Digital Commons Network^™

Cost-Effectiveness Analysis Of Recombinant Zoster Vaccine For The Prevention Of Herpes Zoster In Immunocompromised Adults Diagnosed With Select Cancers In The United States, Desmond Curran, Brandon Patterson, Justin Carrico, Ahmed Salem, Elizabeth La, Stephane Lorenc, Katherine Hicks, Sara Poston, Christopher Carpenter

Conference Presentation Abstracts

Introduction / Background / Significance: Immunocompromised (IC) populations diagnosed with cancer are at increased risk for herpes zoster (HZ) due to their underlying disease and/or therapy. This risk is highest among individuals receiving hematopoietic stem cell transplant (HSCT) to treat multiple myeloma, lymphomas, or other diseases. HZ is characterized by a painful vesicular rash. IC populations with HZ are also at increased risk of developing HZ-related complications such as postherpetic neuralgia, a persistent pain that can last for months or years. This study evaluates the cost-effectiveness of recombinant zoster vaccine (RZV) versus no vaccine for the prevention of HZ in …

Free-Ranging And Feral Cats, Alex Dutcher, Kyle Pias, Grant Sizemore, Stephen M. Vantassel

Wildlife Damage Management Technical Series

Domestic cats (Felis catus) are a common household pet in the United States, with an estimated 25.4% of households owning cats (American Veterinary Medical Association 2018). While an increasing number of cat owners keep their pet cats exclusively indoors, a portion of society maintains that domestic cats are entitled to a free-ranging lifestyle and may even consider unowned domestic cats to be wildlife. Although wildlife managers recognize the beliefs of many concerned stakeholders, including advocates who use strong emotional appeals on behalf of cats, it remains that free-ranging and feral domestic cats are an invasive species spread by humans (Lowe …

Sustainable Agriculture Curriculum For 9th-12th Graders, Michaela Gallup

School of Education and Leadership Student Capstone Projects

According to the research conducted by Ziska, L. H. climate change and the agricultural industry’s fates are tightly tied. As the effects of climate change continue to worsen, food production will become more challenging. Inorder to help address these issues, this curriculum will introduce student to the causes of climate change, how climate change and agriculture impact each other, evaluate agricultural technologies that could help diminish the effects of climate change, and finally have students propose solutions to agricultural and climate related issues in their communities. The pedagogical practices used in this curriculum is a combination of traditional teaching styles, …

Dipl 6130 International Security, Richard M. O'Meara Ph.D.

Diplomacy Syllabi

This is an interdisciplinary course which seeks to answer the questions what do we- states, international institutions, groups, and individuals-want when we seek security and what steps can we take to accomplish security goals? A recent summary of the discipline summarizes it as follows:

“International security, also called global security , is the measures taken by states and international organizations, such as the United Nations. European Union, and others, to ensure mutual survival and safety. These measures include military action and diplomatic agreements such as treaties and conventions. International and national security are invariably linked. International security is national security …

An Opportunistic Survey Reveals An Unexpected Coronavirus Diversity Hotspot In North America, Hon S. Ip, Kathryn M. Griffin, Jeffrey D. Messer, Megan E. Winzeler, Susan A. Shriner, Mary Lea Killian, Mia Kim Torchetti, Thomas J. Deliberto, Brian R. Amman, Caitlin M. Cossaboom, R. Reid Harvey, Natalie M. Wendling, Hannah Rettler, Dean Taylor, Jonathan S. Towner, Casey Barton Behravesh, David S. Blehert

United States Department of Agriculture Wildlife Services: Staff Publications

In summer 2020, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected on mink farms in Utah. An interagency One Health response was initiated to assess the extent of the outbreak and included sampling animals from on or near affected mink farms and testing them for SARS-CoV-2 and non-SARS coronaviruses. Among the 365 animals sampled, including domestic cats, mink, rodents, raccoons, and skunks, 261 (72%) of the animals harbored at least one coronavirus. Among the samples that could be further characterized, 127 alphacoronaviruses and 88 betacoronaviruses (including 74 detections of SARS-CoV-2 in mink) were identified. Moreover, at least 10% (n …

New Mexico Health Care Workforce Committee 2021 Annual Report, University Of New Mexico - Health Sciences Center

New Mexico Health Care Workforce Committee (2013-ongoing)

Each year the New Mexico Health Care Workforce Committee studies the supply and distribution of health care providers in order to provide a report to the Legislature by October 1. The committee also makes recommendations for improving recruitment and retention of providers in New Mexico's rural and underserved areas.

Urgent Need For Integrated Pandemic Policies On Pathogen Spillover, Pallavi A. Kache, Sonila Cook, Nigel Sizer, Lee Hannah, Neil M. Vora

Publications and Research

No abstract provided.

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report On 30 Patients, Hasan Hashem, Giorgia Bucciol, Seza Ozen, Sule Unal, Ikbal Ok Bozkaya, Nurten Akarsu, Mervi Taskinen, Minna Koskenvuo, Janna Saarela, Dimana Dimitrova, Dennis D. Hickstein, Amy P. Hsu, Steven M. Holland, Robert Krance, Ghadir Sasa, Ashish R. Kumar, Ingo Müller, Monica Abreu De Sousa, Selket Delafontaine, Leen Moens, Florian Babor, Federica Barzaghi, Maria Pia Cicalese, Robbert Bredius, Joris Van Montfrans, Valentina Baretta, Simone Cesaro, Polina Stepensky, Neven Benedicte, Despina Moshous, Guillaume Le Guenno, David Boutboul, Jignesh Dalal, Joel P. Brooks, Elif Dokmeci, Jasmeen Dara, Carrie L. Lucas, Sophie Hambleton, Keith Wilson, Stephen Jolles, Yener Koc, Tayfun Güngör, Caroline Schnider, Fabio Candotti, Sandra Steinmann, Ansgar Schulz, Chip Chambers, Michael Hershfield, Amanda Ombrello, Jennifer A. Kanakry, Isabelle Meyts

Pediatrics Research and Scholarship

PURPOSE: Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). Tumor necrosis factor (TNF-α) blockade is the treatment of choice for the vasculopathy, but often fails to reverse refractory cytopenia. We aimed to study the outcome of hematopoietic cell transplantation (HCT) in patients with DADA2.

METHODS: We conducted a retrospective study on the outcome of HCT in patients with DADA2. The primary outcome was overall survival (OS).

RESULTS: Thirty DADA2 patients …

Variations, Validations, Degradations, And Noninvasive Determination Of Pregnancy Using Fecal Steroid Metabolites In Free-Ranging Pronghorn, Cole A. Bleke, Eric M. Gese, Susannah S. French

United States Department of Agriculture Wildlife Services: Staff Publications

Pregnancy status is a key parameter used to assess reproductive performance of a species as it represents a starting point for measuring vital rates. Vital rates allow managers to determine trends in populations such as neonate survival and recruitment; two important factors in ungulate population growth rates. Techniques to determine pregnancy have generally involved capture and restraint of the animal to obtain blood samples for determining serum hormone levels. Non-invasive pregnancy assessment, via feces, eliminates any hazards between handler and animal, as well as removes handling-induced physiological biases. Using noninvasive fecal sampling, we conducted hormone validations, investigated pregnancy rates, and …

Implementation Of Anyaka Makwiri: A Multicomponent Mentoring Program For Adolescent Girls And Young Women In Uganda, Kate Plourde, Geeta Nanda, Elise Healy, Dennis Kibwola

Journal of Youth Development

This article describes the development and implementation of the Anyaka Makwiri program and summarizes results from the qualitative assessment of participant experiences. Anyaka Makwiri is a multicomponent mentoring program developed for adolescent girls and young women (AGYW) ages 15 to 24 in Gulu, Uganda. The comprehensive program consisted of a curriculum covering sexual and reproductive health (SRH), financial capabilities, soft skills, and gender-based violence and gender equality; activities designed to improve participants’ social connectedness; optional onsite testing for sexually transmitted infections (STIs), HIV, and pregnancy along with STI treatment; group-based savings; and links to SRH services, including contraceptive and gender-based …

Classified Information: The Newsletter Of The Lloyd Sealy Library, Lloyd Sealy Library, Cuny John Jay College Of Criminal Justice

Reports and Publications from John Jay College

Classified Information was a publication that informed the College about Library services, personnel, upcoming events, new technologies, and available resources.

Neuron-Specific Mitochondrial Oxidative Stress Results In Epilepsy, Glucose Dysregulation And A Striking Astrocyte Response, Ruth E Fulton, Jennifer N Pearson-Smith, Christopher Q Huynh, Timothy Fabisiak, Li-Ping Liang, Stefanos Aivazidis, Brigit A High, Georgia Buscaglia, Timothy Corrigan, Robert Valdez, Takahiko Shimizu, Manisha N Patel

Faculty, Staff and Students Publications

Mitochondrial superoxide (O2.−) production is implicated in aging, neurodegenerative disease, and most recently epilepsy. Yet the specific contribution of neuronal O2.− to these phenomena is unclear. Here, we selectively deleted superoxide dismutase-2 (SOD2) in neuronal basic helix-loop-helix transcription factor (NEX)-expressing cells restricting deletion to a subset of excitatory principle neurons primarily in the forebrain (cortex and hippocampus). This resulted in nSOD2 KO mice that lived into adulthood (2-3 months) with epilepsy, selective loss of neurons, metabolic rewiring and a marked mitohormetic gene response. Surprisingly, expression of an astrocytic gene, glial fibrillary acidic protein (GFAP) was significantly increased relative …

Chairs Of Excellence Annual Report 2021, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Study Of The Effect Of B-Cell-Intrinsic Mhcii Antigen Presentation On Germinal Center B Cell Evolution Using The Brainbow Mouse Model, Nia Hall

Theses and Dissertations

Major histocompatibility complex class II (MHCII) are molecules that are essential for B cell activation, as well as clonal competition among activated B cell clones during germinal center (GC) reactions. However, it is unknown to what extent MHCII drives the selection of some clones over others. This is of particular importance since MHCII is highly polymorphic with the ability to indirectly alter gutmicrobiome composition by altering the immunoglobulin A (IgA) repertoire. To study this, we utilized a novel triple-transgenic mouse model to assess how B-cellintrinsic MHCII influences GC responses and GC clonal diversity, with an eyeforward to understanding the relevance …

The Immune Modulatory Role Of Endocannabinoid Anandamide To Suppress Inflammation Through Regulation Of Microrna And Microbiome, Muthanna Ali Sultan

Theses and Dissertations

Cannabinoids are group of compounds that exerts their anti-inflammatory action through activation of CB1 and CB2 receptors and other minor receptors. In the current study, we investigated the effect of Anandamide (AEA) on Acute Respiratory Distress Syndrome (ARDS) induced by exposure to Staphylococcus Enterotoxin B (SEB) intranasally. We found that C57BL/6 mice treated with AEA showed improvement in the clinical functions of the lungs, accompanied by a decrease in the infiltration of inflammatory cells in the lung tissue, and a decrease in the secretion of pro-inflammatory cytokines. Furthermore, AEA regulated the miRNA profile of the mononuclear cells in the lungs …

Cytoarchitectural Characteristics Associated With Cognitive Flexibility In Raccoons, Joanna Jacob, Molly Kent, Sarah Benson-Amram, Suzana Herculano-Houzel, Mary Ann Raghanti, Emily Ploppert, Jack Drake, Bilal Hindi, Nick R. Natale, Sarah Daniels, Rachel Fanelli, Anderson Miller, Tim Landis, Amy Gilbert, Shylo Johnson, Annie Lai, Molly Hyer, Amanda Rzucidlo, Chris Anchor, Stan Gehrt, Kelly Lambert

United States Department of Agriculture Wildlife Services: Staff Publications

With rates of psychiatric illnesses such as depression continuing to rise, additional preclinical models are needed to facilitate translational neuroscience research. In the current study, the raccoon (Procyon lotor) was investigated due to its similarities with primate brains, including comparable proportional neuronal densities, cortical magnification of the forepaw area, and cortical gyrification. Specifically, we report on the cytoarchitectural characteristics of raccoons profiled as high, intermediate, or low solvers in a multiaccess problem-solving task. Isotropic fractionation indicated that high-solvers had significantly more cells in the hippocampus (HC) than the other solving groups; further, a nonsignificant trend suggested that this …

Satellite-Detected Ammonia Changes In The United States: Natural Or Anthropogenic Impacts, Yaqian He, Rongting Xu, Stephen A. Prior, Di Yang, Anni Yang, Jian Chen

United States Department of Agriculture Wildlife Services: Staff Publications

Ammonia (NH3) is the most abundant alkaline component and can react with atmospheric acidic species to form aerosols that can lead to numerous environmental and health issues. Increasing atmospheric NH3 over agricultural regions in the US has been documented. However, spatiotemporal changes of NH3 concentrations over the entire US are still not thoroughly understood, and the factors that drive these changes remain unknown. Herein, we applied the Atmospheric Infrared Sounder (AIRS) monthly NH3 dataset to explore spatiotemporal changes in atmospheric NH3 and the empirical relationships with synthetic N fertilizer application, livestock manure production, and climate factors across the entire US …

Adaptation Of An Artificial Bait To An Automated Aerial Delivery System For Landscape-Scale Brown Treesnake Suppression, Rafael A. Garcia, Thomas W. Mcauliffe, Lorelie P. Bumanlag, Shane R. Siers, Bruce A. Kimball

United States Department of Agriculture Wildlife Services: Staff Publications

Dead neonatal mice are currently used as bait for delivery of toxin to invasive brown treesnakes (Boiga irregularis) on Guam; once deployed in the field the mice are highly attractive to the snakes but only for about four days. An artificial bait containing a mixture of fats mimicking those in skin of the mice is also highly attractive to the snakes and remains attractive 2–3 times longer. The artificial bait, however, costs more than the mice, and is more difficult to attach to the capsules of a novel aerial bait delivery system. This paper describes a reformulation of the bait …

Movement, Space-Use And Resource Preferences Of European Golden Jackals In Human-Dominated Landscapes: Insights From A Telemetry Study, Skye Fenton, Paul R. Moorcroft, Duško Ćirović, József Lanszki, Miklós Heltai, Francesca Cagnacci, Stewart Breck, Neda Bogdanović, Ilija Pantelić, Kornél Ács, Nathan Ranc

United States Department of Agriculture Wildlife Services: Staff Publications

During the last half-century, the distribution of golden jackals (Canis aureus) has rapidly increased throughout Europe. Today, golden jackals are thriving in human-dominated landscapes across Southeastern and Central Europe. Most studies on golden jackals have focused on large-scale distribution patterns; to date, little is known about the species’ fine-scale spatial ecology. In this study, we analyzed the movement behavior, space-use and resource selection of six golden jackals fitted with GPS-GSM collars in two study areas in Hungary and Serbia. Two of the jackals were a breeding pair. We found that home range size averaged 11.2 km² (90% …

Effects Of Translocation On Survival Of Nuisance Bears, Javan Bauder, D. Ruid, N. M. Roberts, B. Kohn, M. L. Allen

United States Department of Agriculture Wildlife Services: Staff Publications

Effective mitigation of human–wildlife conflict should aim to reduce conflicts while also minimizing wildlife mortality. Translocation is often used to mitigate human–wildlife conflict but translocated individuals may have reduced survival, which could negatively affect population growth and social acceptance of translocation as a management tool. Yet, non-translocated nuisance individuals may also have low survival due to inherent risks associated with nuisance behavior. We used a 38-year dataset of 1233 marked and translocated nuisance American black bears (Ursus americanus) as a model system with which to evaluate the impacts of translocation on nuisance bear survival. We used multi-state mark-recapture models to …

Threading The Needle: How Humans Influence Predator–Prey Spatiotemporal Interactions In A Multiple-Predator System, Asia Murphy, Duane R. Diefenbach, Mark Ternent, Matt Lovallo, David Miller

United States Department of Agriculture Wildlife Services: Staff Publications

Perceived predation risk and the resulting antipredator behaviour varies across space, time and predator identity. Communities with multiple predators that interact and differ in their use of space, time of activity and hunting mode create a complex landscape for prey to avoid predation. Anthropogenic presence and disturbance have the potential to shift interactions among predators and prey and the where and when encounters occur. We examined how white-tailed deer Odocoileus virginianus fawn spatiotemporal antipredator behaviour differed along an anthropogenic disturbance gradient that had black bears Ursus americanus, coyotes Canis latrans, bobcats Lynx rufus and humans present. We quantified (a) spatial …

High-Throughput Next-Generation Sequencing Respiratory Viral Panel: A Diagnostic And Epidemiologic Tool For Sars-Cov-2 And Other Viruses, Nikhil S. Sahajpal, Ashis K. Mondal, Allan Njau, Zachary Petty, Jiani Chen, Sudha Ananth, Pankaj Ahluwalia, Colin Williams, Ted M. Ross, Alka Chaubey

Pathology, East Africa

Two serious public health challenges have emerged in the current COVID-19 pandemic namely, deficits in SARS-CoV-2 variant monitoring and neglect of other co-circulating respiratory viruses. Additionally, accurate assessment of the evolution, extent, and dynamics of the outbreak is required to understand the transmission of the virus. To address these challenges, we evaluated 533 samples using a high-throughput next-generation sequencing (NGS) respiratory viral panel (RVP) that includes 40 viral pathogens. The performance metrics revealed a PPA, NPA, and accuracy of 95.98%, 85.96%, and 94.4%, respectively. The clade for pangolin lineage B that contains certain distant variants, including P4715L in ORF1ab, Q57H …

Plastic-Eating Microbes: A New Potential Solution To Waste Mitigation?, Megan Forbes

University Honors Theses

Plastic waste is problematic for marine and terrestrial ecosystems due to the mass production of polyethylene terephthalate (PET) single use plastics. What is unclear is a well-thought-out solution to solve pollution problems that will not further damage the environment. Throughout this literature review, I will investigate the role microbes play in plastic degradation, and if plastic eating microbes are an effective solution to the plastic pollution problem. Polyethylene terephthalate (PET) is the chemical name for polyester. It is a clear, strong, and lightweight plastic that is typically used for food and beverage packaging, and other single-use purposes. The most well …

Geneseo Authors Celebration 2021, Milne Library

Geneseo Authors Celebration

No abstract provided.

Disability Without Documentation, Katherine A. Macfarlane

Fordham Law Review

Disability exists regardless of whether a doctor has confirmed its existence. Yet in the American workplace, employees are not disabled, or entitled to reasonable accommodations, until a doctor says so. This Article challenges the assumption that requests for reasonable accommodations must be supported by medical proof of disability. It proposes an accommodation process that accepts individuals’ assessments of their disabilities and defers to their accommodation preferences. A documentation-free model is not alien to employment law. In evaluating religious accommodations, employers—and courts—take a hands-off approach to employees’ representations that their religious beliefs are sincere. Disability deserves the same deference. This Article …

Cognitive Barriers To Covid-19 Vaccine Uptake Among Older Adults, Jonathan L. Chia, Andree Hartanto

Research Collection School of Social Sciences

The COVID-19 pandemic has resulted in tremendous loss of life. As of late-July 2021, there have been more than 191 million confirmed cases and over 4.1 million deaths recorded (1). Although most nations have developed some competency in COVID-19 containment (2–4), there are new challenges. The continual spread of COVID-19 has resulted in new variants (5–7). These new variants are posited to have a significantly higher transmissibility (8–10), with higher fatality rates (11, 12).

2021 Fall Vol. 38 No. 2, Alumni Affairs School Of Medicine

Medicinews

No abstract provided.

Barriers To Human Papillomavirus Vaccine Uptake Among Racial/Ethnic Minorities: A Systematic Review, Trisha L Amboree, Charles Darkoh

Faculty, Staff and Student Publications

BACKGROUND: Human papillomavirus (HPV) is associated with poor health outcomes, including cervical cancer. Racial/ethnic minority populations experience poor health outcomes associated with HPV at higher rates. A vaccine is available to protect against HPV infections and prevent HPV-related sequelae; however, vaccination rates have remained low in the United States (U.S.) population. Thus, there is an urgent need to increase the HPV vaccination rate. Moreover, little is known about barriers to HPV vaccination in racial/ethnic minority groups. This paper highlights the most recent findings on barriers experienced by these groups.

METHODS: The PubMed database was searched on July 30, 2020, for …

The Holistic Self-Care Learning Experience Of Rn-To-Bsn Students: A Phenomenological Study Of Meaning And Value, Elaina C. Mahlan

Doctor of Education (Ed.D)

The health of the nursing workforce is a critical aspect of high-quality health care and community health promotion, but extensive research indicates that too many nurses neglect selfcare and suffer negative health outcomes. While nursing education must provide self-care learning experiences to improve the health of nurses, the value and influence of a learning experience must be interpreted from the learner’s point of view. The purpose of this phenomenological study was to elicit the personal value that RN-to-BSN students ascribed to a self-care learning experience within a holistic nursing course at a public university. The holistic nursing paradigm offers a …

The Influences Of Covid-19 On The Job Satisfaction Of Student Conduct Administrators At Institutions Of Higher Education In The State Of Florida, Kenneth L. Maddox

Doctor of Education (Ed.D)

The purpose of this qualitative phenomenological study was to explore the job satisfaction of student conduct administrators (SCAs) at institutions of higher education in the state of Florida during times of COVID-19. Student conduct issues constantly change on college campuses, and the demands for SCAs to evolve with the changes take a toll on their mental and physical health. SCAs are responsible for maintaining ethical, academic, and social integrity by providing oversight and enforcement of codes of student conduct at institutions of higher education. In times of crisis, like the COVID-19 pandemic, the role of the SCA increases to take …