Digital Commons Network^™

Ct For Estimating Adequacy Of Lymph Node Dissection In Patients With Squamous Cell Carcinoma Of The Head And Neck, Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar

Dartmouth Scholarship

Background: Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods: Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and …

A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker

Dartmouth Scholarship

The specific neural systems underlying the subjective feeling of fear are debated in affective neuroscience. Here, we combine functional MRI with machine learning to identify and evaluate a sensitive and generalizable neural signature predictive of the momentary self-reported subjective fear experience across discovery (n = 67), validation (n = 20) and generalization (n = 31) cohorts. We systematically demonstrate that accurate fear prediction crucially requires distributed brain systems, with important contributions from cortical (e.g., prefrontal, midcingulate and insular cortices) and subcortical (e.g., thalamus, periaqueductal gray, basal forebrain and amygdala) regions. We further demonstrate that the neural representation of subjective fear …

Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza

Dartmouth Scholarship

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and …

Associations Between The Gut Microbiome And Metabolome In Early Life, Quang P. Nguyen, Margaret R. Karagas, Juliette C. Madan, Erika Dade, Thomas J. Palys, Hilary G. Morrison, Wimal W. Pathmasiri, Susan Mcritche, Susan J. Sumner, H. Robert Frost, Anne G. Hoen

Dartmouth Scholarship

Background: The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function in order to characterize the taxa-function relationship in early life. Results: Stool samples collected from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) …

Addressing The Mental Health Needs Of Children Affected By Hiv In Rwanda: Validation Of A Rapid Depression Screening Tool For Children 7–14 Years Old, Agnes Binagwaho, Eric Remera, Alice Uwase Bayingana, Darius Gishoma, Kirstin Woody Scott, Madeline Goosman, Eliza Campbell, Mawuena Agbonyitor, Yvonne Kayiteshonga, Sabin Nsanzimana

Dartmouth Scholarship

Background: Depression in children presents a significant health burden to society and often co-exists with chronic illnesses, such as human immunodeficiency virus (HIV). Research has demonstrated that 10–37% of children and adolescents living with HIV also suffer from depression. Low-and-middle income countries (LMICs) shoulder a disproportionate burden of HIV among other health challenges, but reliable estimates of co-morbid depression are lacking in these settings. Prior studies in Rwanda, a LMIC of 12 million people in East Africa, found that 25% of children living with HIV met criteria for depression. Though depression may negatively affect adherence to HIV treatment among children …

Sprd: A Surface Plasmon Resonance Database Of Common Factors For Better Experimental Planning, Purushottam B. Tiwari, Camelia Bencheqroun, Mario Lemus, Taryn Shaw, Marilyn Kouassi-Brou, Adil Alaoui, Aykut Üren

Dartmouth Scholarship

Background: Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surface plasmon resonance is a very powerful tool in different stages of small molecule drug development and antibody characterization. Both academic institutions and pharmaceutical industry extensively utilize this method for screening and validation studies involving direct molecular interactions. In most applications of the surface plasmon resonance technology, one of the studied molecules is immobilized on a microchip, while the second molecule is delivered through a microfluidic system over the immobilized molecules. Changes in total mass on …

Genome-Resolved Metagenomics Reveals Role Of Iron Metabolism In Drought-Induced Rhizosphere Microbiome Dynamics, Ling Xu, Zhaobin Dong, Dawn Chiniquy, Grady Pierroz, Siwen Deng, Cheng Gao, Spencer Diamond, Tuesday Simmons, Heidi M.L. Wipf, Daniel Caddell, Nelle Varoquaux, Mary A. Madera, Robert Hutmacher, Adam Deutschbauer, Jeffery A. Dahlberg, Mary Lou Guerinot, Elizabeth Purdom, Jillian F. Banfield, John W. Taylor, Peggy G. Lemaux

Dartmouth Scholarship

Recent studies have demonstrated that drought leads to dramatic, highly conserved shifts in the root microbiome. At present, the molecular mechanisms underlying these responses remain largely uncharacterized. Here we employ genome-resolved metagenomics and comparative genomics to demonstrate that carbohydrate and secondary metabolite transport functionalities are overrepresented within drought-enriched taxa. These data also reveal that bacterial iron transport and metabolism functionality is highly correlated with drought enrichment. Using time-series root RNA-Seq data, we demonstrate that iron homeostasis within the root is impacted by drought stress, and that loss of a plant phytosiderophore iron transporter impacts microbial community composition, leading to significant …

Turning Orphans For A Profit: The Orphan Drug Act Is Due For An Overhaul, Kelly L. Mckinney

Hofstra Law Review

No abstract provided.

Prenatal Exposure To Per- And Polyfluoroalkyl Substances And Child Neurodevelopment, Jiwon Oh

Earth & Environmental Sciences Dissertations - Archive

Pregnant women are exposed to per- and polyfluoroalkyl substances (PFAS) primarily via ingestion of contaminated food, water, and house dust. PFAS in pregnant women can be transferred to their child through the placenta during pregnancy. Many long-chain PFAS have been frequently detected in blood of pregnant women, amniotic fluid, and umbilical cord blood for the last few decades. Prenatal exposure to PFAS has shown potential to adversely affect offspring’s neurodevelopment in laboratory animals. However, epidemiological evidence on associations between prenatal PFAS exposure and child neurodevelopment remains inconsistent. My dissertation research consists of four sub-studies whose objectives are (1) to examine …

Hplc Analysis Of Potentially Counterfeit Samples Of Amoxicillin, Hunter Noel

Undergraduate Honors Theses

The global phenomenon of drug counterfeiting is a threat to both patients and healthcare systems alike. Counterfeit drugs can build bacterial resistance to antibiotics, undermine public trust in prescribed medications, fail to alleviate sickness, or even hurt the patient. Annually, thousands of people die from ingesting fake drugs (Blackstone et al., 2014). In order to combat the global prevalence of drug counterfeiting, it is important to test suspect drugs for legitimacy and then report findings back to relevant authorities that can enforce drug quality standards (Lieberman, 2018). High performance liquid chromatography (HPLC) is an analytical method that can determine the …

Can A Large-Landscape Conservation Vision Contribute To Achieving Biodiversity Targets?, Mark Hebblewhite, Jodi A. Hilty, Sara Williams, Harvey Locke, Charles Chester, David Johns, Gregory Kehm, Wendy L. Francis

Political Science Faculty Publications and Presentations

Founded in 1993, the Yellowstone to Yukon (Y2Y) vision was one of the earliest large-landscape conservation visions. Despite growing recognition of large-landscape conservation strategies, there have been few tests to date of conservation gains achieved through such approaches. We tested for conservation gains in the Y2Y region of North America following initiation of the Y2Y conservation vision in 1993 using a counterfactual spatiotemporal comparison and tracking change in five different conservation metrics. First, we enumerated the area of land within Y2Y in designated protected areas. We then compared the rate of change of protected area growth before- and after-initiation of …

Raps Sheet, December 2021, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

Development Of Bioaffinity Based Assays For Forensic Applications, Juliana Maria Agudelo Cano

Legacy Theses & Dissertations (2009 - 2024)

In the field of forensic science, body fluids are a major contributor of evidence in investigations. However, body fluids are usually used only for their genetic content, overlooking its unique composition of proteins and low-molecular-weight compounds that often serve as biomarkers in clinical diagnostics. This investigation aimed to develop simple, effective, and economical models that can be used to identify different attributes of the originator. The focus of this research was to develop biocatalytic cascades that could analyze body fluids by using UV-Vis spectroscopy. These models could be implemented in forensic settings, as well as in biometric authentications. The central …

The Assemblage Of The Dead : Speech, Subjectivity, And Being Human, Nazia Manzoor

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT“The Assemblage of the Dead: Speech, Subjectivity, and Being Human” reimagines the construct of the human as a political subject of the state through a bio(necro)political lens. The project re-envisions the conceptual framework of biopolitics through an engagement with the figure of the living dead, centralized in Giorgio Agamben’s work through his casting of the figure of the Muselmann as the cipher that reveals the limits of humanity and being human. With a bid to counter-narrate the twinning of death and resistance and death and subjectivity as foundational markers of humanity in current critical scholarship of the field, this project …

Modulation Of Rho Termination : Expectation Vs Reality, Kavya Sri Sai Chegireddy

Legacy Theses & Dissertations (2009 - 2024)

Transcription termination factor Rho is an essential protein in many bacteria. Rho is an ATP-dependent RNA helicase that accounts for 20-50% of termination events in Escherichia coli and plays an important role in preventing pervasive transcription that otherwise might be lethal to bacteria. Rho termination usually occurs in the 3’ UTRs and non-coding regions of the DNA, and the actively transcribing RNA is believed to be protected by translating ribosomes from Rho termination since both transcription and translation are a simultaneous process in prokaryotes. However, in reality, Rho terminates transcription of some protein-coding genes, and fails to terminate transcription of …

Sex Differences In Context Fear Neural Circuitry And Behavior Across Development, Lorianna Marie Colon

Legacy Theses & Dissertations (2009 - 2024)

Over the span of five decades, staggering progress has been made in elucidating the neural circuits involved in fear learning. Research focused on rodents and healthy individuals has been instrumental in elucidating how abnormalities in this circuitry may lend to increased prevalence of various fear and anxiety disorders. However, many of the key findings concerning the acquisition, storage, and retrieval of fear memories have been established in the adult male rodent, leaving a gap in knowledge as to whether females and developing animals process fear and stress inducing information in a similar fashion. Compared to men, women are twice as …

Development Of Visible-Light-Mediated Photoredox Catalysis, Sarbjeet Kaur

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

Empowering Melatonin Therapeutics With Drosophila Models, Cassandra Millet-Boureima, Caroline C. Ennis, Jurnee Jamison, Shana Mcsweeney, Anna Park, Chiara Gamberi

Biology

Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved amongst mammals. Other melatonin-binding proteins exist. Non-receptor-mediated activities involve regulating the mitochondrial function and antioxidant cascade, which are frequently affected by normal aging as well as disease. Several pathologies display diseased or dysfunctional mitochondria, suggesting melatonin may be used therapeutically. Drosophila models have extensively been employed to study disease pathogenesis …

Adverse Childhood Experiences And Social Determinants Of Health In Relation To Pediatric Intensive Care Unit Admissions, Kasey Davis

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This literature review was conducted in order to examine the correlation between adverse childhood experiences (ACEs), social determinants of health and pediatric intensive care unit (PICU) admissions. Oftentimes, those admitted as patients in the PICU come from homes in which social determinants of health, such as poverty and lack of access to healthcare, and ACEs, such as abuse and neglect, are prevalent. Systematic studies of existing literature and experience in the hospital setting revealed the ways in which these conditions often cause children to reach such poor health conditions that they must be admitted to the PICU. In order to …

Implementing 2nd Milk’S Use Of The World Health Organization Standardized Growth Charts To Better Track The Growth And Development Of The Malnourished And Orphaned Infants In Their Supplemental Nutrition Program In Malawi, Allie Wycoff

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This article considers the history and implications of the World Health Organization (WHO) standardized growth charts as well as the significant impact that growth chart utilization may have on 2^ndMilk’s ability to understand and track the nutritional status of the malnourished orphaned infants in their formula program. Specifically, this literature review examines whether or not the WHO growth charts are a meaningful tool for 2^ndMilk to adopt into their monthly baby assessments. The WHO growth charts are calibrated to express an accepted international “norm” for what an adequately nourished child looks like. In a recent service-learning …

Toward Lignin Valorization: Development Of Rhodococcus Opacus Pd630 As A Chassis For Triacylglycerol (Tag) Production From Recalcitrant Aromatic Feedstocks, Rhiannon R. Carr

McKelvey School of Engineering Graduate Student Theses & Dissertations

The advent of the industrial era was precipitated by the discovery of fossil fuels, and ushered in unprecedented changes for humanity included but not limited to the development of rapid transit and communications, improvements to food distribution and preservation, the mass production of goods, and a radical rearrangement of communities from relatively small enclaves to metropolises. With all the benefits, however, come considerable costs, especially to the global environment. Greenhouse gas emissions, built up over centuries of unregulated combustion, have precipitated a rate of global temperature change unparalleled in the 4.5 billion-year history of this planet. In order to preserve …

Increased Use Of Opioids Perioperatively Leads To Unmanaged Postoperative Pain, Halida Sehic

Nursing | Senior Theses

Background: Total knee and total hip joint arthroplasty are two frequently preformed surgeries, with 5.2 million total knee arthroplasties performed the United States between the year 2000 and 2010 (Williams et al., 2015). Opioids are widely used to manage pain for patients undergoing total joint arthroplasty. However, use of opioids is associated with undesirable adverse effects, such as nausea and respiratory depression, (Johnson et al., 2011). In postoperative patients following total joint replacement, 75 % of the patients complain of inadequately controlled moderate to severe pain (De Luca et al., 2018). Increased use and overprescribing increase tolerance to opioids …

Tdec 2021 Annual Report, Tennessee. Department Of Environment & Conservation.

Annual Report

No abstract provided.

Second Look Commission 2021 Annual Report, Tennessee. Commission On Children And Youth.

Second Look Commission Annual Report

No abstract provided.

Kaleidoscopic Katas: An Intercultural Somatic Curriculum For Holistic Health, Emily Seymour

Master's Theses

The intent of this research study was to combine three African and Eastern somatic movement practices into a modern dance curriculum. Few studies have investigated the therapeutic value of subtle body awareness in a dance class context. This integrative study combined psychological, physiological, and contemplative pedagogical approaches, which led to the development of a comprehensive five-part workshop with five adult participants. This ten-hour online class series involved learning a traditional Afro-Haitian serpent dance called the Yanvalou, the Tantric practice of Chakra Yoga, and the Five Animals qigong. The original curricular goal was to combine these three modalities into five sequential …

Balancing Increased Physical Demands: An Analysis Of Cross-Training Practices In Young Adult Ballet Dancers, Brooke Yuspeh

Master's Theses

The purpose of this study was to see what young adult ballet dancers knew about cross-training and if they found cross-training methods they practiced effective in supporting their dance technique and helping to prevent injuries. To uncover this information, the researcher used the following essential questions to guide this project: Q1: How do young adult ballet dancers practice cross-training? Q2: Which of these cross-training modalities are considered most effective? The research instruments used in this study included a survey consisting of multiple-choice, multiple-selection, and open-ended questions and an optional journal reflection consisting of open-ended questions. There were a total of …

Knowledge And Practice On Pest Management Of Ethnic Potato Farmers In Southern Shan State, Myanmar, Pyae Pa Pa Aung, Supawan Visetnoi

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

Potato is cultivated as the main tuber crop which is essential for ethnic farmers’ household income in Southern Shan State, Myanmar. Most ethnic farmers use chemicals widely to enhance crop yield and reduce pests. Overuse and misuse of pesticides could lead to a series of health impacts and environmental issues. The main aim of the study is to explore farmers’ current practices and knowledge level on pesticides in potato production. The participants of 100 farmers were chosen from each village with a cluster and purposive sampling technique using structured questionnaires to collect the data from a village in Kalaw Township. …

Biodiversity Scale-Dependence And Opposing Multi-Level Correlations Underlie Differences Among Taxonomic, Phylogenetic And Functional Diversity, Nadejda A. Mirochnitchenko, Erica F. Stuber, Joseph J. Fontaine

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Aim: Biodiversity is a multidimensional property of biological communities that represents different information depending on how it is measured, but how dimensions relate to one another and under what conditions is not well understood. We explore how taxonomic, phylogenetic, and functional diversity can differ in scale-of-effect dependence and habitat-biodiversity relationships, and subsequently how spatial differences among biodiversity dimensions may arise. Location: Nebraska, United States. Taxon: Birds. Methods: Across 2016 and 2017, we conducted 2,641 point counts at 781 sites. We modeled the occupancy of 141 species using Bayesian Bernoulli-Bernoulli hierarchical logistic regressions. We calculated species richness (SR), phylogenetic diversity (PD), …

If You Think Ai Won't Eclipse Humanity, You're Probably Just A Human, Gary D. Brown

William & Mary Bill of Rights Journal

Building machines that can replicate human thinking and behavior has fascinated people for hundreds of years. Stories about robots date from ancient history through da Vinci to the present. Whether designed to save labor or lives, to provide companionship or protection, loyal, capable, productive machines are a dream of humanity.

The modern manifestation of this interest in using human-like technology to advance social interests is artificial intelligence (AI). This is a paper about what that interest in AI means and how it might develop in the world of national security.

This abstract has been adapted from the author's introduction.

Facing Injustice: How Face Recognition Technology May Increase The Incidence Of Misidentifications And Wrongful Convictions, Laura Moy

William & Mary Bill of Rights Journal

Part I of this Article explains how face recognition is used in conjunction with eyewitness identification in the law enforcement context. Part II explores how and why the growing use of face recognition technology may increase, rather than decrease, misidentifications and therefore wrongful convictions. Part III recommends policy changes that should be considered, including some of the reforms to eyewitness identification procedures that have been advanced by others.

This abstract has been adapted from the author's introduction.