Digital Commons Network^™

Relation Between Epithelial-Mesenchymal Transition And Colorectal Cancer Prognosis: Impact Of Smad4 And Β-Catenin Markers, Mona Emile, Dina Ibrahim, Amr El-Karef, Ibrahim Eldosoky, Mohammed Awad

Mansoura Medical Journal

Colorectal cancer (CRC) is one of the most prevalent and deadly neoplasms. It develops through several molecular pathways and varies in clinical presentation and patient prognosis. The prognosis of CRC is influenced by variable pathologic and molecular variables. Understanding the molecular basis that promote CRC progression, invasive and metastatic features, is important for establishing effective CRC therapeutic strategies. Epithelial mesenchymal transition (EMT) is regarded to be key hallmark of CRC carcinogenesis, providing metastatic capacities to cancer cells by promoting motility and invasion. During this process, epithelial markers such as E-cadherin are down-regulated, whereas mesenchymal markers such as Vimentin are up-regulated. …

Clinical Scoring For Early Detection Of Prediabetes In Egyptian Population, Ahmed Abdel-Hamid, Enas Elkhamisy, Megahed Abo Elmagd

Mansoura Medical Journal

Background: Prediabetes is a wide spread condition where blood glucose is above normal, but it does not measure up to the criteria of diabetes mellitus. Yet there is no national scoring system for prediabetes according to the potential risk factors. Methods: A case-control study has been carried out in Mansoura Specialized Hospital. Subjects have been recruited from out-patients clinic in the period from October 2018 to August 2019. Those with prediabetes had been assigned to be the case group whereas control subjects were those who had a normal HbA1C. A scoring system was based on risk factors of prediabetes by …

Non-Resectional Procedures As Treatment Options For Hemorrhoidal Disease., Esraa Daif, Hossam Elfeki, Ashraf Shoma

Mansoura Medical Journal

Hemorrhoids have been recorded through hundreds of years of history. It is a very common condition affecting millions of people around the world every year with an estimated prevalence of 4.4% of the population in the United States. Hemorrhoids are defined as the pathological enlargement and downward displacement of the anal cushions. The risk factors of this condition include a low-fiber diet, constipation, and prolonged straining. It is clinically manifested by painless bleeding with the bowel movement with or without prolapse. Other symptoms like pain or pruritus that affect the patients’ quality of life. Hemorrhoids can be managed by multiple …

Recent Updates In Management Of Borderline Ovarian Tumors, Sara Abodabesh, Khalid Gaballah, Ashraf Shoma

Mansoura Medical Journal

Borderline ovarian tumors(BOTs) are the epithelial neoplasm which need to be differentiated from ovarian carcinomas as their presentation and management differs from each other. The important differentiating feature on histopathological examination is the absence of stromal invasion. Considering the degree of aggressiveness between epithelial ovarian carcinoma and benign ovarian neoplasms like cystadenoma, borderline neoplasms are closer to benign ovarian neoplasms as regards the clinical behavior. Surgery with intention of removal of all visible tumors is the most important pillar in treatment. Patients treated conservatively with fertility sparing surgery and good results with laparoscopic surgery has low recurrence rate which makes …

Reconstruction Of Glossectomy Defects Post Oncologic Resection, Sara Elbaz, Shadi Awny, Ashraf Shoma

Mansoura Medical Journal

The tongue is a muscular organ completely covered by mucous membrane and made up of two portions divided by the V-shaped sulcus terminalis: an anterior 2/3 (oral tongue) and a posterior 1/3 (tongue base). The tongue is essential to normal speech as well as swallowing process, and healthy tongue function is vital within the general quality of life. Tongue cancers are aggressive tumors with poor prognosis, so the early detection markedly raises the possibility of cure with minimal impairment and deformity. Management needs a surgical, medical and radiation oncologist in association with speech therapist, physical rehabilitation, and psychologists. In addition …

Searching For Imaging Biomarkers Of Psychotic Dysconnectivity, Amanda L. Rodrigue, Dana Mastrovito, Oscar Esteban, Joke Durnez, Marinka M. G. Koenis, Ronald Janssen, Aaron Alexander-Bloch, Emma M. Knowles, Samuel R. Mathias, John Blangero

School of Medicine Publications

Background: Progress in precision psychiatry is predicated on identifying reliable individual-level diagnostic biomarkers. For psychosis, measures of structural and functional connectivity could be promising biomarkers given consistent reports of dysconnectivity across psychotic disorders using magnetic resonance imaging.

Methods: We leveraged data from four independent cohorts of patients with psychosis and control subjects with observations from approximately 800 individuals. We used group-level analyses and two supervised machine learning algorithms (support vector machines and ridge regression) to test within-, between-, and across-sample classification performance of white matter and resting-state connectivity metrics.

Results: Although we replicated group-level differences in brain connectivity, individual-level classification …

Reassessing Associations Between White Matter And Behaviour With Multimodal Microstructural Imaging, Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Olof Jens Van Der Werf, Ainslie Johnstone, Zeena-Britt Sanders, Cassandra Sampaio-Baptista, Nicole Eichert, Anderson M. Winkler

School of Medicine Publications

Several studies have established specific relationships between White Matter (WM) and behaviour. However, these studies have typically focussed on fractional anisotropy (FA), a neuroimaging metric that is sensitive to multiple tissue properties, making it difficult to identify what biological aspects of WM may drive such relationships. Here, we carry out a pre-registered assessment of WM-behaviour relationships in 50 healthy individuals across multiple behavioural and anatomical domains, and complementing FA with myelin-sensitive quantitative MR modalities (MT, R1, R2∗).

Surprisingly, we only find support for predicted relationships between FA and behaviour in one of three pre-registered tests. For one behavioural domain, …

Neuroimaging Association Scores: Reliability And Validity Of Aggregate Measures Of Brain Structural Features Linked To Mental Disorders In Youth, Luiza Kvitko Axelrud, André Rafael Simioni, Daniel Samuel Pine, Anderson M. Winkler, Pedro Mario Pan, João Ricardo Sato, André Zugman, Nadine Parker, Felipe Picon, Andrea Jackowski

School of Medicine Publications

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS …

Anterior-Posterior Axis Of Hippocampal Subfields Across Psychoses: A B-Snip Study, Elisabetta C. Del Re, Victor Zeng, Ney Alliey-Rodriguez, Paulo Lizano, Nicolas Bolo

School of Medicine Publications

Background: The hippocampus (HP) is affected across psychoses, including schizophrenia (SZ), bipolar type 1 (BDP) and schizoaffective (SAD) disorders. We examined HP subfield volumetric abnormalities along the anterior-posterior (ventral-dorsal) axis of the HP in psychosis probands, defined by traditional (DSM) diagnoses and biologically defined subtypes (biotypes, based on cognition and electrophysiology). We hypothesized that biotypes would be better discriminated by HP longitudinal axis subfields abnormalities than DSM. Methods: The sample included 455 probands from the Bipolar Schizophrenia Network for intermediate Phenotypes (BSNIP) dataset (age 35 ± 12.0): 124 unaffected (age 40.4 ± 15.8) and 299 healthy controls (HC; 37 ± …

Clinical Predictors Of Non-Response To Lithium Treatment In The Pharmacogenomics Of Bipolar Disorder (Pgbd) Study, Yian Lin, Adam X. Maihofer, Emma Stapp, Megan Ritchey, Ney Alliey Rodriguez

School of Medicine Publications

Background: Lithium is regarded as a first-line treatment for bipolar disorder (BD), but partial response and non-response commonly occurs. There exists a need to identify lithium non-responders prior to initiating treatment. The Pharmacogenomics of Bipolar Disorder (PGBD) Study was designed to identify predictors of lithium response.

Methods: The PGBD Study was an eleven site prospective trial of lithium treatment in bipolar I disorder. Subjects were stabilized on lithium monotherapy over 4 months and gradually discontinued from all other psychotropic medications. After ensuring a sustained clinical remission (defined by a score of ≤3 on the CGI for 4 weeks) had been …

Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura M. Moy

Georgetown Law Faculty Publications and Other Works

Does law enforcement use of face recognition technology paired with eyewitness identifications increase the incidence of wrongful convictions in U.S. criminal law? This Article explores this critical question and posits that the answer may be yes. Facial recognition is frequently used by law enforcement agencies to help generate investigative leads that are then presented to eyewitnesses for positive identification. But erroneous eyewitness accounts are the number one cause of wrongful convictions, and the use of face recognition to generate investigative leads may create the conditions for erroneous eyewitness identifications to take place. This is because face recognition technology is designed …

Augmentation Of Pedicle Screws Using Bone Grafting In Patients With Spinal Osteoporosis, Andrey Evgenievich Bokov, Anatoliy Bulkin, I S. Bratsev, Svetlana Ya Kalinina, Sergey G. Mlyavykh, David G. Anderson

Department of Neurosurgery Faculty Papers

The aim of the study was to develop a new method of vertebral augmentation based on autologous and allogeneic bone chips to be used in pedicle screw fixation and to compare this method with the technique based on polymethyl methacrylate (PMMA). Materials and Methods. This prospective non-randomized study included 164 patients with degenerative pathologies or traumatic injuries of the lumbar spine and transitional thoracolumbar segments; 153 of the operated patients were followed up for 18 months. In these patients, radiodensity of the cancellous bone tissue was below 110 HU by the Hounsfield scale. Patients with degenerative spinal disorders underwent pedicle …

Relative Success Of Native Plants In Curb Cut Rain Gardens, Ana Singh, Rachel Warners, Jonathan Walt, Patrick Jonker, David P. Warners

Faculty and Professional Research

No abstract provided.

English-To-Ipa Transcription, Riley Roberts

Undergraduate Honors Capstone Projects

The purpose of this project was to create a tool that could automate English-to-IPA (International Phonetic Alphabet) transcription. Research was done to determine what would be required to perform such a transcription. After researching and experimenting with existing tools, it was determined that developing the signal processing and Artificial Intelligence model portion of the application would be too intensive to successfully complete within the timeframe of this project.

The choice was made to develop an iOS application, with the Python library Allosaurus used to do the speech processing and as the Artificial Intelligence model. This model was then deployed in …

The Relationship Between Mindfulness, Social Anxiety Traits, And Emotions, Maria Jackeline Diaz

Theses and Dissertations

The relationship between mindfulness, social anxiety traits, and emotion processing is the first study of its kind to be looked over. In this study we will assess similarities and differences, plus how they work together to provide further research and understanding of these complexities when combined. Such research can be helpful in making us understand our emotions, as well as how our emotions can be perceived in social functioning and communication.

Assessment And Monitoring Of Deltaic Wetlands And Fluvial Systems: Refining And Validating A Multimetric Index Of Resaca Ecosystem Health, David Lecusay Jr.

Theses and Dissertations

Resacas are ancient distributary channels of the lower Rio Grande River historically serving as floodwater drainage pathways onto the Laguna Madre, Texas. Resacas provide numerous ecosystem services and critical habitat for many species. Mainly influenced by urbanization, integrating a multimetric index for assessing and monitoring resaca ecosystem health is required for adaptive management. The Resaca Health Index (RHI) integrates structural and functional components: (1) nonredundant metrics describing fish communities (Fish Community Index); (2) Trophic State Index derived from Secchi depth; (3) decay constant from riparian vegetation leaf litter decomposing in the water column; and (4) a riparian quality index based …

Total Synthesis Of E Stereoisomers Of Bilirubin Oxidation Products, Tess C. Ruiz

Theses and Dissertations

The purpose of the research was to synthesize the E stereoisomer of Bilirubin Oxidation Products that had not been synthesized through a total organic synthesis at the start of this project. There were numerous different procedures for the bromination of citraconic anhydride performed in an attempt to optimize yield and purity. A proposed scheme for the total synthesis of the E isomers was constantly updated and altered while the project was ongoing. The bioactivity of the compounds was to be tested if the project had been finished. This might have contributed to a greater understanding of their function and association …

Resiliency Of Utah's Road Network: A Logit-Based Approach, Max Evan Barnes

Theses and Dissertations

The Utah Department of Transportation (UDOT) manages and maintains a complex state-wide network of highways. Recent incidents such as the collapse of the I-35W bridge in Min- neapolis, Minnesota, and the I-85/Piedmont Road fire and subsequent bridge collapse in Atlanta, Georgia, have brought identification of transportation network vulnerabilities to the forefront of UDOT’s planning efforts. Traditional estimates of transportation network impacts have focused on increases to user travel time or the volume of affected traffic, but studies of these disasters have revealed that when facing a degraded transportation network, people adjust their trip making in terms of destination, mode, and …

Action Leveraging Evidence To Reduce Perinatal Mortality And Morbidity (Alert): Study Protocol For A Stepped-Wedge Cluster-Randomised Trial In Benin, Malawi, Tanzania And Uganda, Joseph Akuze, Kristi Sidney Annerstedt, Lenka Benova, Effie Chipeta, Jean-Paul Dossou, Mechthild M. Gross, Hussein Kidanto, Bruno Marchal, Helle Mölsted Alvesson, Andrea B. Pembe

Obstetrics and Gynaecology, East Africa

Background: Insufficient reductions in maternal and neonatal deaths and stillbirths in the past decade are a deterrence to achieving the Sustainable Development Goal 3. The majority of deaths occur during the intrapartum and immediate postnatal period. Overcoming the knowledge-do-gap to ensure implementation of known evidence-based interventions during this period has the potential to avert at least 2.5 million deaths in mothers and their offspring annually. This paper describes a study protocol for implementing and evaluating a multi-faceted health care system intervention to strengthen the implementation of evidence-based interventions and responsive care during this crucial period.

Methods: This is a cluster …

Using Fuzzy Clustering To Detect The Tumor Area In Stomach Medical Images, Ekhlas Falih Naser, Suhiar Mohammed Zeki

Baghdad Science Journal

Although the number of stomach tumor patients reduced obviously during last decades in western countries, but this illness is still one of the main causes of death in developing countries. The aim of this research is to detect the area of a tumor in a stomach images based on fuzzy clustering. The proposed methodology consists of three stages. The stomach images are divided into four quarters and then features elicited from each quarter in the first stage by utilizing seven moments invariant. Fuzzy C-Mean clustering (FCM) was employed in the second stage for each quarter to collect the features of …

2021 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2021.

The Model Of Development Of Precarious Practices During Covid-19 Pandemic: Society, Religion, And Individual, Оlena Honcharova, Valentyna Kuryliak

Occasional Papers on Religion in Eastern Europe

The article examines the phenomenon of precariousness and its development in the context of the COVID-19 pandemic. It is postulated that precariousness is a process of instability, which primarily affects the working class and destabilizes social relations at all levels, including the level of personal relationships. The human way of life has been shifted as a result of the epidemiological situation in the world caused by the COVID-19 infection. This process can be observed in the spheres of employment, medicine, religion, family, leisure activities, etc. Against the background of social turbulence, the processes of precariousness began to develop, which worsen …

Report And Recommendations To Address Race In Washington’S Juvenile Legal System: 2021 Report To The Washington Supreme Court, Task Force 2.0: Race And The Criminal Justice System

Fred T. Korematsu Center for Law and Equality

Report and Recommendations to Address Race in Washington’s Juvenile Legal System: 2021 Report to the Washington Supreme Court

Young And Dangerous: The Role Of Youth In Risk Assessment Instruments, Ingrid Yin

Michigan Law Review

States are increasingly adopting risk assessment instruments (RAIs) to help judges determine the appropriate type and length of punishment for an offender. Although this sentencing practice has been met with a wide variety of scholarly criticism, there has been virtually no discussion of how RAIs treat youth as a strong factor contributing to a high risk score. This silence is puzzling. Not only is youth undoubtedly the most powerful risk factor in most RAIs, but youth also holds a special place in the criminal justice system as a “mitigating factor of great weight.” This Comment presents the first in-depth critique …

Nmr Spectroscopy-Based Metabolomics Of Platelets To Analyze Brain Tumors, Shivanand Pudakalakatti, Alessandra Audia, Anirudh Mukhopadhyay, José S Enriquez, Dontrey Bourgeois, Nabihah Tayob, Niki M Zacharias, Steven W Millward, Daniel Carson, Mary C Farach-Carson, Frederick F Lang, Amy B Heimberger, Krishna P Bhat, Pratip K Bhattacharya

Faculty, Staff and Student Publications

"Tumor-educated platelets" have recently generated substantial interest for the diagnosis of cancer. We hypothesized that tumor educated platelets from patients with brain tumors will reflect altered metabolism compared to platelets from healthy volunteers. Here, in a pilot study, we have employed nuclear magnetic resonance (NMR) spectroscopy in platelets from brain tumor patients to demonstrate altered metabolism compared to the platelets obtained from healthy volunteers.

Autonomous Feature Detection For Capture Path Planning For Rendezvous And Docking With Non-Cooperative Spacecraft, Trupti Mahendrakar

Theses and Dissertations

With the increasing risk of collisions with space debris and the growing interest in on-orbit servicing, the ability to autonomously capture non-cooperative, tumbling target objects remains an unresolved challenge. This thesis provides an autonomous and artificial intelligence solution to either inspect, avoid, or perform on-orbit spacecraft servicing of an uncooperative resident space object (RSO). The solution is built on the fundamentals of Convolutional Neural Networks (CNN), which is used to classify the four most targeted features of a spacecraft essential for docking and collision avoidance during rendezvous, such as solar panels, antennas, spacecraft bodies, and thrusters. The solution was then …

The Effects Of A Flipped Classroom Compared To A Traditional Classroom On Students’ Mathematics Achievement And Critical Thinking Skills At Benghazi University, Tarik O. Hamed Beltaib

Theses and Dissertations

This study aimed to compare the effects of two different instructional models (flipped and traditional) on students’ mathematics achievement and critical thinking skills (CTS) at Benghazi University. This study used a quasi-experimental non-equivalent control group design involving intact classes of 80 students. The primary dependent variables were mathematics achievement and critical thinking skills, and the primary independent variable was the instructional methods. The data collection instruments consisted of several different assessments:(1) A pre-and post-test (Placement test and Final test) designed by the mathematics department (2) the California Critical Thinking Skills Test (CCTST) was administered at the beginning and end of …

Optimism And Physical Health-Related Quality Of Life In Chronic Illness: Mediating Effects Of Control Beliefs And Health Behaviors, Morgan Treaster

Electronic Theses and Dissertations

Among persons living with, or recovering from, chronic illness, poor physical health-related quality of life is a concern, as current and residual illness symptoms and treatment side effects may deleteriously impact physical functioning and fulfillment of daily roles. Numerous cognitive, emotional, and behavioral factors may impact perceptions of health status. Optimism, for example, is conceptualized as belief in the occurrence of positive future outcomes, and is beneficially associated with physical health-related quality of life. Further, optimism may contribute to enhanced perceptions of control and efficacy over disease symptoms and general health, manifesting as proactive health behaviors (e.g., wellness behaviors; treatment …

Remixed, Remastered: Investigating Organizational Adaptation In Higher Music Education, Jacob Bruce Hertzog

Graduate Theses and Dissertations

Higher music education presents a unique opportunity to examine change within higher education due to the digital revolution in the music industry over the past two decades. The purpose for conducting this study was to describe, map, and explain the strategies that higher music education programs are using to adapt to the digital revolution in the music industry. This study was grounded in organizational adaptation theory, drawing upon nine well-established theories: population ecology, life cycles, strategic choice, isomorphism, symbolic action, resource dependence, cybernetics, and network theory. Critical concepts of the turbulent environment, environmental perception, and organizational adaptation strategy emerged from …

Queering The Metanarrative Of Domesticity: Chosen Families In Late Nineteenth- Century American Women's Literature, Sharla Rosenbaum

Graduate Theses and Dissertations

My primary purpose in this project is to dispel the notion that the white, bourgeois, patriarchal, nuclear family believed by millions of US citizens to have once monopolized the United States’s cultural landscape through an examination of how women authors in the United States constructed families in literature immediately following the Civil War. Not only do the novels under examination reflect diverse representations of families, but they also reflect those images from diverse perspectives. I will use a Marxist lens to explore class and ideologic interpellation; a renegade global feminist lens to explore failure and differential consciousness; a queer and …