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Faculty Senate Agenda, February 1, 2021, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 7, 2021
• PRPC Subcommittee 400 Code Rewrite
• Title IX Policy and Procedure
• Office of Research Annual Report
• School of Graduate Studies Annual Report
• 404.3.6 Code Changes Full Code/Track Changes (Second reading)
• Promotion and Tenure Survey

Evolutionary Dynamics And Structural Consequences Of De Novo Beneficial Mutations And Mutant Lineages Arising In A Constant Environment, Margie Kinnersley, Katja Schwartz, Dong Dong Yang, Gavin Sherlock, Frank Rosenzweig

Biological Sciences Faculty Publications

Background: Microbial evolution experiments can be used to study the tempo and dynamics of evolutionary change in asexual populations, founded from single clones and growing into large populations with multiple clonal lineages. High-throughput sequencing can be used to catalog de novo mutations as potential targets of selection, determine in which lineages they arise, and track the fates of those lineages. Here, we describe a long-term experimental evolution study to identify targets of selection and to determine when, where, and how often those targets are hit. Results: We experimentally evolved replicate Escherichia coli populations that originated from a mutator/nonsense suppressor ancestor …

Annotated Bibliography Of Research In The Teaching Of English, Anne Crampton, Lisa Ortmann, Amy Frederick, Bridget Kelley, Kate Brodeur, Stephanie M. Madison, Candace Doerr-Stevens, Madeleine Israelson, Anne Ittner, Robin Jocius, Lauren Aimonette Liang, Tracey Murphy, Ian O'Byrne, Jeff Share, Sara K. Sterner, Erin Stutelberg, Mark Sulzer, Amanda Haertling Thein, Stephanie Rollag Yoon

Publications

Since 2003, RTE has published the annual “Annotated Bibliography of Research in the Teaching of English,” and we are proud to share these curated and annotated citations once again. The goal of the annual bibliography is to offer a synthesis of the research published in the area of English language arts within the past year that may be of interest to RTE readers. Abstracted citations and those featured in the “Other Related Research” sections were published, either in print or online, between June 2019 and June 2020. The bibliography is divided into nine subject area sections. A three-person team of …

Reirradiation Practices For Children With Diffuse Intrinsic Pontine Glioma, Chantel Cacciotti, Kevin X. Liu, Daphne A. Haas-Kogan, Katherine E. Warren

Paediatrics Publications

Background: Diffuse intrinsic pontine gliomas (DIPGs) are a leading cause of brain tumor deaths in children. Current standard of care includes focal radiation therapy (RT). Despite clinical improvement in most patients, the effect is temporary and median survival is less than 1 year. The use and benefit of reirradiation have been reported in progressive DIPG, yet standardized approaches are lacking. We conducted a survey to assess reirradiation practices for DIPG in North America. Methods: A 14-question REDCap survey was disseminated to 396 North American physicians who care for children with CNS tumors. Results: The response rate was 35%. Participants included …

Internal Needs Assessments: A Worthwhile Endeavor?, Carolyn Prescott, Mary Ann Walker, Daniel D. Isgrigg, Angela Sample

College of Science and Engineering Faculty Research and Scholarship

On May 1, 2020, the Needs Assessment Committee submitted their final report of findings and recommendations to the dean of the Oral Roberts University Library, Dr. Mark Roberts. The report represented the culmination of approximately six months of a broad-based investigation of the Library, including an internal examination of the Library and an external study of Library resources, services, and staff. This Needs Assessment was unique in that a team of Library faculty and staff conducted it. Internal members of an organization rarely perform needs assessments for many reasons, including inherent bias and the potential distrust of those not on …

Therapeutic Enhancement Of Radiation And Immunomodulation By Gold Nanoparticles In Triple Negative Breast Cancer, Brana Janic, Stephen L. Brown, Ryan Neff, Fangchao Liu, Guangzhao Mao, Yalei Chen, Latoya Jackson, Indrin J. Chetty, Benjamin Movsas, Ning Wen

Radiation Oncology Articles

Gold nanoparticles (AuNPs) have been shown to enhance cancer radiotherapy (RT) gain by localizing the absorption of radiation energy in the tumor while sparing surrounding normal tissue from radiation toxicity. Previously, we showed that AuNPs enhanced RT induced DNA damage and cytotoxicity in MCF7 breast cancer cells. Interestingly, we found that cancer cells exhibited a size-dependent AuNPs intracellular localization (4 nm preferentially in the cytoplasm and 14 nm in the nucleus). We extended those studies to an in vivo model and examined the AuNPs effects on RT cytotoxicity, survival and immunomodulation of tumor microenvironment (TME) in human triple negative breast …

Wild 563.R01: Advanced Topics In Habitat Ecology, Mark Hebblewhite

University of Montana Course Syllabi

No abstract provided.

Examination Of Staphylococcus Aureus Prophages Circulating In Egypt, Adriana Ene, Taylor Miller-Ensminger, Carine R. Mores, Silvia Giannattasio-Ferraz, Alan J. Wolfe, Alaa Abouelfetouh, Catherine Putonti

Biology: Faculty Publications and Other Works

Staphylococcus aureus infections are of growing concern given the increased incidence of antibiotic resistant strains. Egypt, like several other countries, has seen alarming increases in methicillin-resistant S. aureus (MRSA) infections. This species can rapidly acquire genes associated with resistance, as well as virulence factors, through mobile genetic elements, including phages. Re-cently, we sequenced 56 S. aureus genomes from Alexandria Main University Hospital in Alexandria, Egypt, complementing 17 S. aureus genomes publicly available from other sites in Egypt. In the current study, we found that the majority (73.6%) of these strains contain intact prophages, including Biseptimaviruses, Phietaviruses, and Triaviruses. Further investigation …

[Accepted Manuscript] The Global Society On Migration, Ethnicity, Race And Health, Raj Bhopal, Laurence Gruer, Charles Agyemang, Nadav Davidovitch, Ama De-Graft Aikins, Allan Krasnik, Ana P. Martinez-Donate, J. Jaime Miranda, Kevin Pottie, Uma Segal, Anthony Zwi, Bernadette Kumar

Social Work Faculty Works

No abstract provided.

Polyamines Drive Myeloid Cell Survival By Buffering Intracellular Ph To Promote Immunosuppression In Glioblastoma, Jason Miska, Aida Rashidi, Catalina Lee-Chang, Peng Gao, Aurora Lopez-Rosas, Peng Zhang, Rachel Burga, Brandyn Castro, Ting Xiao, Yu Han, David Hou, Samay Sampat, Alex Cordero, Joshua S. Stoolman, Craig M. Horbinski, Mark Burns, Yana Reshetnyak, Navdeep S. Chandel, Maciej S. Lesniak

Physics Faculty Publications

Glioblastoma is characterized by the robust infiltration of immunosuppressive tumor-associated myeloid cells (TAMCs). It is not fully understood how TAMCs survive in the acidic tumor microenvironment to cause immunosuppression in glioblastoma. Metabolic and RNA-seq analysis of TAMCs revealed that the arginine-ornithine-polyamine axis is up-regulated in glioblastoma TAMCs but not in tumor-infiltrating CD8⁺ T cells. Active de novo synthesis of highly basic polyamines within TAMCs efficiently buffered low intracellular pH to support the survival of these immunosuppressive cells in the harsh acidic environment of solid tumors. Administration of difluoromethylornithine (DFMO), a clinically approved inhibitor of polyamine generation, enhanced animal survival …

Targeting Critical Kinases And Anti-Apoptotic Molecules Overcomes Steroid Resistance In Mll-Rearranged Leukaemia., Anne P De Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D. Shultz, Shuki Mizutani, Fumihiko Ishikawa

Faculty Research 2021

BACKGROUND: Acute lymphoblastic leukaemia with mixed lineage leukaemia gene rearrangement (MLL-ALL) frequently affects infants and is associated with a poor prognosis. Primary refractory and relapsed disease due to resistance to glucocorticoids (GCs) remains a substantial hurdle to improving clinical outcomes. In this study, we aimed to overcome GC resistance of MLL-ALL.

METHODS: Using leukaemia patient specimens, we performed bioinformatic analyses to identify target genes/pathways. To test inhibition of target pathways in vivo, we created pre-clinical therapeutic mouse patient-derived xenograft (PDX)-models by transplanting human MLL-ALL leukaemia initiating cells (LIC) into immune-deficient NSG mice. Finally, we conducted B-cell lymphoma-2 (BCL-2) homology domain …

Wild 480.01: The Upshot - Applied Wildlife Management, Erim Gomez

University of Montana Course Syllabi

No abstract provided.

Interaction Of Alpha-Crystallin With Phospholipid Membranes, Laxman Mainali, William J. O'Brien, Raju Timsina

Physics Faculty Publications and Presentations

Purpose/Aim: The amount of membrane-bound α-crystallin increases significantly with age and cataract formation, accompanied by a corresponding decline in the level of α-crystallin in the lens cytoplasm. The purpose of this research is to evaluate the binding affinity of α-crystallin to the phospholipid membranes as well as the physical properties of the membranes after α-crystallin binding.

Materials and Methods: The continuous wave and saturation recovery electron paramagnetic resonance (EPR) methods were used to obtain the information about the binding affinity and the physical properties of the membrane. In this approach, the cholesterol analogue spin label CSL was incorporated in the …

Tuning The Magnetic Properties Of Two-Dimensional Mxenes By Chemical Etching, Kemryn Allen-Perry, Weston Straka, Danielle Keith, Shubo Han, Lewis Reynolds, Bhoj Gautam, Daniel E. Autrey

College of Health, Science, and Technology

Two-dimensional materials based on transition metal carbides have been intensively studied due to their unique properties including metallic conductivity, hydrophilicity and structural diversity and have shown a great potential in several applications, for example, energy storage, sensing and optoelectronics. While MXenes based on magnetic transition elements show interesting magnetic properties, not much is known about the magnetic properties of titanium-based MXenes. Here, we measured the magnetic properties of Ti3 C2 Tx MXenes synthesized by different chemical etching conditions such as etching temperature and time. Our magnetic measurements were per-formed in a superconducting quantum interference device (SQUID) vibrating sample. These data …

Review: Advances In The Methodology And Application Of Tracing In Karst Aquifers, Ralf Benischke

KIP Articles

Tracer methods have been widely used in many fields of environmental and natural sciences, and also in human health sciences. In particular, tracers are used in the study of karst hydrogeology, typically focusing on phenomena such as sinkholes, sinking rivers and large karst springs. It is known that tracers have been used since antiquity. The aim of tracer tests has been to investigate underground flow paths, transport processes and water–rock interactions, and to get an insight into the functioning of a karst aquifer. In karst hydrogeology, tracer methods are the most important investigation tools beside conventional hydrological methods. In early …

University Of Dayton Magazine, Spring 2021, University Of Dayton

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of University Marketing and Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD.

Constraining Southern Ocean Co2 Flux Uncertainty Using Uncrewed Surface Vehicle Observations, A. J. Sutton, Nancy L. Williams, B. Tilbrook

Marine Science Faculty Publications

Remote, harsh conditions of the Southern Ocean challenge our ability to observe the region’s influence on the climate system. Southern Ocean air-sea CO2 flux estimates have significant uncertainty due to the reliance on limited ship-dependent observations in combination with satellite-based and interpolated data products. We utilize a new approach, making direct measurements of air-sea CO2, wind speed, and surface ocean properties on an Uncrewed Surface Vehicle (USV). In 2019, the USV completed the first autonomous circumnavigation of Antarctica providing hourly CO2 flux estimates. Using this unique data set to constrain potential error in different measurements and propagate those through the …

Documentation Of Atlantic Tarpon (Megalops Atlanticus) Space Use And Move Persistence In The Northern Gulf Of Mexico Facilitated By Angler Advocates, J. Marcus Drymon, Matthew B. Jargowsky, Michael A. Dance, Mitchell Lovell, Crystal Lou Allen Hightower, Amanda E. Jefferson, Andrea M. Kroetz, Sean P. Powers

Faculty Publications

Atlantic tarpon (Megalops atlanticus, hereafter tarpon) are facing a multitude of stressors and are considered Vulnerable by the IUCN; however, significant gaps remain in our understanding of tarpon space use and movement. From 2018 to 2019, citizen scientists facilitated tagging of 23 tarpon with SPOT tags to examine space use and movement across the northern Gulf of Mexico. Movement-based kernel densities were used to estimate simplified biased random bridge-based utilization distributions and a joint move persistence model was used to estimate a behavioral index for each fish. Tarpon showed consistent east–west movement from the Alabama/Florida border to Louisiana, and utilization …

G2pminer: A Genome To Phenome Literature Review Approach, John M.A. Wojahn, Stephanie J. Galla, Anthony E. Melton, Sven Buerki

Biology Faculty Publications and Presentations

There is a gap in the conceptual framework linking genes to phenotypes (G2P) for non-model organisms, as most non-model organisms do not yet have genomic resources readily available. To address this, researchers often perform literature reviews to understand G2P linkages by curating a list of likely gene candidates, hinging upon other studies already conducted in closely related systems. Sifting through hundreds to thousands of articles is a cumbersome task that slows down the scientific process and may introduce bias into a study. To fill this gap, we created G2PMineR, a free and open source literature mining tool developed specifically for …

Digital Scholarship Services On A Budget: Using Open Source Methods For Growth Of Research Sharing, Amy Gay

Library Scholarship

This presentation was at the International Conference of Agricultural Librarians & Users Community (ICALUC-2021), whose theme this year was "Management of Knowledge Resource Centres in the Networked Digital Environment: Trends, Challenges, and Opportunities". This conference was held in Bengaluru, India.

Gouldian Finch Non Breeding Population And Habitat Assessment 2020: Ord-East Kimberley Expansion Project - Weaber Plain Development Area, Nigel Jackett

Irrigated Agricultural Development in the North

The Weaber Plain Development Project (the Project) is an irrigated agricultural development located approximately 30 km north-north-east of Kununurra in Western Australia. The Project was approved by the Department of Sustainability, Environment, Water, Population and Communities in 2011 under EPBC 2010/5491 Condition 6.

In order to offset the potential impacts of the Project on the endangered Gouldian Finch (Erythrura gouldiae), a Gouldian Finch Conservation Plan was prepared. The Gouldian Finch Conservation Plan was prepared to ensure appropriate management of the Gouldian Finch and its habitat during construction and operation of the Project. An action arising from the Conservation Plan was …

Infusion Reaction To Infliximab Biosimilar After Transitioning From Infliximab, Reem Kashlan, Alexis B. Lyons, Shanthi Narla, Iltefat H. Hamzavi

Dermatology Articles

No abstract provided.

Assessment Of The Diagnostic Accuracy Of Core Needle Biopsy In The Diagnosis Of Lymphoma, Christopher A. Gardner, Xiangyun Ye, Catherine Tucker, Md, Austin Redilla, Guldeep Uppal, Md, Adam F. Binder

Phase 1

Introduction: Excisional biopsy (EB) of lymph nodes is the gold standard for diagnosing lymphoma. Recent literature suggests that diagnostic techniques such as immunohistochemistry, flow cytometry and FISH/Cytogenetics yield similar diagnostic adequacy rates when paired with less invasive procedures, like Core Needle Biopsy (CNB). We were interested in comparing the diagnostic odds ratio and adequacy of patients suspected of lymphoma who underwent CNB to EB at Thomas Jefferson University Hospital (TJUH).

Methods: We performed a retrospective cohort study on biopsies collected from 01/01/2016 and 12/31/2019 at TJUH. Specimens were considered diagnostically inadequate if there was not enough lesional tissue for …

2021 February, Cleveland-Marshall College Of Law

2020s

No abstract provided.

Should Biomedical Research With Great Apes Be Restricted? A Systematic Review Of Reasons, Bernardo Aguilera, Javiera Perez Gomez, David Degrazia

Philosophy Faculty Research and Publications

Background

The use of great apes (GA) in invasive biomedical research is one of the most debated topics in animal ethics. GA are, thus far, the only animal group that has frequently been banned from invasive research; yet some believe that these bans could inaugurate a broader trend towards greater restrictions on the use of primates and other animals in research. Despite ongoing academic and policy debate on this issue, there is no comprehensive overview of the reasons advanced for or against restricting invasive research with GA. To address this gap, we conducted a systematic review of the reasons reported …

February 2021 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

The Role Of Mirnas, Mirna Clusters, And Isomirs In Development Of Cancer Stem Cell Populations In Colorectal Cancer., Victoria A Stark, Caroline O B Facey, Vignesh Viswanathan, Bruce M Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

MicroRNAs (miRNAs or miRs) have a critical role in regulating stem cells (SCs) duringdevelopment and altered expression can cause developmental defects and/or disease. Indeed,aberrant miRNA expression leads to wide-spread transcriptional dysregulation which has beenlinked to many cancers. Mounting evidence also indicates a role for miRNAs in the developmentof the cancer SC (CSC) phenotype. Our goal herein is to provide a review of: (i) current researchon miRNAs and their targets in colorectal cancer (CRC), and (ii) miRNAs that are differentiallyexpressed in colon CSCs. MicroRNAs can work in clusters or alone when targeting different SC genesto influence CSC phenotype. Accordingly, we discuss …

Factors Associated With The Compliance Of Standard Precaution; Review Article, Shah Zeb, Tazeen Saeed Ali

School of Nursing & Midwifery

Compliance with standard precautions is very important for healthcare workers because studies have shown that it helps in minimising the transmission of infectious diseases and healthcare-associated infections which is directly proportional to the patient cost and stay of the patient in hospitals. As healthcare associated infections increase, the cost and the stay of the patient will increase. Researchers suggest that all healthcare workers need to follow the standard precautions guideline and it can be possible with the help of health education, training, provision of equipment and supervision by the management. Barriers to the compliance identified are lack of education, heavy …

329200 - Turfs And Grasses, Stepdhanie Weatherbee

Division 32 – Exterior Improvements

No abstract provided.

Effect Of Ferrate And Monochloramine Disinfection On The Physiological And Transcriptomic Response Of Escherichia Coli At Late Stationary Phase, Sahar Daer, Joseph E. Goodwill, Kaoru Ikuma

Civil & Environmental Engineering Faculty Publications

Biological mechanisms of disinfection not only vary by disinfectant but also remain not well understood. We investigated the physiological and transcriptomic response of Escherichia coli at late stationary phase to ferrate and monochloramine in amended lake water. Although ferrate and monochloramine treatments similarly reduced culturable cell concentrations by 3-log10, 64% and 11% of treated cells were viable following monochloramine and ferrate treatment, respectively. This observed induction of viable but non-culturable (VBNC) state following monochloramine treatment but not ferrate is attributed to slower monochloramine disinfection kinetics (by 2.8 times) compared to ferrate. Transcriptomic analysis of E. coli at 15 min of …