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Functional Seizures Are Not Less Important Than Epilepsy, A A Asadi-Pooya, Francesco Brigo, Benjamin Tolchin, Kette D. Valente

Department of Neurology Faculty Papers

Functional seizures (FS) are frequently encountered in neurology clinics, often affect young adults, and have significant negative impacts on many aspects of a person's life. In the current narrative review, we searched the literature regarding some of the consequences of FS (i.e., psychiatric comorbidities, social consequences, costs that are associated with the condition, cognitive impairment in patients with FS, the quality of life of the people with FS, and the increased risk of mortality that is associated with FS). Evidence shows that FS have significant negative consequences, comparable in their magnitude to those affecting patients with epilepsy. The clinical and …

Media And Information Literate Citizens: Think Critically, Click Wisely!, Alton Grizzle, Carolyn Wilson, Ramon Tuazon, Chi Kim Cheung, Jesus Lau, Rachel Fischer, Dorothy Gordon, Kwame Akyempong, Jagtar Singh, Paul R. Carr, Kristine N. Stewart, Samy Tayie, Olunifesi Suraj, Maarit Jaakkola, Gina Thésée, Curmira Gulston

All Works

Can we improve our societies by clicking wisely?

Content providers such as libraries, archives, museums, media and digital communications companies can enable inclusive and sustainable development. However, they do not always live up to these ideals, which creates challenges for the users of these services. Content providers of all types open up new opportunities for lifelong learning. But at the same time, they open up challenges such as misinformation and disinformation, hate speech, and infringement of online privacy, among others.

Media and information literacy is a set of competencies that help people to maximize advantages and minimize harms. Media and …

Online Library Skills Of Music Educators And Music Students In Nigeria, Edith Nwakaego Nwokenna, Ogechukwu Vivian Amanambu, Blessing Chisom Umeano

Library Philosophy and Practice (e-journal)

Tertiary institution libraries have expanded the traditional library model, which focuses on the management of physical resources and activities, to include an online library model, which converts resources and services into digital formats to support teaching, learning, and research, as academic library functions and activities continue to evolve. This change has had an impact on professional roles and activities of both educators and students as a result of the increased skills required. The purpose of this research is to investigate the extent of online library skills among music educators and music students in Nigerian tertiary institutions. A study sample of …

Characteristics Of Rural Stem Clubs And Implications For Students With Disabilities, Karin M. Fisher, Peggy Shannon-Baker, Kelly Brooksher, Kania Greer

Elementary & Special Education: Faculty Publications

There are many benefits for students to participate in extracurricular science, technology, engineering, and mathematics (STEM) activities or clubs. It is also known that students with disabilities (SWD) do not participate as much as their peers without disabilities (SWOD). However, there is a lack of research on SWD and their participation in STEM clubs. This sequential explanatory mixed method study explored teachers’ perceptions of the types and characteristics of STEM clubs and their participants, and their professional development (PD) to work with SWD in their clubs. Findings suggest a variety of STEM clubs are offered with an average of 20 …

Long Runs Of Homozygosity Are Associated With Alzheimer’S Disease, Sonia Moreno-Grau, Maria Victoria Fernández, Fabiana Farias, John P. Budde, Carlos Cruchaga, O. Maroñas, Et Al.

Open Access Publications

No abstract provided.

Association Of Pet-Based Estradiol-Challenge Test For Breast Cancer Progesterone Receptors With Response To Endocrine Therapy, Farrokh Dehdashti, Ningying Wu, Cynthia X. Ma, Michael J. Naughton, John A. Katzenellenbogen, Barry A. Siegel

Open Access Publications

No abstract provided.

Improving Hindlimb Locomotor Function By Non-Invasive Aav-Mediated Manipulations Of Propriospinal Neurons In Mice With Complete Spinal Cord Injury, Benedikt Brommer, Miao He, Zicong Zhang, Zhiyun Yang, Jessica C. Page, Junfeng Su, Yu Zhang, Junjie Zhu, Emilia Gouy, Jing Tang, Philip Williams, Wei Dai, Qi Wang, Ryan Solinsky, Bo Chen, Zhigang He

Open Access Publications

No abstract provided.

Anti-Inflammatory Dopamine- And Serotonin-Based Endocannabinoid Epoxides Reciprocally Regulate Cannabinoid Receptors And The Trpv1 Channel, William R. Arnold, Lauren N. Carnevale, Zili Xie, Javier L. Baylon, Emad Tajkhorshid, Hongzhen Hu, Aditi Das

Open Access Publications

No abstract provided.

Effect And Correction Of Optode Coupling Errors In Breast Imaging Using Diffuse Optical Tomography, Shuying Li, Kexin Huang, Menghao Zhang, K. M. Shihab Uddin, Quing Zhu

Open Access Publications

No abstract provided.

Analysis Of Post-Transplant Lymphoproliferative Disorder (Ptld) Outcomes With Epstein-Barr Virus (Ebv) Assessments-A Single Tertiary Referral Center Experience And Review Of Literature, Eric Lau, Lawrence Liu, Et Al

Open Access Publications

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoid or plasmacytic proliferations ranging from polyclonal reactive proliferations to overt lymphomas that develop as consequence of immunosuppression in recipients of solid organ transplantation (SOT) or allogeneic bone marrow/hematopoietic stem cell transplantation. Immunosuppression and Epstein-Barr virus (EBV) infection are known risk factors for PTLD. Patients with documented histopathologic diagnosis of primary PTLD at our institution between January 2000 and October 2019 were studied. Sixty-six patients with PTLD following SOT were followed for a median of 9.0 years. The overall median time from transplant to PTLD diagnosis was 5.5 years, with infant transplants showing the longest …

Type 2 Diabetes Prevention Focused On Normalization Of Glycemia: A Two-Year Pilot Study, Amy L Mckenzie, Shaminie J Athinarayanan, Jackson J Mccue, Rebecca N Adams, Monica Keyes, James P Mccarter, Jeff S Volek, Stephen D Phinney, Sarah J Hallberg

Open Access Publications

The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m

Acupuncture And Oxytocinergic System: The Promising Treatment For Autism, Tangfeng Su, Lei Pei

Open Access Publications

No abstract provided.

Tumor-Associated Neutrophils (Tans) In Human Carcinoma-Draining Lymph Nodes: A Novel Tan Compartment, Silvia Lonardi, William Vermi, Et Al.

Open Access Publications

No abstract provided.

Think Big, Start Small: How Nanomedicine Could Alleviate The Burden Of Rare Cns Diseases, Abdelfattah Faouzi, Valérie Gaëlle Roullin

Open Access Publications

The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding any type of undesirable exogenous exchanges. The disruption of these barriers is usually associated with the development of neuropathologies which can be the consequence of genetic disorders, local antigenic invasions, or autoimmune diseases. These disorders can take the shape of rare CNS-related diseases (other than Alzheimer's and Parkinson's) which a exhibit relatively low or moderate prevalence and could be part of a potential line of …

Achieving A Diverse, Equitable, And Inclusive Environment For The Black Orthopaedic Surgeon: Part 1: Barriers To Successful Recruitment Of Black Applicants, Gabriella E Ode, Letitia Bradford, William A Ross, Eric W Carson, Jaysson T Brooks

Open Access Publications

No abstract provided.

Sex Differences In Clinical Outcomes Following Surgical Treatment Of Femoroacetabular Impingement, Tristan Maerz, Jeffrey J Nepple, Asheesh Bedi, Ira Zaltz, Étienne Belzile, Paul E Beaulé, Ernest L Sink, John C Clohisy, Anchor Group

Open Access Publications

BACKGROUND: Sex-based differences in clinical outcomes following surgical treatment of femoroacetabular impingement remain largely uncharacterized; this prospective, multicenter study evaluated these differences both directly and adjusted for covariates.

METHODS: Hips undergoing surgical treatment of symptomatic femoroacetabular impingement were prospectively enrolled in a multicenter cohort. Patient demographics, radiographic parameters, intraoperatively assessed disease severity, and history of surgical procedures, as well as patient-reported outcome measures, were collected preoperatively and at a mean follow-up of 4.3 years. A total of 621 (81.6%) of 761 enrolled hips met the minimum 1 year of follow-up and were included in the analysis; 56.7% of analyzed hips …

Imputation, Modelling And Optimal Sampling Design For Digital Camera Data In Recreational Fisheries Monitoring, Ebenezer Afrifa-Yamoah

Theses: Doctorates and Masters

Digital camera monitoring has evolved as an active application-oriented scheme to help address questions in areas such as fisheries, ecology, computer vision, artificial intelligence, and criminology. In recreational fisheries research, digital camera monitoring has become a viable option for probability-based survey methods, and is also used for corroborative and validation purposes. In comparison to onsite surveys (e.g. boat ramp surveys), digital cameras provide a cost-effective method of monitoring boating activity and fishing effort, including night-time fishing activities. However, there are challenges in the use of digital camera monitoring that need to be resolved. Notably, missing data problems and the cost …

Flow And Heat Transfer Characteristics Of Turbulent Swirling Impinging Jets [Thesis], Muhammad Ikhlaq

Theses: Doctorates and Masters

Numerous industrial applications rely on impinging jets to impart convective heat and mass transfer in processes ranging from the cooling of electronic devices and gas turbine blades to drying of paper and food products. Conventionally, non-swirling impinging jets have been employed, but some studies have shown that inducing swirl allows better control of uniformity and improved convective fluxes. A better understanding of the underlying physical mechanisms that lead to such behaviour warrants deeper insights into the flow and heat transfer characteristics of impinging jets, both swirling and non-swirling. Whilst important to achieve, the flow field of an impinging jet is …

An Exploration Of The Relationship Between Aphasia Therapy, Depression And Quality Of Life In Post-Stroke Patients After Rehabilitation At 12 And 26 Weeks After Stroke: A Verse Sub-Study, Alia Rashid Khan

Theses: Doctorates and Masters

Background: Depression is a common consequence of stroke, and people with aphasia (PWA) post-stroke have a higher risk of developing depression compared to stroke survivors without aphasia. However, current stroke interventions featuring aphasia therapy tend to neglect the effect of the treatment on mood. There is also a lack of evidence on the impact of stroke education and counselling on PWA in early stroke recovery. Additionally, the research on post-stroke depression often excludes or insufficiently describes PWA in study populations. The influence of direct aphasia therapy on depression in PWA is undetermined. This sub-study investigated: i) the effect of …

Pore-Forming Transmembrane Domains Control Ion Selectivity And Selectivity Filter Conformation In The Kirbac1.1 Potassium Channel, Marcos Matamoros, Colin G. Nichols

Open Access Publications

Potassium (K+) channels are membrane proteins with the remarkable ability to very selectively conduct K+ ions across the membrane. High-resolution structures have revealed that dehydrated K+ ions permeate through the narrowest region of the pore, formed by the backbone carbonyls of the signature selectivity filter (SF) sequence TxGYG. However, the existence of nonselective channels with similar SF sequences, as well as effects of mutations in other regions on selectivity, suggest that the SF is not the sole determinant of selectivity. We changed the selectivity of the KirBac1.1 channel by introducing mutations at residue I131 in transmembrane helix 2 (TM2). These …

Task-Generic And Task-Specific Connectivity Modulations In The Adhd Brain: An Integrated Analysis Across Multiple Tasks, Roselyne J. Chauvin, Jan K. Buitelaar, Emma Sprooten, Marianne Oldehinkel, Barbara Franke, Catharina Hartman, Dirk J. Heslenfeld, Pieter J. Hoekstra, Jaap Oosterlaan, Christian F. Beckmann, Maarten Mennes

Open Access Publications

No abstract provided.

Trem2 Sustains Macrophage-Hepatocyte Metabolic Coordination In Nonalcoholic Fatty Liver Disease And Sepsis, Jinchao Hou, Yingyue Zhou, Marco Colonna, Et Al

Open Access Publications

Sepsis is a leading cause of death in critical illness, and its pathophysiology varies depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver disease (NAFLD) as an independent risk factor for sepsis in a large clinical cohort and showed a link between mortality in NAFLD-associated sepsis and hepatic mitochondrial and energetic metabolism dysfunction. Using in vivo and in vitro models of liver lipid overload, we discovered a metabolic coordination between hepatocyte mitochondria and liver macrophages that express triggering receptor expressed on myeloid cells-2 (TREM2). Trem2-deficient macrophages released exosomes that impaired hepatocytic mitochondrial structure and energy supply because of …

Cost-Effectiveness Of Exercise Medicine For Prostate Cancer, Kim Edmunds

Theses: Doctorates and Masters

Background

Androgen deprivation therapy (ADT) is associated with numerous adverse effects that impact on quality of life and contribute further to the cost burden of prostate cancer (PCa) via treatment and supportive care. Exercise medicine is effective in slowing PCa progression, reversing treatment adverse effects and improving quality of life and survival of patients, however, no economic analyses have been conducted to determine whether exercise is cost-effective in this population.

Objectives

Firstly, to examine the adverse effects of ADT for PCa and the evidence supporting the use of exercise medicine in their management. Secondly, to conduct the first economic evaluations …

Assessment Of The Clinical Validity Of Ctdna Analysis For Melanoma Management, Anda-Gabriela Marsavela

Theses: Doctorates and Masters

Metastatic melanoma is responsible for almost 80% of all skin cancer-related deaths and the incidence of people affected continues to rise worldwide. The emergence of targeted therapy and immune-checkpoint inhibitors has improved the clinical management of melanoma, but durable survival benefit is only seen in a minority of patients. The use of these very expensive systemic therapies on all appropriate patients also poses a high economic burden on health systems across numerous countries. Currently, surveillance for treatment failure is not optimal. Thus, reliable and accurate biomarkers of patient disease status are urgently required.

Circulating tumour DNA (ctDNA) analysis has emerged …

Digital Representation For Assessment Of Spoken Efl At University Level: A Case Study In Vietnam, Thi Bich Hiep Vu

Theses: Doctorates and Masters

Assessing the speaking performance of students who are studying English as a Foreign Language (EFL) has mainly been conducted with face-to-face speaking tests. While such tests are undoubtedly interactive and authentic, they have been criticised for subjective scoring, as well as lacking an effective test delivery method and recordings for later review.

Technology has increasingly been integrated into speaking tests over the last decade and become known as computer-assisted or computer-based assessment of speaking. Although this method is widely acknowledged to measure certain aspects of language speaking effectively, such as pronunciation and grammar, it has not yet proved to be …

Cerebral Expression Of Metabotropic Glutamate Receptor Subtype 5 In Idiopathic Autism Spectrum Disorder And Fragile X Syndrome: A Pilot Study, James Robert Brašić, Ayon Nandi, David S Russell, Danna Jennings, Olivier Barret, Samuel D Martin, Keith Slifer, Thomas Sedlak, John P Seibyl, Dean F Wong, Dejan B Budimirovic

Open Access Publications

Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR

Partitioning Of Gene Expression Among Zebrafsh Photoreceptor Subtypes, Yohey Ogawa, Joseph C. Corbo

Open Access Publications

No abstract provided.

White Matter Integrity Of Contralesional And Transcallosal Tracts May Predict Response To Upper Limb Task-Specific Training In Chronic Stroke, Daniela J S Mattos, Jerrel Rutlin, Xin Hong, Kristina Zinn, Joshua S Shimony, Alexandre R Carter

Open Access Publications

OBJECTIVE: To investigate white matter (WM) plasticity induced by intensive upper limb (UL) task specific training (TST) in chronic stroke.

METHODS: Diffusion tensor imaging data and UL function measured by the Action Research Arm Test (ARAT) were collected in 30 individuals with chronic stroke prior to and after intensive TST. ANOVAs tested the effects of training on the entire sample and on the Responders [ΔARAT ≥ 5.8, N = 13] and Non-Responders [ΔARAT < 5.8, N = 17] groups. Baseline fractional anisotropy (FA) values were correlated with ARATpost TST controlling for baseline ARAT and age to identify voxels predictive of response to TST.

RESULTS: While ARAT scores increased following training (p < 0.0001), FA changes within major WM tracts were not significant at p < 0.05. In the Responder group, larger baseline FA of both contralesional (CL) and transcallosal tracts predicted larger ARAT scores post-TST. Subcortical lesions and more severe damage to transcallosal tracts were more pronounced in the Non-Responder than in the Responder group.

CONCLUSIONS: The motor improvements post-TST in the Responder group may reflect the engagement of interhemispheric processes not available to …

A Ligand-Insensitive Unc5b Splicing Isoform Regulates Angiogenesis By Promoting Apoptosis, David Pradella, William Vermi, Et Al

Open Access Publications

No abstract provided.

Disordered Eating, Food Insecurity, And Weight Status Among Transgender And Gender Nonbinary Youth And Young Adults: A Cross-Sectional Study Using A Nutrition Screening Protocol, Whitney R. Linsenmeyer, Ian M. Katz, Jamie L. Reed, Andrea M. Giedinghagen, Christopher B. Lewis, Sarah K. Garwood

Open Access Publications

No abstract provided.