Digital Commons Network^™

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis In The Retina And Causes Visual Dysfunction In Mice, Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H.C. Van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes

School of Medicine Faculty Publications

Patients lacking multifunctional protein 2 (MFP2), the central enzyme of the peroxisomal β-oxidation pathway, develop retinopathy. This pathway is involved in the metabolism of very long chain (VLCFAs) and polyunsaturated (PUFAs) fatty acids, which are enriched in the photoreceptor outer segments (POS). The molecular mechanisms underlying the retinopathy remain, however, elusive. Here, we report that mice with MFP2 inactivation display decreased retinal function already at the age of 3 weeks, which is accompanied by a profound shortening of the photoreceptor outer and inner segments, but with preserved photoreceptor ultrastructure. Furthermore, MFP2 deficient retinas exhibit severe changes in gene expression with …

2021-February-02-Etsu Alumni Elects New Board Officers Members, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Feb. 2, 2021) – The East Tennessee State University National Alumni Association announces the election of alumni board officers and new members, which took place during the recent annual board meeting.

2021 ETSU Alumni Board Officers and New Members

The Alumni Association elected Bryan Daniels of the classes of 1995 and 1997 to serve as president. He is the CEO of the Blount County Partnership in Maryville. Tom …

Alcohol Intake And Alcohol–Snp Interactions Associated With Prostate Cancer Aggressiveness, Hui Yi Lin, Xinnan Wang, Tung-Sung Tseng, Yu Hsiang Kao, Zhide Fang, Patricia E. Molina, Chia Ho Cheng, Anders E. Berglund, Rosalind A. Eeles, Kenneth R. Muir, Nora Pashayan, Christopher A. Haiman, Hermann Brenner, Jong Y. Park

School of Public Health Faculty Publications

Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake’s impact on prostate cancer (PCa) aggressiveness. The objective is to test the alcohol–SNP interactions of the 7501 SNPs in the four pathways (angiogenesis, mitochondria, miRNA, and androgen metabolism-related pathways) associated with PCa aggressiveness. We evaluated the impacts of three excessive alcohol intake behaviors in 3306 PCa patients with European ancestry from the PCa Consortium. We tested the alcohol–SNP interactions using logistic models with the discovery-validation study design. All three excessive alcohol intake …

Japanese Quail (Coturnix Japonica) As A Novel Model To Study The Relationship Between The Avian Microbiome And Microbial Endocrinology-Based Host-Microbe Interactions, James Keane, Joshua M. Lyte, Julia Eckenberger, Nicholas Anthony, Sandip Shrestha, Daya Marasini, Karrie M. Daniels, Valentina Caputi, Annie M. Donoghue, Mark Lyte

Articles

Background

Microbial endocrinology, which is the study of neuroendocrine-based interkingdom signaling, provides a causal mechanistic framework for understanding the bi-directional crosstalk between the host and microbiome, especially as regards the effect of stress on health and disease. The importance of the cecal microbiome in avian health is well-recognized, yet little is understood regarding the mechanisms underpinning the avian host-microbiome relationship. Neuroendocrine plasticity of avian tissues that are focal points of host-microbiome interaction, such as the gut and lung, has likewise received limited attention. Avian in vivo models that enable the study of the neuroendocrine dynamic between host and microbiome are …

Social And Cultural Dynamics Of Non-Native Invasive Species, John Schelhas, Janice Alexander, Mark W. Brunson, Tommy Cabe, Alycia Crall, Michael J. Dockry, Marla R. Emery, Susan J. Frankel, Nina Hapner, Caleb R. Hickman, Rebecca Jordan, Michael J. Lavoie, Zhao Ma, Joe Starinchak, Jelena Vukomanovic

Environment and Society Faculty Publications

Invasive species and their management represent a complex issue spanning social and ecological systems. Invasive species present existing and potential threats to the nature of ecosystems and the products and services that people receive from them. Humans can both cause and address problems through their complex interactions with ecosystems. Yet, public awareness of invasive species and their impact is highly uneven, and public support for management and control of invasive species can be variable. Public perceptions often differ markedly from the perspectives of concerned scientists, and perceptions and support for management are influenced by a wide range of social and …

Nuclear Terrorism: Statutory Shortcomings And Prosecutorial Opportunities, Rohan Mishra

International Law Studies

In 2016, President Barack Obama warned that “[t]he danger of a terrorist group obtaining and using a nuclear weapon is one of the greatest threats to global security.” Thus far, however, U.S. and international efforts to address nuclear terrorism have faced a fundamental dilemma: While the importance of preventing this threat is unquestioned, there has been limited opportunity or need to conduct prosecutions that hinge on nuclear terrorism charges. This dilemma reflects the current piecemeal approach to nuclear terrorism, which prioritizes policies that address the “back-end” risk of nuclear terrorism (i.e., the detonation of nuclear weapons or attack of nuclear …

Life History And Ecology Of Bluenose Warehou (Hyperoglyphe Antarctica, Centrolophidae) In The Southern Atlantic, James B. Bell, Vladimir Laptikhovsky, David K.A. Barnes, Ramon Benedet, Amelia E. Bridges, J Glass, W Glass, Rodney Green, Simon A. Morley, Simon Robertson, Georgia R. Robson, Harry Stanton, Freja Azzopardi, Clive N. Trueman, Oliver Yates, Martin A. Collins

School of Biological and Marine Sciences

Bluenose warehou (Hyperoglyphe antarctica) is a popular commercial fish in Australia and New Zealand, but its biology and ecology are very poorly known in other regions where it is found. We present here the first life history data for this species from the south Atlantic, focusing upon the exclusive economic zone (EEZ) of the United Kingdom Overseas Territory (UKOT) of Tristan da Cunha (TdC). Here, bluenose is known from several seamounts and island margins, typically occurring in waters between 200 and 1,000 m depth and is the target species of trawl and longline fishery operating since 1997. We use a …

Removal Of Pharmaceutical Residues From Water And Wastewater Using Dielectric Barrier Discharge Methods—A Review, Emile S. Massima Mouele, Jimoh O. Tijani, Kassim O. Badmus, Omoniyi Pereao, Omotola Babajide, Cheng Zhang, Tao Shao, Eduard Sosnin, Victor Tarasenko, Ojo O. Fatoba, Katri Laatikainen, Leslie F. Petrik

Mining Engineering Faculty Research & Creative Works

Persistent pharmaceutical pollutants (PPPs) have been identified as potential endocrine disruptors that mimic growth hormones when consumed at nanogram per liter to microgram per liter concentrations. Their occurrence in potable water remains a great threat to human health. Different conventional technologies developed for their removal from wastewater have failed to achieve complete mineralization. Advanced oxidation technologies such as dielectric barrier discharges (DBDs) based on free radical mechanisms have been identified to completely decompose PPPs. Due to the existence of pharmaceuticals as mixtures in wastewater and the recalcitrance of their degradation intermediate by-products, no single advanced oxidation technology has been able …

Re-Analysis Of Abdominal Gland Volatilome Secretions Of The Africanweaver Ant, Oecophylla Longinoda (Hymenoptera: Formicidae), Bethelihem Mekonnen, Xavier Cheseto, Christian Pirk, Abdullahi Yusuf, Sunday Ekesi, Emilie Deletre, Baldwyn Torto

All Peer-Reviewed Publications

The African weaver ant, Oecophylla longinoda, is used as a biological control agent for the management of pests. The ant has several exocrine glands in the abdomen, including Dufour’s, poison, rectal, and sternal glands, which are associated with pheromone secretions for intra-specific communication. Previous studies have analyzed the gland secretions of Dufour’s and poison glands. The chemistry of the rectal and sternal glands is unknown. We re-analyzed the secretions from Dufour’s and poison glands plus the rectal and sternal glands to compare their chemistries and identify additional components. We used the solid-phase microextraction (SPME) technique to collect gland headspace volatiles …

Characterization Of The Strain-Rate–Dependent Mechanical Response Of Single Cell–Cell Junctions, Amir Monemian Esfahani, Jordan Rosenbohm, Bahareh Tajvidi Safa, Nickolay V. Lavrik, Grayson Minnick, Quan Zhou, Fang Kong, Xiaowei Jin, Eunju Kim, Ying Liu, Yongfeng Lu, Jung Yul Lim, James K. Wahl Iii, Ming Dao, Changjin Huang, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

Cell–cell adhesions are often subjected to mechanical strains of different rates and magnitudes in normal tissue function. However, the rate-dependent mechanical behavior of individual cell– cell adhesions has not been fully characterized due to the lack of proper experimental techniques and therefore remains elusive. This is particularly true under large strain conditions, which may potentially lead to cell–cell adhesion dissociation and ultimately tissue fracture. In this study, we designed and fabricated a single-cell adhesion micro tensile tester (SCAμTT) using twophoton polymerization and performed displacement-controlled tensile tests of individual pairs of adherent epithelial cells with a mature cell–cell adhesion. Straining the …

Cape Gooseberry Husk For The Removal Of Cecs From Wastewater: A Biosorption Study, Jehan Abdel Salam

Theses and Dissertations

Food and beverage industries produce large amounts of fruit wastes that are normally discarded every year. Meanwhile, these industries along with the pharmaceutical industries discharge wastewater effluents that are loaded with contaminants of emerging concern (CECs). Recent research is directed towards finding alternative cost effective and sustainable solutions for treating wastewater. In this regard, we investigated cape gooseberry husk as a potential biosorbent for the removal of caffeine (CA) and salicylic acid (SA), as examples of CECs, from wastewater. Three different types of husk were investigated; un-activated husk (H), and chemically activated husks (H350 and H500) prepared by acid treatment …

Autophagic Reprogramming Of Bone Marrow-Derived Macrophages, Mayada Mahmoud Zaki Mohamed Mazher

Theses and Dissertations

ABSTRACT Background: Macroautophagy is a highly conserved catabolic process among eukaryotes. Autophagosome is a piece of double-membrane machinery that fuses with lysosomes during macroautophagy to form autolysosomes. Autolysosome degrades organelles and organizes the pathogen engulfment during phagocytosis in innate immunity. Macrophages are highly dynamic immune cells that orchestrate the host-pathogen interaction. Interestingly, autophagy is implicated in disease pathophysiologies such as Crohn’s disease, cancer, and neurodegenerative diseases. Therefore, we studied the interplay between autophagy and macrophage polarization (activation) through two approaches: 1- Systems biology approach to construct the genetic regulatory network and pathway analysis. And to predict the target proteins that …

Autophagic Reprogramming Of Macrophages Polarization, Mayada Mahmoud Zaki Mohamed Mazher

Theses and Dissertations

Background: Macroautophagy is a highly conserved catabolic process among eukaryotes. Autophagosome is a piece of double-membrane machinery that fuses with lysosomes to form autolysosomes. Autolysosome degrades organelles and organizes the pathogen engulfment during phagocytosis in innate immunity. Macrophages are highly dynamic immune cells that orchestrate the host-pathogen interaction. Interestingly, autophagy is implicated in disease pathophysiologies such as Crohn’s disease, cancer, and neurodegenerative diseases. Therefore, this work aimed to study the interplay between autophagy and macrophage polarization (activation) through two approaches, first to construct the genetic regulatory network and pathway analysis. And to predict the target proteins that mediate the interplay …

Promoting The Educational Research Through An Open Access Institutional Repository Of Shanghai Cooperation Organisation (Sco) Countries: An Analytical Study, Satyajit Nayak, Ayush Kumar Patel, Avadhesh Kumar Patel, Bijayananda Pradhan

Library Philosophy and Practice (e-journal)

The present study proposed to focus on the current status of SCO countries Open Access Institutional Repositories. Nowadays, institutional repositories play a vital role in promoting higher education systems and research and development. Data were obtained from the Directory of Open Access Institutional Repositories (DOAR) website. Then collected data have been analysed and represented in graphical formats to clearly understand the study results. The researchers also assessed the SCO countries’ contribution to various parameters such as type of repository, disciplines, languages interface, and software used to build institutional repository. The study's findings revealed that out of 214 repositories, the highest …

Molecular Speciation Of Size Fractionated Particulate Water-Soluble Organic Carbon By Two-Dimensional Nuclear Magnetic Resonance (Nmr) Spectroscopy, Marie-Cecile Chalbot, Salma Siddiqui, Ilias G. Kavouras

Publications and Research

Particulate matter is associated with increased morbidity and mortality; its effects depend on particle size and chemical content. It is important to understand the composition and resultant toxicological profile of particulate organic compounds, the largest and most complex fraction of particulate matter. The objective of the study was to delineate the nuclear magnetic resonance (NMR) spectral fingerprint of the biologically relevant water-soluble organic carbon (WSOC) fraction of size fractionated urban aerosol. A combination of one and two-dimensional NMR spectroscopy methods was used. The size distribution of particle mass, water-soluble extract, non-exchangeable organic hydrogen functional types and specific biomarkers such as …

Traveling Wave Phenomena In A Nonlocal Dispersal Predator-Prey System With The Beddington-Deangelis Functional Response And Harvesting, Zhihong Zhao, Yan Li, Zhaosheng Feng

School of Mathematical & Statistical Sciences Faculty Publications

This paper is devoted to studying the existence and nonexistence of traveling wave solution for a nonlocal dispersal delayed predator-prey system with the Beddington-DeAngelis functional response and harvesting. By constructing the suitable upper-lower solutions and applying Schauder's fixed point theorem, we show that there exists a positive constant c∗ such that the system possesses a traveling wave solution for any given c>c∗. Moreover, the asymptotic behavior of traveling wave solution at infinity is obtained by the contracting rectangles method. The existence of traveling wave solution for c=c∗ is established by means of Corduneanu's theorem. The nonexistence of traveling wave …

Vicia Species, An Alternative Forage Crop In Semiarid Regions Of Mexico, Miguel A. Flores‐O., U. Figueroa‐V., F. Echavarría‐Ch.

IGC Proceedings (1977-2023)

No abstract provided.

Productivity Of Designed Silvopastoral Systems In Five Agro‐Ecological Regions Of India, M. M. Roy, B. Ekambaram, K. S. Dutta, S. M. Taley, P. Tripathi

IGC Proceedings (1977-2023)

No abstract provided.

The Innovations Of Contemporary Grassland Law And Its Differences From Nomadic Laws In Ming Dynasty, Chao Di, Yan Sun

IGC Proceedings (1977-2023)

No abstract provided.

Facial Recognition And The Fourth Amendment In The Wake Of Carpenter V. United States, Matthew Doktor

University of Cincinnati Law Review

No abstract provided.

Untangling Discrimination: The Crown Act And Protecting Black Hair, Alesha Hamilton

University of Cincinnati Law Review

No abstract provided.

Learning Without Contingencies Induces Higher Order Asynchrony In Brain Networks In Schizophrenia, Elizabeth L. Martin, Asadur Chowdury, Vaibhav Diwadkar, Sazid Hasan, Munajj Ul-Huq, Shahira Baajour, Dalal Khatib, Usha Rajan, Jeffrey Stanley

Medical Student Research Symposium

Schizophrenia (SCZ) is characterized by both cognitive and reward impairments. A recent study suggests that SCZ is associated with a loss of synchrony between learning and reward circuits (Robison et al., 2019) and higher levels of dis-organization of functional brain networks may underpin failures in learning that characterize SCZ (Hütt et al., 2014). Therefore, here we examined inter-group (HC ≠ SCZ) 4^th order differences in statistical regularity across a connectome of cognition and reward brain circuits. The analyses were conducted on fMRI time series data from a previous learning paradigm (Stanley et al., 2017) with periods of Encoding and …

Hospital-Acquired Venous Thromboembolism Or Bleeding Following Total Joint Arthroplasty: A Systematic Review And Meta-Analysis For The Association Of The Gene Polymorphism., Michael Debeau

Medical Student Research Symposium

This review seeks to understand the current existing literature on genetic polymorphisms to VTE following orthopedic surgery. Using PRISMA guidelines, 234 studies were retrieved from PubMed and Cochrane. The eligibility assessment yielded 16 studies including a systematic review. A STREGA and STROBE quality assessment found these studies to have high methodological quality. A significant association was found between the PAI-1 4G/4G genotype and resistance to anticoagulation therapy (OR = 2.692; 95% CI = 1.302 - 4.702). Moreover, the MTHFR C677T and A1298C polymorphisms significantly increased the incidence of VTE in patients that are compound heterozygotes (OR = 2.89; 95% CI …

Research Contribution Of Kalasalingam Academy Of Research And Education, Tamil Nadu, India: A Scientometric Evaluation, D Gnanasekaran

Library Philosophy and Practice (e-journal)

The study aims to evaluate the research performance of Kalasalingam Academy of Research and Education (KARE), Tamil Nadu, India. The 1933 research publications produced by KARE during the year 2001-2018 were retrieved from Scopus database and taken up for the study. Ms-Excel and IBM SPSS Statistics software were used to analyze the data and bibliometric indicators were applied for evaluation. The publication production found increased year by year but the growth rate is not on par with the quantity growth. 98.2% of the total publications were multi-authored and 98.4% of the publications were produced by research collaborations with the organizations …

Effects Of Nonlinearity And Network Architecture On The Performance Of Supervised Neural Networks, Nalinda Kulathunga, Nishath Rajiv Ranasinghe, Daniel Vrinceanu, Zackary Kinsman, Lei Huang, Yunjiao Wang

Faculty Publications

The nonlinearity of activation functions used in deep learning models is crucial for the success of predictive models. Several simple nonlinear functions, including Rectified Linear Unit (ReLU) and Leaky-ReLU (L-ReLU) are commonly used in neural networks to impose the nonlinearity. In practice, these functions remarkably enhance the model accuracy. However, there is limited insight into the effects of nonlinearity in neural networks on their performance. Here, we investigate the performance of neural network models as a function of nonlinearity using ReLU and L-ReLU activation functions in the context of different model architectures and data domains. We use entropy as a …

Cle Working Paper No.1/2021--Grassroots And Litigation-Based Approaches To Advancing Indigenous Rights: Lessons From Extractive Industry Resistance In Mesoamerica, Justin Wiebe

Centre for Law and the Environment

Indigenous peoples are frequently recognized as excellent stewards of their traditional territories. These territories, which often exhibit extraordinary levels of biodiversity, face disproportionate and growing threats from extractive industry. In opposing these threats, Indigenous peoples increasingly rely on internationally-defined Indigenous rights, including those set out in UNDRIP and ILO Convention 169. It is uncertain, however, how these rights are most effectively advanced. In this paper, I tease out strategies — both grassroots-based and litigation-based — that show promise in this regard. Drawing on Waorani resistance to an oil auction in Ecuador and Indigenous resistance to a large-scale mining project in …

Collaborating To Build And Implement A Shared Health Equity Research Agenda: A Report On The Three Campus Community Conversation, University At Albany, State University Of New York

Three Campus Community Conversation Final Report

In March of 2020 New York State’s Gov. Andrew Cuomo charged Havidan Rodríguez, President of the University at Albany, SUNY, with leading a team of public health, social welfare, emergency preparedness and other experts from both research and practice in a study of the environmental, socioeconomic and occupational factors causing Latinx and Black individuals in the state to be disproportionately harmed by COVID-19. See www.albany.edu/mhd.

In pursing this charge and at the request of President Rodríguez, the Vice President for Research at the University at Albany, Dr. James Dias partnered with the Vice President for Research from SUNY Downstate Health …

Up Close And Personal With Smu President Prof Lily Kong, Lily Kong

Oral History Collection

On the occasion of SMU’s coming of age (21st anniversary), alumnus Terence Quek (MCM 2013) 'Zoomed' SMU President Professor Lily Kong, and through a host of questions discovered her leadership challenges, why she ran 248km, and how she plans to keep SMU “glowing”.The interview was published in the February 2021 edition of SMU CIRCLE.

Honors Oracle, February 2021, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Evolution Of Protein-Mediated Biomineralization In Scleractinian Corals, Tal Zaquin, Assaf Malik, Jeana L. Drake, Hollie M. Putnam, Tali Mass

Biological Sciences Faculty Publications

While recent strides have been made in understanding the biological process by which stony corals calcify, much remains to be revealed, including the ubiquity across taxa of specific biomolecules involved. Several proteins associated with this process have been identified through proteomic profiling of the skeletal organic matrix (SOM) extracted from three scleractinian species. However, the evolutionary history of this putative “biomineralization toolkit,” including the appearance of these proteins’ throughout metazoan evolution, remains to be resolved. Here we used a phylogenetic approach to examine the evolution of the known scleractinians’ SOM proteins across the Metazoa. Our analysis reveals an evolutionary process …