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2021

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Local History Collection On Sri Chaitanya Mahaprabhu In The Public Libraries In Nabadwip, Shekhor Modak Jan 2021

Local History Collection On Sri Chaitanya Mahaprabhu In The Public Libraries In Nabadwip, Shekhor Modak

Library Philosophy and Practice (e-journal)

This study investigates the local history collection on Sri Chaitanya Mahaprabhu in public libraries of Nabadwip. It focuses on the local history collection on Sri Chaitanya Mahaprabhu needed by the patron of the library, tourist, historians, writers. It also tries to find out what type of documents or resources needed by the information seeker, their frequency to visit the library to achieve their information queries and their satisfaction level towards library collection services and facilities provided by the library. A descriptive method used, and the data collected through a questionnaire from library users. Findings are made on the basis of …


Influence Of Demographic Factors On Information-Seeking Behaviour Of Medical Doctors In Teaching Hospitals In Nigeria, Oluyomi Folorunso Jan 2021

Influence Of Demographic Factors On Information-Seeking Behaviour Of Medical Doctors In Teaching Hospitals In Nigeria, Oluyomi Folorunso

Library Philosophy and Practice (e-journal)

Information-seeking Behaviour (IB) of medical doctors is crucial to satisfying information needs relating to patients’ treatment and improvement of healthcare service delivery. Previous studies on doctors’ IB have focused largely on information sources and utilisation without consideration for factors predicting their IB; particularly Doctors’ Demographic Factors (DDF). This study, therefore, was designed to determine DDF (age, gender, marital status, specialty and medical job experience) as predictors of medical doctors’ IB in teaching hospitals in Nigeria. The survey design of correlational type was adopted and multi-stage procedure was used. Six teaching hospitals across five geo-political zones in Nigeria were randomly selected, …


Reading Habits Of Lakhimpur District Library Of Assam: A Case Study Of Covid-19 Pre And Post Lockdown, Hima Jyoti Deka Jan 2021

Reading Habits Of Lakhimpur District Library Of Assam: A Case Study Of Covid-19 Pre And Post Lockdown, Hima Jyoti Deka

Library Philosophy and Practice (e-journal)

This paper is based on the District library, Lakhimpur , Assam, India, which is an endeavor to highlight the reading habits of users in Pre & Post lockdown period (pre lockdown period refer as April 2019 to 24th March 2020 and post Lockdown as after 30th June 2020 to 20th March 2021) of Lakhimpur District Library ( LDL) . The aim of the present study is also to find out the time used by the users of the Lakhimpur district library in different age groups. The finding of the study also reveals that there is scope for development …


Relationship Between Students’ Information Literacy Skills And Availability Of Digital Information Resources In Universities Library Of Azad Jammu And Kashmir, Muhammad Ramzan Jan 2021

Relationship Between Students’ Information Literacy Skills And Availability Of Digital Information Resources In Universities Library Of Azad Jammu And Kashmir, Muhammad Ramzan

Library Philosophy and Practice (e-journal)

The present study was conducted with an aim to determine the relationship between students’ information literacy skills and availability information resources in universities library of Azad Jammu & Kashmir. A survey research design was used to collect data from the participants. The population of this study were post-graduate students enrolled in public sector universities of AJ&K. A convenience sampling technique was used to collect the data. A statistical package for social sciences (SPSS-20) was used for the analysis of data. The descriptive statistics was used to determine percentage, frequency, mean and standard deviation, and inferential statistic was used to determine …


Information Age And Knowledge Society: Implication For Libraries, Faith O. Mesagan, Christopher Eje Ogar, Olalekan F. Adurota, Eucharia N. Aye, Joseph O. Wogu Jan 2021

Information Age And Knowledge Society: Implication For Libraries, Faith O. Mesagan, Christopher Eje Ogar, Olalekan F. Adurota, Eucharia N. Aye, Joseph O. Wogu

Library Philosophy and Practice (e-journal)

The paper highlighted the concepts of information age and knowledge society and their implication for libraries. Basic concepts such as information and knowledge society were defined. A brief historical role of information and knowledge from the pre-historic period to modern concepts or information and knowledge society were examined. The role of libraries as facilitators to information age and knowledge society were also highlighted in the context of information and communication technology (ICT) in the present-day society, the arising need for ICT competencies was advocated. The paper concluded by making some recommendations like developing a workable ICT adequate and functional ICT …


Highly Cited Papers In Library And Information Science Field In The Web Of Science From 1983 To 2018: A Bibliometric Study, Mohammad Kharabati-Neshin, Nayyer Yousefi, Seyedeh Zahra Mirezati, Mohammad Karim Saberi Jan 2021

Highly Cited Papers In Library And Information Science Field In The Web Of Science From 1983 To 2018: A Bibliometric Study, Mohammad Kharabati-Neshin, Nayyer Yousefi, Seyedeh Zahra Mirezati, Mohammad Karim Saberi

Library Philosophy and Practice (e-journal)

Abstract

This bibliometric study set out to evaluate and analyze highly cited papers in Library and Information Science field (LIS) in the Web of Science database from 1983 to 2018. In this bibliometric study, the required data were extracted from the Web of Science database. First, all documents under the rubric of LIS subject area, including 366,756 documents, were retrieved. The search was then limited to the highly cited papers. Of these papers, 433 ones were in the top-1% percentile rank. Finally, after the bibliometric data of the highly cited papers were extracted in plain text format, Excel and VOSviewer …


Knowledge And Use Of Electronic Information Resources By Post Graduate Engineering Students Of Karnataka State: A Study, Chandrashekar K L, Dharani Kumar P Jan 2021

Knowledge And Use Of Electronic Information Resources By Post Graduate Engineering Students Of Karnataka State: A Study, Chandrashekar K L, Dharani Kumar P

Library Philosophy and Practice (e-journal)

The present study is an attempt to know the knowledge and use of electronic information resources by post graduate engineering students studying in 16 Autonomous engineering colleges of Karnataka state. The study involved 1064 post graduate engineering students and found that 100% students use electronic information resources. The study also revealed that e-journals are the most preferred e-resources and the library notice board along with library websites are the major sources of creating awareness about the availability of e-resources. However, the trial and error method was highly used to use e-resources followed by self-study and library orientation. The study found …


Bibliometric Analysis Of The Health Information And Libraries Journal (2005-2021): With Special Reference To Web Of Science Core Collection Database, Jignesh Amin Dr., Yogesh Parekh Dr., Pragnesh Parekh Jan 2021

Bibliometric Analysis Of The Health Information And Libraries Journal (2005-2021): With Special Reference To Web Of Science Core Collection Database, Jignesh Amin Dr., Yogesh Parekh Dr., Pragnesh Parekh

Library Philosophy and Practice (e-journal)

The present bibliometric study of the Health Information and Libraries Journal was conducted using Web of Science SCIE. Total 727 documents retrieved including 481 articles, 7 early access articles, 3 proceedings papers, 25 bibliography and related items, 10 book reviews, 8 article corrections, 130 editorial materials, and 63 reviews. The outcome parameters were the number of publications, citations, top countries, authors, organizations/institutions, and citation analysis, impact factor, most frequent author keywords were presented as visualization map, etc.


Extent Of Student-Counsellors' Satisfaction With Library Services Offered At The University Of Nigeria, Nsukka, Joy Onah, Patience Ugwueke, Mkpoikanke S. Otu, Chiedu Eseadi, Kay C.N. Onyechi Jan 2021

Extent Of Student-Counsellors' Satisfaction With Library Services Offered At The University Of Nigeria, Nsukka, Joy Onah, Patience Ugwueke, Mkpoikanke S. Otu, Chiedu Eseadi, Kay C.N. Onyechi

Library Philosophy and Practice (e-journal)

This study was designed to investigate the extent of student-counsellors' satisfaction with library services offered at the University of Nigeria, Nsukka. The study is a descriptive survey comprising all the full-time undergraduate student-counsellors at the University of Nigeria, Nsukka, from the first year to final year. A structured questionnaire was used for obtaining data. The findings showed that there was a high extent of student-counsellors’ satisfaction with the registration, lending, shelving, renewal/replacement and reserve services offered by the university library. There is a need to take regular feedback from the students regarding the various services provided by the library.


Information Literacy Skills And Utilisation Of Electronic Information Resources By Postgraduate Students In Nigeria, Jeremiah Emeka Ugwulebo, Omorodion Okuonghae Jan 2021

Information Literacy Skills And Utilisation Of Electronic Information Resources By Postgraduate Students In Nigeria, Jeremiah Emeka Ugwulebo, Omorodion Okuonghae

Library Philosophy and Practice (e-journal)

The study investigated information literacy skills and utilization of electronic information resources by postgraduate students in Nigeria. The study adopted the ex post facto research design to investigate the relationship that exists between information literacy skill variables and the utilization of electronic information resources by postgraduate students in Nigeria. The population of the study comprised 3,744 postgraduate students from three federal universities in Nigeria, namely; University of Uyo, Uyo; University of Calabar, Calabar and University of Port Harcourt, Choba, Port Harcourt. The sample size for the study is 374 respondents which was determined using the Taro Yamane’s (1969) method for …


A Bibliometric Review On Information Seeking Behaviour Research Literature In Library And Information Science Using Histcite And Vosviewer, Abhijit Thakuria, Indranil Chakraborty Jan 2021

A Bibliometric Review On Information Seeking Behaviour Research Literature In Library And Information Science Using Histcite And Vosviewer, Abhijit Thakuria, Indranil Chakraborty

Library Philosophy and Practice (e-journal)

The study provides a bibliometric review of 920 research studies on Information Seeking Behaviour (ISB) in the discipline of Library and Information Science of last thirty years i.e., 1991-2020, published in 68 academic journals, authored by 1614 authors. We extracted the bibliographical data from the Web of Science database and analyzed using HistCite for citation counts and VOSviewer for bibliographic coupling and cartography analysis of network visualization. The main purpose of the study is to find out the most influential authors, articles, journals, institutions and countries of last thirty years. Furthermore, by applying bibliographic coupling and co-occurrence of keywords analysis, …


Big Data Analytics In Public Sector University Libraries In Pakistan, Sadaf Shahid, Rafat Parveen Siddiqui Jan 2021

Big Data Analytics In Public Sector University Libraries In Pakistan, Sadaf Shahid, Rafat Parveen Siddiqui

Library Philosophy and Practice (e-journal)

This study examines librarians' perceptions, capabilities, and understandings of Big Data analytics in public sector university libraries in Karachi, Pakistan. To acquire the desired results, a survey was conducted and using a quantitative approach. The study's target audience was library administrators at public sector university libraries in Karachi, all of which are recognized by Pakistan's Higher Education Commission and chartered by the Sindh Government. All respondents were sent an e-mail inviting them to participate in the survey on their own time. This study is important because it fills a large vacuum in the literature about the perspectives of Karachi's public …


Assessing The Information Seeking Behaviour Of Researchers At The Okavango Research Institute, Botswana, Mosepele Mabutho, Janneke Mostert Jan 2021

Assessing The Information Seeking Behaviour Of Researchers At The Okavango Research Institute, Botswana, Mosepele Mabutho, Janneke Mostert

Library Philosophy and Practice (e-journal)

The Okavango Research Institute (ORI), a branch of the University of Botswana (UB), located in the North Western region of Botswana, serves researchers in the natural and social sciences. ORI researchers need information to support research that contributes towards sustainable use of Botswana’s wetlands, which includes the Okavango Delta and other related wetlands. This study investigated the information seeking behaviour of ORI’s researchers. The aim of the study was to understand how they seek information, the information sources they use, and the problems they encounter when seeking information. Since ORI is a small institution, all the organization’s researchers were included …


Strategies Adopted By Library Science Research Scholars To Cope With Challenges In Dissertation-Writing, Sana Ul Haq, Khurram Shahzad, Muhammad Naeem Jan 2021

Strategies Adopted By Library Science Research Scholars To Cope With Challenges In Dissertation-Writing, Sana Ul Haq, Khurram Shahzad, Muhammad Naeem

Library Philosophy and Practice (e-journal)

The objective of this study was to explore the strategies adopted by Library and Information Science (LIS) Postgraduate M. Phil. and Ph.D. Students to cope with challenges in dissertation-writing. Firstly, an in-depth analysis of the relevant literature was done. A quantitative approach followed by a survey research design was followed to meet the set objective of the study. The population of the study was 98 research scholars of which 72 were enrolled in M.Phil. Program and 26 in Ph.D. Program. The findings of the study show that researchers face several problems during dissertation writing and they adopt different strategies to …


Reflection On Supervising Information Science And Technology Postgraduate Students At South African Universities: Best Practices For Transformational Learning, Tlou Maggie Masenya Jan 2021

Reflection On Supervising Information Science And Technology Postgraduate Students At South African Universities: Best Practices For Transformational Learning, Tlou Maggie Masenya

Library Philosophy and Practice (e-journal)

Supervising postgraduate students especially online supervision can be a daunting task that brings several unique challenges. This article reflects on my supervision experiences, the challenges faced by research supervisors in Higher Education Institutions (HEIs) and the strategies to improve the research supervision practices. The article draws upon my own experiences at both residential and distance learning universities and for the past four years as a research supervisor. My supervision reflection begins with my time at the University of South Africa (UNISA), where I cut my teeth as a Senior Lecturer, and have learned several valuable experiences and practices related to …


Library And Information Science Integrated Language Teaching Approach And Students’ Achievement In English Grammar, Cajethan I. Egbe Phd, Grace C. Offorma Prof, Goodluck Kadiri Phd Jan 2021

Library And Information Science Integrated Language Teaching Approach And Students’ Achievement In English Grammar, Cajethan I. Egbe Phd, Grace C. Offorma Prof, Goodluck Kadiri Phd

Library Philosophy and Practice (e-journal)

Different studies have shown that students perform poorly in English grammar. Thus, the study investigated the effect of Library and Information Science Integrated Language Teaching Approach on students’ achievement in English grammar. The achievement of students taught with ILTA were compared with those of students taught with the Form Based Approach (FAB). A quasi-experimental design was adopted. A total of 296 senior secondary school two students (83 males and 73 females) constituted the sample. They were assigned into experimental and control groups using a multi-stage sampling technique. The English Grammar Achievement Test (EGAT) was used for data collection. Treatment lasted …


Methods Adopted By University Library Professionals For Acquiring Icts Competencies, Faria Munawar, Khurram Shahzad, Naveed Anwar Jan 2021

Methods Adopted By University Library Professionals For Acquiring Icts Competencies, Faria Munawar, Khurram Shahzad, Naveed Anwar

Library Philosophy and Practice (e-journal)

The major objective of the study was to explore methods adopted by library professionals of South Punjab to acquire ICTs competencies. The population of the study was all the universities of South Punjab, Pakistan. Purposeful Sampling was applied by the researchers. The tool of the questionnaire was formed to gather data from the participants. The findings of the study show that the respondents of South Punjab sectors' libraries used tele/video conferencing methods, LIS schools, self-study, and tours of other institutions for acquiring ICT skills. The study discovered that respondents faced problems during acquiring ICT competencies included tight working schedules, lack …


Global Visibility Through The Use Of Institutional Repositories: The Struggles Of Local Content Resources In Selected Nigerian Tertiary Institutions In South-East Geo-Political Zone., Ebubechukwu E. Uba Cln, Ebubechukwu A. Okonkwo Cln Jan 2021

Global Visibility Through The Use Of Institutional Repositories: The Struggles Of Local Content Resources In Selected Nigerian Tertiary Institutions In South-East Geo-Political Zone., Ebubechukwu E. Uba Cln, Ebubechukwu A. Okonkwo Cln

Library Philosophy and Practice (e-journal)

The aim of this paper is to investigate the struggles of local content resources in gaining global research visibility through institutional repositories in selected Nigerian tertiary institutions in the South-East geo-political zone. Specifically, the study identified the different local content resources acquired and available to be published in the institution’s repository, how institutional repositories are managed or enhanced to improve global visibility, challenges and strategies for enhancing local content resources visibility through the use of institutional repositories. Descriptive survey research design was employed in carrying out the study which had a population comprised of 3 university librarians and 93 other …


Evaluative Study Of Ph. D. Lis Dissertations Of Pakistani Library & Information Science Schools, Syed Habib Akhter Jaffri, Khurram Shahzad, Muhammad Tariq Dr. Jan 2021

Evaluative Study Of Ph. D. Lis Dissertations Of Pakistani Library & Information Science Schools, Syed Habib Akhter Jaffri, Khurram Shahzad, Muhammad Tariq Dr.

Library Philosophy and Practice (e-journal)

The main objectives of the study were to acquire knowledge about the Information Sources used in LIS Doctoral research, to explore the use of impact factor research sources in their research productivity, to find out the used Pakistani journals fall in HEC criteria (W, X, Y, Z), to know the citation style which is mostly used and to know the geographical affiliations of journals and other resources. This research deals with Quantitative research design, in this research. Researchers used statistical methods with help of an excel sheet to check the sources used by Ph.D. researchers. Sources of Journals, books, theses, …


Clinicopathologic Implications Of Complement Genetic Variants In Kidney Transplantation, Zhen Ren, Stephen J Perkins, Latisha Love-Gregory, John P Atkinson, Anuja Java Jan 2021

Clinicopathologic Implications Of Complement Genetic Variants In Kidney Transplantation, Zhen Ren, Stephen J Perkins, Latisha Love-Gregory, John P Atkinson, Anuja Java

2020-Current year OA Pubs

Genetic testing has uncovered rare variants in complement proteins associated with thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are classified as variants of uncertain significance (VUS). Clinical risk assessment of patients carrying a VUS remains challenging primarily due to a lack of functional information, especially in the context of multiple confounding factors in the setting of kidney transplantation. Our objective was to evaluate the clinicopathologic significance of genetic variants in TMA and C3G in a kidney transplant cohort. We used whole exome next-generation sequencing to analyze complement genes in 76 patients, comprising 60 patients with a TMA and …


Health Disparities And Treatment Approaches In Portopulmonary Hypertension And Idiopathic Pulmonary Arterial Hypertension: An Analysis Of The Pulmonary Hypertension Association Registry, Hilary M Dubrock, Murali Chakinala, Et Al. Jan 2021

Health Disparities And Treatment Approaches In Portopulmonary Hypertension And Idiopathic Pulmonary Arterial Hypertension: An Analysis Of The Pulmonary Hypertension Association Registry, Hilary M Dubrock, Murali Chakinala, Et Al.

2020-Current year OA Pubs

Compared to idiopathic pulmonary arterial hypertension (IPAH), patients with portopulmonary hypertension (POPH) have worse survival. Health disparities may contribute to these differences but have not been studied. We sought to compare socioeconomic factors in patients with POPH and IPAH and to determine whether socioeconomic status and/or POPH diagnosis were associated with treatment and health-care utilization. We performed a cross-sectional study of adults enrolled in the Pulmonary Hypertension Association Registry. Patients with IPAH (n = 344) and POPH (n = 57) were compared. Compared with IPAH, patients with POPH were less likely to be college graduates (19.6% vs. 34.9%, p = …


Does Circulating Progesterone Mediate The Associations Of Single Nucleotide Polymorphisms In Progesterone Receptor (Pgr)-Related Genes With Mammographic Breast Density In Premenopausal Women?, Favour A Akinjiyan, Yunan Han, Jingqin Luo, Adetunji T Toriola Jan 2021

Does Circulating Progesterone Mediate The Associations Of Single Nucleotide Polymorphisms In Progesterone Receptor (Pgr)-Related Genes With Mammographic Breast Density In Premenopausal Women?, Favour A Akinjiyan, Yunan Han, Jingqin Luo, Adetunji T Toriola

2020-Current year OA Pubs

UNLABELLED: Progesterone is a proliferative hormone in the breast but the associations of genetic variations in progesterone-regulated pathways with mammographic breast density (MD) in premenopausal women and whether these associations are mediated through circulating progesterone are not clearly defined. We, therefore, investigated these associations in 364 premenopausal women with a median age of 44 years. We sequenced 179 progesterone receptor (PGR)-related single nucleotide polymorphisms (SNPs). We measured volumetric percent density (VPD) and non-dense volume (NDV) using Volpara. Linear regression models were fit on circulating progesterone or VPD/NDV separately. We performed mediation analysis to evaluate whether the effect of a SNP …


Loss Of Angiotensin Ii Type 2 Receptor Improves Blood Pressure In Elastin Insufficiency, Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, Carmen M Halabi Jan 2021

Loss Of Angiotensin Ii Type 2 Receptor Improves Blood Pressure In Elastin Insufficiency, Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, Carmen M Halabi

2020-Current year OA Pubs

There is ample evidence supporting a role for angiotensin II type 2 receptor (AT


Effective Connectivity Extracts Clinically Relevant Prognostic Information From Resting State Activity In Stroke, Mohit H Adhikari, Joseph Griffis, Joshua S Siegel, Michel Thiebaut De Schotten, Gustavo Deco, Andrea Instabato, Matthieu Gilson, Maurizio Corbetta Jan 2021

Effective Connectivity Extracts Clinically Relevant Prognostic Information From Resting State Activity In Stroke, Mohit H Adhikari, Joseph Griffis, Joshua S Siegel, Michel Thiebaut De Schotten, Gustavo Deco, Andrea Instabato, Matthieu Gilson, Maurizio Corbetta

2020-Current year OA Pubs

Recent resting-state functional MRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity between homotopic regions of the same network, and an abnormal increase of ipsi-lesional functional connectivity between task-negative and task-positive resting-state networks. Whole-brain computational modelling studies, at the individual subject level, using undirected effective connectivity derived from empirically measured functional connectivity, have shown a reduction of measures of integration and segregation in stroke as compared to healthy brains. Here we employ a novel method, first, to infer whole-brain directional effective connectivity from zero-lagged and lagged covariance matrices, then, …


Smaller Spared Subcortical Nuclei Are Associated With Worse Post-Stroke Sensorimotor Outcomes In 28 Cohorts Worldwide, Sook-Lei Liew, Catherine E Lang, Anup K Bhattacharya, Et Al. Jan 2021

Smaller Spared Subcortical Nuclei Are Associated With Worse Post-Stroke Sensorimotor Outcomes In 28 Cohorts Worldwide, Sook-Lei Liew, Catherine E Lang, Anup K Bhattacharya, Et Al.

2020-Current year OA Pubs

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T


Perceived Barriers To Assessing Understanding And Appreciation Of Informed Consent In Clinical Trials: A Mixed-Method Study, Erin D Solomon, Jessica Mozersky, Kari Baldwin, Matthew P Wroblewski, Meredith V Parsons, Melody Goodman, James M Dubois Jan 2021

Perceived Barriers To Assessing Understanding And Appreciation Of Informed Consent In Clinical Trials: A Mixed-Method Study, Erin D Solomon, Jessica Mozersky, Kari Baldwin, Matthew P Wroblewski, Meredith V Parsons, Melody Goodman, James M Dubois

2020-Current year OA Pubs

INTRODUCTION: Participants and research professionals often overestimate how well participants understand and appreciate consent information for clinical trials, and experts often vary in their determinations of participant's capacity to consent to research. Past research has developed and validated instruments designed to assess participant understanding and appreciation, but the frequency with which they are utilized is unknown.

METHODS: We administered a survey to clinical researchers working with older adults or those at risk of cognitive impairment (

RESULTS: We found that using a validated assessment of consent is relatively uncommon, being used by only 44% of researchers who had an opportunity. …


Teaching For Implementation: A Framework For Building Implementation Research And Practice Capacity Within The Translational Science Workforce, Aaron L Leppin, Ana A Baumann, Maria E Fernandez, Brittany N Rudd, Kathleen R Stevens, David O Warner, Bethany M Kwan, Rachel C Shelton Jan 2021

Teaching For Implementation: A Framework For Building Implementation Research And Practice Capacity Within The Translational Science Workforce, Aaron L Leppin, Ana A Baumann, Maria E Fernandez, Brittany N Rudd, Kathleen R Stevens, David O Warner, Bethany M Kwan, Rachel C Shelton

2020-Current year OA Pubs

Implementation science offers a compelling value proposition to translational science. As such, many translational science stakeholders are seeking to recruit, teach, and train an implementation science workforce. The type of workforce that will make implementation happen consists of both implementation researchers and practitioners, yet little guidance exists on how to train such a workforce. We-members of the Advancing Dissemination and Implementation Sciences in CTSAs Working Group-present the Teaching For Implementation Framework to address this gap. We describe the differences between implementation researchers and practitioners and demonstrate what and how to teach them individually and in co-learning opportunities. We briefly comment …


A Genetic Mouse Model With Postnatal Nf1 And P53 Loss Recapitulates The Histology And Transcriptome Of Human Malignant Peripheral Nerve Sheath Tumor, Akira Inoue, Laura J Janke, Brian L Gudenas, Hongjian Jin, Yiping Fan, Joshua Paré, Michael R Clay, Paul A Northcott, Angela C Hirbe, Xinwei Cao Jan 2021

A Genetic Mouse Model With Postnatal Nf1 And P53 Loss Recapitulates The Histology And Transcriptome Of Human Malignant Peripheral Nerve Sheath Tumor, Akira Inoue, Laura J Janke, Brian L Gudenas, Hongjian Jin, Yiping Fan, Joshua Paré, Michael R Clay, Paul A Northcott, Angela C Hirbe, Xinwei Cao

2020-Current year OA Pubs

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas. Somatic inactivation of

METHODS: We combined 2 genetically modified alleles, an

RESULTS: Postnatal

CONCLUSIONS: The NP-Plp model recapitulates human MPNST genetically, histologically, and molecularly.


A Phase Ii Study Of Laser Interstitial Thermal Therapy Combined With Doxorubicin In Patients With Recurrent Glioblastoma, Omar H Butt, Alice Y Zhou, Jiayi Huang, William A Leidig, Alice E Silberstein, Milan G Chheda, Tanner M Johanns, George Ansstas, Jingxia Liu, Grayson Talcott, Ruth Nakiwala, Joshua S Shimony, Albert H Kim, Eric C Leuthardt, Jian L Campian, Et Al. Jan 2021

A Phase Ii Study Of Laser Interstitial Thermal Therapy Combined With Doxorubicin In Patients With Recurrent Glioblastoma, Omar H Butt, Alice Y Zhou, Jiayi Huang, William A Leidig, Alice E Silberstein, Milan G Chheda, Tanner M Johanns, George Ansstas, Jingxia Liu, Grayson Talcott, Ruth Nakiwala, Joshua S Shimony, Albert H Kim, Eric C Leuthardt, Jian L Campian, Et Al.

2020-Current year OA Pubs

BACKGROUND: The blood-brain barrier (BBB) is a major limiting factor for drug delivery in brain tumors. Laser interstitial thermal therapy (LITT) disrupts the peritumoral BBB. In this study, we examine survival in patients with recurrent glioblastoma (GBM) treated with LITT followed by low-dose doxorubicin, a potent anti-neoplastic drug with poor BBB permeability.

METHODS: Forty-one patients with recurrent GBM were enrolled; thirty patients were evaluable. Participants underwent LITT followed by 6 weekly doxorubicin treatments starting within one week (Early Arm) or at 6-8 weeks (Late Arm) after LITT. The overall survival (OS), local progression-free survival (PFS), and any PFS were compared …


The Next Generation Of Ocular Pathogen Detection, Sharon L. Sabapathypillai, Hayley R. James, Rachael R. L. Lyerla, Lynn Hassman Jan 2021

The Next Generation Of Ocular Pathogen Detection, Sharon L. Sabapathypillai, Hayley R. James, Rachael R. L. Lyerla, Lynn Hassman

2020-Current year OA Pubs

Metagenomic next-generation sequencing is a powerful method for pathogen detection that combines advanced genome sequencing technology with cutting-edge bioinformatics to analyze microbial populations. Metagenomic next-generation sequencing has the potential to identify uncommon, unculturable, and even previously unidentified pathogens from a clinical isolate. Of particular interest to ophthalmology, this robust data extraction can occur from very small volume clinical samples. Here we discuss the opportunities and limitations of this technique and their current and future application to ophthalmic diagnostics.