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Memories From The Great War: An Analysis Of Jackson Purchase Veteran’S Changes In Perspective Since 1914

Jackson Purchase Historical Society Journal Archive

Memories From the Great War: An Analysis of Jackson Purchase Veteran’s Changes in Perspective Since 1914

David J. Wallace

Book Reviews

Jackson Purchase Historical Society Journal Archive

Tecumseh and the Prophet: The Shawnee Brothers Who Defied a Nation by Peter Cozzens

Ted Franklin Belue

Finding Daniel Boone: His Last Days in Missouri and the Strange Fate of His Remains by Ted Franklin Belue

Dale Ray Phillips

West Tennessee: The Land Between the Rivers by Sam McGowan

Marvin Downing

T. R. M. Howard: Doctor, Entrepreneur, Civil Rights Pioneer by David T. Beito and Linda Royster Beito

Melinda Meador

A Beautiful Star, The Life of Lois Etoile Brewer by Bobbie Smith Bryant

Bruce Dobyns

Creating A 'Community Of Inquiry': A Framework For Optimizing The Virtual Education Experience, Betty Lee Ligon, Audrea Burns, Satid Thammasitboon

Faculty, Staff and Students Publications

This article was migrated. The article was marked as recommended.

Background: Medical educators must learn to implement technologic advances to create meaningful learning experiences, implementing media tools that are effective in meeting evolving academic needs and fostering interpersonal engagement. The increasing time constraints in a department of more than 1,600 faculty interspersed throughout a large metropolitan complex served as the catalyst for utilizing technology to create a framework for providing virtual faculty development.

Objective: To use a Community of Inquiry (CoI) as a framework to guide the development of an interactive, virtual writing retreat.

Methods: We used the three elements …

Open Problems In Extracellular Rna Data Analysis: Insights From An Ercc Online Workshop, Roger P Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E A Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L Van Nostrand, Emily Laplante, Bogdan Mateescu, Brian S White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M Spengler

Faculty, Staff and Students Publications

We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of disease, and form the basis of new strategies for disease treatment. The Extracellular RNA Communication Consortium (ERCC) hosted a two-day online workshop (April 19–20, 2021) on the unique challenges of exRNA data analysis. The goal was to foster an open dialog about best practices and discuss open problems in the field, focusing initially on small exRNA sequencing data. Video recordings of workshop …

Lrrtm4 Is A Member Of The Transsynaptic Complex Between Rod Photoreceptors And Bipolar Cells, Melina A Agosto, Theodore G Wensel

Faculty, Staff and Students Publications

Leucine rich repeat transmembrane (LRRTM) proteins are synaptic adhesion molecules with roles in synapse formation and signaling. LRRTM4 transcripts were previously shown to be enriched in rod bipolar cells (BCs), secondary neurons of the retina that form synapses with rod photoreceptors. Using two different antibodies, LRRTM4 was found to reside primarily at rod BC dendritic tips, where it colocalized with the transduction channel protein, TRPM1. LRRTM4 was not detected at dendritic tips of ON-cone BCs. Following somatic knockout of LRRTM4 in BCs by subretinal injection and electroporation of CRISPR/Cas9, LRRTM4 was abolished or reduced in the dendritic tips of transfected …

Ketamine: Neuroprotective Or Neurotoxic?, Divya Choudhury, Anita E Autry, Kimberley F Tolias, Vaishnav Krishnan

Faculty, Staff and Students Publications

Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has been employed clinically as an intravenous anesthetic since the 1970s. More recently, ketamine has received attention for its rapid antidepressant effects and is actively being explored as a treatment for a wide range of neuropsychiatric syndromes. In model systems, ketamine appears to display a combination of neurotoxic and neuroprotective properties that are context dependent. At anesthetic doses applied during neurodevelopmental windows, ketamine contributes to inflammation, autophagy, apoptosis, and enhances levels of reactive oxygen species. At the same time, subanesthetic dose ketamine is a powerful activator of multiple parallel neurotrophic signaling cascades …

Secretion Of Von Willebrand Factor And Suppression Of Adamts-13 Activity By Markedly High Concentration Of Ferritin, Dalia A Bashir, Qi Da, Subhashree Pradhan, Nitin Sekhar, Christian Valladolid, Fong Lam, Danielle Guffey, Jordana Goldman, Moreshwar S Desai, Miguel A Cruz, Carl Allen, Trung C Nguyen, K Vinod Vijayan

Faculty, Staff and Students Publications

Hyperferritinemia is associated with poor outcomes in critically ill patients with sepsis, hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndromes (MAS) and coronavirus disease 19 (COVID-19). Autopsies of hyperferritinemic patients that succumbed to either sepsis, HLH, MAS or COVID-19 have revealed disseminated microvascular thromboses with von Willebrand factor (VWF)-, platelets-, and/or fibrin-rich microthrombi. It is unknown whether high plasma ferritin concentration actively promotes microvascular thrombosis, or merely serves as a prognostic biomarker in these patients. Here, we show that secretion of VWF from human umbilical vein endothelial cells (HUVEC) is significantly enhanced by 100,000 ng/ml of recombinant ferritin heavy chain protein (FHC). …

The Bile Acid Induced Hepatokine Orosomucoid Suppresses Adipocyte Differentiation, Sung Ho Lee, Jong Min Choi, Sung Yun Jung, Aaron R Cox, Sean M Hartig, David D Moore, Kang Ho Kim

Faculty, Staff and Students Publications

Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explain the salutary effects of serum bile acid elevation remain unclear. Here, proteomic profiling identified a new hepatokine, Orosomucoid (ORM) that governs liver-adipose tissue crosstalk. Hepatic ORMs were highly induced by both genetic and dietary bile acid overload. To address the direct metabolic effects of ORM, purified ORM proteins were administered during adipogenic differentiation of 3T3-L1 cells …

Mucins, Gut Microbiota, And Postbiotics Role In Colorectal Cancer, Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K Roy, Michael Bouvet, Surinder K Batra

Faculty, Staff and Students Publications

An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host …

An International Study Of Interobserver Variability Of “String Sign” Of Pancreatic Cysts Among Experienced Endosonographers, Seifeldin Hakim, Emmanuel Coronel, Graciela M Nogueras González, Philip S Ge, Suresh T Chari, Nirav Thosani, Srinivas Ramireddy, Ricardo Badillo, Tomas Davee, Marc F Catalano, Robert J Sealock, Sreeram Parupudi, Lyndon V Hernandez, Virendra Joshi, Atsushi Irisawa, Surinder Rana, Sundeep Lakhtakia, Peter Vilmann, Adrian Saftoiu, Siyu Sun, Marc Giovannini, Matthew H Katz, Michael P Kim, Manoop S Bhutani

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: No single optimal test reliably determines the pancreatic cyst subtype. Following EUS-FNA, the "string sign" test can differentiate mucinous from nonmucinous cysts. However, the interobserver variability of string sign results has not been studied.

METHODS: An experienced endosonographer performed EUS-FNA of pancreatic cysts on different patients and was recorded on video performing the string sign test for each. The videos were shared internationally with 14 experienced endosonographers, with a survey for each video: "Is the string sign positive?" and "If the string sign is positive, what is the length of the formed string?" Also asked "What is …

Case Report: Dupilumab Successfully Controls Severe Eczema In A Child With Elevated Ige Levels And Recurrent Skin Infections, Tejas P Joshi, Sara Anvari, Meera R Gupta, Carla M Davis, Joud Hajjar

Faculty, Staff and Students Publications

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and …

ระบบประเมินความพร้อมในการยอมรับเทคโนโลยี Software-As-A-Service สำหรับวิสาหกิจขนาดกลางและขนาดย่อม (Smes), ดลินี ศาสตระรุจิ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยแบบผสมผสานนี้มีวัตถุประสงค์ 4 ข้อ ประกอบด้วย ศึกษาวิธีการประเมินความพร้อม และปัจจัยที่ส่งผลต่อความพร้อมในการยอมรับเทคโนโลยี SaaS ของ SMEs สร้างกรอบ (Framework) ในการประเมินความพร้อมในการยอมรับเทคโนโลยี SaaS สำหรับ SMEs พัฒนาและทดสอบประสิทธิภาพนวัตกรรมต้นแบบระบบประเมินความพร้อมในการยอมรับเทคโนโลยี SaaS สำหรับ SMEs และศึกษาการยอมรับและความเป็นไปได้เชิงพาณิชยกรรมของต้นแบบระบบประเมินความพร้อมในการยอมรับเทคโนโลยี SaaS สำหรับ SMEs การวิจัยเชิงคุณภาพใช้การสัมภาษณ์เชิงลึกแหล่งข้อมูลจาก 3 แหล่ง (Triangulation of Source) ประกอบด้วย ผู้เชี่ยวชาญและผู้ทรงคุณวุฒิ ผู้ให้บริการ SaaS Accounting และเจ้าของกิจการ SMEs จำนวนรวม 17 คน โดยคัดเลือกกลุ่มตัวอย่างด้วยวิธีแนะนำต่อกันเป็นลูกโซ่ (Snowball Sampling) ร่วมกับการกำหนดโควตาของแหล่งข้อมูล และวิเคราะห์เนื้อหา (Content Analysis) อย่างเป็นระบบ การวิจัยเชิงปริมาณใช้การเก็บข้อมูลผ่านแบบสอบถามจากเจ้าของกิจการ SMEs จำนวน 317 คน โดยคัดเลือกกลุ่มตัวอย่างด้วยวิธีแนะนำต่อกันเป็นลูกโซ่ (Snowball Sampling) และวิเคราะห์องค์ประกอบเชิงยืนยัน (Confirmatory Factor Analysis : CFA) การพัฒนาและทดสอบระบบประเมินความพร้อมในการยอมรับเทคโนโลยีสำหรับ SaaS อิงกับแนวคิดทางทฤษฎีในด้าน New Service Development และหลักการเรียนรู้ของเครื่อง (Machine Learning) โดยใช้อัลกอริธึมการเรียนรู้แบบมีผู้สอน (Supervised Learning) ประเภทต้นไม้ตัดสินใจ ประกอบเป็นนวัตกรรมต้นแบบ SaaSAdvice แผนงานความเป็นไปได้เชิงพาณิชย์ประกอบด้วยการทดสอบและสำรวจความคิดเห็นเจ้าของกิจการ SMEs ต่อต้นแบบนวัตกรรม SaaSAdvice ตามแบบจำลองการยอมรับเทคโนโลยี Technology Acceptance Model (TAM) จำนวน 63 ราย อยู่ในระดับเห็นด้วยอย่างยิ่ง ค่าเฉลี่ยเท่ากับ 4.34 และวิเคราะห์ความเป็นไปได้ในการนำต้นแบบนวัตกรรม SaaSAdvice ไปใช้ประโยชน์ตามแนวคิด Business Model Canvas โดยประโยชน์ที่ได้รับจากการวิจัยในเชิงวิชาการ ได้แก่ กรอบแนวคิดเทคโนโลยี …

Safety And Efficacy Of Fecal Microbiota Transplantation To Treat And Prevent Recurrent Clostridioides Difficile In Cancer Patients, Hiba Ali, Shruti Khurana, Weijie Ma, Yuanzun Peng, Zhi-Dong Jiang, Herbert Dupont, Hao Chi Zhang, Anusha S Thomas, Pablo Okhuysen, Yinghong Wang

Faculty, Staff and Students Publications

Background: Cancer patients are at increased risk of recurrent Clostridioides difficile infection (rCDI) due to malignancy itself, cancer therapy, and frequent antibiotic use and have a lower response rate to standard oral antibiotics. There are limited data on the safety and efficacy of fecal microbiota transplantation (FMT) for treating rCDI in cancer patients. We aim to describe our experience of using FMT to treat rCDI at a tertiary cancer center.

Methods: We conducted a retrospective study of cancer patients who underwent FMT for rCDI at The University of Texas MD Anderson Cancer Center from June 2017 through January 2020. Baseline …

Metabolite Profile And Biological Activities Of Crude Early Immature Durian Durio Zibethinus Fruit Extracts, Putthamas Pewlong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Durian (Durio zibethinus) is a popularly consumed fruit in Thailand. To maintain the quality of fruit including size and taste, lots of early immature durian fruit (30-45 days after anthesis) were thinned. Therefore, the fruit at this stage is considered as an agricultural waste and there is no study focusing on this waste yet. The aim of the present study was to investigate the metabolite profile and biological activities related to human skin and hair dermal papilla cells. Four groups of primary metabolites (sugars, organic acids, amino acids, and miscellaneous) were annotated using GC-MS, meanwhile HPLC-Q-TOF-MS/MS analysis was performed to …

Enhancing Glucose Metabolism Via Gluconeogenesis Is Therapeutic In A Zebrafish Model Of Dravet Syndrome, Rajeswari Banerji, Christopher Huynh, Francisco Figueroa, Matthew T Dinday, Scott C Baraban, Manisha Patel

Faculty, Staff and Students Publications

Energy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental disorders. Here, we focussed on correcting metabolic defects in a catastrophic paediatric epilepsy, Dravet syndrome which is caused by mutations in sodium channel NaV1.1 gene, SCN1A. We utilized a translatable zebrafish model of Dravet syndrome (scn1lab) which exhibits key characteristics of patients with Dravet syndrome and shows metabolic deficits accompanied by down-regulation of gluconeogenesis genes, pck1 and pck2. Using a metabolism-based small library screen, we identified compounds that increased gluconeogenesis via up-regulation of pck1 gene expression in scn1lab larvae. Treatment with PK11195, a pck1 activator …

The Sglt2 Inhibitor Empagliflozin Attenuates Interleukin-17a-Induced Human Aortic Smooth Muscle Cell Proliferation And Migration By Targeting Traf3ip2/Ros/Nlrp3/Caspase-1-Dependent Il-1Β And Il-18 Secretion, Sergiy Sukhanov, Yusuke Higashi, Tadashi Yoshida, Srinivas Mummidi, Annayya R. Aroor, Jacob Jeffrey Russell, Shawn B. Bender, Vincent G. Demarco, Bysani Chandrasekar

School of Medicine Publications

Chronic inflammation and persistent oxidative stress contribute to the development and progression of vascular proliferative diseases. We hypothesized that the proinflammatory cytokine interleukin (IL)-17A induces oxidative stress and amplifies inflammatory signaling in human aortic smooth muscle cells (SMC) via TRAF3IP2-mediated NLRP3/caspase-1-dependent mitogenic and migratory proinflammatory cytokines IL-1β and IL-18. Further, we hypothesized that these maladaptive changes are prevented by empagliflozin (EMPA), an SGLT2 (Sodium/Glucose Cotransporter 2) inhibitor. Supporting our hypotheses, exposure of cultured SMC to IL-17A promoted proliferation and migration via TRAF3IP2, TRAF3IP2-dependent superoxide and hydrogen peroxide production, NLRP3 expression, caspase-1 activation, and IL-1β and IL-18 secretion. Furthermore, NLRP3 knockdown, …

La Vacunación En El Contexto De La Pandemia De Covid-19 [Vaccination In The Context Of The Covid-19 Pandemic], Alvaro Diaz-Badillo, Guadalupe Nayely Garibay-Nieto, Ana L. Navas-Figueroa, Adriana L. Perales-Torres, María Concepción Morales-Gómez, Juan C. Lopez-Alvarenga

School of Medicine Publications

En esta revisión se describen el historial de vacunación, los diferentes tipos de vacunas y cómo la cobertura de vacunación se ha visto afectada por la pandemia actual de COVID-19. Se analiza la efectividad de las vacunas en condiciones metabólicas del huésped, especialmente cuando las personas han perdido su inmunocompetencia, como los pacientes con enfermedad renal crónica que están en tratamiento de diálisis. Las vacunas se producen con una variedad de métodos industriales, modificando los costos. El nuevo campo de la vacunómica incluye el conjunto de respuestas inmunitarias, los niveles satisfactorios de anticuerpos neutralizantes, la producción de metabolitos y la …

Involvement Of Tgfβ Signaling Pathway In Oxidative Stress And Diabetic Retinopathy, Reanna Rodriguez, Kristine L. Lowe, Megan Keniry, Andrew Tsin

School of Medicine Publications

Diabetic Retinopathy (DR) is a leading cause of blindness in the U.S. However, not much is known of underlying molecular mechanism and how oxidative stress contributes to its development. In the present study, we investigated the involvement of TGFβ signaling pathway on the effect of oxidative stress on VEGF secretion and viability of retinal cells. VEGF is the hallmark that exacerbates DR progression in prolonged diabetes. Some major concerns that have arisen are the underlying effects of antioxidants in elevating VEGF secretion in diabetes. In this study, we evaluated how hypoxia (or low oxygen) impacts viability and VEGF secretion using …

Protein-Functionalized Poly(Ethylene Glycol) Hydrogels As Scaffolds For Monolayer Organoid Culture, Reid L Wilson, Ganesh Swaminathan, Khalil Ettayebi, Carolyn Bomidi, Xi-Lei Zeng, Sarah E Blutt, Mary K Estes, K Jane Grande-Allen

Faculty, Staff and Students Publications

Stem cell-derived, organotypic in vitro models, known as organoids, have emerged as superior alternatives to traditional cell culture models due to their unparalleled ability to recreate complex physiological and pathophysiological processes. For this reason, they are attractive targets of tissue-engineering efforts, as constructs that include organoid technology would be expected to better simulate the many functions of the desired tissue or organ. While the 3D spheroidal architecture that is the default architecture of most organoid models may be preferred for some applications, 2D monolayer arrangements remain the preferred organization for many applications in tissue engineering. Therefore, in this work, we …

If Not Otitis Externa...Then What?, Elizabeth A. Flasch, Sadia Ansari, Timothy Martin

College of Nursing Faculty Research and Publications

Ear pain is one of the most common presentations in urgent care, especially among pediatric patients. Further, acute otitis media (AOM) is the most common condition for which antibacterial agents are prescribed for children in the United States. Clinician visits make up 634 per 100 children during 2005-2006. It is imperative that clinicians differentiate AOM from new onset of otorrhea not due to acute otitis externa (AOE), the most common diagnoses made by clinicians with regional variations based on age and geography.1

The majority of AOE-related visits occur during the summer months (June through August); visits occur most commonly in …

When Pandemics Collide: The Impact Of Covid-19 On Childhood Obesity, Nancy T. Browne, Julia A. Snethen, Cindy Smith Greenberg, Marilyn Frenn, Jill F. Kilanowsky, Bonnie Gance-Cleveland, Pamela J. Burke, Linda Lewandowski

College of Nursing Faculty Research and Publications

• Children with obesity face increased biopsychosocial risks during COVID-19.

• Stress exacerbates inflammation and immune response in obesity and COVID-19.

• The COVID-19 pandemic has significantly interrupted children's daily routines.

• The health effects of the obesogenic environment are exacerbated by COVID-19.

• Access to timely, comprehensive healthcare is critical during COVID-19.

The Association Between Polygyny Statuses Of Currently Married And In-Union Women And Attitude Towards Intimate Partner Violence Against Women In Ghana, Dorcas Adewale, Nutifaga Eugene Yaw Dey, Kenneth Owusu Ansah, Henry Ofori Duah, Pascal Agbadi

College of Nursing Faculty Research and Publications

Polygyny is a common family structure in sub-Saharan African countries. Previous studies have documented that women in this family structure have favourable attitudes towards intimate partner violence (IPV). Nevertheless, there is limited recent research concerning this association in Ghana. This study sought to investigate the association between polygynous statuses and endorsement of IPV among Ghanaian reproductive-aged married and in-union women while controlling for covariates. The study used the nationally representative data from the 2017/2018 Ghana Multiple Indicator Cluster Survey. The sample comprised 7800 married/in-union women aged 15–49. Data analyses included tests of association and multivariable modelling using binary logistic …

2021 Research Symposium: International Conference On Cancer Health Disparities (Icchd-2021), The University Of Texas Rio Grande Valley. School Of Medicine

School of Medicine Publications

No abstract provided.