Digital Commons Network^™

Jlsc Board Editorial 2021, Anne Gilliland, Rebekah Kati, Jennifer Solomon, Dave S. Ghamandi, Jill Cirasella, David Lewis, Dede Dawson

Publications and Research

It hardly needs to be said that 2020 was a difficult year for the world. COVID-19 has infected over 120 million people and killed over 2 million as of March 2021 (Johns Hopkins). At the same time, police violence against people of color continues, even as communities engage in long-overdue reckoning initiatives. Across the globe, researchers, governments, and communities needed quick, open, up-to-date information on testing for, treating, and preventing COVID-19. Our increased dependence on technology during lockdowns provided some with safety and continuity, while others experienced the widening of the digital divide. There is no greater urgency than the …

A Refined Experimentalist Governance Approach To Incremental Policy Change: The Case Of Process-Tracing China’S Central Government Infrastructure Ppp Policies Between 1988 And 2017, Huanming Wang, Bin Chen, Joop Koppenjan

Publications and Research

This article was originally published in Journal of Chinese Governance, available at https://doi.org/10.1080/23812346.2021.1898151

This work is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs International License (CC BY-NC-ND 4.0).

Urban School Violence Prevention: A Suggested Intervention Utilizing Liberation Psychology, Meghan K. Hogan

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

In the past decades, numerous programs have been developed in attempts to reduce the rates of violence facing students in American schools. The spotlight on these programs have increased since horrific mass shooting events have taken place throughout the country. Many of these programs have utilized varied methods in their attempt to reduce school-based violence, from the implementation of hardline policies meant to act as violence deterrents to the development of risk assessment teams aimed at identifying and intervening against potential threats; however, few of the existing programs have shown substantial efficacy rates. Additionally, several of the violence prevention programs …

Extracellular Vesicles Released By Human Retinal Pigment Epithelium Mediate Increased Polarised Secretion Of Drusen Proteins In Response To Amd Stressors, Miguel Flores-Bellver, Jason Mighty, Silvia Aparicio-Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick Mcgrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto-Soler

Publications and Research

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression. The mechanisms underlying drusen biogenesis, however, remain mostly unknown. Here we demonstrate that under homeostatic conditions extracellular vesicles (EVs) secreted by retinal pigment epithelium (RPE) cells are enriched in proteins associated with mechanisms involved in AMD pathophysiology, including oxidative stress, immune response, inflammation, complement system and drusen composition. Furthermore, we provide first evidence that drusen-associated proteins are released as cargo of extracellular …

Human Retinal Organoids Release Extracellular Vesicles That Regulate Gene Expression In Target Human Retinal Progenitor Cells, Jing Zhou, Miguel Flores‑Bellver, Jianbo Pan, Alberto Benito‑Martin, Cui Shi, Onyekwere Onwumere, Jason Mighty, Jiang Qian, Xiufeng Zhong, Tasmim Hogue, Baffour Amponsah‑Antwi, Linda Einbond, Rajendra Gharbaran, Hao Wu, Bo‑Juen Chen, Zhiliang Zheng, Tatyana Tchaikovskaya, Xusheng Zhang, Hector Peinado, Maria Valeria Canto‑Soler, Stephen Redenti

Publications and Research

The mechanisms underlying retinal development have not been completely elucidated. Extracellular vesicles (EVs) are novel essential mediators of cell‑to‑cell communication with emerging roles in developmental processes. Nevertheless, the identification of EVs in human retinal tissue, characterization of their cargo, and analysis of their potential role in retina development has not been accomplished. Three‑dimensional retinal tissue derived from human induced pluripotent stem cells (hiPSC) provide an ideal developmental system to achieve this goal. Here we report that hiPSC‑derived retinal organoids release exosomes and microvesicles with small noncoding RNA cargo. EV miRNA cargo‑predicted targetome correlates with Gene Ontology (GO) pathways involved in …

Detection Of Subsurface, Nanometer-Scale Crystallographic Defects By Nonlinear Light Scattering And Localization, Farbod Shafiei, Tommaso Orzali, Alexey Vert, Mohammad-Ali Miri, Pui Yee Hung, Man Hoi Wong, Andrea Alù, Gennadi Bersuker, Michael C. Downer

Publications and Research

Heteroepitaxial crystalline films underlie many electronic and optical technologies but are prone to forming defects at their heterointerfaces. Atomic-scale defects such as threading dislocations that propagate into a film impede the flow of charge carriers and light degrading electrical/optical performance of devices. Diagnosis of subsurface defects traditionally requires time-consuming invasive techniques such as cross-sectional transmission electron microscopy. Using III–V films grown on Si, noninvasive, bench-top diagnosis of subsurface defects have been demonstrated by optical second-harmonic scanning probe microscope. A high-contrast pattern is observed of subwavelength “hot spots” caused by scattering and localization of fundamental light by defect scattering sites. Size …

Framing Inclusion: The Media Treatment Of Irregular Immigrants' Right To Health Care In Spain, Alisa Petroff, Anahí Viladrich, Sònia Parella

Publications and Research

With the passing of Royal Decree-Law 16/2012, Spain’s national health system switched from a model defined by universal and free health care principles, to a private insurance system that excluded large population groups. Based on a qualitative research design, this paper examines the media treatment of undocumented immigrants’ prerogatives to public health care in Spain (2012–2018). The analysis of 234 articles, drawn from three major Spanish newspapers, reveals three frames that underscore the media’s "rhetorics of inclusion," which argue for the extension of free medical services to irregular immigrants a topic traditionally underestimated by the literature. The moralist frame, supported …

Toward An Integrative Geological And Geophysical View Of Cascadia Subduction Zone Earthquakes, Maureen A.L. Walton, Lydia M. Staisch, Tina Dura, Jessie K. Pearl, Brian Sherrod, Joan Gomberg, Simon Engelhart, Ray E. Wells, Multiple Additional Authors

Geology Faculty Publications and Presentations

The Cascadia subduction zone (CSZ) is an exceptional geologic environment for recording evidence of land-level changes, tsunamis, and ground motion that reveals at least 19 great megathrust earthquakes over the past 10 kyr. Such earthquakes are among the most impactful natural hazards on Earth, transcend national boundaries, and can have global impact.Reducing the societal impacts of future events in the US Pacific Northwest and coastal British Columbia, Canada, requires improved scientific understanding of megathrust earthquake rupture, recurrence, and corresponding hazards. Despite substantial knowledge gained from decades of research, large uncertainties remain about the characteristics and frequencies of past CSZ earthquakes. …

Effect Of Contract Attribute Levels On Willingness To Participate In A Working Wetlands Program, Haley Coffield

Agribusiness and Applied Economics

Wetlands are an integral part of duck habitat in the Prairie Pothole Region, which covers three Canadian provinces and five U.S. states. They often overlap with cropland, creating issues for farmers. A program that provided funding to farmers who agree to not alter wetlands and continue to farm the land was introduced in North Dakota called the Working Wetlands Program. After four years, participating farmers were surveyed. A choice experiment was used to investigate the effect of program contract attributes including payment, length, and whether the contract is binding, on willingness to enroll. A random parameters logit model was estimated. …

The Interface And Instrumentality Of Eurorack Modular Synthesis, Eliot Bates

Publications and Research

In this essay, I will examine a couple of aspects of hardware modular synthesizers which, despite not being a “new” morphological form (most commercially sold synthesizers from the 1960s through the early 1970s were modular), experienced an extremely unlikely expansion of interest and activity in the mid-1990s. With a contemporary modular synth, users buy a powered rack that holds modules specific to one of several competing formats. For the two most widely adopted formats, Eurorack (sometimes called 3U in reference to the height of modules, or Doepfer A-100 after the first branded system to adopt this panel height) and MOTM/MU …

Pathos, Winter 2021, Portland State University. Student Publications Board

Pathos

Editor: Claire Miller

Raps Sheet, January 2021, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

‘The Environment Is Us’: Settler Cartographies Of Indigeneity And Blackness In Prophecy (1979), Kali Simmons

Indigenous Nations Studies Faculty Publications and Presentations

This article examines the triangulation of whiteness, Blackness, and Indigeneity in the ‘creature feature’ sf-horror film Prophecy (Frankenheimer US 1979), arguing that the film’s renderings of environmental racism ultimately function to justify white supremacist hetero-patriarchal maintenance and surveillance of Black and Indigenous lands and bodies. A close examination of Prophecy’s representational and ideological shortfalls – in particular its renderings of Black and Indigenous maternity – reveals troubling entanglements between settler-colonial logics of geography, ecology, monstrosity, and subjectivity.

Toward A Law And Politics Of Racial Solidarity, Luis Fuentes-Rohwer, Guy-Uriel Charles

Articles by Maurer Faculty

The killings of George Floyd, Michael Brown, Trayvon Martin, and others have occurred under different factual circumstances, in different states, at the hands of both state and private actors, and have engendered different levels of outrage on the basis of their perceived egregiousness. Collectively and cumulatively, they have forced Americans to, once again, wrestle with the visible manifestation of racism and structural inequality. This confrontation is not simply a function of the inability to avert one’s eyes when faced with incontrovertible evidence of evident inhumanity and abject degradation, though it is in part that. After all, how to justify the …

Subito 2021, Portland State University. School Of Music & Theater

Subito: Student Voices from Portland State University School of Music & Theater

Issue 4, Spring 2021

Renowned women composers of nineteenth century Europe; jazz musicians reflecting upon the roots of African-American music; punks defining the music of a generation; a Portlander composer offering a haunting work on the death of Mulugeta Seraw.

Pdxscholar Annual Report 2020, Karen Bjork, Sherry Buchanan, David Coate, Bertrand Robinson, Stacey Schlatter

Library Faculty and Staff Publications and Presentations

This report details the tenth year of operation for PDXScholar, Portland State University's institutional repository. The report covers the period between January 1, 2020 and December 31, 2020.

The 2020 report highlights the exponential growth of PDXScholar with almost 2.1 million (2,094,796) full text downloads. This is an increase of approximately 800,000 downloads from 2019, representing a 62% increase.

The report also focuses on our work to bring online new collections and to highlight research impacting our communities, academics, and personal lives.

Measurement Of American Indian And Alaska Native Racial Identity Among Medical School Applicants, Matriculants, And Graduates, 1996-2017, Erik Brodt, Steele Valenzuela, Amanda Bruegl, Dove Spector, Miguel Marino, Patricia A. Carney

OHSU-PSU School of Public Health Faculty Publications and Presentations

IMPORTANCE:

Accurate racial/ethnic identity measurement is needed to understand the effectiveness of outreach, recruitment, and programs to support American Indian and Alaska Native (AIAN) people becoming physicians.

OBJECTIVE:

To examine how changes in race/ethnicity data collection by the American Medical College Application System are associated with trends in applicants, matriculants, and graduates self reporting as AIAN.

DESIGN, SETTING, AND PARTICIPANTS:

In this cohort study, interrupted time series regression was conducted using data from the American Medical College Application system identifying medical school applicants and graduates between January 1, 1996, and December 31, 2017, who identified as AIAN. The number of …

Time Enough For Counting: A Unicorn Retrospective, Abraham Cable

Faculty Scholarship

No abstract provided.

"I Would If Only I Could": How California Cities Can Use State Law To Overcome Neighborhood Resistance To New Housing, Christopher S. Elmendorf, Eric Biber, Paavo Monkkonen, Moira O’Neill

Faculty Scholarship

No abstract provided.

State Administrative Review Of Local Constraints On Housing Development: Improving The California Model, Christopher S. Elmendorf, Eric Biber, Paavo Monkkonen, Moira O’Neill

Faculty Scholarship

Starting in the 1970s, the West Coast states coalesced around roughly similar responses to the problem of excessive local restrictions on housing supply. Local governments were charged with making plans to accommodate projected population growth, subject to review and approval by a state agency. In California, a city’s housing plan must also analyze, mitigate, and remove “constraints” to the development of housing in general. This component of the plan has received little attention, and, according to a recent report of the State Auditor, it hasn’t accomplished much. We argue that it could accomplish much more—if the state housing agency develops …

Experimental? It Doesn't Mean What You Think It Means, Dorit Rubenstein Reiss, Arthur J. Caplan

Faculty Scholarship

No abstract provided.

Enhancing Glucose Metabolism Via Gluconeogenesis Is Therapeutic In A Zebrafish Model Of Dravet Syndrome, Rajeswari Banerji, Christopher Huynh, Francisco Figueroa, Matthew T Dinday, Scott C Baraban, Manisha Patel

Faculty, Staff and Students Publications

Energy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental disorders. Here, we focussed on correcting metabolic defects in a catastrophic paediatric epilepsy, Dravet syndrome which is caused by mutations in sodium channel NaV1.1 gene, SCN1A. We utilized a translatable zebrafish model of Dravet syndrome (scn1lab) which exhibits key characteristics of patients with Dravet syndrome and shows metabolic deficits accompanied by down-regulation of gluconeogenesis genes, pck1 and pck2. Using a metabolism-based small library screen, we identified compounds that increased gluconeogenesis via up-regulation of pck1 gene expression in scn1lab larvae. Treatment with PK11195, a pck1 activator …

Ketamine: Neuroprotective Or Neurotoxic?, Divya Choudhury, Anita E Autry, Kimberley F Tolias, Vaishnav Krishnan

Faculty, Staff and Students Publications

Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has been employed clinically as an intravenous anesthetic since the 1970s. More recently, ketamine has received attention for its rapid antidepressant effects and is actively being explored as a treatment for a wide range of neuropsychiatric syndromes. In model systems, ketamine appears to display a combination of neurotoxic and neuroprotective properties that are context dependent. At anesthetic doses applied during neurodevelopmental windows, ketamine contributes to inflammation, autophagy, apoptosis, and enhances levels of reactive oxygen species. At the same time, subanesthetic dose ketamine is a powerful activator of multiple parallel neurotrophic signaling cascades …

Creating A 'Community Of Inquiry': A Framework For Optimizing The Virtual Education Experience, Betty Lee Ligon, Audrea Burns, Satid Thammasitboon

Faculty, Staff and Students Publications

This article was migrated. The article was marked as recommended.

Background: Medical educators must learn to implement technologic advances to create meaningful learning experiences, implementing media tools that are effective in meeting evolving academic needs and fostering interpersonal engagement. The increasing time constraints in a department of more than 1,600 faculty interspersed throughout a large metropolitan complex served as the catalyst for utilizing technology to create a framework for providing virtual faculty development.

Objective: To use a Community of Inquiry (CoI) as a framework to guide the development of an interactive, virtual writing retreat.

Methods: We used the three elements …

Mucins, Gut Microbiota, And Postbiotics Role In Colorectal Cancer, Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K Roy, Michael Bouvet, Surinder K Batra

Faculty, Staff and Students Publications

An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host …

Open Problems In Extracellular Rna Data Analysis: Insights From An Ercc Online Workshop, Roger P Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E A Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L Van Nostrand, Emily Laplante, Bogdan Mateescu, Brian S White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M Spengler

Faculty, Staff and Students Publications

We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of disease, and form the basis of new strategies for disease treatment. The Extracellular RNA Communication Consortium (ERCC) hosted a two-day online workshop (April 19–20, 2021) on the unique challenges of exRNA data analysis. The goal was to foster an open dialog about best practices and discuss open problems in the field, focusing initially on small exRNA sequencing data. Video recordings of workshop …

Secretion Of Von Willebrand Factor And Suppression Of Adamts-13 Activity By Markedly High Concentration Of Ferritin, Dalia A Bashir, Qi Da, Subhashree Pradhan, Nitin Sekhar, Christian Valladolid, Fong Lam, Danielle Guffey, Jordana Goldman, Moreshwar S Desai, Miguel A Cruz, Carl Allen, Trung C Nguyen, K Vinod Vijayan

Faculty, Staff and Students Publications

Hyperferritinemia is associated with poor outcomes in critically ill patients with sepsis, hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndromes (MAS) and coronavirus disease 19 (COVID-19). Autopsies of hyperferritinemic patients that succumbed to either sepsis, HLH, MAS or COVID-19 have revealed disseminated microvascular thromboses with von Willebrand factor (VWF)-, platelets-, and/or fibrin-rich microthrombi. It is unknown whether high plasma ferritin concentration actively promotes microvascular thrombosis, or merely serves as a prognostic biomarker in these patients. Here, we show that secretion of VWF from human umbilical vein endothelial cells (HUVEC) is significantly enhanced by 100,000 ng/ml of recombinant ferritin heavy chain protein (FHC). …

Lrrtm4 Is A Member Of The Transsynaptic Complex Between Rod Photoreceptors And Bipolar Cells, Melina A Agosto, Theodore G Wensel

Faculty, Staff and Students Publications

Leucine rich repeat transmembrane (LRRTM) proteins are synaptic adhesion molecules with roles in synapse formation and signaling. LRRTM4 transcripts were previously shown to be enriched in rod bipolar cells (BCs), secondary neurons of the retina that form synapses with rod photoreceptors. Using two different antibodies, LRRTM4 was found to reside primarily at rod BC dendritic tips, where it colocalized with the transduction channel protein, TRPM1. LRRTM4 was not detected at dendritic tips of ON-cone BCs. Following somatic knockout of LRRTM4 in BCs by subretinal injection and electroporation of CRISPR/Cas9, LRRTM4 was abolished or reduced in the dendritic tips of transfected …

Is Digital Humanities Adjuncting Infrastructurally Significant?, Kathi Inman Berens

English Faculty Publications and Presentations

This essay examines the infrastructural causes of digital humanities adjunct invisibility and proposes two remedies: to motivate DH adjunct self-identification by convening DH adjunct-specific prizes and bursaries; and what I call "microbenefactions": small actions by senior faculty that extend opportunities to adjuncts that cost little effort and can give adjuncts access to payment, prize-worthy work opportunities, or other benefits. The unspoken assumption is that DH skills are so much in demand that people with these skills are protected from adjuncting. As I interviewed seven DH adjuncts, their heterogeneous responses to standard questions reminded me that happy families are all alike; …

Second Thoughts On Fda's Covid-Era Mental Health App Policy, Michael Mattioli

Articles by Maurer Faculty

As the coronavirus pandemic swept across the globe in April 2020, the US Food and Drug Administration (FDA) made an unusual decision. The agency announced that it would relax its enforcement of compliance rules for “digital therapeutics”—smartphone apps designed to address mental health disorders. The measure was a response to widely reported upticks in symptoms of anxiety, depression, and substance abuse brought on by the pandemic. As an added benefit, the agency explained, digital therapeutics could promote social distancing by removing patients’ need to visit health care providers.

This essay explores the possible lasting effects of the FDA’s temporary suspension …