Digital Commons Network^™

Sustainability Of Semi‐Arid Extensive Livestock Systems In Senegal: Elements For Modelling Animal‐Plant Interactions, G. Chirat, F. Bocquier, F. Bousquet, A. Ickowicz

IGC Proceedings (1977-2023)

No abstract provided.

Medical School Watercooler Newsletter - January 28, 2021, Lindsey Lyle

Watercooler Newsletter

This is the January 28, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Mark your calendar for upcoming grand rounds
• Meet a Med Student: Jelani Bender
• New trauma/critical care and burn surgeon joins surgery faculty
• Researcher studies when too much NAD+ can go rogue
• Medical Alumni Association to host 'Social Determinants of Health: A Focus on Poverty'

Curricular Changes Proposed For 2021-2023 Morris Catalog Humanities And Interdisciplinary Studies Pt. 2, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Sex, Diabetes Status And Cognition: Findings From The Study Of Longevity In Diabetes, Chris Moran, Paola Gilsanz, Michal S. Beeri, Rachel A. Whitmer, Mary E. Lacy

Epidemiology and Environmental Health Faculty Publications

INTRODUCTION: Women comprise two-thirds of people with dementia, making female sex a significant dementia risk factor. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) are known dementia risk factors with an increasing global incidence. Understanding whether subtle sex differences persist in cognitive function prior to dementia in the context of diabetes may help elucidate the magnitude of sex effects on dementia risk.

RESEARCH DESIGN AND METHODS: We examined cross-sectional data from the Study of Longevity in Diabetes (SOLID), a prospective cohort study of members of Kaiser Permanente Northern California aged 60 years and older with T1D (n=758), T2D …

Dissecting The Regulatory Roles Of Orm Proteins In The Sphingolipid Pathway Of Plants, Adil Alsiyabi, Ariadna Gonzalez Solis, Edgar B. Cahoon, Rajib Saha

Center for Plant Science Innovation: Faculty Publications

Sphingolipids are a vital component of plant cellular endomembranes and carry out multiple functional and regulatory roles. Different sphingolipid species confer rigidity to the membrane structure, facilitate trafficking of secretory proteins, and initiate programmed cell death. Although the regulation of the sphingolipid pathway is yet to be uncovered, increasing evidence has pointed to orosomucoid proteins (ORMs) playing a major regulatory role and potentially interacting with a number of components in the pathway, including both enzymes and sphingolipids. However, experimental exploration of new regulatory interactions is time consuming and often infeasible. In this work, a computational approach was taken to address …

Minutes, College Of Liberal Arts Executive Committee Meeting, Thursday, January 28, 2021, College Of Liberal Arts Executive Committee

Executive Committee Minutes

No abstract provided.

Generating Pennycress (Thlaspi Arvense) Seed Triacylglycerols And Acetyl-Triacylglycerols Containing Medium-Chain Fatty Acids, Maliheh Esfahanian, Tara J. Nazarenus, Meghan M. Freund, Gary Mcintosh, Winthrop B. Phippen, Mary E. Phippen, Timothy P. Durrett, Edgar B. Cahoon, John C. Sedbrook

Department of Biochemistry: Faculty Publications

Thlaspi arvense L. (pennycress) is a cold-tolerant Brassicaceae that produces large amounts of seeds rich in triacylglycerols and protein, making it an attractive target for domestication into an offseason oilseed cash cover crop. Pennycress is easily genetically transformed, enabling synthetic biology approaches to tailor oil properties for specific biofuel and industrial applications. To test the feasibility in pennycress of producing TAGs and acetyl-TAGs rich in medium-chain fatty acids (MCFAs; C6–C14) for industrial, biojet fuel and improved biodiesel applications, we generated transgenic lines with seed-specific expression of unique acyltransferase (LPAT and diacylglycerol acyltransferase) genes and thioesterase (FatB) genes isolated from Cuphea …

Essays On Behavioral Industrial Organization And Welfare., Priyanka Kothari Dr.

Doctoral Theses

Many traits of economic agents are well studied and understood by psychologists that are yet to be captured by economic theory. This thesis, in the field of behavioral economics, is yet another attempt at unifying the different approaches of the two well-established disciplines - we ask what does economics predict of the behavior of economic agents ... once the psychology behind their decisions is accounted for. In a nutshell, this thesis is about the implications of choice-making among available alternatives.We begin with the idea that an economic agent only derives satisfaction from what he consumes without worrying at all (let …

Spatial Patterns And Drivers Of Nonperennial Flow Regimes In The Contiguous United States, Kendra Kaiser

Geosciences Faculty Publications and Presentations

Over half of global rivers and streams lack perennial flow, and understanding the distribution and drivers of their flow regimes is critical for understanding their hydrologic, biogeochemical, and ecological functions. We analyzed nonperennial flow regimes using 540 U.S. Geological Survey watersheds across the contiguous United States from 1979 to 2018. Multivariate analyses revealed regional differences in no-flow fraction, date of first no flow, and duration of the dry-down period, with further divergence between natural and human-altered watersheds. Aridity was a primary driver of no-flow metrics at the continental scale, while unique combinations of climatic, physiographic and anthropogenic drivers emerged at …

Gender Role As A Mediating Factor In Gender Pay Equity Analysis, Jillian Ann Girard

Dissertations and Theses

The gender wage gap has been persistent despite the introduction of new laws designed to address the disparity. One of the challenges in addressing this inequity is the lack of complete understanding of the driving factors of the pay gap. One yet unexplored factor is the impact of the gender role, which is a social role based on sex/gender which provides a structure and expectations for social relationships. The purpose of this research was to explore the relationship between gender role, biological sex, and base pay. A matched, cross-sectional sample drawn from large U.S. cities was utilized to test the …

Rsif Weekly Vol.2 No.3 - Opportunities To Join The Rsif Team, Regional Scholarship And Innovation Fund (Rsif)

Rsif Newsletters

No abstract provided.

Chemical Composition, Bacteriostasis And Enzyme Inhibition Of Cinnamomumcamphora Ct. Cineole Volatile Oil, Li Jia-Nan, Chen Xiao-Hua, Hao Hao, Liu Xiang, Zhang Xiao-Ying, Chen Chen

Food and Machinery

Gas chromatography-mass spectrometry (GC-MS) was used to determine the chemical composition of Ravansaravolatile oil. The in vitro bacteriostasis experiment was carried out by the paper diffusion method and the microdilution broth method. And its inhibitory effect on pancreatic lipase and α-glucosidase activity was determined. The results characterized 17 chemical components, accounting for 98.5% of the total volatile oils. The main components were 1,8-cineole (30.89%), camphor (21.67%), (-)-allo-aromadendrene (12.38%), p-cymene (10.14%), β-pinene (6.01%). The minimum inhibitory concentrationrange of volatile oils for 18 tested bacteria was 1.25~40.00 mg/mL. At the concentration of 100 mg/mL, the inhibition rates of pancreatic lipase and α-glucosidase …

Bacterial Composition Analysis Of Frozen Mussels Based On High-Throughput Sequencing, Jiang Hui-Li, Shui Shan-Shan, Wu Qiong-Jing, Chen Xiao-Nan, Zhang Bin, Su Lai-Jin

Food and Machinery

After opening the shell with steam, the microorganisms on the surface of fresh mussel meat (FS), frozen mussel meat at -18 ℃ for 1 week (FS-1), frozen mussel meat for 3 weeks (FS-3) and frozen mussel meat for 9 weeks (FS-9) were extracted with DNA extraction kit and then analyzed by high-throughput sequencing. The effective sequences in all samples ranged from 31 896 to 42 812, and the operational taxonomic unit (OTU) ranged from 289 to 681. Among them, the OTU of FS-9 was the lowest, and the OTU of FS was the highest. Diversity index analysis showed that the …

Extrusion Assisted Alkaline-Enzyme Extraction Process Optimization Of Protein Hydrolysate From Tie Guanyin Tea Residue And Its Functionalities, Guo Feng-Xian, Zheng Zong-Ping, Huang Cheng-Fang, Zhao Wei, Yao Yuan

Food and Machinery

Taking Tie Guanyin residues as the research object, through single factor experiment and response surface methodology, the effects of extrusion water content, sleeve temperature and screw frequency on its assisted alkaline-enzyme combined extraction of tea residue protein hydrolysates (TPH) were discussed, and the functionalities of TPH was then investigated. The optimal extrusion assisted extractions were water content of tea residue material 15%, sleeve temperature 97 ℃, screw frequency 40 Hz. Under the conditions the extraction rate of TPH was improved to (71.37±0.09)%, which was close to the predicted result. The results of TPH antioxidant activity showed the IC₅₀ values …

Gardner-Webb Is A Place Where Lasting Friendships Are Forged, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University celebrates a historic milestone in 2021—the 50 anniversary of senior college status. Transitioning to a four-year college in 1971 was the result of 10 years of planning and meeting goals. To celebrate this anniversary, Gardner-Webb will publish a series of articles highlighting the stories of former faculty, staff, alumni and supporters who experienced this significant achievement.

View the history timeline here. Gardner-Webb’s Class of 1971 were trailblazers in the College’s effort to achieve accreditation as a four-year college from the Southern Association of Colleges and Schools (SACS). The requirements stated that at least one group of students must …

We Still Have Lessons To Learn From Woburn, And Flint Is A Good Place To Start, Rose Mooney

Notre Dame Law Review

By analyzing a previous water contamination lawsuit, this Note offers advice to litigants battling their current water crises. Specifically, this Note assesses the water contamination crisis that occurred in Woburn, Massachusetts, from the mid- to late-twentieth century and offers guidance to litigants fighting for clean water in Flint, Michigan, today. There is strength in this type of comparison: “Change in legislative actions and policy- making often result from previous environmental disasters out of which the public demands a change. In other words, we arguably learn from these disasters and effect changes to prevent them from occurring again.” The Woburn litigation …

Algorithmic Legal Metrics, Dan L. Burk

Notre Dame Law Review

Predictive algorithms are increasingly being deployed in a variety of settings to determine legal status. Algorithmic predictions have been used to determine provision of health care and social services, to allocate state resources, and to anticipate criminal behavior or activity. Further applications have been proposed to determine civil and criminal liability or to “personalize” legal default rules. Deployment of such artificial intelligence (AI) systems has properly raised questions of algorithmic bias, fairness, transparency, and due process. But little attention has been paid to the known sociological costs of using predictive algorithms to determine legal status. A large and growing social …

Development Of A Mind Body Program For Obese Knee Osteoarthritis Patients With Comorbid Depression, Cale A. Jacobs, Ryan A. Mace, Jonathan Greenberg, Paula J. Popok, Mira Reichman, Christian Lattermann, Jessica L. Burris, Eric A. Macklin, Ana-Maria Vranceanu

Orthopaedic Surgery and Sports Medicine Faculty Publications

Knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Depression and obesity are highly comorbid among knee OA patients, and the combination of obesity and depression is associated with decreased physical activity, higher pain and disability, and more rapid cartilage degradation. Depression, obesity and OA exacerbate one another and share a common pathophysiology involving systemic inflammation and pro-inflammatory cytokines, reflecting a complex mind-body interaction. Current treatments for knee OA offer little to no benefit over placebo, and do not emphasize mind-body practices or physical activity to target the underlying pathophysiology. Mind-body …

Delineating Knowledge Domains In Scientific Domains In Scientific Literature Using Machine Learning (Ml), Abhay Maurya, Smarajit Paul Choudhury Mr., Kshitij Jaiswal Mr.

Library Philosophy and Practice (e-journal)

The recent years have witnessed an upsurge in the number of published documents. Organizations are showing an increased interest in text classification for effective use of the information. Manual procedures for text classification can be fruitful for a handful of documents, but the same lack in credibility when the number of documents increases besides being laborious and time-consuming. Text mining techniques facilitate assigning text strings to categories rendering the process of classification fast, accurate, and hence reliable. This paper classifies chemistry documents using machine learning and statistical methods. The procedure of text classification has been described in chronological order like …

High Altitude Science Experiments Aboard Nasa’S Wb-57 Airborne Research Platform, Pedro Llanos, Kristina Andrijauskaite, Sathya Gangadharan

Publications

Purpose: Exposure to space radiation may place astronauts at significant health risks. This is an under-investigated area of research and therefore more knowledge is needed to better plan long-term space missions. The purpose of this study was to assess the effect of radiation on murine naïve and activated T lymphocytes (T cells) and to test the effectiveness of thermal, radiation and flight tracking technology in biological scientific payloads. We cultured cells in specific cytokines known to increase their viability and exposed them to either flight or had them as ground controls. Flight cells were kept under proper environmental conditions by …

Carveol A Naturally-Derived Potent And Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity, Zaif Ur Rahman, Lina Tariq Al Kury, Abdullah Alattar, Zhen Tan, Reem Alshaman, Imran Malik, Haroon Badshah, Zia Uddin, Atif Ali Khan Khalil, Naveed Muhammad, Saifullah Khan, Amjad Ali, Fawad Ali Shah, Jing Bo Li, Shupeng Li

All Works

Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in liver injury, using molecular and in silico approaches. Male BALB/c mice were divided into two experimental cohorts, to identify the best dose and to further assess the role of carveol in the nuclear factor E2-related factor; nuclear factor erythroid 2; p45-related factor 2 (Nrf2) pathway. The results demonstrated that carveol significantly modulated the detrimental effects of APAP by boosting endogenous antioxidant mechanisms, such as nuclear translocation of …

Effects Of 1-Mcp Combined With Membrane Air Conditioning Treatments On The Storage Quality Of Estuarine Bananas, Li Yan-Jiao, Zhang Yue-Jiang, Xing Jiang-Yan, Zhao Xiao-Ling, Ling Qi, Bao Yuan-Yun

Food and Machinery

To study the effects of 1-MCP (0.00, 0.08, 0.16, 0.32 g/L) on the quality of banana in Hekou, Yunnan Province The changes of soluble solids, hardness, disease index, yellowing index, pod enzyme (peroxidase), weight loss rate, respiration rate and titratable acid of banana during storage were studied. The results showed that: 1-MCP + PBI modified atmosphere preservation bag delayed soluble solids, disease index, yellowing index, pod enzyme activity compared with other treatments (P ≤ 0.05); 1-MCP + microporous membrane significantly delayed the decline of fruit firmness (P ≤ 0.05), inhibited the increase of titratable acid content (P ≤ 0.05), but …

Hematopoietic Cell-Mediated Dissemination Of Murine Cytomegalovirus Is Regulated By Nk Cells And Immune Evasion., Shunchuan Zhang, Lauren E Springer, Han-Zhi Rao, Renee G Espinosa Trethewy, Lindsey M Bishop, Meaghan H Hancock, Finn Grey, Christopher M. Snyder

Department of Microbiology and Immunology Faculty Papers

Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV from the site of infection. In theory, such dissemination should expose CMV to cell-mediated immunity and thus necessitate evasion of T cells and NK cells. However, this hypothesis remains untested. We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR-142-3p in the essential viral gene IE3. This virus disseminated poorly to the salivary gland following intranasal or footpad infections but …

Transcriptional Coupling And Repair Of 8-Oxog Activate A Reca-Dependent Checkpoint That Controls The Onset Of Sporulation In Bacillus Subtilis, Valeria P. Suárez, Lissett E. Martínez, Hilda C. Leyva-Sánchez, Luz I. Valenzuela-García, Reyna Lara-Martínez, Luis F. Jiménez-García, Norma Ramírez-Ramírez, Armando Obregon-Herrera, Mayra Cuéllar-Cruz, Eduardo A. Robleto, Mario Pedraza-Reyes

Life Sciences Faculty Research

© 2021, The Author(s). During sporulation Bacillus subtilis Mfd couples transcription to nucleotide excision repair (NER) to eliminate DNA distorting lesions. Here, we report a significant decline in sporulation following Mfd disruption, which was manifested in the absence of external DNA-damage suggesting that spontaneous lesions activate the function of Mfd for an efficient sporogenesis. Accordingly, a dramatic decline in sporulation efficiency took place in a B. subtilis strain lacking Mfd and the repair/prevention guanine oxidized (GO) system (hereafter, the ∆GO system), composed by YtkD, MutM and MutY. Furthermore, the simultaneous absence of Mfd and the GO system, (i) sensitized sporulating …

Mfd Affects Global Transcription And The Physiology Of Stressed Bacillus Subtilis Cells, Holly Anne Martin, Anitha Sundararajan, Tatiana S. Ermi, Robert Heron, Jason Gonzales, Kaiden Lee, Diana Anguiano-Mendez, Faye Schilkey, Mario Pedraza-Reyes, Eduardo A. Robleto

Life Sciences Faculty Research

© Copyright © 2021 Martin, Sundararajan, Ermi, Heron, Gonzales, Lee, Anguiano-Mendez, Schilkey, Pedraza-Reyes and Robleto. For several decades, Mfd has been studied as the bacterial transcription-coupled repair factor. However, recent observations indicate that this factor influences cell functions beyond DNA repair. Our lab recently described a role for Mfd in disulfide stress that was independent of its function in nucleotide excision repair and base excision repair. Because reports showed that Mfd influenced transcription of single genes, we investigated the global differences in transcription in wild-type and mfd mutant growth-limited cells in the presence and absence of diamide. Surprisingly, we found …

Ultrasound Measurements Of Subcutaneous Fat Thickness Are Robust Against Hydration Changes, Dale R. Wagner, James D. Cotter

Kinesiology and Health Science Faculty Publications

Ultrasound is an appealing tool to assess body composition, combining the portability of a field method with the accuracy of a laboratory method. However, unlike other body composition methods, the effect of hydration status on validity is unknown. This study evaluated the impact of acute hydration changes on ultrasound measurements of subcutaneous fat thickness and estimates of body fat percentage. In a crossover design, 11 adults (27.1 ± 10.5 years) completed dehydration and hyperhydration trials to alter body mass by approximately ±2%. Dehydration was achieved via humid heat (40 °C, 60% relative humidity) with exercise, whereas hyperhydration was via ingestion …

In Silicoidentification Of Toxins And Their Effect Onhost Pathways: Feature Extraction, Classificationand Pathway Prediction., Rishika Sen Dr.

Doctoral Theses

Identification of toxins, which are either proteins or small molecules, from pathogens is of paramount importance due to their crucial role as first-line invaders infiltrating a host, often leading to infection of the host. These toxins can affect specific proteins, like enzymes that catalyze metabolic pathways, affect metabolites that form the basis of metabolic reactions, and prevent the progression of those pathways, or more generally they may affect the regular functioning of other proteins in signaling pathways in the host. In this regard, the thesis addresses the problem of identification of toxins, and the effect of perturbations by toxins on …

Mangrove Gastropods As Biomonitors For Heavy Metal Contamination, Farhathul Manas

Student Works (2020-2029)

A process called biomonitoring can be used to analyze the factors that affect the ecosystem. In this study, gastropods and sediments were used to observeits impact on the study sites under the Klang Islands Mangrove Forest Reserve (KIMFR): Pulau Klang (Klang Island), Pulau Carey (Carey Island) and Telok Gong representing the natural mangrove, agricultural and industrial environments, respectively. Environmental monitoring was performed using gastropods and sediments that were collected and tested for heavy metals including arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg). The inductive coupled plasma mass spectrometry (ICP-MS) was used for heavy metal testing in gastropods whereas …

Purification And Characterization Of Metmyoglobin Reductase In Beef Longissimus Muscle, Zhao Li-Jun, Zhao Ke, Zhao Gai-Ming, Ma Yang-Yang, Zhu Yao-Di, Li Miao-Yun, Huang Ming-Yuan

Food and Machinery

The longissimus muscle from chilled beef was used as raw material to preliminary study the purification and characteristics of metmyoglobin reductase. The effect of temperature, pH and metal ions on the metmyoglobin reductase activity was investigated. Results revealed that the metmyoglobin reductase of longissimus muscle could be crudely purified with ammonium sulfate (65% saturation) and ultrafiltration (>50 kDa). SDS-PAGE analysis showed that the molecular weight of the metmyoglobin reductase of longissimus muscle was 29.0~66.4 kDa, mainly. The proper temperature of the metmyoglobin reductase of longissimus muscle was 40 ℃, with the proper pH 6.0. Cu²⁺ could inhibit the …

Analysis Of Free Fatty Acids And Flavor Characteristics Of Sauced Duck From Jiangxi Local Brands, Liu Guang-Xian, Li Xue, Wang Li, Cheng Wen-Long, Chen Zhi-Wei

Food and Machinery

The free fatty acids and the flavor characteristics of the time-honored sauced duck, Huangshanghuang sauced ducks and Xiangtang sauced duck in Jiangxi province were investigated by gas chromatography-mass spectrometry (GC-MS) and amino acid analysis. The results showed that twenty-three kinds of free fatty acids were detected in the three kinds of sauced duck, which cis-9-oleic acid, palmitic acid and linoleic acid were the main free fatty acids in Jiangxi sauced duck. The glutamic acid content of Xiangtang sauced duck was higher than that of the other two sauced duck significantly, which was 9.27 g /100 g. Ninety-two volatile flavor compounds …