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2021

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Assessment Of Child Physical Abuse Among Mothers In Mala A Fandi Health Care Centre/Erbil City, Hanaa O. Saadi, Yasin K. Amin, Abass A. Ahmed Dec 2021

Assessment Of Child Physical Abuse Among Mothers In Mala A Fandi Health Care Centre/Erbil City, Hanaa O. Saadi, Yasin K. Amin, Abass A. Ahmed

Polytechnic Journal

Child physical abuse is an important cause of pediatric morbidity and mortality and is associated with major physical and mental health problems that can extend into adulthood. The main research purpose was to assess sociodemographic characteristics of mothers and find out the most common types and physical abuse among children. This descriptive study is conducted on Mothers of Abused Child at Mala A fandi Health Care Centre in Erbil city of Kurdistan region of Iraq. A convenient sampling was used to choose 100 Mothers who visited particular health center. Questionnaire was used as a tool for collecting data from Mothers …


Influence Of Mixture Proportions On Fresh And Mechanical Properties Of Self-Consolidating Concrete, Ghafur H. Ahmed Dec 2021

Influence Of Mixture Proportions On Fresh And Mechanical Properties Of Self-Consolidating Concrete, Ghafur H. Ahmed

Polytechnic Journal

Self-consolidating concrete (SCC) is a concrete that able to flow and consolidate under its own weight, and it is cohesive enough to fill spaces of almost any size and shape without segregation or bleeding. In this study, workability and strength characteristics of seven SCC mixes were examined and compared with two additional vibrated mixes of normal and high strength. For this purpose, the flowability, deformability, and passing ability of fresh concrete mixes were tested through slump test, slump flow, T500, and the J-ring tests. Furthermore, the hardened concrete specimens were tested for mechanical properties with the variation in shape and …


Molecular Phylodiagnosis Of Taenia Hydatigena From Stray Dogs In Erbil Province-Kurdistan Region/Iraq, Zuber I. Hassan Dec 2021

Molecular Phylodiagnosis Of Taenia Hydatigena From Stray Dogs In Erbil Province-Kurdistan Region/Iraq, Zuber I. Hassan

Polytechnic Journal

Taenia hydatigena is one of the most prevalent taeniid species of livestock and dogs. A total of 52 fecal samples were collected from September 2019 to May 2020. The highest prevalence rate was observed in Rural area (21.15%, 11/52), as compared to Urban area (15.38%, 8/52). Nineteen (9 males and 10 females) out of 52 dogs were infected with T. hydatigena; there were no significant differences in prevalence based on molecular technique was observed between females (19.23%) and males (17.31%). The DNA’s of taeniid eggs were extracted, amplified, and sequenced by targeting of mitochondrial cytochrome c oxidase subunit 1 (cox1). …


Survey Of Public Knowledge And Implementation Regarding Covid-19 In Sulaymaniyah City, Ismail Y. Maolood, Abdulrahman A. Mhmood Dec 2021

Survey Of Public Knowledge And Implementation Regarding Covid-19 In Sulaymaniyah City, Ismail Y. Maolood, Abdulrahman A. Mhmood

Polytechnic Journal

The currently pandemic virus called SARS-CoV-2 is an international health issue that we have interacted with since World War II. The virus was discovered in the Chinese city of Wuhan in 2019 and has since spread worldwide. Globally, the number of cases is increasing, with new cases being reported in Asia, Africa, the Americas, and Europe. This paper is intended to analyze 2019 novel coronavirus (COVID-19) knowledge, perceptions, and behaviors toward the substance within the general population in the city of Sulaymaniyah. The study was conducted as a cross-sectional survey with 100 adults from various locations throughout Sulaymaniyah. These places …


Identification Of Relationships Between Fingerprint Patterns And Gender In Koya, Kurdistan Region, Iraq., Zaitoon A. Hamad, Hemn R. Salih, Layla K. Ali Dec 2021

Identification Of Relationships Between Fingerprint Patterns And Gender In Koya, Kurdistan Region, Iraq., Zaitoon A. Hamad, Hemn R. Salih, Layla K. Ali

Polytechnic Journal

According to this research probe the correlation between fingerprints and the gender for all 10 fingerprints. For this inquiry, 4939 samples were collected from 247 females and 247 male’s ages between 7 and 13 years old. This is the first systematic research of its kind to check at ten fingerprints for people from Koya, Kurdistan region north of Iraq. As per the findings, gender identity is accurate for people with any of their ten fingerprints. After magnifying the obviously acquired photos, the four basic fingerprint structures were identified and registered: Arch, Radial loop, Ulner loop, and Whorl. Statistical analysis was …


Computational Fluid Dynamic Optimization Of Supply And Return Duct Position For Zone Air Distribution, Bashir E. Kareem, Younis K. Khdir Dec 2021

Computational Fluid Dynamic Optimization Of Supply And Return Duct Position For Zone Air Distribution, Bashir E. Kareem, Younis K. Khdir

Polytechnic Journal

Air conditioning accounts for roughly half of all energy consumption in residential buildings. Today’s issue is optimizing the air conditioning system and methods of conveying heated and cooled air to prevent additional energy consumption. The optimal supply and return duct position is studied and the results based on the minimum air temperature and pressure in the room, while the room air distribution is taken into account. The main objective of air conditioning, which is impacted by duct position, is to provide thermal comfort in the room. Using Computational Fluid Dynamic, a controlled zone is designed and analyzed in the room …


Challenges In The Implementation Of The Bologna Process, Jabbar H. Ade Dec 2021

Challenges In The Implementation Of The Bologna Process, Jabbar H. Ade

Polytechnic Journal

Bologna process is the instruction for reshaping in the higher education system, which created significant obstacles for its implementation. The objective of this study is to investigate the issues and challenges faced Kurdistan universities during the implementation of the Bologna process. In this study, three universities have been focused; two public and a private university. A questionnaire form was designed or the three universities’ staff (Erbil Polytechnic University [EPU], Soran University, and Cihan University) which included several questions about the challenges faced them during European Credit Transfer System (ECTS) implementation. The results show that Cihan University provides more knowledge about …


Occurrence Of Blatem Among Pseudomonas Aeruginosa Strains Isolated From Different Clinical Samples In Erbil City, Sevan H. Bakir, Fattma A. Ali, Bashdar M. Hussen, Shahin H. Mustafa, Ahmed Akil, Shilan S. Ahmad Dec 2021

Occurrence Of Blatem Among Pseudomonas Aeruginosa Strains Isolated From Different Clinical Samples In Erbil City, Sevan H. Bakir, Fattma A. Ali, Bashdar M. Hussen, Shahin H. Mustafa, Ahmed Akil, Shilan S. Ahmad

Polytechnic Journal

Pseudomonas aeruginosa was a significant source of nosocomial infection with the presence of extended-spectrum β-lactamases (ESBLs) and metallo-β-lactamases (MBL) genes in P. aeruginosa being progressively documented globally. The purpose of this investigation was to detection the occurrence of MBL and ESBL in P. aeruginosa isolates acquired from diverse clinical samples, as well as the prevalence of blaTEM genes producing ESBLs. A total of 227 samples were obtained from various clinical specimens (wound, urine, sputum, bronchial wash, and burn) at public hospitals in Erbil region. Microorganism was obtained, treated, and recognized using normal microbiological culture procedures, biochemical testing, DNA extraction, and …


Molecular Characterization Of Proteus Spp. From Patients Admitted To Hospitals In Erbil City, Treska Dh. Kamil, Sanaria F. Jarjes Dec 2021

Molecular Characterization Of Proteus Spp. From Patients Admitted To Hospitals In Erbil City, Treska Dh. Kamil, Sanaria F. Jarjes

Polytechnic Journal

The study was carried out to detect the identity of Proteus spp. isolated from various clinical specimens in Erbil City by polymerase chain reaction (PCR) technique. Specimens were of urine, wounds swabs, burn swabs, vaginal swabs, ear swabs, eye swabs, and sputum. Fifty-one Proteus isolates, (47) Proteus mirabilis, and (4) Proteus vulgaris, were undergone PCR assay using specific primers, targeting the genes ureR and Urease C (ureC), that encode for urease enzyme as a virulence factor of Proteus species. It was found that all isolates of Proteus mirabilis yielded positive result for ureR gene with an amplicon length of 225 …


The Dissolution Enhancement Of Meloxicam Tablets From The Synergistic Effect Of Hydrotropic And Sublimating Agent, Hemn L. Qader, Tara A. Abdula, Huner K. Omer Dec 2021

The Dissolution Enhancement Of Meloxicam Tablets From The Synergistic Effect Of Hydrotropic And Sublimating Agent, Hemn L. Qader, Tara A. Abdula, Huner K. Omer

Polytechnic Journal

Background and Objective: Drugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability. The improvement of the dissolution rate of this class of drug is an important issue for enhancing their bioavailability and therapeutic efficacy. The objective of this study is to investigate the magnitude of enhancement of the dissolution rate of Class II drug “Meloxicam (MLX)” by using more than one solubility enhancement technique. Methods: MLX-sodium benzoate solid dispersion at different ratios were prepared by kneading method to enhance the solubility, then MLX tablets were prepared by …


Hypoglycemic And Hypolipidemic Potential Of Ginger-Thyme Combined Extract In Sucrose-Induced Hyperglycemic Rates, Burhan A. Salih, Dilzar S. Asaad Dec 2021

Hypoglycemic And Hypolipidemic Potential Of Ginger-Thyme Combined Extract In Sucrose-Induced Hyperglycemic Rates, Burhan A. Salih, Dilzar S. Asaad

Polytechnic Journal

The current study is designed to investigate the in vivo action of ginger- thyme combined crude extract on hyperglycemia and obesity related measurements in sucrose induced chronic hyperglycemia experimental model in albino male rats. Twenty-five male albino rats were divided into five groups (N=5 for each); First group was regarded as control which consists of rats feed with normal diet and water ad libitum, while second group was the model which consists of rats fed with high sucrose fed (HSF) (50%sucrose). and other three groups were rats which treated with three different doses of ginger-thyme combination extract (125mg/kg, 250 mg/kg …


A Bibliometric Study Of Iaslic Bulletin:2016-2020, Mahendra Kumar Dec 2021

A Bibliometric Study Of Iaslic Bulletin:2016-2020, Mahendra Kumar

Library Philosophy and Practice (e-journal)

Purpose: The main purpose of this paper is to examine the growth patterns of Library and Information Science literature on the basis of bibliometric study and to analyze the articles of IASLIC Bulletin published from the year 2016 to2020.

Methodology: For the present study IASLIC Bulletin has been selected as the source journal. IASLIC Bulletin is one of the leading publications in the field of Library and Information Science in India. All the lead articles and research paper of five volumes (Vol 61-Vol 65) containing 20 issues published during 2016-2020 have been taken up for the study. Statistical tools, like …


Perempuan Pekerja Migran Non-Reguler: Konflik Hukum Dalam Pengaturan Perdagangan Orang Dan Penyelundupan Orang, Sriwiyanti Eddyono Dec 2021

Perempuan Pekerja Migran Non-Reguler: Konflik Hukum Dalam Pengaturan Perdagangan Orang Dan Penyelundupan Orang, Sriwiyanti Eddyono

Jurnal Hukum & Pembangunan

This paper analyzes the extent to which Indonesian law regulates the position and protection of irregular women migrant workers and the implication of the arrangement of law for irregular women migrant workers who experience human trafficking and people smuggling. This paper follows up on field findings on human trafficking in the Kalimantan border which was carried out in 2018-2019. This paper finds that there are complications in the regulation on laws and regulations, related to the regulation of Irregular Migrant Workers. Even though the law which is based on international conventions explicitly regulates Non-Regular Migrant Workers (Migrant Workers Convention 1990) …


Evaluasi Kebijakan Peradilan Elektronik (E-Court) Mahkamah Agung Republik Indonesia, Abdul Rachmat Ariwijaya, Palupi Lindiasari Samputra Dec 2021

Evaluasi Kebijakan Peradilan Elektronik (E-Court) Mahkamah Agung Republik Indonesia, Abdul Rachmat Ariwijaya, Palupi Lindiasari Samputra

Jurnal Hukum & Pembangunan

This study aims to evaluate the administrative policies and electronic trial (E-Court) of the Supreme Court of the Republic of Indonesia and the judicial bodies under it in achieving the principles of administering judicial power, namely: simple, fast, and low-cost justice. The research method uses a retrospective evaluation theory that directs the present results after implementing the E-Court policy. The data used consisted of secondary data (documents) and primary data through in-depth interviews from experts and E-Court policymakers. The results showed that the E-Court policy succeeded in clarifying the Supreme Court of the Republic of Indonesia's organization in realizing simple, …


Rekonstruksi Undang-Undang Perbankan Untuk Mewujudkan Perlindungan Nasabah Penyimpan Yang Integratif Dan Berkepastian Hukum, Danu Febrianto, Joni Emirzon, Febrian Febrian Dec 2021

Rekonstruksi Undang-Undang Perbankan Untuk Mewujudkan Perlindungan Nasabah Penyimpan Yang Integratif Dan Berkepastian Hukum, Danu Febrianto, Joni Emirzon, Febrian Febrian

Jurnal Hukum & Pembangunan

Banks have an important role in economic development through their function by collecting funds from the public in the form of deposits and channeling them to the public in the form of credit in order to improve the standard of living of the people at large. Currently the banking business is regulated in Act Number 7 of 1992 concerning Banking as amended by Act Number 10 of 1998 (abbreviated as "Banking Act”). In a period of 20 years from 1998 to 2018, there have been developments in regulations relating to the depositors protection which are scattered in various laws and …


Potensi Pengembangan Wakaf Saham Sebagai Objek Wakaf Baru Di Indonesia: Perspektif Hukum Islam, Fahrul Fauzi Dec 2021

Potensi Pengembangan Wakaf Saham Sebagai Objek Wakaf Baru Di Indonesia: Perspektif Hukum Islam, Fahrul Fauzi

Jurnal Hukum & Pembangunan

Share waqf is holding one or more shares owned by wakif in a company that is engaged in a field that is permitted under sharia, the profits of which are used according to the purpose of waqf both for public and private in the framework of worshiping Allah SWT. The regulation of share waqf in Indonesia is still incorporated in the provisions of waqf in general. The existence of this regulation is the result of ijtihad by Indonesian ulama who adjusts to the needs and current social conditions. Shares in Islamic law are categorized as a form of Syirkah. The …


Tindak Pidana Pencucian Uang Yang Dilakukan Oleh Korporasi: Studi Kasus Putusan Pengadilan Negeri Nomor: 64/Pid.Sus/Tpk/2016/Pn.Bgl, Jeanny Jessica Dec 2021

Tindak Pidana Pencucian Uang Yang Dilakukan Oleh Korporasi: Studi Kasus Putusan Pengadilan Negeri Nomor: 64/Pid.Sus/Tpk/2016/Pn.Bgl, Jeanny Jessica

Jurnal Hukum & Pembangunan

The typologies of money laundering are very closely related to corporate activities, which the activities of corporation are involved indirectly or are associated with financial institutions that made corporations very high risk as criminal offender of money laundering crimes. The handling of money laundering cases that corporation as subjects have only been carried out in Bengkulu with the corruption as primary criminal act, whereas will be expected that the application of corporations as subjects of money laundering crimes will also trigger other law enforcement agencies to uncover money laundering cases that made by corporations


Eksistensi Perlindungan Paten Atas Vaksin Covid-19, Adzhani Tharifah, Agus Sardjono Dec 2021

Eksistensi Perlindungan Paten Atas Vaksin Covid-19, Adzhani Tharifah, Agus Sardjono

Jurnal Hukum & Pembangunan

The Covid-19 vaccine is expected to be a solution to return to normal life. However, the need for vaccines that are global in nature raises several questions in the community, especially regarding the existence of patent protection. For this reason, this paper will answer these questions by discussing the patentability of the Covid-19 vaccine as well as how to implement patent protection in the midst of a pandemic and public concerns about limited access to vaccines. The research method used in the writing of this thesis is normative juridical with a qualitative approach where the data comes from literature studies …


The Health Status Of Labor Force In East Kalimantan Province: Effect Of Individual Characteristics And Household Conditions, Jaka Eben Heizer Dec 2021

The Health Status Of Labor Force In East Kalimantan Province: Effect Of Individual Characteristics And Household Conditions, Jaka Eben Heizer

Jurnal Ekonomi Kesehatan Indonesia

The aims of this research are first, to explore the factors that are associated with health status. Second, to address the individual characteristics and household conditions that affect the health status of labor force, taking into account the urban-rural differences. This research utilized data from SUSENAS Cor 2018, and employed a cross sectional - multinomial logistic regression analysis method. The dependent variable is the health conditions of the labor force. The findings show that, age and number of household members were significant for both sick and very sick health status in all two type of areas analyzed. In urban and …


Kajian Sistematis: Perkembangan Sistem Pembayaran Kapitasi Berbasis Penyesuaian Risiko Di Berbagai Negara, Aulia Agustina, Budi Hidayat Dec 2021

Kajian Sistematis: Perkembangan Sistem Pembayaran Kapitasi Berbasis Penyesuaian Risiko Di Berbagai Negara, Aulia Agustina, Budi Hidayat

Jurnal Ekonomi Kesehatan Indonesia

Capitation is a payment method to primary health care providers. The application of capitation without considering risk adjustment could have a negative impact. There are several models of risk adjustment capitation payments. This study aims to review the development of the capitation payment system with risk adjustment for primary care in several countries. This study used the PRISMA method and got the articles from three online databases, namely Pubmed, EBSCOhost Medline, and Scopus. A total of 212 articles were collected, and 7 articles meet the criteria for further review. The review focuses on the risk-adjusted capitation payment system model. The …


Pengaruh Pembatasan Sosial Dan Variabel Ekonomi Terhadap Prevalensi Pandemi Covid-19 Di Provinsi Jawa Barat, Jordi Aperdanaste, Alfiah Hasanah, Adiatma Y. M. Siregar Dec 2021

Pengaruh Pembatasan Sosial Dan Variabel Ekonomi Terhadap Prevalensi Pandemi Covid-19 Di Provinsi Jawa Barat, Jordi Aperdanaste, Alfiah Hasanah, Adiatma Y. M. Siregar

Jurnal Ekonomi Kesehatan Indonesia

There are numerous factors that might affect social restrictions regulation on the reduction of the number of Covid-19 cases in 27 cities and districts in West Java Province. This study aims to identify the effect of social restrictions and economic variables on Covid-19 pandemic in West Java Province. The investigation uses several data sourced from the Covid-19 Information & Coordination Center of West Java Province, and the Central Bureau of Statistics in West Java Province. The dependent variable in this study is the average increase in daily Covid-19 cases. Meanwhile, the independent variable in this study are dummy of social …


Evaluasi Capaian Peta Jalan Jkn Di Provinsi Bengkulu Studi Kasus Sectio Caesarea Tahun 2014 Sampai 2019, Susilo Wulan Dec 2021

Evaluasi Capaian Peta Jalan Jkn Di Provinsi Bengkulu Studi Kasus Sectio Caesarea Tahun 2014 Sampai 2019, Susilo Wulan

Jurnal Ekonomi Kesehatan Indonesia

Bengkulu is one of the provinces in Indonesia where SC rate has increased significantly over the last five years after the implementation of JKN. Previous studies into SC trend in Indonesia indicate that both overutilization and underutilization of SC exist reflected inequality. SC is a public health concern since it absorbs a huge amount of JKN funds and is indicated to contribute to the BPJS deficit. This study evaluates the achievement of the SC case equity target in Bengkulu Province based on the 2014- 2019 JKN roadmap. Combining qualitative and quantitative approaches, analyzing secondary data from the BPJS routine data …


Impact Of E-Libraries On Youth Development: Evidence From The Punjab E-Library Project In Pakistan, Naila Shams Ul-Haq, Muhammad Younus Dec 2021

Impact Of E-Libraries On Youth Development: Evidence From The Punjab E-Library Project In Pakistan, Naila Shams Ul-Haq, Muhammad Younus

Library Philosophy and Practice (e-journal)

The study aimed to explore the impact of e-libraries on youth development in Punjab, Pakistan. The quantitative research method was adopted to address research questions of the study. A questionnaire using the five domains of Youth Development Index of the Commonwealth was developed to collect the quantitative data from young users (aged between 15-29 years) of four e-libraries developed under the Punjab E-Library Project in Punjab, Pakistan. The findings illustrate that e-libraries had a significant positive impact on youth development in all the five domains. The respondents acknowledged the multidimensionality of the e-libraries on holistic uplift and advancement of youth …


Transition Administration, Michael Herz, Katherine A. Shaw Dec 2021

Transition Administration, Michael Herz, Katherine A. Shaw

Articles

The period from November 3, 2020 to January 20, 2021, was unlike any presidential transition in our history. President Donald Trump refused to accept his ballot-box defeat, instead battling to overturn the election’s outcome. This dramatic public campaign was waged in state and federal courts, state legislatures, the offices of state and local election officials, the Department of Justice, and finally the halls of Congress, where on January 6, 2021, a mob incited by the President stormed the Capitol with the explicit goal of preventing the final counting of electoral votes for Joe Biden. These efforts had more mundane and …


Awareness Of Predatory Journals In Library And Information Science Faculties In India, Madhuri Kumari, Subaveerapandiyan A Dec 2021

Awareness Of Predatory Journals In Library And Information Science Faculties In India, Madhuri Kumari, Subaveerapandiyan A

Library Philosophy and Practice (e-journal)

Predatory journals that pretended to resemble refereed journals but are used for money-making purposes. Predatory publishers produce less quality scientific and research papers; it is a severe academic threat in scientific publications. Researchers are ensuring the quality of the journal and peer-reviewing process before submitting the manuscript. This paper aims to know the Indian Library and Information Science faculties awareness and knowledge about Predatory journals. To this study, 67 LIS (Library and Information Science) faculties took part, and they are working as Assistant Professors (67.2%), Associate Professors (16.4%) and Professors (16.4%) of various states (31.3%) and central universities (68.7%) in …


Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company Dec 2021

Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company Dec 2021

Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Does Androgen Deprivation Impact Associations Between Cognition And Strength, Fitness And Function In Community-Dwelling Men With Prostate Cancer? A Cross-Sectional Study, Niamh L. Mundell, Patrick J. Owen, Jack Dalla Via, Helen Macpherson, Robin M. Daly, Steve F. Fraser Dec 2021

Does Androgen Deprivation Impact Associations Between Cognition And Strength, Fitness And Function In Community-Dwelling Men With Prostate Cancer? A Cross-Sectional Study, Niamh L. Mundell, Patrick J. Owen, Jack Dalla Via, Helen Macpherson, Robin M. Daly, Steve F. Fraser

Research outputs 2014 to 2021

Objectives:

We investigated whether there were differences in associations between cognition with muscle strength, fitness and function in men with prostate cancer (PCa) treated with, and without androgen deprivation therapy (ADT) and non-PCa controls. A secondary aim was to compare differences in the prevalence of cognitive impairment.

Design:

This cross-sectional study compared 70 ADT-treated men with PCa aged 50-85 years to non-ADT-treated men (n=52) and non-PCa controls (n=70).

Setting:

University clinical exercise laboratory.

Interventions:

Nil.

Primary and secondary outcome measures:

Standardised assessments were conducted for cognition (learning, memory, attention, processing speed and executive function), muscle strength (grip strength and leg …


Library Consortia Development Analysis With Special Reference To India, Subhash Reddy B Dr., Ravi B. Venkat Dr., Krishnamurthy Madaiah Dr, Dec 2021

Library Consortia Development Analysis With Special Reference To India, Subhash Reddy B Dr., Ravi B. Venkat Dr., Krishnamurthy Madaiah Dr,

Library Philosophy and Practice (e-journal)

The study examines the library consortia research publications of the past two decades in order to gain insight into the development of library consortia, with a special emphasis on Indian contributions adopting Scientometrics analysis technique. Data was collected using the Web of Science abstracting and citation database, which retrieved 983 publications dating from 2001 to 2020. For the study, 326 relevant publications were selected and analysed using Biblioshny, Citespace and VOSviewer software. The analysis revealed a consistent research interest in library consortia, as shown by the increase in the number of publications and the number of keywords. India has secured …


Characterization Of A New Whim Syndrome Mutant Reveals Mechanistic Differences In Regulation Of The Chemokine Receptor Cxcr4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, Jeffrey L Benovic Dec 2021

Characterization Of A New Whim Syndrome Mutant Reveals Mechanistic Differences In Regulation Of The Chemokine Receptor Cxcr4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, Jeffrey L Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

WHIM syndrome is a rare immunodeficiency disorder that is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis. While several gain-of-function mutations that lead to C-terminal truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified in WHIM syndrome patients, the functional effect of these mutations are not fully understood. Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 (S339fs5) and compare the properties of S339fs5 with wild-type CXCR4 and a previously identified WHIM syndrome mutant, R334X. The S339fs5 and R334X mutants exhibited significantly increased signaling compared …