urban ecosystems, and rely on blood meals taken from vertebrates. We used DNA from freshly blood-fed mosquitoes to characterize the diversity of vertebrate host species in the San Juan Metropolitan Area, Puerto Rico. We collected two mosquito species that fed on a variety of vertebrates. Culex quinquefasciatus fed on 17 avian taxa (81.2% of blood meals), seven mammalian taxa (17.9%), and one reptilian taxon (0.85%). Aedes aegypti blood meals were …

Best Management Practices For Trapping Furbearers In The United States, H. Bryant White, Gordon R. Batcheller, Edward K. Boggess, Clifford L. Brown, Joseph W. Butfiloski, Thomas A. Decker, John D. Erb, Michael W. Fall, David A. Hamilton, Tim L. Hiller, George F. Hubert Jr., Matthew J. Lovallo, John F. Olson, Nathan M. Roberts

United States Department of Agriculture Wildlife Services: Staff Publications

Humans have used wild furbearers for various purposes for thousands of years. Today, furbearers are sustainably used by the public for their pelts, leather, bones, glands, meat, or other purposes. In North America, contemporary harvest of furbearers has evolved along with trap technologies and societal concerns, and is now highly regulated and more closely coupled with harvest analysis and population monitoring. Traps and regulated trapping programs provide personal or cultural rewards that can also support conservation, and can assist with advancing ecological knowledge through research, protecting endangered species, restoring populations or habitats, protecting personal property, and enhancing public health and …

Strategic Considerations For Invasive Species Managers In The Utilization Of Environmental Dna (Edna): Steps For Incorporating This Powerful Surveillance Tool, Jeffrey Morisette, Stanley Burgiel, Kelsey Brantley, Wesley M. Daniel, John Darling, Jeanette Davis, Thomas Franklin, Keith Gaddis, Margaret Hunter, Richard Lance, Tracy Leskey, Yale Passamaneck, Antoinette Piaggio, Brian Rector, Adam Sepulveda, Melissa Smith, Carol A. Stepien, Taylor Wilcox

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive species surveillance programs can utilize environmental DNA sampling and analysis to provide information on the presence of invasive species. Wider utilization of eDNA techniques for invasive species surveillance may be warranted. This paper covers topics directed towards invasive species managers and eDNA practitioners working at the intersection of eDNA techniques and invasive species surveillance. It provides background information on the utility of eDNA for invasive species management and points to various examples of its use across federal and international programs. It provides information on 1) why an invasive species manager should consider using eDNA, 2) deciding if eDNA can …

Reproductive Trade-Offs In The Colorado Checkered Whiptail Lizard (Aspidoscelis Neotesselatus): An Examination Of The Relationship Between Clutch And Follicle Size, Hannah E. Caracalas, S. S. French, S. B. Hudson, B. M. Kluever, A. C. Webb, D. Eifler, A. J. Lehmicke, Lise M. Aubry

United States Department of Agriculture Wildlife Services: Staff Publications

Life history theory predicts that there should be an inverse relationship between offspring size and number, because individuals cannot simultaneously maximize both when resources are limited. Although extensively studied in avian species, the occurrence and determinants of reproductive tradeoffs in oviparous reptiles are far less understood, particularly in parthenogenetic species. We studied this trade-off in the Colorado Checkered Whiptail, Aspidoscelis neotesselatus, a female-only parthenogenetic lizard. Using data previously collected in 2018 and 2019, we tested for clutch and egg size trade-offs and determined whether this relationship could be influenced by female size and aspects of physiological condition. Physiological condition …

Modelling The Factors Affecting The Probability For Local Rabies Elimination By Strategic Control, Johann L. Kotzé, John Duncan Grewar, Aaron M. Anderson

United States Department of Agriculture Wildlife Services: Staff Publications

Dog rabies has been recognized from ancient times and remains widespread across the developing world with an estimated 59,000 people dying annually from the disease. In 2011 a tri-partite alliance consisting of the OIE, the WHO and the FAO committed to globally eliminating dog-mediated human rabies by 2030. Regardless of global support, the responsibility remains with local program managers to implement successful elimination programs. It is well known that vaccination programs have a high probability of successful elimination if they achieve a population-coverage of 70%. It is often quoted that reducing population turnover (typically through sterilizations) raises the probability for …

Biological & Biomedical Seminar | Genetic Diagnosis For Pediatric Hearing Loss: Challenges And Opportunities, Jan. 25, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Recommending Collaborations Using Link Prediction, Nikhil Chennupati

Browse all Theses and Dissertations

Link prediction in the domain of scientific collaborative networks refers to exploring and determining whether a connection between two entities in an academic network may emerge in the future. This study aims to analyze the relevance of academic collaborations and identify the factors that drive co-author relationships in a heterogeneous bibliographic network. Using topological, semantic, and graph representation learning techniques, we measure the authors' similarities w.r.t their structural and publication data to identify the reasons that promote co-authorships. Experimental results show that the proposed approach successfully infer the co-author links by identifying authors with similar research interests. Such a system …

Tera Dispositions, Alec Rovensky

Renée Crown University Honors Thesis Projects - All

No abstract provided.

The Wolf We Feed: Democracy, Caste, And Legitimacy, Benjamin Justice, Tracey L. Meares

Michigan Law Review Online

Procedure is central to American public legal discourse. From the soaring rhetoric of the Declaration of Independence to the Due Process Clause of the Fourteenth Amendment, the American legal tradition rests on the principle that law must be both derived and applied according to fair process. Consider that in the 2020 election the Trump Administration resorted to fervent and false allegations of widespread voter fraud—that the election process was fundamentally unfair—in order to weaponize Republican voters’ ostensible commitments to fairness against what was, objectively, one of the least procedurally unfair elections in history. Yet the four-year period of the Trump …

Office Of The Vice Provost For Research Annual Report - 2021, Office Of The Vice Provost For Research, East Tennessee State University

Annual Reports

No abstract provided.

Buddhas And Body Language: The Literary Trope Of The Buddha's Smile, David Fiordalis

Faculty Publications

This essay explores how classical Buddhist literature, across a variety of traditional genres, portrays the wondrous smile of the Buddha. Despite its literary register, the Buddha’s smile is first and foremost a nonverbal gesture, and if we are to understand its significance, then we must employ a theoretical approach that treats it as such. Multimodality provides such an approach. While an emergent body of psychological research has argued that the smile is a universal human gesture connected to a rather limited set of emotional states like happiness, the recognition that smiles can be voluntary acts highlights the importance of situational …

Comparing The Condition Of Deformed And Non-Deformed Walleyes In Long Lake, Mn, Clayton Beck

Journal of Earth and Life Science

Walleye Sander vitreus is a popular game fish in Minnesota. Walleye’s have become such a popular game fish for anglers that it has led agencies to raise Walleye in rearing ponds. Farm raised fish can show deformities due to environmental, genetic, nutritional, infectious, and toxic factors. Due to this phenomenon, the purpose of this study was to determine if the condition of the Walleye differed between those with and without deformities in Long Lake, MN. Angling was the method of capture during the months of September 2020 through July 2021. There was no evidence to suggest condition differed between non-deformed …

Childhood Trauma And Ptsd Symptoms: Disentangling The Roles Of Emotion Regulation And Distress Tolerance, Jenna E. Russo, Deepali M. Dhruve, Arazais D. Oliveros

CAS Publications

Background: Research documents that individuals with a history of childhood trauma experience greater emotion regulation difficulties (ED), as well as lower distress tolerance (DT), two constructs that independent lines of research implicate as transdiagnostic factors in post-traumatic stress disorder (PTSD). To help elucidate how such mechanisms may influence the etiology, maintenance, and treatment of PTSD, the current study investigates the distinct mediating roles of ED and DT and explores which accounts for more unique variance.

Methods: Participants (N = 385, aged 18-48) with a childhood trauma history provided self-ratings of cumulative trauma exposure, and endorsed current ED, DT, and …

Rollins Magazine, Winter 2021, Rollins College Office Of Marketing And Communications

Rollins Magazine

No abstract provided.

Rollins Magazine, Summer 2021, Rollins College Office Of Marketing And Communications

Rollins Magazine

No abstract provided.

Rollins Magazine, Fall 2021, Rollins College Office Of Marketing And Communications

Rollins Magazine

No abstract provided.

Lumos - Low And Intermediate Grade Glioma Umbrella Study Of Molecular Guided Therapies At Relapse: Protocol For A Pilot Study, Benjamin Y Kong, Hao-Wen Sim, Anna K Nowak, Sonia Yip, Elizabeth H Barnes, Bryan W Day, Michael E Buckland, Roel G W Verhaak, Terrance Johns, Cleo Robinson, Et Al

Faculty Research 2021

Grades 2 and 3 gliomas (G2/3 gliomas), when combined, are the second largest group of malignant brain tumours in adults. The outcomes for G2/3 gliomas at progression approach the dismal outcomes for glioblastoma (GBM), yet there is a paucity of trials for Australian patients with relapsed G2/3 gliomas compared with patients with GBM. LUMOS will be a pilot umbrella study for patients with relapsed G2/3 gliomas that aims to match patients to targeted therapies based on molecular screening with contemporaneous tumour tissue. Participants in whom no actionable or no druggable mutation is found, or in whom the matching drug is …

The Gut Microbiome And Substance Use Disorder., Jordan T Russell, Yanjiao Zhou, George M. Weinstock, Jason A. Bubier

Faculty Research 2021

Substance use disorders (SUDs) remain a significant public health challenge, affecting tens of millions of individuals worldwide each year. Often comorbid with other psychiatric disorders, SUD can be poly-drug and involve several different substances including cocaine, opiates, nicotine, and alcohol. SUD has a strong genetic component. Much of SUD research has focused on the neurologic and genetic facets of consumption behavior. There is now interest in the role of the gut microbiome in the pathogenesis of SUD. In this review, we summarize current animal and clinical evidence that the gut microbiome is involved in SUD, then address the underlying mechanisms …

Gender-Based Deep Learning Firefly Optimization Method For Test Data Generation., Wenning Zhang, Chongyang Jiao, Qinglei Zhou, Yang Liu, Ting Xu

Faculty Research 2021

Software testing is a widespread validation means of software quality assurance in industry. Intelligent optimization algorithms have been proved to be an effective way of automatic test data generation. Firefly algorithm has received extensive attention and been widely used to solve optimization problems because of less parameters and simple implement. To overcome slow convergence rate and low accuracy of the firefly algorithm, a novel firefly algorithm with deep learning is proposed to generate structural test data. Initially, the population is divided into male subgroup and female subgroup. Following the randomly attracted model, each male firefly will be attracted by another …

Interpretation Of Psychiatric Genome-Wide Association Studies With Multispecies Heterogeneous Functional Genomic Data Integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, Elissa J Chesler

Faculty Research 2021

Genome-wide association studies and other discovery genetics methods provide a means to identify previously unknown biological mechanisms underlying behavioral disorders that may point to new therapeutic avenues, augment diagnostic tools, and yield a deeper understanding of the biology of psychiatric conditions. Recent advances in psychiatric genetics have been made possible through large-scale collaborative efforts. These studies have begun to unearth many novel genetic variants associated with psychiatric disorders and behavioral traits in human populations. Significant challenges remain in characterizing the resulting disease-associated genetic variants and prioritizing functional follow-up to make them useful for mechanistic understanding and development of therapeutics. Model …

A New Graph-Based Clustering Method With Application To Single-Cell Rna-Seq Data From Human Pancreatic Islets., Hao Wu, Disheng Mao, Yuping Zhang, Zhiyi Chi, Michael L. Stitzel, Zhengqing Ouyang

Faculty Research 2021

Traditional bulk RNA-sequencing of human pancreatic islets mainly reflects transcriptional response of major cell types. Single-cell RNA sequencing technology enables transcriptional characterization of individual cells, and thus makes it possible to detect cell types and subtypes. To tackle the heterogeneity of single-cell RNA-seq data, powerful and appropriate clustering is required to facilitate the discovery of cell types. In this paper, we propose a new clustering framework based on a graph-based model with various types of dissimilarity measures. We take the compositional nature of single-cell RNA-seq data into account and employ log-ratio transformations. The practical merit of the proposed method is …

A Validated Integrated Clinical And Molecular Glioblastoma Long-Term Survival-Predictive Nomogram., Sherise D Ferguson, Tiffany R Hodges, Nazanin K Majd, Kristin Alfaro-Munoz, Wajd N Al-Holou, Dima Suki, John F De Groot, Gregory N Fuller, Lee Xue, Miao Li, Carmen Jacobs, Ganesh Rao, Rivka R Colen, Joanne Xiu, Roel G W Verhaak, David Spetzler, Mustafa Khasraw, Raymond Sawaya, James P Long, Amy B Heimberger

Faculty Research 2021

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adulthood. Despite multimodality treatments, including maximal safe resection followed by irradiation and chemotherapy, the median overall survival times range from 14 to 16 months. However, a small subset of GBM patients live beyond 5 years and are thus considered long-term survivors.

Methods: A retrospective analysis of the clinical, radiographic, and molecular features of patients with newly diagnosed primary GBM who underwent treatment at The University of Texas MD Anderson Cancer Center was conducted. Eighty patients had sufficient quantity and quality of tissue available for next-generation sequencing and immunohistochemical …

Decreased Glucocerebrosidase Activity And Substrate Accumulation Of Glycosphingolipids In A Novel Gba1 D409v Knock-In Mouse Model., Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave

Faculty Research 2021

Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically by homozygous mutations in GBA1, is linked to the lysosomal storage disorder Gaucher's disease (GD) and distinct or heterozygous mutations in GBA1 are associated with increased Parkinson's disease (PD) risk. While numerous genes have been linked to heritable PD, GBA1 mutations in aggregate are the single greatest risk factor for development of idiopathic PD. The importance of GCase in PD necessitates preclinical models in which to study GCase-related mechanisms …

Improving Hindlimb Locomotor Function By Non-Invasive Aav-Mediated Manipulations Of Propriospinal Neurons In Mice With Complete Spinal Cord Injury, Benedikt Brommer, Miao He, Zicong Zhang, Zhiyun Yang, Jessica C. Page, Junfeng Su, Yu Zhang, Junjie Zhu, Emilia Gouy, Jing Tang, Philip Williams, Wei Dai, Qi Wang, Ryan Solinsky, Bo Chen, Zhigang He

Open Access Publications

No abstract provided.

A Synthetic Mechanogenetic Gene Circuit For Autonomous Drug Delivery In Engineered Tissues, Robert J Nims, Lara Pferdehirt, Noelani B Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan Kassab, Alison K Ross, Christopher J O'Conor, Wolfgang B Liedtke, Bo Zhang, Amy L Mcnulty, Farshid Guilak

Open Access Publications

Mechanobiologic signals regulate cellular responses under physiologic and pathologic conditions. Using synthetic biology and tissue engineering, we developed a mechanically responsive bioartificial tissue that responds to mechanical loading to produce a preprogrammed therapeutic biologic drug. By deconstructing the signaling networks induced by activation of the mechanically sensitive ion channel transient receptor potential vanilloid 4 (TRPV4), we created synthetic TRPV4-responsive genetic circuits in chondrocytes. We engineered these cells into living tissues that respond to mechanical loading by producing the anti-inflammatory biologic drug interleukin-1 receptor antagonist. Chondrocyte TRPV4 is activated by osmotic loading and not by direct cellular deformation, suggesting that tissue …

Optimal Method For Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging, Jinwoo Hong, Hyuk Jin Yun, Gilsoon Park, Seonggyu Kim, Yangming Ou, Lana Vasung, Caitlin K Rollins, Cynthia M Ortinau, Emiko Takeoka, Shizuko Akiyama, Tomo Tarui, Judy A Estroff, Patricia Ellen Grant, Jong-Min Lee, Kiho Im

Open Access Publications

The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification of brain abnormalities and the risk of adverse developmental outcomes. This study aimed to propose a method for predicting fetal brain age using MRIs from 220 healthy fetuses between 15.9 and 38.7 weeks of gestational age (GA). We built a 2D single-channel convolutional neural network (CNN) with multiplanar MRI slices in different orthogonal planes without correction for interslice motion. In each fetus, multiple age predictions from different slices were generated, and the brain age was obtained using the mode that determined the most …