Digital Commons Network^™

Talin Mechanosensitivity Is Modulated By A Direct Interaction With Cyclin-Dependent Kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jd Humphries, Claus Jørgensen, Mj Humphries, Benjamin T. Goult

Peninsula Medical School

Talin (TLN1) is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behavior of its multiple rod domains that modulate interactions with its binding partners. Cyclin-dependent kinase-1 (CDK1) is a key regulator of the cell cycle, exerting its effects through synchronized phosphorylation of a large number of protein targets. CDK1 activity maintains adhesion during interphase, and its inhibition is a prerequisite for the tightly choreographed changes in cell shape and adhesion that are required for successful mitosis. Using a combination of biochemical, structural, and cell biological approaches, we …

What Is The Global Prevalence Of Dental Healthcare Needs And Unmet Dental Needs Among Adolescents?, Martha Paisi, Robert Witton, Philip Radford, Anastasios Plessas

School of Nursing and Midwifery

No abstract provided.

Hospital Readmission Among People Experiencing Homelessness In England: A Cohort Study Of 2772 Matched Homeless And Housed Inpatients, Dan Lewer, Dee Menezes, Michelle Cornes, Ruth M. Blackburn, Richard Byng, Michael Clark, Spiros Denaxas, Hannah Evans, James Fuller, Nigel Hewett, Alan Kilmister, Serena April Luchenski, Jill Manthorpe, Martin Mckee, Joanne Neale, Alistair Story, Michela Tinelli, Martin Whiteford, Fatima Wurie, Alexei Yavlinsky, Andrew Hayward, Robert Aldridge

Peninsula Medical School

BackgroundInpatients experiencing homelessness are often discharged to unstable accommodation or the street, which may increase the risk of readmission.MethodsWe conducted a cohort study of 2772 homeless patients discharged after an emergency admission at 78 hospitals across England between November 2013 and November 2016. For each individual, we selected a housed patient who lived in a socioeconomically deprived area, matched on age, sex, hospital, and year of discharge. Counts of emergency readmissions, planned readmissions, and Accident and Emergency (A&E) visits post-discharge were derived from national hospital databases, with a median of 2.8 years of follow-up. We estimated the cumulative incidence of …

Scope, Context And Quality Of Telerehabilitation Guidelines For Physical Disabilities: A Scoping Review, Krithika Anil, Jennifer A. Freeman, Sarah Buckingham, Sara Demain, Hilary Gunn, Ray B. Jones, Angela Logan, Jonathan Marsden, Diane Playford, Kim Sein, Bridie Kent

School of Health Professions

ObjectiveTo identify the available guidance and training to implement telerehabilitation movement assessments for people (adults and children) with a physical disability, including those recovering from COVID-19.DesignRapid scoping review.Included sources and articlesPubMed, CINAHL, PsychInfo, Cochrane, Embase, Web of Science, PEDro, UK Health Forum, WHO, National Archives and NHS England were searched using the participant–concept–context framework from 2015 to August 2020. Primary studies that recruited individuals with physical disabilities and guidance documents aimed at providers to implement movement-related telerehabilitation were included.Results23 articles (11 primary research studies, 3 systematic reviews and 9 guidance documents) were included out of 7857 that were identified from …

Wave Power Extraction From A Hybrid Oscillating Water Column-Oscillating Buoy Wave Energy Converter, Lin Cui, Siming Zheng, Yongliang Zhang, Jon Miles, Gregorio Iglesias

School of Engineering, Computing and Mathematics

No abstract provided.

A Review Of Bast Fibres And Their Composites: Part 4 ~ Organisms And Enzyme Processes, John Summerscales

School of Engineering, Computing and Mathematics

No abstract provided.

Potential Hazards Of Metal-Contaminated Soils In An Estuarine Impoundment, Gillian A. Glegg, Cally Barratt, Alex Taylor, Emily Gulson, Geoffrey E. Millward

School of Biological and Marine Sciences

No abstract provided.

Cross-Sectional Flattening-Induced Nonlinear Damped Vibration Of Elastic Tubes Subjected To Transverse Loads, Jue Zhu, Wei Bin Yuan, Long Yuan Li

School of Engineering, Computing and Mathematics

No abstract provided.

An International Genome-Wide Meta-Analysis Of Primary Biliary Cholangitis: Novel Risk Loci And Candidate Drugs, Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Andrade M De, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Steven Flack

Peninsula Medical School

No abstract provided.

Lifting The Lid On Perioperative Goal-Directed Therapy, Daniel S. Martin

Peninsula Medical School

No abstract provided.

Tool Use And Function Knowledge Shape Visual Object Processing, Francois R. Foerster, Jeremy Goslin

School of Psychology

Perceiving the environment automatically informs how we can interact with it through affordance mechanisms. However, it remains unknown how our knowledge about the environment shapes how it is perceived. In this training study, we evaluated whether motor and function knowledge about novel objects affects visual object processing. Forty-three participants associated a usage or function to a novel object in interactive virtual reality while their EEG was recorded. Both usage and function influenced the mu-band (8–12 Hz) rhythms, suggesting that motor and function object information influence motor processing during object recognition. Learning the usage also prevented the reduction of the theta-band …

Trait Evaluations Of Faces And Voices: Comparing Within- And Between-Person Variability, Nadine Lavan, Mila Mileva, Andrew W. Young, A. Mike Burton, Carolyn Mcgettigan

School of Psychology

Human faces and voices are rich sources of information that can vary in many different ways. Most of the literature on face/voice perception has focused on understanding how people look and sound different to each other (between-person variability). However, recent studies highlight the ways in which the same person can look and sound different on different occasions (within-person variability). Across three experiments, we examined how within- and between-person variability relate to one another for social trait impressions by collecting trait ratings attributed to multiple face images and voice recordings of the same people. We find that within-person variability in social …

Multiple-Image Arrays In Face Matching Tasks With And Without Memory, Kay L. Ritchie, Robin S.S. Kramer, Mila Mileva, Adam Sandford, A. Mike Burton

School of Psychology

No abstract provided.

Where Are The Children? An Autoethnography Of Deception In Dementia In An Acute Hospital, G Hodge

School of Nursing and Midwifery

An acute hospital environment is a confusing place for many patients requiring admission, especially when they are presenting as acutely unwell. This can be particularly difficult for people living with dementia. As cognition changes it is not uncommon for people living with dementia to have difficulties with their ability to orientate to time, place and person. These disorientating moments can lead to personal distress, and at times behavioural changes. As well as being distressing for the person living with dementia, it can also be emotionally and ethically challenging for acute hospital staff; including nurses. One area found to be particularly …

Legal Impact Of The Finance Act 2019 On Taxation, Mergers And Other Business Combinations In Nigeria, Chidi Halliday, Goodtime Okara

School of Law, Humanities and Social Sciences

No abstract provided.

Geopolitics Of Finance In Africa: Birth Of Financial Centres, Not Monetary Unions, Elizabeth Cobbett

School of Law, Humanities and Social Sciences

No abstract provided.

Marine Temperatures Underestimated For Past Greenhouse Climate, Madeleine L. Vickers, Stefano M. Bernasconi, Clemens V. Ullmann, Stefanie Lode, Nathan Looser, Luiz Grafulha Morales, Gregory D. Price, Philip R. Wilby, Iben Winther Hougård, Stephen P. Hesselbo, Christoph Korte

School of Geography, Earth and Environmental Sciences

AbstractUnderstanding the Earth’s climate system during past periods of high atmospheric CO2 is crucial for forecasting climate change under anthropogenically-elevated CO2. The Mesozoic Era is believed to have coincided with a long-term Greenhouse climate, and many of our temperature reconstructions come from stable isotopes of marine biotic calcite, in particular from belemnites, an extinct group of molluscs with carbonate hard-parts. Yet, temperatures reconstructed from the oxygen isotope composition of belemnites are consistently colder than those derived from other temperature proxies, leading to large uncertainties around Mesozoic sea temperatures. Here we apply clumped isotope palaeothermometry to two distinct carbonate phases from …

How Does A Country’S Developmental Status Affect Ambient Air Quality With Respect To Particulate Matter?, R. Johnson, J. Rieuwerts, S. D.W. Comber

School of Geography, Earth and Environmental Sciences

No abstract provided.

To The Bitter End: Affect, Experience And Chemical Ecology, H Drayson

School of Art, Design and Architecture

This article explores taste in its chemical, gustemological and affective senses, asking what we speak of when we talk about “bitter experience.” Drawing lines of connection between human affect and chemical ecology, it suggests a way of thinking about taste as a chemical entanglement of affective qualities and ecological relations. Two observations underpin the argument. First, the ambiguous resonance of bitter-tasting compounds in human culture is grounded in their ambiguous medical meaning, the same drug may serve as poison or cure. Second, plants interact with many other life-forms by producing chemical compounds, many of which are bitter tasting, that have …

Atomic Spectrometry Update: Review Of Advances In The Analysis Of Metals, Chemicals And Materials, Simon Carter, Robert Clough, Andy Fisher, Bridget Gibson, Ben Russell

School of Geography, Earth and Environmental Sciences

This review covers advances in the analysis of advanced materials, metals, fuels and lubricants, nanostructures, ceramics, refractories, organic and inorganic chemicals, catalysts and nuclear materials by a range of techniques including X-ray, ICP, LIBS, mass spectrometry, synchrotron-based techniques, plus non-destructive and ablation surface techniques.

On The Diversity And Distribution Of A Data Deficient Habitat In A Poorly Mapped Region: The Case Of Sabellaria Alveolata L. In Ireland, Louise B. Firth, Amelia Curd, Stephen J. Hawkins, Antony M. Knights, Julie A. Blaze, Michael T. Burrows, Stanislas F. Dubois, Hugh Edwards, Andy Foggo, Paul E. Gribben, Lisa Grant, Daniel Harris, Nova Mieszkowska, Flavia L.D. Nunes, Julia D. Nunn, Anne Marie Power, Ruth M. O'Riordan, David Mcgrath, Christina Simkanin, Nessa E. O'Connor

School of Biological and Marine Sciences

Data that can be used to monitor biodiversity through time are essential for conservation and management. The reef-forming worm, Sabellaria alveolata (L. 1767) is currently classed as ‘Data Deficient’ due to an imbalance in the spread of data on its distribution. Little is known about the distribution of this species around Ireland. Using data archaeology, we collated past and present distribution records and discovered that S. alveolata has a discontinuous distribution with large gaps between populations. Many regions lack data and should be targeted for sampling. Biodiversity surveys revealed that S. alveolata supported diverse epibiotic algal communities. Retrograding (declining) reefs …

Imputation, Modelling And Optimal Sampling Design For Digital Camera Data In Recreational Fisheries Monitoring, Ebenezer Afrifa-Yamoah

Theses: Doctorates and Masters

Digital camera monitoring has evolved as an active application-oriented scheme to help address questions in areas such as fisheries, ecology, computer vision, artificial intelligence, and criminology. In recreational fisheries research, digital camera monitoring has become a viable option for probability-based survey methods, and is also used for corroborative and validation purposes. In comparison to onsite surveys (e.g. boat ramp surveys), digital cameras provide a cost-effective method of monitoring boating activity and fishing effort, including night-time fishing activities. However, there are challenges in the use of digital camera monitoring that need to be resolved. Notably, missing data problems and the cost …

Applications Of Béla Bartók's Techniques Of Pitch Organisation To Jazz Improvisation, Niran Jay Dasika

Theses: Doctorates and Masters

The music of Hungarian composer Béla Bartók (1881-1945) reconciles hauntingly lyrical beauty with harsh, atonal dissonance, appealing to music fans, musicians, and theorists alike for over a century and suggesting a rich resource of inspiration for improvising musicians. The composer Pierre Boulez commented that “Whether it is in a brutal violence animating a sound material in fusion, or in a tranquil gentleness glowing in a halo of grating sounds and colours… Bartók is incomparable and remains unique”. Informed by Bartók theorists Elliott Antokoletz, János Kárpáti, Erno Lendvai, and by Bartók’s own writings, this research identifies four melodic techniques: ‘mistuning’, ‘chromatic …

Performer Training Evolutions: Nsp The Firstborn Son Of Smat, Chelsea Crothers

Theses: Doctorates and Masters

This study examined the Nobbs Suzuki Praxis (NSP), a performer training that evolved as an Australian variant of the Japanese Suzuki Method of Actor Training (SMAT). There has been little research on NSP up until now and this study seeks to establish its importance as a training approach that has the potential to be transformative for the performers who practice it. The study utilised a multi-modal approach that included traditional and practice as research methodologies. The origins of NSP in SMAT were traced to identify similarities and differences, and reveal NSP’s inspirations and the reasons for its subsequent divergent evolution. …

Factors Associated With Intimate Partner Homicide In A West Australian Context, William Anthony Thompson

Theses: Doctorates and Masters

Domestic Violence (DV) is prevalent within Australian society with one in four women experiencing some form ofDV (ABS 2017) in their life. The Australian homicide rate is about 250 deaths per year, of which 52% are domestic related (Virueda & Payne 2010). Domestic homicides include Intimate Partner Homicide (IPH), where the victim and offender shared, or formerly shared an intimate relationship (for example married, defacto and ex partners; Bryant & Cussen 2015). This study analysed the factors of West Australian (WA) IPHs from 2012-2017 inclusive. The aim was to identify aetiologies of IPH offending across ethnicity and gender to understand …

Application Of The Vortex Fluid Device (Vfd) In Polysulfone Synthesis And Ultra-Filtration Membrane Fabrication For Water Treatment Purposes, Aghil Igder

Theses: Doctorates and Masters

Extensive studies have been performed to improve key properties of filtration membranes via controlling the fabrication process conditions as well as physical and/or chemical modification of the polymers used in membrane fabrication. The Vortex Fluid Device (VFD) is a newly invented platform which has found many applications in materials science and clean technology. The unique features of the VFD originate from a combination of different effects (e.g., micro-mixing, viscous drag, microfluidic flow, enhanced mass transfer) all resulting in faster, greener, and more efficient and better controlled chemical reactions. The main aims of this project are: (i) to investigate the utility …

Power Network And Smart Grids Analysis From A Graph Theoretic Perspective, Hossein Parast Vand

Theses: Doctorates and Masters

The growing size and complexity of power systems has given raise to the use of complex network theory in their modelling, analysis, and synthesis. Though most of the previous studies in this area have focused on distributed control through well established protocols like synchronization and consensus, recently, a few fundamental concepts from graph theory have also been applied, for example in symmetry-based cluster synchronization. Among the existing notions of graph theory, graph symmetry is the focus of this proposal. However, there are other development around some concepts from complex network theory such as graph clustering in the study.

In spite …

Using Dartmoor Ponies In Conservation Grazing To Reduce Molinia Caerulea Dominance And Encourage Germination Of Calluna Vulgaris In Heathland Vegetation On Dartmoor, Uk, Paul H. Lunt, Jakob L. Leigh, Samantha A. Mcneil, Malcolm J. Gibb

School of Geography, Earth and Environmental Sciences

The increasing dominance of purple moor-grass Molinia caerulea in heathland ecosystems in the UK is of growing concern due to its detrimental impact on plant and animal diversity on sites of nature conservation interest. The use of free-ranging ponies to reduce Molinia dominance was investigated from 2017 to 2019 within a 425 ha site on Dartmoor, UK. Salt blocks were used to attract the ponies to a Molinia-dominated area of heath within the site, away from their previously-preferred grazing areas. The impact of pony grazing was assessed by measurements of vegetation structure and plant species composition. The increased presence of …

Virtually Renovating The Trauma Film Paradigm: Comparing Virtual Reality With On-Screen Presentation Of An Analogue Trauma., Grace Baptie, Jackie Andrade, Alison M. Bacon, Alyson Norman

School of Psychology

No abstract provided.

Antimony Release From Polyester Textiles By Artificial Sweat Solutions: A Call For A Standardized Procedure, Marc Biver, Andrew Turner, Montserrat Filella

School of Geography, Earth and Environmental Sciences

No abstract provided.