Digital Commons Network^™

(A Few) Golden Moments With David Harrison, Ann Gifford

Michigan Reading Journal

No abstract provided.

Teachers As Writers, Michigan Reading Journal

Michigan Reading Journal

No abstract provided.

Note-Taking Rules, So Please Teach It!, Toni S. Walters

Michigan Reading Journal

No abstract provided.

Bookends: Reviews Of Young Adult Literature, Jennifer Cramer

Michigan Reading Journal

No abstract provided.

The Well-Stocked Bookshelf: Great Books To Start The School Year, Ed Spicer

Michigan Reading Journal

No abstract provided.

An Interview With Nic Bishop, Judi Hicks

Michigan Reading Journal

No abstract provided.

Sexually Transmitted Neisseria Gonorrhoeae Infections—Update On Drug Treatment And Vaccine Development, A. Jefferson, A. Smith, P. S. Fasinu, D. K. Thompson

Pharmaceutical Sciences

No abstract provided.

Modeling The Release And Spreading Of Permanganate From Aerated Slow-Release Oxidants In A Laboratory Flow Tank, Ann Kambhu, Yusong Li, Troy E. Gilmore, Steve D. Comfort

School of Natural Resources: Faculty Publications

Aerated, slow-release oxidants are a relatively new technology for treating contaminated aquifers. A critical need for advancing this technology is developing a reliable method for predicting the radius of influence (ROI) around each drive point. In this work, we report a series of laboratory flow tank experiments and numerical modeling efforts designed to predict the release and spreading of permanganate from aerated oxidant candles (oxidant-wax composites). To mimic the design of the oxidant delivery system used in the field, a double screen was used in a series of flow tank experiments where the oxidant was placed inside the inner screen …

Beauty That Moves: Dance For Parkinson’S Effects On Affect, Self-Efficacy, Gait Symmetry, And Dual Task Performance, Cecilia Fontanesi, Joseph F. X. Desouza

Publications and Research

Background: Previous studies have investigated the effects of dance interventions on Parkinson’s motor and non-motor symptoms in an effort to develop an integrated view of dance as a therapeutic intervention. This within-subject study questions whether dance can be simply considered a form of exercise by comparing a Dance for Parkinson’s class with a matched-intensity exercise session lacking dance elements like music, metaphorical language, and social reality of art-partaking.

Methods: In this repeated-measure design, 7 adults with Parkinson’s were tested four times; (i) before and (ii) after a Dance for Parkinson’s class, as well as (iii) before and (iv) after a …

Campus Stem Innovation From A Foothold In Mathematics: Lessons Learned From A Place Where It Happened, Angie Hodge-Zickerman, Janice Rech, Kelly Gomez Johnson

Teacher Education Faculty Publications

A metropolitan university, has had a productive journey in science, technology, engineering, and mathematics (STEM), which eventually led to a campus STEM priority, endowed STEM Community Chairs, an increase in external grants, disciplinary degree pathways for high school teachers and even a Citywide STEM Ecosystem organization. Much of this journey surfaced from collaborations originating in mathematics education, which then synergized into campus wide efforts. This article describes one campus’ journey into STEM and how transforming the mathematics teacher education program represented a “springboard” for formalizing STEM collaboration and innovation. It is offered to aid other institutions who want to make …

Potential Functional Variants In Ahr Signaling Pathways Are Associated With Age At Puberty In Swine, Dan Nonneman, Clay A. Lents, Lea A. Rempel, Gary A. Rohrer

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Puberty in female pigs is defined as age at first estrus and gilts that have an earlier age at puberty are more likely to have greater lifetime productivity. Because age at puberty is predictive for sow longevity and lifetime productivity, but not routinely measured in commercial herds, it would be beneficial to use genomic or marker-assisted selection to improve these traits. A GWAS at the US Meat Animal Research Center (USMARC) identified several loci associated with age at puberty in pigs. Candidate genes in these regions were scanned for potential functional variants using sequence information from the USMARC swine population …

Pull Back The Curtain And Look "Behind The Science" Of Covid-19 With Uab Frontline Doctors, Brianna Hoge

Browse All News

No abstract provided.

Gwu English Department Hosts Author, Kathryn Schwille, In Webinar On Feb. 25, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University Department of English Language and Literature is hosting author Kathryn Schwille in a Zoom webinar on Feb. 25 from 4 to 5 p.m. This program is part of the Darlene J. Gravett Visiting Writer Series and is open to the public.

Gardner-Webb Alumna’S Hip-Hop Music Featured On N.C. Arts Council Program, Office Of University Communications

Gardner-Webb NewsCenter Archive

In celebration of Black History Month during February, Gardner-Webb University will introduce you to alumni who are making a difference in the world around them. Through their jobs and creative passions, these alumni are inspiring others to achieve their dreams.

Throughout history, artists have used their music as a commentary on social issues. Affected by the racial inequalities she’s witnessed close to home and on newsfeeds, Troya Pope, a 2012 alumna of Gardner-Webb University, decided to write a song to her younger cousins. She wants to encourage them to pursue their dreams. A newcomer among North Carolina’s hip-hop artists, Pope’s …

Gwu President Downs Hosts Panel Discussion On Covid-19 In First Event Of New Series, Office Of University Communications

Gardner-Webb NewsCenter Archive

As part of Gardner-Webb’s commitment to serve the community, the University recently began an informative series called “Webb Connections.” Hosted by GWU President Dr. William M. Downs, these programs will feature a panel of experts discussing topics of national, regional and local interest. Because of COVID-19 safety guidelines, a small audience of students was invited to attend. The program was recorded live and is available online for everyone to view. The series, held monthly through April, will cover topics surrounding health, diversity, faith and education.

Using Current Legal Tools To Achieve Net Zero Greenhouse Gas Emissions From New And Existing Federal Oil And Gas Leases, Jamie Gibbs Pleune, Nada Wolff Culver, John C. Ruple

Utah Law Faculty Scholarship

Fossil fuel development on federal lands accounts for 24% of all U.S. carbon dioxide (CO2) emissions. These emissions can be reduced significantly by requiring federal oil and gas development activity to mitigate greenhouse gas (GHG) emissions. The Bureau of Land Management (BLM) has authority to define the terms and conditions of new oil and gas leases and to impose conditions of approval on existing leases at the drilling stage. Using this authority, the BLM could require net zero emissions on some existing and all new oil and gas leases without waiting for congressional action or regulatory changes. Applying existing legal …

Chimes: February 5, 2021, Calvin University

Chimes

Virtual January Series reaches 96,000 viewers globally by Alex Raycroft

One-third of professors sign letter opposing CRC sexuality report by Juliana Knot

Grand Rapids restaurants respond to increased costs during pandemic by Jamison Van Andel

Health students share COVID vaccine experiences by Abigail Ham

Calvin Peacemakers hope to bridge Knollcrest, Handlon campuses, promote restorative justice by Katherine Benedict

New men's basketball roster off to a promising start by Ellington Smith

'Stay vigilant': Students encouraged to observe COVID-19 rules by Sarah Gibes

Meet the Dutch House: the Christian fraternity at the University of Michigan started by Calvin alum by Afua Brantuo

Consequences Of Covid-19 Crisis For Persons With Hiv: The Impact Of Social Determinants Of Health, Kristie Cason Waterfield, Gulzar H. Shah, Gina D. Etheredge, Osaremhen Ikhile

Health Policy & Community Health: Faculty Publications

Background

With the indiscriminate spread of COVID-19 globally, many populations are experiencing negative consequences such as job loss, food insecurity, and inability to manage existing medical conditions and maintain preventive measures such as social distancing and personal preventative equipment. Some of the most disadvantaged in the COVID-19 era are people living with HIV/AIDS and other autoimmune diseases.

Discussion

As the number of new HIV infections decrease globally, many subpopulations remain at high risk of infection due to lack of or limited access to prevention services, as well as clinical care and treatment. For persons living with HIV or at higher …

Safety And Efficacy Of Hypofractionated Stereotactic Radiosurgery For High-Grade Gliomas At First Recurrence: A Single-Center Experience., Yun Guan, Ji Xiong, Mingyuan Pan, Wenyin Shi, Jing Li, Huaguang Zhu, Xiu Gong, Chao Li, Guanghai Mei, Xiaoxia Liu, Li Pan, Jiazhong Dai, Yang Wang, Enmin Wang, Xin Wang

Department of Radiation Oncology Faculty Papers

BACKGROUND: The optimal treatment for recurrent high-grade gliomas (rHGGs) remains uncertain. This study aimed to investigate the efficacy and safety of hypofractionated stereotactic radiosurgery (HSRS) as a first-line salvage treatment for in-field recurrence of high-grade gliomas.

METHODS: Between January 2016 and October 2019, 70 patients with rHGG who underwent HSRS were retrospectively analysed. The primary endpoint was overall survival (OS), and secondary endpoints included both progression-free survival (PFS) and adverse events, which were assessed according to Common Toxicity Criteria Adverse Events (CTCAE) version 5. The prognostic value of key clinical features (age, performance status, planning target volume, dose, use of …

Evaluation Of Triclosan Exposures On Secretion Of Pro-Inflammatory Cytokines From Human Immune Cells, Wendy J. Wilburn, Sara Jamal, Farah Ismail, Dylan Brooks, Margaret Whalen

Chemistry Faculty Research

Triclosan (TCS) is widely used in personal hygiene products, such as mouthwash and toothpaste, and is found in human tissues. Interleukin (IL)-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) are pro-inflammatory cytokines and inappropriately elevated levels of each have been associated with pathologies including rheumatoid arthritis and certain cancers. Here we examine effects of TCS on the secretion of the pro-inflammatory cytokines from human immune cell preparations. TCS at concentrations between 0.05–5 μM consistently increased the secretion of IL-1β, IL-6, and TNFα within 24 h of exposure and the increases often maintained out to 6 …

February 5, 2021 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Investigating The Relevance Of Major Signaling Pathways In Cancer Survival Using A Biologically Meaningful Deep Learning Model, Jiarui Feng, Heming Zhang, Fuhai Li

2020-Current year OA Pubs

BACKGROUND: Survival analysis is an important part of cancer studies. In addition to the existing Cox proportional hazards model, deep learning models have recently been proposed in survival prediction, which directly integrates multi-omics data of a large number of genes using the fully connected dense deep neural network layers, which are hard to interpret. On the other hand, cancer signaling pathways are important and interpretable concepts that define the signaling cascades regulating cancer development and drug resistance. Thus, it is important to investigate potential associations between patient survival and individual signaling pathways, which can help domain experts to understand deep …

Impaired Eif5a Function Causes A Mendelian Disorder That Is Partially Rescued In Model Systems By Spermidine., Víctor Faundes, Martin D. Jennings, Siobhan Crilly, Sarah Legraie, Sarah E. Withers, Sara Cuvertino, Sally J. Davies, Andrew G L Douglas, Andrew E. Fry, Victoria Harrison, Jeanne Amiel, Daphné Lehalle, William G. Newman, Patricia Newkirk, Judith Ranells, Miranda Splitt, Laura A. Cross, Carol J. Saunders, Bonnie Sullivan, Jorge L. Granadillo, Christopher T. Gordon, Paul R. Kasher, Graham D. Pavitt, Siddharth Banka

Manuscripts, Articles, Book Chapters and Other Papers

The structure of proline prevents it from adopting an optimal position for rapid protein synthesis. Poly-proline-tract (PPT) associated ribosomal stalling is resolved by highly conserved eIF5A, the only protein to contain the amino acid hypusine. We show that de novo heterozygous EIF5A variants cause a disorder characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphism. Yeast growth assays, polysome profiling, total/hypusinated eIF5A levels and PPT-reporters studies reveal that the variants impair eIF5A function, reduce eIF5A-ribosome interactions and impair the synthesis of PPT-containing proteins. Supplementation with 1 mM spermidine partially corrects the yeast growth defects, improves the polysome profiles …

Dietary Vitamin A Impacts Refractory Telogen., Liye Suo, Christine Vanburen, Eylul Damla Hovland, Natalia Y Kedishvili, John P Sundberg, Helen B Everts

Faculty Research 2021

Hair follicles cycle through periods of growth (anagen), regression (catagen), rest (telogen), and release (exogen). Telogen is further divided into refractory and competent telogen based on expression of bone morphogenetic protein 4 (BMP4) and wingless-related MMTV integration site 7A (WNT7A). During refractory telogen hair follicle stem cells (HFSC) are inhibited. Retinoic acid synthesis proteins localized to the hair follicle and this localization pattern changed throughout the hair cycle. In addition, excess retinyl esters arrested hair follicles in telogen. The purpose of this study was to further define these hair cycle changes. BMP4 and WNT7A expression was also used to distinguish …

A Distributed Geospatial Approach To Describe Community Characteristics For Multisite Studies, Patrick H. Ryan, Cole Brokamp, Jeff Blossom, Nathan Lothrop, Rachel L. Miller, Paloma I. Beamer, Cynthia M. Visness, Antonella Zanobetti, Howard Andrews, Leonard B. Bacharier, Tina Hartert, Christine C. Johnson, Dennis Ownby, Robert F. Lemanske, Heike Gibson, Weeberb Requia, Brent Coull, Edward M. Zoratti, Anne L. Wright, Fernando D. Martinez, Christine M. Seroogy, James E. Gern, Diane R. Gold

Public Health Sciences Articles

Understanding place-based contributors to health requires geographically and culturally diverse study populations, but sharing location data is a significant challenge to multisite studies. Here, we describe a standardized and reproducible method to perform geospatial analyses for multisite studies. Using census tract-level information, we created software for geocoding and geospatial data linkage that was distributed to a consortium of birth cohorts located throughout the USA. Individual sites performed geospatial linkages and returned tract-level information for 8810 children to a central site for analyses. Our generalizable approach demonstrates the feasibility of geospatial analyses across study sites to promote collaborative translational research.

Mutations In Hiv-1 Vpr Affect Pathogenesis In T-Lymphocytes And Novel Strategies To Contain The Current Covid-19 Pandemic, Antonio Solis Leal

Theses and Dissertations

Background SARS-CoV-2 is the virus responsible for the current global pandemic, COVID-19. Because this virus is novel, little is known about its sensitivity to disinfection. Methods We performed suspension tests against SARS-CoV-2 using three commercially available quaternary ammonium compound (Quat) disinfectants and one laboratory-made 0.2% benzalkonium chloride solution. Findings Three of the four formulations completely inactivated the virus within 15 s of contact, even in the presence of a soil load or when diluted in hard water. Conclusion Quats rapidly inactivate SARS-CoV-2, making them potentially useful for controlling SARS-CoV-2 spread in hospitals and the community.

High-Precision U-Pb Age Constraints On The Permian Floral Turnovers, Paleoclimate Change, And Tectonics Of The North China Block, Qiong Wu, Jahandar Ramezani, Hua Zhang, Jun Wang, Wan Yang, For Full List Of Authors, See Publisher's Website.

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The Permian marine-terrestrial system of the North China block provides an exceptional window into the evolution of northern temperate ecosystems during the critical transition from icehouse to greenhouse following the late Paleozoic ice age (LPIA). Despite many studies on its rich hydrocarbon reserves and climate-sensitive fossil flora, uncertain temporal constraints and correlations have hampered a thorough understanding of the records of geologic, biologic, and climatic change from the North China block. We present a new chronostratigraphy based on high-precision U-Pb chemical abrasion-isotope dilution-thermal ionization mass spectrometry (CA-ID-TIMS) geochronology of tuffs from a near-complete latest Carboniferous-Permian succession in North China. The …

Differential Privacy For Industrial Internet Of Things: Opportunities, Applications And Challenges, Bin Jiang, Houbing Song, Jianqiang Li, Guanghui Yue

Publications

The development of Internet of Things (IoT) brings new changes to various fields. Particularly, industrial Internet of Things (IIoT) is promoting a new round of industrial revolution. With more applications of IIoT, privacy protection issues are emerging. Specially, some common algorithms in IIoT technology such as deep models strongly rely on data collection, which leads to the risk of privacy disclosure. Recently, differential privacy has been used to protect user-terminal privacy in IIoT, so it is necessary to make in-depth research on this topic. In this paper, we conduct a comprehensive survey on the opportunities, applications and challenges of differential …

Reperfusion Of Retinal Ischemia In Retinal Occlusive Vasculitis With Nicotinic Acid And Infliximab In Adamantiades-Behçet's Disease, Ahmad Al-Moujahed, Doan Luong Hien, Amir Akhavanrezayat, Brandon Huy Pham, Ngoc Trong Tuong Than, Huy Luong Doan, Çigdem Yaşar, Sherin Lajevardi, Huy Vu Nguyen, Quan Dong Nguyen

Student Publications

Purpose: To describe a case of ischemic retinal vasculitis in Adamantiades-Behçet disease (ABD) that demonstrated significant resolution of retinal ischemia following treatment with nicotinic acid and infliximab.

Observations: A 12-year-old male with a history of recurrent oral ulcers, fevers, and failure to thrive was admitted to the hospital with fever, oral and perirectal mucositis, and poor oral intake one month before presentation to uveitis clinic. He was suspected to have ABD and was treated with three doses of intravenous (IV) methylprednisolone (30 mg/kg/day) which led to improvement in his systemic symptoms. One week after admission, he complained of decreased …

Nexstem Scholars Present Research Virtually, Kailee Galloway, Rachel Mccarthy

News and Events (Discontinued Series)

No abstract provided.