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Racism In Medicine And Science, Samantha Soriano

USF St. Petersburg campus Honors Program Theses (Undergraduate)

The history of racism and prejudice in the United States is not limited to segregation, slavery, and discrimination. Medical and scientific racism continue to disproportionately affect Black and Indigenous People of Color (BIPOC). BIPOC have been used for scientific advancement without full disclosure of potential harm or adequate compensation. Scientists and medical providers have dehumanized minority individuals by disrespecting their autonomy and targeting vulnerable populations. This thesis consists of a literature review that surrounds the history of medical and scientific exploitation of people of color, ethical guidelines surrounding research, eugenics, and how assumptions affect the quality of care that minority …

Genomic Chronicle Of Sars-Cov-2: A Mutational Analysis With Over 1 Million Genome Sequences, Osman Mutluhan Uğurel, Oğuz Ata, Di̇lek Balik

Turkish Journal of Biology

Use of information technologies to analyse big data on SARS-CoV-2 genome provides an insight for tracking variations and examining the evolution of the virus. Nevertheless, storing, processing, alignment and analyses of these numerous genomes are still a challenge. In this study, over 1 million SARS-CoV-2 genomes have been analysed to show distribution and relationship of variations that could enlighten development and evolution of the virus. In all genomes analysed in this study, a total of over 215M SNVs have been detected and average number of SNV per isolate was found to be 21.83. Single nucleotide variant (SNV) average is observed …

Pathogenesis And Treatment Of Cytokine Storm In Covid-19, Mehmet Soy, Gökhan Keser, Mehmet Pami̇r Atagündüz

Turkish Journal of Biology

COVID-19 is a viral infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that killed a large number of patients around the world. A hyperinflammatory state resulting in a cytokine storm and adult respiratory distress syndrome seems to be the major cause of the death. Many mechanisms have been suggested in the pathogenesis of COVID-19 associated cytokine storm (COVID-CS). Insufficient viral clearance and persistence of a strong cytokine response despite inadequate antiviral immunity seem to be the main mechanisms underlying the pathogenesis. The diagnosis of COVID-19 is based on relatively constant clinical symptoms, clinical findings, laboratory tests, and …

Novel Approaches For Covid-19 Diagnosis And Treatment: A Nonsystematic Review, Şebnem Gari̇p Ustaoğlu, Hakan Kaygusuz, Mehmet Di̇nçer Bi̇lgi̇n, Feri̇de Severcan

Turkish Journal of Biology

Since COVID-19 pandemic has been continuously rising and spreading, several original contributions and review articles on COVID-19 started to appear in the literature. The review articles are mainly focus on the current status of the pandemic along with current status of the corona diagnosis and treatment process. Due to some disadvantages of the currently used methods, the improvement on the novel promising diagnosis and treatment methods of corona virus is very important issue. In this review, after briefly discussing the status of current diagnosis and treatment methods, we present to the scientific community, novel promising methods in the diagnosis and …

An Update Comprehensive Review On The Status Of Covid-19: Vaccines, Drugs, Variants And Neurological Symptoms, Ebru Özkan Oktay, Sali̇h Tuncay, Tuğba Kaman, Ömer Faruk Karasakal, Öznur Özge Özcan, Tuğçe Soylamiş, Mesut Karahan, Muhsi̇n Konuk

Turkish Journal of Biology

Various recently reported mutant variants, candidate and urgently approved current vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many current situations with severe neurological damage and symptoms as well as respiratory tract disorders have begun to be reported. In particular, drug, vaccine, and neutralizing monoclonal antibodies (mAbs) have been developed and are currently being evaluated in clinical trials. Here, we review lessons learned from the use of novel mutant variants of the COVID-19 virus, immunization, new drug solutions, and antibody therapies for infections. Next, we focus on the B 1.1.7, B 1.351, P.1, and B.1.617 lineages or variants of …

Neuropathy In Covid-19 Associated With Dysbiosis-Related Inflammation, Busra Aktas, Belma Aslim

Turkish Journal of Biology

Although COVID-19 affects mainly lungs with a hyperactive and imbalanced immune response, gastrointestinal and neurological symptoms such as diarrhea and neuropathic pains have been described as well in patients with COVID-19. Studies indicate that gut-lung axis maintains host homeostasis and disease development with the association of immune system, and gut microbiota is involved in the COVID-19 severity in patients with extrapulmonary conditions. Gut microbiota dysbiosis impairs the gut permeability resulting in translocation of gut microbes and their metabolites into the circulatory system and induce systemic inflammation which, in turn, can affect distal organs such as the brain. Moreover, gut microbiota …

Ss-Carboline Alkaloids Induce Structural Plasticity And Inhibition Of Sars-Cov-2 Nsp3 Macrodomain More Potently Than Remdesivir Metabolite Gs-441524: Computational Approach, Yusuf Oloruntoyin Ayipo, Sani Najib Yahaya, Halimah Funmilayo Babamale, Iqrar Ahmad, Harun Patel, Mohd Nizam Mordi

Turkish Journal of Biology

The nsp3 macrodomain is implicated in the viral replication, pathogenesis and host immune responses through the removal of ADP-ribosylation sites during infections of coronaviruses including the SARS-CoV-2. It has ever been modulated by macromolecules including the ADP-ribose until Ni and co-workers recently reported its inhibition and plasticity enhancement unprecedentedly by remdesivir metabolite, GS-441524, creating an opportunity for investigating other biodiverse small molecules such as ß-Carboline (ßC) alkaloids. In this study, 1497 ßC analogues from the HiT2LEAD chemical database were screened, using computational approaches of Glide XP docking, molecular dynamics simulation and pk-CSM ADMET predictions. Selectively, ßC ligands, 129, 584, 1303 …

Targeting Cov-2 Spike Rbd And Ace-2 Interaction With Flavonoids Of Anatolian Propolis By In Silico And In Vitro Studies In Terms Of Possible Covid-19 Therapeutics, Hali̇l İbrahi̇m Güler, Fulya Ay Şal, Zehra Can, Yakup Kara, Oktay Yildiz, Ali̇ Osman Beldüz, Sabri̇ye Çanakçi, Sevgi̇ Kolayli

Turkish Journal of Biology

Propolis is a multi-functional bee product rich in polyphenols. In this study, the inhibitory effect of Anatolian propolis against SARS-coronavirus-2 (SARS-CoV-2) was investigated in vitro and in silico. Raw and commercial propolis samples were used, and both samples were found to be rich in caffeic acid, p-coumaric acid, ferulic acid, t-cinnamic acid, hesperetin, chrysin, pinocembrin, and caffeic acid phenethyl ester (CAPE) at HPLC-UV analysis. Ethanolic propolis extracts (EPE) were used in the ELISA screening test against the spike S1 protein (SARS-CoV-2): ACE-2 interaction for in vitro study. The binding energy values of these polyphenols to the SARS-CoV-2 spike and ACE-2 …

The Potential Use Of Drosophila As An In Vivo Model Organism For Covid-19-Related Research: A Review, Eşref Demi̇r

Turkish Journal of Biology

The world urgently needs effective antiviral approaches against emerging viruses, as shown by the coronavirus disease 2019 (COVID-19) pandemic, which has become an exponentially growing health crisis. Scientists from diverse backgrounds have directed their efforts towards identifying key features of SARS-CoV-2 and clinical manifestations of COVID-19 infection. Reports of more transmissible variants of SARS-CoV-2 also raise concerns over the possibility of an explosive trajectory of the pandemic, so scientific attention should focus on developing new weapons to help win the fight against coronaviruses that may undergo further mutations in the future. Drosophila melanogaster offers a powerful and potential in vivo …

Determination Of The Interaction Between The Receptor Binding Domain Of 2019-Ncov Spike Protein, Tmprss2, Cathepsin B And Cathepsin L And Glycosidic And Aglycon Forms Of Some Flavonols, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Paulo Augusto Netz, Cengi̇z Sarikürkcü, İbrahi̇m Hali̇l Kiliç, Bektaş Tepe

Turkish Journal of Biology

The novel coronavirus (COVID-19, SARS-CoV-2) is a rapidly spreading disease with a high mortality. In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane protease, serine 2 (TMPRSS2), and cathepsins (CatB and CatL) were analyzed. According to the relative binding capacity index (RBCI) calculated based on the free energy of binding and calculated inhibition constants, it was determined that robinin (ROB) and gossypetin (GOS) were the most effective flavonols on all targets. While the binding free energy of ROB with the spike glycoprotein RBD, TMPRSS2, CatB, and CatL were -5.02, -7.57, -10.10, and -6.11 …

Cannabinoids For Sars-Cov-2 And Is There Evidence Of Their Therapeutic Efficacy?, Ahmet Onay, Abdulselam Ertaş, Veysel Süzerer, İsmai̇l Yener, Mustafa Abdullah Yilmaz, Emi̇ne Ayaz Ti̇lkat, Remzi̇ Eki̇nci̇, Nesri̇n Bozhan, Sevgi̇ İrtegün

Turkish Journal of Biology

To combat the coronaviruses and their novel variants, therapeutic drugs and the development of vaccines that are to be effective throughout human life are urgently needed. The endocannabinoid system (ECS) acts as a modulator in the activation of the microcirculation, immune system, and autonomic nervous system, along with controlling pharmacological functions such as emotional responses, homeostasis, motor functions, cognition, and motivation. The ECS contains endogenous cannabinoids, cannabinoid receptor (CBRs), and enzymes that regulate their biosynthesis, transport, and degradation. Moreover, phytocannabinoids and synthetic cannabinoids that mimic the action of endocannabinoids also play an essential role in the modulation of the ECS. …

Reduced Recidivism In Drug Offenders By Treatment Involving Motivational Interviewing, Meleeka Clary

Walden Dissertations and Doctoral Studies

AbstractIncarcerated substance users frequently recidivate because of a lack of substance treatment; it was not known whether motivational interviewing (MI) significantly reduces recidivism among substance users. The purpose of this quantitative study was to evaluate the effectiveness of MI as a treatment method for reducing recidivism among incarcerated individuals with substance use disorders. Social cognitive and extrinsic motivation theories served as the theoretical foundation for the study. Motivation is an important factor in offender engagement with treatment and has been linked to improved treatment outcomes. The research questions asked whether the availability of MI in detention facilities was significantly related …

Multimorbidity, Healthcare Processes, And Mortality Among Tb/Hiv Patients Treated With Antiretroviral Therapy In Uganda, Abel Nkolo

Walden Dissertations and Doctoral Studies

Globally, Uganda is one of the 30 tuberculosis (TB) and human immunodeficiency virus (HIV) high burden countries with high antiretroviral therapy (ART) coverage, yet mortality is still high among TB/HIV patients on ART. The reasons for the high mortality have not been fully explored. The purpose of this study was to determine the association between multimorbidity, age, sex, marital status, phase of TB treatment, timing of initiation for ART, and type of TB and mortality among TB/HIV patients on ART in Uganda. The health outcomes conceptual framework with 3 domains that directly or indirectly affect the outcome domain was used …

How Women Who Have Recidivated Describe Their Readiness For Employment After Release From Prison, Simba Kathleen Fox

Walden Dissertations and Doctoral Studies

Since the 1980s, the population of women prisoners incarcerated in the state of California had significantly increased by 500% more than that of the male prisoners. The United States had more incarcerated women than any other country. Along with this alarming rise in female incarceration, recidivism rates were also higher among female inmates. This problem has negatively affected women in California; whereas 57% of the women released from prison were rearrested within three to seven years. The purpose of this qualitative phenomenological research study was to investigate how 18 women who had recidivated with the same or a different criminal …

Risk Factors For Foodborne Illness Outbreaks In Retail Food Establishments, Brendalee Viveiros

Walden Dissertations and Doctoral Studies

Despite policies and interventions over the last two decades, foodborne illness remains a significant public health concern. According to the CDC’s Foodborne Disease Outbreak Surveillance System, 60% of reported foodborne illness outbreaks involved food that was prepared at a restaurant. Reducing foodborne illness outbreaks that occur at restaurants would have a significant impact on the overall number of foodborne illnesses that occur each year. The purpose of this study was to quantitatively analyze the differences in risk factors in food establishments that have had a foodborne illness outbreak compared to food establishments that have not. This study used Reckwitz’s theory …

Bubonic Plague: Public Health Warnings From An Ancient Disease, Mikenzie E. Chessman

2022 Award Winners

No abstract provided.

Rapid Deployment Of A Statewide Covid-19 Echo Program For Frontline Clinicians: Early Results And Lessons Learned., Anna L. Steeves-Reece, Nancy C Elder, Tuesday A Graham, Miriam L Wolf, Isabel Stock, Melinda M Davis, Ronald D Stock

Project ECHO Bibliography

No abstract provided.

Unm Health Sciences Center Data Book 2020-21, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.

Lactate Promotes Macrophage Hmgb1 Lactylation, Acetylation, And Exosomal Release In Polymicrobial Sepsis, Kun Yang, Min Fan, Xiaohui Wang, Jingjing Xu, Yana Wang, Fei Tu, P. S. Gill, Tuanzhu Ha, Li Liu, David L. Williams, Chuanfu Li

ETSU Faculty Works

High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis. The present study demonstrated a novel role of lactate in HMGB1 lactylation and acetylation in macrophages during polymicrobial sepsis. We found that macrophages can uptake extracellular lactate via monocarboxylate transporters (MCTs) to promote HMGB1 lactylation via a p300/CBP-dependent mechanism. We also observed that lactate stimulates HMGB1 acetylation by Hippo/YAP-mediated suppression of deacetylase SIRT1 and β-arrestin2-mediated recruitment of acetylases p300/CBP to the nucleus via G protein-coupled receptor 81 (GPR81). …

The Impact Of Hiv-And Art-Induced Mitochondrial Dysfunction In Cellular Senescence And Aging, Madison Schank, Juan Zhao, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure and is associated with viral persistence, residual inflammation, and metabolic disturbances. Indeed, due to the presence of viral reservoirs, lifelong ART therapy is required to control viremia and prevent disease progression into acquired immune deficiency syndrome (AIDS). Successful ART treatment allows people living with HIV (PLHIV) to achieve a similar life expectancy to uninfected individuals. However, recent studies have illustrated the …

Hydroxychloroquine: A Comprehensive Review And Its Controversial Role In Coronavirus Disease 2019, Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya B. Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis

ETSU Faculty Works

Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus …

Selective Oxidative Stress Induces Dual Damage To Telomeres And Mitochondria In Human T Cells, Ling Wang, Zeyuan Lu, Juan Zhao, Madison Schank, Dechao Cao, Xindi Dang, Lam N. Nguyen, Lam N. Nguyen, Sushant Khanal, Jinyu Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress-mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells—the major effectors of host adaptive immunity against infection and malignancy—is poorly understood due to the pleiotropic effects of ROS. Here we employed a novel chemoptogenetic tool that selectively produces a single oxygen (1O2) only at telomeres or mitochondria in Jurkat T cells. We found that targeted 1O2 production at telomeres triggered not only telomeric DNA damage but also mitochondrial dysfunction, resulting in …

Pharmacy Student Opinions Related To Question, Persuade, And Refer (Qpr) Suicide Prevention Training, Alexandra Sutphin

MPA/MPP/MPFM Capstone Projects

Suicide is one of the leading causes of death in the United States (Centers for Disease Control and Prevention [CDC], 2017). The Coronavirus Disease 2019 (COVID-19) pandemic has increased concerns related to suicide, with additional attention placed on the potential long-term negative impact of COVID-19 on mental health. Pharmacists are healthcare providers who are readily accessible and underutilized in suicide prevention efforts. This study uses survey methodology and comparative analyses to develop recommendations for the timing and administration of Question, Persuade, and Refer (QPR) suicide prevention training in the Doctor of Pharmacy (PharmD) curriculum at the University of Kentucky College …

Covid-19 And Comparative Corporate Governance, Martin Gelter, Julia M. Puaschunder

Faculty Scholarship

With the pandemic caused by the novel coronavirus SARS-CoV-2 raging around the world, many countries’ economies are at a crucial juncture. The COVID-19 external shock to the economy has the potential to affect corporate governance profoundly. This Article explores its possible impact on comparative corporate governance. For an economy to operate successfully, a society must first find a politically sustainable social equilibrium. In many countries, historical crises—such as the Great Depression and World War II—have resulted in a reconfiguration of corporate governance institutions that set the course for generations. While it is not yet clear whether COVID-19 will have a …

Cost Of Co-Infection In Peromyscus Leucopus Mice, Ananya Sagar

Scripps Senior Theses

Abstract

Co-infections occur frequently across humans & wildlife, and can have effects on host health. Despite the prevalence of microparasite-helminth co-infections, majority of the research focuses either on singular infections or on concurrent infections in a laboratory setting. This fails to take into account the interspecific interactions between the multiple parasites and the host in natural settings. The interactions could be direct by resource competition, or indirect via the host immune system. In our research, we studied the relationship between nematodes and coccidia in their host, Peromyscus leucopus mice, at the Mountain Lake Biological Station, Virginia. We further evaluated the …

College Athletes’ Safe Return To Play: Perceptions Of Strength And Conditioning Training In A Midwest University, Reid Peters

The Journal of Advancing Education Practice

This study focused on exploring the lived experiences of student-athletes during the COVID-19 pandemic at a midwestern university in the United States of America. Survey responses from collegiate athletes regarding perceptions of strength and conditioning training during the pandemic uncovered meaningful information to inform practices of strength and conditioning personnel during unexpected disruption to daily operations. Sixteen student athletes from a Midwest university were the respondents providing feedback to open-ended survey questions during fall semester of the 2021-2022 academic year. Student perspectives offer important insight about cares and concerns that athletic administrators, coaches and institutional leaders should consider when developing …

Fracture Patterns: Communicating The Surreal Through Dance Film, Chloe C. Lesh

Scripps Senior Theses

This thesis project and its associated dance film were created in a surrealistic time period initiated by the pandemic. The resulting everyday surrealism ignited my interest within dreams, nightmares, and surreality[1], and how these cerebral and psychological experiences translate to physiological responses and movement. My dance film fracture is the manifestation of these themes. The film presents surrealistic imagery in an abstracted narrative and connects to personal struggles with surreality brought on by the pandemic. The movement, as well as the rationale for the choreographic, filming, and editing choices are explained. Dance films by Neels Castillon and …

Effects Of E-Cigarette Vapor On Zebrafish Cell Regeneration And Wound Healing, Alyssa A. Grismer, Jenna E. Pumneo, Brian Bagatto

Williams Honors College, Honors Research Projects

In regards to wound healing, smoking traditional tobacco cigarettes is known to have negative effects on wound healing (Akoz, 2002). An increased risk of skin necrosis has been observed in patients who smoke throughout the surgical process (Akoz, 2002). It is known that nicotine, whether introduced through inhalation or intravenously, leads to peripheral skin vasoconstriction (Akoz, 2002). The full physiological effects of e-cigarettes are not known and research is being done to improve our understanding on the effects that these products may have on our bodies. This research is intended for that purpose. Zebrafish have recently been used as a …

Climate-Induced Human Displacement And Conservation Lands, Jessica Owley

Articles

As climate change leads to both internal displacement and mass migrations, we need not only new places for people to live but also new locations for infrastructure projects and other public needs. Some of the most attractive areas for these new land uses are currently unoccupied land, including land set aside for conservation. Numerous laws restrict the availability and possible uses of public conservation land. Individual agreements and property restrictions encumber private conservation land, varying in the ease with which the restrictions can be modified. For example, privately protected areas in the United States are often encumbered with perpetual conservation …

Catching Up With Hpv Immunization: An Educational Video For College Students, Behrooz R. Soleimani

Doctor of Nursing Practice Projects

HPV is the most common sexually transmitted infection in the US, and it can lead to minor health problems such as genital warts and serious problems like cancer in men and women. HPV vaccination can effectively prevent HPV-related cancers and is recommended by ACIP to individuals aged 9-26. HPV vaccine uptake is low among adolescents and young adults in the US. College students have a window of opportunity to catch up with their HPV immunizations, and are often uninformed about HPV, the HPV vaccine, their eligibility to receive the HPV vaccine, and where they can obtain the HPV vaccine. An …