Digital Commons Network^™

Relating Spontaneous Activity And Cognitive States Via Neurodynamic Modeling, Matthew Singh

Arts & Sciences Graduate Student Theses and Dissertations

Stimulus-free brain dynamics form the basis of current knowledge concerning functional integration and segregation within the human brain. These relationships are typically described in terms of resting-state brain networks—regions which spontaneously coactivate. However, despite the interest in the anatomical mechanisms and biobehavioral correlates of stimulus-free brain dynamics, little is known regarding the relation between spontaneous brain dynamics and task-evoked activity. In particular, no computational framework has been previously proposed to unite spontaneous and task dynamics under a single, data-driven model. Model development in this domain will provide new insight regarding the mechanisms by which exogeneous stimuli and intrinsic neural circuitry …

Understanding The Roles Of Dna Methylation And Mecp2 In Neuronal Enhancer Control, Adam Clemens

Arts & Sciences Graduate Student Theses and Dissertations

The development of organisms relies on complex spatial and temporal patterning of gene expression to define cell types and facilitate their functions. Cis-regulatory elements in our genome are responsible for the control of gene expression across tissues and cell types. Regulation of these elements themselves depends on a balance of activation and repression through epigenetic modifications and molecular regulatory components. Disruption of cis-regulatory element control is emerging as a cause of neurodevelopmental disease. An important contributor to gene regulation in development is methylation of cytosine in DNA, disruption of which has been associated with disease. Notably, while all cell types …

Targeting The Phgdh-Mtor Metabolic Axis In Osteosarcoma, Richa Rathore

Arts & Sciences Graduate Student Theses and Dissertations

Altering cellular energy metabolism has been highlighted as one of the emerging hallmarks of cancer. The reprogramming of bioenergetic pathways towards enhanced glycolysis, rather than the mitochondrial oxidative phosphorylation indicative of normal cells, results in increased biomass production and is associated with the activation of various oncogenes. The increased or decreased expression of key metabolic enzymes has been identified as a potential family of biomarkers that could serve as the targets for novel metabolic-based therapies in cancer.The serine, glycine, and one-carbon (SGOC) metabolism pathway consists of a series of enzymes and metabolites that drive protein and lipid production, enhanced DNA …

Modularity Of Feedback For State-Dependent Guidance Of Navigation In Mouse Visual Cortex, Andrew M. Meier

Arts & Sciences Graduate Student Theses and Dissertations

Navigating through unpredictable environments requires an efficiently organized sensory system capable of adapting to behavioral demands. In the mammalian visual system, two adaptations which have arisen to meet these demands are parallel processing and top-down feedback of internally generated expectations and contextual information for adjusting responses to match the needs of the current behavioral task. Mouse visual cortex exhibits the latter of these organizing principles, like other mammals, in the form of a molecular layer (Layer 1) which receives feedback to contextually adapt sensory responses from the outside world. The first of these organizing principles, parallel processing streams, generally takes …

The Roles Of Plasmepsins Ix And X In Malaria Parasite Biology, Armiyaw Sebastian Nasamu

Arts & Sciences Graduate Student Theses and Dissertations

Proteases of the malaria parasite Plasmodium falciparum have been targeted for drug discovery for decades. The P. falciparum genome encodes ten aspartic proteases called plasmepsins, which are involved in diverse cellular processes. In this work we address the roles of two of these plasmepsins, plasmepsins IX and X (PM IX and X), the two least studied aspartic proteases in blood stage malaria parasites till date. We explore the essentiality of these proteases in parasite development, attempt to identify their substrates and the ability to drug them. We show that PM IX is essential for erythrocyte invasion, acting on rhoptry secretory …

Adaptation To Water‐Poor Conditions: An Experimental Study With Buchloe Dactyloides, X. L. Sun, J. Z. Niu, He Zhou

IGC Proceedings (1977-2023)

No abstract provided.

Pasture Management Strategies To Support Sustainable Production Of Dual Purpose Farms In Western Venezuela, Dario Osechas, Ligia Becerra

IGC Proceedings (1977-2023)

No abstract provided.

Traditional Uses Of Wild Grasses Amongst Three Kenyan Farming Communities, N. M. Nganga, F. N. Muyekho, Z. R. Khan, R. S. Copeland

IGC Proceedings (1977-2023)

No abstract provided.

January Agenda, Wku Graduate Council

Graduate School

Meeting agenda. Includes minutes of November 12th meeting; Graduate Council curriculum report tracking; Student Research Grant requests; graduate enrollment report; thesis, and special project & dissertation guidelines.

Volume 9, Issue 2, Fall/Winter 2020/21, Stacy Creel Ph.D., Teresa S. Welsh Ph.D.

SLIS Connecting

SLIS Connecting refereed open-access e-journal, Volume 9, Issue 2 (Fall/Winter 2020/21)

Exploring Data Mining Research In West Africa: A Bibliometric Analysis, Oladosu O. Oladimeji, Olayanju O. Oladimeji

SLIS Connecting

This research paper's main objective is to quantify and analyze the research output of data mining in West Africa, including (1) growth in publications as measured by the Relative Growth Rate (RGR) and Doubling Time (Dt), (2) productivity and quantification of research output for different institutions of the region (West Africa).

Restriction Of Placing Certain Single-Use Plastic Products On The Hungarian Market, Anita Boros

Journal of Environmental Sustainability

One of the means of rationalizing Hungarian waste management -in the context of the waste hierarchy- is to increase the rate of waste recycling and reprocessing. Although the Hungarian plastics industry is a very dynamically developing area, the Hungarian legislator has also recognized that the use of certain products is extremely harmful in the long run. Accordingly, stricter measures than the EU directive have been taken and accordingly a number of single-use plastic products from July 2021 are to be banned. In addition, in the case of plastic carrier bags, economic tools have been developed and further improved, which, according …

Dames Paving Pathways To Directorships. A Study About Female Leaders In Art Museums In The United States, Mechele Manno

Dissertations

Purpose: The purpose of this qualitative phenomenological study was to examine and describe the career pathways of female art museum directors in the United States

Methodology: This phenomenological study described lived experiences of eight female art museum directors with over five years of directorship experience from museums with operating budgets over $10 million and in states that receive the highest private funding: CA, DC, IL, MA, NY, OH, PA, and TX. Data collection consisted of in-depth interviews using a scripted interview guide in research categories: a) motivation; b) career advancement; c) barriers; and d) support.

Findings: All major findings were …

Lee Receives $220,000 Grant To Continue Growth Hormone, Fat Cell Research, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Experimental And Computational Observations Of Immunogenic Cobalt Porphyrin Lipid Bilayers: Nanodomain-Enhanced Antigen Association., Jasmin Federizon, Conrard Giresse Tetsassi Feugmo, Wei-Chiao Huang, Xuedan He, Kazutoyo Miura, Aida Razi, Joaquin Ortega, Mikko Karttunen, Jonathan F Lovell

Chemistry Publications

Cobalt porphyrin phospholipid (CoPoP) can incorporate within bilayers to enable non-covalent surface-display of antigens on liposomes by mixing with proteins bearing a polyhistidine tag (his-tag); however, the mechanisms for how this occurs are poorly understood. These were investigated using the his-tagged model antigen Pfs25, a protein antigen candidate for malaria transmission-blocking vaccines. Pfs25 was found to associate with the small molecule aquocobalamin, a form of vitamin B12 and a cobalt-containing corrin macrocycle, but without particle formation, enabling comparative assessment. Relative to CoPoP liposomes, binding and serum stability studies indicated a weaker association of Pfs25 to aquocobalamin or cobalt nitrilotriacetic acid …

Minutes, College Of Liberal Arts Executive Committee Meeting, Thursday, January 14, 2021, College Of Liberal Arts Executive Committee

Executive Committee Minutes

No abstract provided.

Comparison Of N- And C-Terminally Endogenously Gfp-Tagged Wee-1.3 Strains In, Lourds M Fernando, Kyrionna Golliday, Ruby Boateng, Anna K Allen

Faculty Research 2021

We have generated a WEE-1.3 strain in C. elegans where we have endogenously tagged the C-terminus with GFP. In this publication we demonstrate that this new strain exhibits the same expression localization pattern as the WEE-1.3 antibody and N-terminally endogenously GFP-tagged WEE-1.3 strain that have been previously published. We also show for the first time that endogenously tagging WEE-1.3 at either termini does not affect the reproductive function of the worms.

Hydroperiod And Salinity Interactions Control Mangrove Root Dynamics In A Karstic Oceanic Island In The Caribbean Sea (San Andres, Colombia), Jairo Humberto Medina-Calderón, José Ernesto Mancera-Pineda, Edward Castañeda-Moya, Víctor H. Rivera-Monroy

Faculty Publications

Mangroves sustain high soil accretion and carbon sequestration rates, yet it is still unknown if they can keep pace with increasing sea level rise (SLR) across a wider range of coastal geomorphic settings. Because accretion rates are controlled by mineral sediment inputs and organic matter accumulation, it is paramount to assess the relative contribution of root productivity to soil formation. Here, we evaluated root biomass, production, and turnover in three mangrove ecotypes to evaluate the role of soil nutrient limitation, stressors, and hydroperiod in controlling root dynamics in San Andres Island (SAI), a karstic oceanic island in the Caribbean Sea. …

Heroic Work, Eric F. Spina

President's Blog: From the Heart

With a lead time of just a dozen days, hundreds of University of Dayton faculty hastily moved last spring’s courses to Zoom rooms. Many had never taught online, and some found themselves helping their young children adapt to virtual classes, too. Their teaching space blurred into their living space as the pandemic turned all of our lives upside down in a blink.

Abundance, Distribution, And Growth Characteristics Of Three Keystone Vachellia Trees In Gebel Elba National Park, South-Eastern Egypt, Ahmed M. Abbas, Mohammed Al-Kahtani, Stephen J. Novak, Wagdi Saber Soliman

Biology Faculty Publications and Presentations

This study was conducted to evaluate the abundance and distribution pattern of three keystone Vachellia taxa in wadi Khoda and wadi Rahaba, Gebel Elba National Park, a protected area in south-eastern Egypt. These taxa included Vachellia tortilis subsp. tortilis, Vachellia tortilis subsp. raddiana, and Vachellia ehrenbergiana. In wadi Khoda, only two of these taxa were detected (V. tortilis subsp. raddiana and V. tortilis subsp. tortilis), while all three taxa were encountered in wadi Rahaba. The density of trees in wadi Khoda was 34.3 plant ha⁻¹ compared to 26.3 plant ha⁻¹ in …

Design Of Fibril Forming Collagen Mimetic Peptides: Heterotrimers And Nucleation Domains, Sally Tan

Theses and Dissertations

This paper attempts to design collagen mimetic peptides where the triple-helical region mimics that of human Type I Collagen. With consideration for chain selection and chain register, we utilize the NC2 domain of heterotrimeric Type IX Collagen as a nucleation domain for triple-helix folding.

Arginase 1 Insufficiency Precipitates Amyloid-Β Deposition And Hastens Behavioral Impairment In A Mouse Model Of Amyloidosis, Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Alzheimer’s disease (AD) includes several hallmarks comprised of amyloid-β (Aβ) deposition, tau neuropathology, inflammation, and memory impairment. Brain metabolism becomes uncoupled due to aging and other AD risk factors, which ultimately lead to impaired protein clearance and aggregation. Increasing evidence indicates a role of arginine metabolism in AD, where arginases are key enzymes in neurons and glia capable of depleting arginine and producing ornithine and polyamines. However, currently, it remains unknown if the reduction of arginase 1 (Arg1) in myeloid cell impacts amyloidosis. Herein, we produced haploinsufficiency of Arg1 by the hemizygous deletion in myeloid cells using Arg1 …

Biomolecules As Model Indicators Of In Vitro And In Vivo Cold Plasma Safety, Caitlin Heslin, Daniela Boehm, Julianne Megaw, Brendan F. Gilmore, Theresa A. Freeman, Noreen J. Hickok, P. J. Cullen, Paula Bourke

Department of Medicine Faculty Papers

No abstract provided.

A Bumper Crop Of Snps In Soybean Through High-Density Genotyping-By-Sequencing (Hd-Gbs), Davoud Torkamaneh, Jerome Laroche, Brian Boyle, David L. Hyten, Fancois Belzile

Department of Agronomy and Horticulture: Faculty Publications

No abstract provided.

Unm Hsc Education Day Agenda 2020-21, Gary Smith

HSC Education Days

No abstract provided.

Dispersal And Land Cover Contribute To Pseudorabies Virus Exposure In Invasive Wild Pigs, Felipe A. Hernandez, Amanda N. Carr, Michael P. Milleson, Hunter R. Merrill, Michael L. Avery, Brandon M. Parker, Cortney L. Pylant, James D. Austin, Samantha M. Wisely

United States Department of Agriculture Wildlife Services: Staff Publications

We investigated the landscape epidemiology of a globally distributed mammal, the wild pig (Sus scrofa), in Florida (U.S.), where it is considered an invasive species and reservoir to pathogens that impact the health of people, domestic animals, and wildlife. Specifically, we tested the hypothesis that two commonly cited factors in disease transmission, connectivity among populations and abundant resources, would increase the likelihood of exposure to both pseudorabies virus (PrV) and Brucella spp. (bacterial agent of brucellosis) in wild pigs across the Kissimmee Valley of Florida. Using DNA from 348 wild pigs and sera from 320 individuals at 24 sites, we …

The Effect Of National Leaders’ Profiles On Gdp Per Capita, Maha Mostafa Gaber

Theses and Dissertations

A national leader is the policy maker in a country, whose economical decisions hold the power to make a nation either prosper or collapse. Therefore, it becomes crucial to understand the official who enact these decisions. A unique dataset of over 326 world leaders from 51 countries between the period 1972 to 2018 was constructed, building on leader Experience and Attribute Descriptions Database, in order to study the differences in leaders’ characteristics and determine the most important attributes which significantly affect level of GDP per capita. This paper studies the effect of government leaders’ profiles on GDP per capita by …

Isolation And Purification Of Glycoglycerolipids To Induce Apoptosis In Breast Cancer Cells, Muhammad Raisul Abedin, Sutapa Barua

Chemical and Biochemical Engineering Faculty Research & Creative Works

Monogalactosyldiacylglycerol (MGDG) is the most abundant type of glycoglycerolipid found in the plant cell membrane and mostly in the chloroplast thylakoid membrane. The amphiphilic nature of MGDG is attractive in pharmaceutical fields for interaction with other biological molecules and hence exerting therapeutic anti-cancer, anti-viral, and anti-inflammatory activities. In this study, we investigated the therapeutic efficacy of cyanobacteria derived MGDG to inhibit breast cancer cell growth. MGDG was extracted from a cyanobacteria Synechocystis sp. PCC 6803 followed by a subsequent fractionation by column chromatographic technique. The purity and molecular structure of MGDG were analyzed by nuclear magnetic resonance (NMR) spectroscopy analysis. …

Willie Caldwell, Sr.

African American Funeral Programs

Willie_Caldwell_Sr.pdf - Funeral program for Willie Caldwell, Sr.

Multiple Trophic Markers Trace Dietary Carbon Sources In Barents Sea Zooplankton During Late Summer, Doreen Kohlbach, Haakon Hop, Anette Wold, Katrin Schmidt, Lukas Smik, Simon T. Belt, Al-Habahbeh A Keck, Matthias Woll, Martin Graeve, Anna Maria Dąbrowska, Agnieszka Tatarek, Angus Atkinson, Philipp Assmy

School of Geography, Earth and Environmental Sciences

We investigated diets of 24 Barents Sea zooplankton taxa to understand pelagic food-web processes during late summer, including the importance of sea ice algae-produced carbon. This was achieved by combining insights derived from multiple and complementary trophic marker approaches to construct individual aspects of feeding. Specifically, we determined proportions of algal-produced fatty acids (FAs) to reflect the reliance on diatom- versus dinoflagellate-derived carbon, highly branched isoprenoid (HBI) lipids that distinguish between ice-associated and pelagic carbon sources, and sterols to indicate the degree of carnivory. Copepods had the strongest diatom signal based on FAs, while a lack of sea ice algae-associated …