Digital Commons Network^™

The Phase Behavior Of Ubqln Proteins And Implications For Protein Quality Control, Yiran Yang

Dissertations - ALL

The ubiquitin-proteasome system (UPS) and autophagy are essential pathways for maintaining protein quality control (PQC) in cells. Misfolded proteins and large aggregates are cleared by UPS and autophagy signaled by ubiquitin (Ub) or polyubiquitin (polyUb) chains. Shuttle proteins facilitate cargo transporting by interacting with both ubiquitin and degradation machineries. Previously, our lab discovered that the shuttle protein Ubiquilin-2 (UBQLN2) is recruited to stress granules in cells and undergoes liquid-liquid phase separation (LLPS) in vitro. LLPS is a biophysical process by which proteins separate themselves from the surrounding aqueous solution by forming protein-rich droplets. The overarching goals of this work are …

Exploiting Building Demand Flexibility Through Machine Learning For Building-To-Grid Integration, Hannah Charlene Fontenot

Dissertations - ALL

Demand flexibility – the ability to adjust a building's load profile across different timescales – is a key aspect of the ongoing effort to increase interconnectivity between buildings and the power grid. By harnessing their demand flexibility, buildings can provide significant benefits to the grid and bolster grid resilience and reliability. To facilitate the transition toward the "smart grid", new and intelligent control approaches are required that can seamlessly integrate building, occupant, and grid data and effectively control multiple building assets to provide grid services while maintaining occupants' required thermal comfort levels and reducing the building's overall energy consumption and …

Algorithm Hardware Codesign For High Performance Neuromorphic Computing, Haowen Fang

Dissertations - ALL

Driven by the massive application of Internet of Things (IoT), embedded system and Cyber Physical System (CPS) etc., there is an increasing demand to apply machine intelligence on these power limited scenarios. Though deep learning has achieved impressive performance on various realistic and practical tasks such as anomaly detection, pattern recognition, machine vision etc., the ever-increasing computational complexity and model size of Deep Neural Networks (DNN) make it challenging to deploy them onto aforementioned scenarios where computation, memory and energy resource are all limited. Early studies show that biological systems' energy efficiency can be orders of magnitude higher than that …

Direct Single Molecule Imaging Of Enhanced Diffusion For Enzymes And Enzyme-Conjugated Dna Origami, Mengqi Xu

Dissertations - ALL

Enzymes have been shown to diffuse faster in the presence of their substrates. Recently, we revealed new insights into this process of enhanced diffusion using single-particle tracking (SPT) with total internal reflection fluorescence (TIRF) microscopy. We found that the mobility of individual enzymes was enhanced three-fold in the presence of the substrate, and the motion remained Brownian. We showed that the relative increase in diffusion is independent of the total enzyme concentrations; and the oligomerization state of enzymes did not change during the catalytic turnover. These experiments ruled out the possibility that the enhanced enzyme diffusion was caused by the …

A Graduatte Level Immersive-Simulattion Program For Teaching And Assessing Fundamental Skills In Entry Level Clinical Perfusionists., Bruce Searles

Dissertations - ALL

Background: The clinical perfusionist is a member of the open-heart-surgery team and responsible for operating the life support equipment that replaces the function of the patient's heart and lungs and arrests and restarts the patient's heart in the course of a Cardiopulmonary Bypass (CPB) procedure. In the perfusionists scope of practice, the consequence of unskilled actions, inaccurate understanding or delayed decision making may result in significant patient morbidity or even death. Historically, perfusion students have learned and practiced their skills within a clinical preceptorship program in which an experienced clinician allows the novice student to operate the life support equipment …

2012 December University Of Memphis Commencement Program

Commencements

Program for the Fall convocation of the 101st commencement of the University of Memphis at Memphis, Tennessee, held at the FedEx Forum on December 16, 2012.

Realistic Additions To Matlab Simulation Of Active Particles In An Acoustic Field, Emily Ma

Mechanical Engineering and Materials Science Independent Study

Acoustic microfluidics provides a contact-free method of manipulating active particles; however, versatile and quick performance quantification of these methods is needed to further apply acoustofluidic techniques in broader settings. Motile Chlamydomonas reinhardtii algae cells continuously swim and redistribute as they are subject to an acoustic field. For performance quantification, this eliminates the tedious procedure of resetting the experiment after each trial, which is necessary when using passive particles as probes. Thus, this method of calibration using active particles is more efficient than using passive particles. Utilizing an accurate simulation of physical active particle experiments is helpful in quickly predicting how …

Fine Scales, Broad Consequences: Drivers And Effects Of Microclimatic Variation In Great Smoky Mountains National Park, Jordan Rebecca Stark

Theses - ALL

Climate is highly variable at scales that are not captured by most weather and climate models due to local effects of topography and living systems. This variation in microclimate has been noted for many decades but has been difficult to incorporate into quantitative understanding of ecological systems and processes due to the large amount of data and complex models required to adequately describe fine-scale patterns across complex landscapes. In recent years, models of thermal microclimate variation have been developed using low-cost temperature sensors, but few of these models have been used to predict the effects of microclimatic variation on ecological …

First Measurement Of B(Ξc0 → Π−Λ+C ), Michael Kent Wilkinson

Dissertations - ALL

The first measurement of the branching fraction of the Ξc0 baryon in its decay to π− and Λ+c hadrons, B(Ξc0 → π−Λ+c ), is presented. This measurement was conducted with the LHCb detector, located on the Large Hadron Collider, using 13 TeV proton-proton collisions. There have been a number of theoretical predictions for the size of this branching fraction, spanning more than an order of magnitude; this large difference is primarily due to differing assumptions about the internal interactions contributing to the decay. The branching fraction measured here provides the first experimental evidence for the nature of these interactions; it …

A Solid-State Phase Camera For Advanced Gravitational Wave Detectors, Erik Muniz

Dissertations - ALL

I present a novel way of wavefront sensing using a commercially available, continuouswavetime-of- ight camera with QVGA-resolution. This CMOS phase camera is capable of sensing externally modulated light sources with frequencies up to 100 MHz. The high-spatial-resolution of the sensor, combined with our integrated control electronics, allows the camera to image power modulation index as low as -62 dBc/second/pixel. The phase camera is applicable to problems where alignment and mode-mismatch sensing is needed and suited for diagnostic and control applications in gravitationalwave detectors. Specically, I explore the use of the phase camera in sensing the beat signals due to thermal …

Observation Of Ω Contribution In The C1(3872) → Π+Π−J/Ψ Decays, Baasansuren Batsukh

Dissertations - ALL

Resonant structure in the dipion mass spectrum produced via \decay{\Bu}{\X\Kp}, \decay{\X}{\jpsi \pip \pim}, with \decay{\jpsi}{\mu^+\mu^-} is analyzed using Run 1 and Run 2 data samples from the LHCb experiment. The spectrum is dominated by $\rhoz\to\pi^+\pi^-$, but cannot be described by this contribution alone. A significant $\omega\to\pi^+\pi^-$ contribution, interfering with $\rhoz$, is observed for the first time. This is a more significant observation ($>7.1\sigma$) of $\X\to\omega\jpsi$ decays, than previously achieved with $\omega\to\pi^+\pi^-\pi^0$ decays. The relative contribution of $\omega$ to the total $\X\to\pi^+\pi^-\jpsi$ rate is at the level expected from the measured $\X\to(\omega\to\pi^+\pi^-\pi^0)\jpsi$ rate, if the interference between the $\rho^0$ and …

Utilizing Parity Violating Electron Scattering As A Probe To Measure The Neutron Radius Of 208-Pb, David Eric King

Dissertations - ALL

The Lead Radius Experiment 2 (PREX-II) and Calcium Radius Experiment (CREX) carried out in Hall A of the Thomas Jefferson National Accelerator Facility were designed to measure the neutron skins of 208-Pb and 48-Ca nuclei by measuring the parity-violating asymmetry APV of the elastic scattering of polarized electrons on 208-Pb and 48-Ca targets. In order to achieve a precision measurement of the neutron skins of 208-Pb and 48-Ca it is imperative to maintain precise control over many experimental parameters–one of which is a precision measurement of the electron beam polarization (which is the largest contributor to experimental error making control …

Formation Of Pyrroloindolines And Alkylation Of N-Heterocycles With Trichloroacetimidates And Synthesis Of Quinoline Based Small Molecule Inhibitors Of Ghrelin O-Acyltransferase (Goat), Bhaskar Joshi

Dissertations - ALL

Pyrroloindolines and related systems are present in a large number of complex natural products. These core structures have generated considerable synthetic interest, as many of the compounds possess challenging, elaborate structures and interesting biological properties. Recently we have focused on using trichloroacetimidates for the synthesis of these fascinating molecules. Trichloroacetimidates can be used an electrophilic source of an alkyl group to form the pyrroloindoline directly from tryptamine derivatives. In this manner trichloroacetimidates provide a flexible solution to accessing highly functionalized pyrroloindoline core structures, needing only a catalytic amount of a Lewis acid to effect the requisite transformations.

Isatin (1H-indol-2,3-dione) based …

Rational Design Of Supported Metal Catalysts For Carbonyl Reduction During Biomass Upgrading, Xin Gao

Dissertations - ALL

Ketone hydrogenation:A model system of carbonyl (ketone) hydrogenation, acetone hydrogenation over supported Pt catalysts in the gas-phase fixed bed reactor was investigated to understand both the mechanism and rate controlling steps in a fundamental level. The experiments and outcomes include the detailed macro- and micro-kinetic analysis of hydrogenation of acetone. The apparent reaction orders of hydrogen and acetone, apparent activation energies, and observed kinetic isotope effects over a large range of temperatures and concentrations (compound partial pressures) are reported in this document. Generally speaking, the ketone hydrogenation over metal surfaces in vapor phase comply with the mechanism that hydrogen atoms …

Effects Of Nitrogen Fertilization On The Production Of Panicum Maximum Cv. Ipr 86 Under Grazing, S. M. B. Lugão, L. R. De A. Rodrigues, E. B. Malheiros, J. J. Dos S. Abrahão, A. De Morais

IGC Proceedings (1977-2023)

The experiment was conducted at the Experimental Station of Paranavaí/IAPAR-PR-Brazil, from October 1998 to May 1999, to evaluate the effects of N fertilization on Panicum maximum cv. IPR 86 pastures. Four doses of N (0; 150; 300; and 450 kg.ha^-1.year^-1) were applied to pastures under rotational grazing with grazing cycles (GCs) of 40 days (5 days-grazing and 35 days-rest). It was used a randomized complete block design, with split-plots, and two replications per treatment, being the N-doses studied in the main plots and the GCs in the sub-plots. In all GCs the variables dry matter of …

Effects Of Management Strategies On Seed Production And Seedling Recruitment In Birdsfoot Trefoil-White Clover Mixtures, W. Ayalá, M. Carámbula, D. F. Risso, J. Hodgson, Peter D. Kemp

IGC Proceedings (1977-2023)

The effects of grazing management on seed production, seed bank size and seedling emergence patterns of Trifolium repens cv. Zapicán (WC) and Lotus corniculatus cv. San Gabriel (BFT) oversown swards were evaluated. A complete randomized block design with 4 replicate blocks was used, in which 4 grazing strategies (grazing all year (SI), summer spelling for seed production (S2), winter rest plus summer spelling (S3) and autumn rest plus summer spelling (S4)), were combined with two defoliation severalties (4 and 10 cm height post-grazing residuals). Plots of 110 m² were grazed monthly by sheep. Seed production, soil seed bank and …

Contributors' Notes

Exile

No abstract provided.

Bibliometric Analysis Of The Aslib Journal Of Information Management From 2014 To 2021, Satyajit Nayak, Dillip Kumar Parida, Neha Verma, Piyush Kumar Hari

Library Philosophy and Practice (e-journal)

The purpose of this study is to examine the papers published in the ASLIB Journal of Information Management between 2014 to 2021. The Scopus database was chosen for bibliographic data extraction. The VOSviewer software was used to visualize the research results using network maps. During the research period, 311 papers with 2534 citations were discovered. The publication trends of the ASLIB Journal of Information Management have been identified using a variety of bibliometric variables. The findings of the study revealed that, the most documents (n=52) were published in 2020, while the most citations (n=558) were recorded in 2015. In total, …

The Integration Of Art: A Multiple Case Study Of Science, Technology, Engineering, Art, And Math (Steam) Schools In Three Schools In Southern California, Reyna Esther Smith

Dissertations

Purpose: The purpose of this qualitative multi-case study was to describe and analyze how schools that implement a STEAM program include the arts in their integrated program. The study focused on 3 K-12 schools in Southern California that are located in the Antelope Valley high desert region of the state. This multi-case study analyzed an elementary school, a middle school, and a high school that are in different districts in the area.

Methodology: This multi-case study used qualitative data to analyze the research questions regarding art infusion in STEAM programs and teacher and leader perspectives. Drawing from interviews of teachers …

Genetic Contributors Of Incident Stroke In 10,700 African Americans With Hypertension: A Meta-Analysis From The Genetics Of Hypertension Associated Treatments And Reasons For Geographic And Racial Differences In Stroke Studies, Nicole D. Armstrong, Vinodh Srinivasasainagendra, Amit Patki, Rikki M. Tanner, Bertha A. Hidalgo, Hemant K. Tiwari, Nita A. Limdi, Ethan M. Lange, Leslie A. Lange, Donna K. Arnett, Marguerite R. Irvin

Epidemiology and Environmental Health Faculty Publications

Background: African Americans (AAs) suffer a higher stroke burden due to hypertension. Identifying genetic contributors to stroke among AAs with hypertension is critical to understanding the genetic basis of the disease, as well as detecting at-risk individuals.

Methods: In a population comprising over 10,700 AAs treated for hypertension from the Genetics of Hypertension Associated Treatments (GenHAT) and Reasons for Geographic and Racial Differences in Stroke (REGARDS) studies, we performed an inverse variance-weighted meta-analysis of incident stroke. Additionally, we tested the predictive accuracy of a polygenic risk score (PRS) derived from a European ancestral population in both GenHAT and REGARDS AAs …

Progressive Destabilization And Triggering Mechanism Analysis Using Multiple Data For Chamoli Rockslide Of 7 February 2021, Wenfei Mao, Lixin Wu, Ramesh P. Singh, Yuan Qi, Busheng Xie, Yingjia Liu, Yifan Ding, Zilong Zhou, Jia Li

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A catastrophic rockslide occurred on 7 February 2021 in Chamoli area in the high Himalaya. In the absence of field data, multiple satellites data of decade span have been used to investigate and understand the progressive destabilization of rockslide body. A 3D geometric model was developed using geospatial information about geology, terrain, and ice cover to understand the triggering mechanism. Several causes are uncovered as: the pronounced long-term change of land surface temperature facilitated local permafrost degradation and led to ice cover shrinking since 2010; the occurrence of ice avalanche nearby in 2016 accompanying with sidewall-to-bedrock fracturing enhanced the ice …

Nondestructive Detection Of Codling Moth Infestation In Apples Using Pixel-Based Nir Hyperspectral Imaging With Machine Learning And Feature Selection, Nader Ekramirad, Alfadhl Y. Khaled, Lauren E. Doyle, Julia R. Loeb, Kevin D. Donohue, Raul T. Villanueva, Akinbode A. Adedeji

Electrical and Computer Engineering Faculty Publications

Codling moth (CM) (Cydia pomonella L.), a devastating pest, creates a serious issue for apple production and marketing in apple-producing countries. Therefore, effective nondestructive early detection of external and internal defects in CM-infested apples could remarkably prevent postharvest losses and improve the quality of the final product. In this study, near-infrared (NIR) hyperspectral reflectance imaging in the wavelength range of 900–1700 nm was applied to detect CM infestation at the pixel level for three organic apple cultivars, namely Gala, Fuji and Granny Smith. An effective region of interest (ROI) acquisition procedure along with different machine learning and data processing …

Scoring Measures Of Word Dictation Curriculum-Based Measurement In Writing: Effects Of Incremental Administration, Apryl L. Poch, Abigail A. Allen, Erica S. Lembke

Special Education and Communication Disorders Faculty Publications

Spelling has been identified as a key transcription skill that emerges during the elementary years as students learn how to write and subsequently develop fluency with writing, making the assessment of spelling a critical component of evaluation systems within schools. This includes the use of curriculum-based measures of writing (CBM-W). This study examined the extent to which word dictation CBM-W administered during the Fall, Winter, and Spring of an academic year maintained technical adequacy across 1-min time intervals in grades 1–3. Results revealed moderate predictive and concurrent validity estimates with the Spelling subtest of the Weschler Individual Achievement Test-III. Statistically …

Co-Teaching Strategies: Improving Student Engagement By Increasing Opportunities To Respond, Janet E. Nutt

Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children

Research indicates that effective co-teaching using high leverage practices can maximize outcomes across content areas and positively affect student engagement. This paper discusses practical ways to increase student engagement by increasing opportunities to respond in a co-teaching setting. Specific examples are included for a secondary mathematics co-taught classroom, but the principles can be applied in any subject or setting. A proposed model of professional development and coaching to support effective questioning techniques and increase opportunities to respond is also discussed for the purposes of teacher training and professional development.

Adopting Agility In Academia Through Pilot Projects, Omar Ochoa, Massood Towhidnejad

Papers

This innovate practice work in progress paper presents our initial findings about the application of agile process in the day to day operation of an academic department. The benefits of agile methods, which are processes that are lightweight and people-oriented, are well-known. Agile methods provide the ability to respond faster to the changing needs of stakeholders, improved product quality, team over individual goals, and better transparency. Therefore, one would expect adaption of the agile process within academic environment would be welcomed, however, unique issues exist within faculty that impact adoption; faculty have different goals that change through their tenure, and …

Cultivating An Online Network For Mentoring Preservice And In-Service Teachers, Lisa Amick, Joni Meade, Margaret J. Mohr-Schroeder

Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children

This report details the work of two initial teacher certification programs at a major university in Kentucky that are implementing two innovative strategies for preservice teachers to network, build community, and grow in their practice. The utilization of Slack, a free online communication platform, has proven successful in getting preservice teachers to share ideas, pose and respond to professional questions, and program information dissemination. The use of a NIC (Networked Improvement Community) is a grant funded endeavor that brought together preservice teachers, their cooperating teachers, and university faculty members to create a professional learning community where a problem of practice …

Temperature-Immune Self-Referencing Fabry–Pérot Cavity Sensors, Hengky Chandrahalim, Jonathan W. Smith

AFIT Patents

A passive microscopic Fabry-Pérot Interferometer (FPI) sensor an optical fiber a three-dimensional microscopic optical structure formed on a cleaved tip of an optical fighter that reflects a light signal back through the optical fiber. The reflected light is altered by refractive index changes in the three-dimensional structure that is subject to at least one of: (i) thermal radiation; and (ii) volatile organic compounds.

“From Episodic Novel To Serial Tv: The Handmaid’S Tale, Adaptation And Politics.”, Jeroen Gerrits

Comparative Literature Faculty and Student Scholarship

This article analyzes the changes in The Handmaid’s Tale’s moral and political outlook as it tracks different forms of complexity in the novel, the film, and the TV series. While the sense of female empowerment increases with each adaptation of this tale of forced sexual servitude in fictional theocratic state of Gilead, the essay argues that Hulu’s TV series (created by Bruce Miller, 2017–) develops an intriguing interaction between the interiority of Margaret Atwood’s 1985 novel and the exteriority emphasized in Volker Schlöndorff’s 1990 film. In so doing, the TV series Escher-twists across related binaries between activity/passivity and personal/political actions …

The Markov Process As A Model Of Migration Based On The Example Of The Movement Of Banknotes, Arkadiusz Manikowski

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

This paper presents a way of using the Markov chain model for the analysis of migration based on the example of banknote migration between regions in Poland. We have presented the application of the methodology for estimating one-step transition probabilities for the Markov chain based on macro-data gathered during the project conducted in the National Bank of Poland (NBP) in the period of December 2015–2018. We have shown the usefulness of state-aggregated Markov chain not only as a model of banknote migration but as migration in general. The banknotes are considered here as goods, so their migration is strictly related …

Design And Analysis Of Flexible Insulated Pavement For Cold Region Applications, Zhuang Zhuo

Theses and Dissertations

Pavements in cold regions suffer from additional deterioration due to the influences of extreme climate on frost-susceptible subgrade layers. To address this problem, one efficient strategy is to add a thermal insulating layer above the frost-susceptible layer. This study aims to evaluate the insulating effects of four materials: XPS boards, tire chips, foamed glass aggregates, and foamed concrete. Large-scale insulated pavement boxes (1.2m×1.2m×0.8m) were constructed to compare the thermal performance of different materials. The thermal performance of each box was evaluated and graded based on indicators related to the short-term temperature decrease and long-term temperature variation.

Experimental results show that …