Digital Commons Network^™

Harnessing The Neon Data Revolution To Advance Open Environmental Science With A Diverse And Data-Capable Community, R. Chelsea Nagy, Jennifer K. Balch, Erin K. Bissell, Megan E. Cattau, Nancy F. Glenn, Benjamin S. Halpern, Nayani Ilangakoon, Brian Johnson, Maxwell B. Joseph, Sergio Marconi, Catherine O'Riordan, Sydne Record

Biology Faculty Research and Scholarship

It is a critical time to reflect on the National Ecological Observatory Network (NEON) science to date as well as envision what research can be done right now with NEON (and other) data and what training is needed to enable a diverse user community. NEON became fully operational in May 2019 and has pivoted from planning and construction to operation and maintenance. In this overview, the history of and foundational thinking around NEON are discussed. A framework of open science is described with a discussion of how NEON can be situated as part of a larger data constellation—across existing networks …

Addressing Bias In Faculty Retention, Sparkle L. Malone, Sydne Record

Biology Faculty Research and Scholarship

The field of ecology in the United States is not fully harnessing the diverse perspectives of the American population. Two major limitations to advancing diversity and inclusion include insufficient awareness of biased attitudes and the lack of large-scale faculty engagement in diversity and inclusion programs. Academic institutions must recognize and value individuals that participate in diversity and inclusion programs. Valuing this work will motivate all ecologists to accept the responsibility for these efforts and not simply assume that the few minorities in their field can do this work.

Modular Organization Of Engulfment Receptors And Proximal Signaling Networks: Avenues To Reprogram Phagocytosis, Emily A. Britt, Vanessa Gitau, Amara Saha, Adam Williamson

Biology Faculty Research and Scholarship

Transmembrane protein engulfment receptors expressed on the surface of phagocytes engage ligands on apoptotic cells and debris to initiate a sequence of events culminating in material internalization and immunologically beneficial outcomes. Engulfment receptors are modular, comprised of functionally independent extracellular ligation domains and cytosolic signaling motifs. Cognate kinases, adaptors, and phosphatases regulate engulfment by controlling the degree of receptor activation in phagocyte plasma membranes, thus acting as receptor-proximal signaling modules. Here, we review recent efforts to reprogram phagocytes using modular synthetic receptors composed of antibody-based extracellular domains fused to engulfment receptor signaling domains. To aid the development of new phagocyte …

Modular Organization Of Engulfment Receptors And Proximal Signaling Networks: Avenues To Reprogram Phagocytosis, Emily A. Britt, Vanessa Gitau, Amara Saha, Adam Williamson

Biology Faculty Research and Scholarship

Transmembrane protein engulfment receptors expressed on the surface of phagocytes engage ligands on apoptotic cells and debris to initiate a sequence of events culminating in material internalization and immunologically beneficial outcomes. Engulfment receptors are modular, comprised of functionally independent extracellular ligation domains and cytosolic signaling motifs. Cognate kinases, adaptors, and phosphatases regulate engulfment by controlling the degree of receptor activation in phagocyte plasma membranes, thus acting as receptor-proximal signaling modules. Here, we review recent efforts to reprogram phagocytes using modular synthetic receptors composed of antibody-based extracellular domains fused to engulfment receptor signaling domains. To aid the development of new phagocyte …

Critical Race Theory, Andrew P. Johnson

Elementary and Literacy Education Department Publications

Critical race theory (CRT) is one such theory used to explain and understand the phenomenon known as systemic racism. CRT invites us to critically our examine policies, practices, assessment, curriculum, courses, pedagogy, and traditions.

This article is an excerpt from my book: Johnson, A. (2022). Essential Learning theories: The human dimension. Lanham, MD: Rowman and Littlefield.

Polyesters With Main And Side Chain Phosphoesters As Structural Motives For Biocompatible Electrospun Fibres, André E. Polloni, Viviane Chiaradia, Ronaldo José F.C. Do Amaral, Cathal Kearney, Brian Gorey, Débora De Oliveira, José V. De Oliveira, Pedro H.H. De Araújo, Claudia Sayer, Andreas Heise

Articles

Phosphoester containing polymers are promising materials in biomedical applications due to their biocompatibility and biodegradability. Utilising thiol-ene chemistry, the synthesis of two novel structural polymer motives combining polyesters and phophoester groups was explored. The first polymer was obtained by coupling ene-functional poly(thioether-phosphoester) with thiol functional poly(pentadecalactone). While the coupling reaction was successful, yields remained low presumably due to inadequate endgroup stoichiometry. The second polymer comprised phosphoester side groups conjugated to unsaturated poly(globalide). Double bond conversions up to 84% were achieved depending of the type of phosphoester thiol and relative reactant ratios. The resulting polymers transitioned from solid semicrystaline to liquid …

Novel Coumarin-Thiadiazole Hybrids And Their Cu(Ii) And Zn(Ii) Complexes As Potential Antimicrobial Agents And Acetylcholinesterase Inhibitors, Dariusz Karcz, Karolina Starzak, Ewa Ciszkowicz, Katarzyna Lecka-Szlachta, Daniel Kaminski, Bernadette Creaven, Hollie Jenkins, Piotr Radomski, Anna Miło´S, Lidia Slusarczyk, Arkadiusz Matwijczuk

Articles

A series of coumarin-thiadiazole hybrids and their corresponding Cu(II) and Zn(II) complexes were synthesized and characterized with the use of spectroscopic techniques. The results obtained indicate that all the coumarin-thiadiazole hybrids act as bidentate chelators of Cu(II) and Zn(II) ions. The complexes isolated differ in their ligand:metal ratio depending on the central metal. In most cases, the Zn(II) complexes are characteristic of a 1:1 ligand:metal ratio, while in the Cu(II) complexes the ligand:metal ratio is 2:1. All compounds were tested as potential antibacterial agents against Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacterial strains demonstrating activities …

Uni Football 2021 Season Guide, University Of Northern Iowa

Athletics Media Guides

Contents:

Coaches --- 5
2021 Spring Review --- 11
2021 Outlook --- 15
Key Returners --- 25
Roster --- 29
Records --- 41
Destined for the Big Screen --- 49

Physiological Stability During Oral Feeding In Preterm Infants: Associations With Feeding Behaviors And Cues, Cindy M. Lund

Graduate Research Theses & Dissertations

The purpose of this study was to examine the relationship between measures of physiological stability/instability during feeding. An additional aim was to determine if behaviors associated with physiological stability were also perceived as readiness or stress cues. Participants included 5 preterm infants (<37 weeks gestation) with no craniofacial anomalies. Infants were videotaped when they were taking at least 90% of prescribed volume. This study analyzed the common behaviors seen in preterm infants during bottle feeding to determine if there were associations with measures of physiological stability. Behaviors were also analyzed to determine which were perceived as indicating stress or readiness to feed by novice observers. Coding was conducted offline using Noldus Observer software.

Results revealed a statistically significant relationship between behaviors classified as stress cues and HR instability. There was not a significant association between stress cues and RR or SPO2. Binomial testing identified specific preterm infant feeding behaviors that were more often classified as stress cues, with significance noted in audible swallow and vocalization. Several of the specific preterm …

Weatherford: Undergraduate Catalog 2021-2022, Southwestern Oklahoma State University

Undergraduate Catalogs

SWOSU presents the 2021-2022 Undergraduate Catalog for the Weatherford campus!

Structure And Activity Of A Selective Antibiofilm Peptide Sk-24 Derived From The Nmr Structure Of Human Cathelicidin Ll-37, Yingxia Zhang, Jayaram Lakshmaiah Narayana, Qianhui Wu, Xiangli Dang, Guangshun Wang

Journal Articles: Pathology and Microbiology

The deployment of the innate immune system in humans is essential to protect us from infection. Human cathelicidin LL-37 is a linear host defense peptide with both antimicrobial and immune modulatory properties. Despite years of studies of numerous peptides, SK-24, corresponding to the long hydrophobic domain (residues 9–32) in the anionic lipid-bound NMR structure of LL-37, has not been investigated. This study reports the structure and activity of SK-24. Interestingly, SK-24 is entirely helical (~100%) in phosphate buffer (PBS), more than LL-37 (84%), GI-20 (75%), and GF-17 (33%), while RI-10 and 17BIPHE2 are essentially randomly coiled (helix%: 7–10%). These results …

Current State Of Breast Cancer Diagnosis, Treatment, And Theranostics, Arya Bhushan, Andrea Gonsalves, Jyothi Menon

Biomedical and Pharmaceutical Sciences Faculty Publications

Breast cancer is one of the leading causes of cancer-related morbidity and mortality in women worldwide. Early diagnosis and effective treatment of all types of cancers are crucial for a positive prognosis. Patients with small tumor sizes at the time of their diagnosis have a significantly higher survival rate and a significantly reduced probability of the cancer being fatal. Therefore, many novel technologies are being developed for early detection of primary tumors, as well as distant metastases and recurrent disease, for effective breast cancer management. Theranostics has emerged as a new paradigm for the simultaneous diagnosis, imaging, and treatment of …

Neuroendocrine Response To Exogenous Ghrelin Administration, Combined With Alcohol, In Heavy-Drinking Individuals: Findings From A Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study, Mehdi Farokhnia, Kelly M. Abshire, Aaron Hammer, Sara L. Deschaine, Anitha Saravanakumar, Enoch Cobbina, Zhi-Bing You, Carolina L. Haass-Koffler, Mary R. Lee, Fatemeh Akhlaghi, Lorenzo Leggio

Biomedical and Pharmaceutical Sciences Faculty Publications

Background: Accumulating evidence has established a role for the orexigenic hormone ghrelin in alcohol-seeking behaviors. Accordingly, the ghrelin system may represent a potential pharmacotherapeutic target for alcohol use disorder. Ghrelin modulates several neuroendocrine pathways, such as appetitive, metabolic, and stress-related hormones, which are particularly relevant in the context of alcohol use. The goal of the present study was to provide a comprehensive assessment of neuroendocrine response to exogenous ghrelin administration, combined with alcohol, in heavy-drinking individuals.

Methods: This was a randomized, crossover, double-blind, placebo-controlled human laboratory study, which included 2 experimental alcohol administration paradigms: i.v. alcohol self-administration and i.v. alcohol …

Vaccine Delivery Alerts Innate Immune Systems For More Immunogenic Vaccination, Zhoufan Li, Yan Cao, Yibo Li, Yiwen Zhao, Xinyuan Chen

Biomedical and Pharmaceutical Sciences Faculty Publications

Vaccine delivery technologies are mainly designed to minimally invasively deliver vaccines to target tissues with little or no adjuvant effects. This study presents a prototype laser-based powder delivery (LPD) with inherent adjuvant effects for more immunogenic vaccination without incorporation of external adjuvants. LPD takes advantage of aesthetic ablative fractional laser to generate skin microchannels to support high-efficient vaccine delivery and at the same time creates photothermal stress in microchannel-surrounding tissues to boost vaccination. LPD could significantly enhance pandemic influenza 2009 H1N1 vaccine immunogenicity and protective efficacy as compared with needle-based intradermal delivery in murine models. The ablative fractional laser was …

Cytochrome P450 Enzyme Inhibition And Herb-Drug Interaction Potential Of Medicinal Plant Extracts Used For Management Of Diabetes In Nigeria, Ogochukwu Amaeze, Heather Eng, Lauren Horlbogen, Manthena V.S. Varma, Angela Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

Background and Objective

The use of herbal medicines is common in Africa, and patients often use a combination of herbs and drugs. Concurrent herbal and pharmaceuticals treatments can cause adverse effects through herb-drug interactions (HDI). This study evaluated the potential risk of HDI for five medicinal plants, Vernonia amygdalina, Ocimum gratissimum, Moringa oleifera, Azadirachta indica, and Picralima nitida, using in vitro assays. Patients with diabetes and some other disease conditions commonly use these medicinal plants in Nigeria, and little is known regarding their potential for drug interaction, despite their enormous use.

Methods

Crude extracts of the medicinal plants were …

Market Efficiency: Its Economic And Theological Implications, Fan Fei

Faculty Tenure Papers

In finance, market efficiency, or equivalently, the Efficient Market Hypothesis, assumes that the market can transmit information completely, instantly, and freely so that asset prices reflect the fair value of the investment. An efficient market would imply that the prices were always right and that no group of investors should be able to consistently beat the market. In this article, I review the evolution of modern finance and the evidence for and against the Efficient Market Hypothesis. Decades of empirical research and historical events, such as dot-com bubble and the 2007-2008 Global Financial Crisis, resulted in a paradigm shift and …

The Trajectory Of Male Homosexuality In Nazism, Goral Bhatt

Master's Theses and Doctoral Dissertations

Nazism redefined gender and sexual politics for society during the twentieth century, which determined the trajectory of male homosexuality under the Third Reich. While the party did not actively promote homosexuality, early Nazism valued hypermasculinity and homosocial relationships. Right-wing veterans of the First World War were attracted to the Nazi paramilitary unit, Sturmabteilung (SA), led by Ernst Röhm, a well-known gay man. The SA leaders promoted close male bonds among the members, which led to homoerotic relationships. If homoerotism was permitted within the early Nazi Party, why was there a steady decline in the treatment of gay men under the …

Targeted Internet Adoption In Georgetown County, South Carolina, Noor Zalloum

Goal 3: Good Health and Well-Being

No abstract provided.

West Mesa Murders Informational Website, Olivia Jackman, Lauren Hunter

Spectrum

No abstract provided.

Beyond Calculation: A Review Of Robert J. Sawyer’S Calculating God, Jeff Lindsay

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

In an entertaining and provocative science fiction novel, Calculating God, Robert J. Sawyer presents us with a likable alien scientist visiting earth to obtain more data about God’s ongoing work of creation. The alien is astounded that a human scientist does not believe in God despite the obvious evidence. Sawyer’s work introduces a variety of reasonable scientific arguments for the existence of God in a series of cleverly conceived dialogs and uses dramatic events to develop some perspectives on God. Sawyer’s purpose is not to evangelize, and the troubling concept of an utterly impersonal God who emerges in Sawyer’s interplay …

Diversifying Participation: The Rarity Of Reporting Racial Demographics In Neuroimaging Research, Madeline Goldfarb

Pitzer Senior Theses

Background: Functional neuroimaging techniques have been instrumental to progress in the cognitive and behavioral sciences; however, their increasing prevalence has evoked conversations concerning limitations associated with reproducibility and bias (Gilmore et al., 2017). While the literature has explored several mechanisms driving issues of replicability, few discussions have considered the effects of confounding social and environmental variables such as age, sex, socioeconomic status, and race (Sauce & Matzel, 2013). The prevailing racial, cultural, and socioeconomic bias in scientific research and the methodological limitations of EEG perpetuate racial and ethnic homogeneity in participation, eliciting qualms regarding the generalizability of findings (Henrich et …

If God Does Not Exist, Is Everything Permitted?, Daniel C. Peterson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Can people be good without believing in God? Obviously, yes. They can. Is atheistic naturalism capable of supplying a foundation for morality? That is a separate question, to which more than a few theists have answered No. However, a relatively new book by a very prominent student of religion and society suggests otherwise. A rational morality can, it argues, be founded upon atheistic naturalism — but it will necessarily be a modest and quite limited one, lacking universal scope and without a belief in human rights as objective “moral facts.”

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.

Where Does The Music Come From? Musical Meaning And Musical Discourse In Ingmar Bergman's Films, Per F. Broman

College of Musical Arts Faculty Publications

In his last major radio appearance, in 2004 on the Swedish talk show Sommar, Ingmar Bergman devoted most of the time to his musical interests, highlighting his belief that music transcends language and manifests a deeply philosophical vision of life and beyond: music is a gift—a divine one, although Bergman did not mention God—given to provide hints of realities beyond our perception. Through analyses of the films and manuscript materials in the Ingmar Bergman Archives, this chapter focuses on four instances of interaction between music and dialogue in Bergman’s films that resonate with his comments in the show: music is …

2021 Spring And Winter - Schedule Of Classes, Office Of The Registrar, East Tennessee State University

Registration Resources

No abstract provided.

2021 - Etsu Fact Book, Institutional Research, East Tennessee State University

ETSU Fact Books

No abstract provided.

A Comprehensive Study Of Comorbidities And Treatments Including Tnf-⍺ Inhibitors In Patients With Acute Scleritis, Ahmad Abdel-Aty

Yale Medicine Thesis Digital Library

Scleritis is a highly symptomatic inflammatory disease of the sclera. We conducted a retrospective study to identify demographic factors and comorbidities associated with resolution of scleritis, to compare patient outcomes on different treatments for scleritis, and to compare treatment utilization by the different medical specialties that manage scleritis. The medical records of all patients with a CPT code for scleritis seen at a tertiary care center from January 1, 2013 to January 1, 2020 were reviewed. Data was collected on demographic factors, comorbidities, and treatment. The primary outcome measures were time until resolution of disease, defined as quiescence of inflammation …

Characteristics, Motivations, And Experiences Of Women Using Nitrous Oxide During Childbirth, Gwendolyn Towers

Yale Medicine Thesis Digital Library

CHARACTERISTICS, MOTIVATIONS, AND EXPERIENCES OF WOMEN USING NITROUS OXIDE IN CHILDBIRTH

Gwendolyn Towers, Michelle Telfer, Jessica L. Illuzzi. Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT

Nitrous oxide labor analgesia is growing in popularity in the United States, with little known regarding the factors driving this trend or about women’s experiences with the method. This study, which includes both a quantitative and a qualitative component, contributes to our understanding of the use of nitrous oxide labor analgesia in the US by exploring the following: (1) who uses the method and how these women …

The Future Of Global Interventional Radiology, Austin-Marley Windham-Herman

Yale Medicine Thesis Digital Library

Interventional Radiology (IR) has become an integral component of modern, developed healthcare systems. The minimally invasive, image-guided procedures that the field offers are highly effective and often lead to significantly less morbidity than alternative surgical options. The growth of IR globally is in an early phase; however, patients and healthcare systems stand to benefit from its rapid expansion and integration around the world.

Globally, billions of people are without access to safe surgery and diagnostic imaging. However, the democratization of radiology resources such as portable ultrasound and low-cost medical devices is making IR more accessible than ever before. Global healthcare …

2021-2022 - Quillen College Of Medicine Operating Budget (October), Budget And Financial Planning, East Tennessee State University

College of Medicine Operating Budgets and Analysis

No abstract provided.