Digital Commons Network^™

The Impact Of Hiv-And Art-Induced Mitochondrial Dysfunction In Cellular Senescence And Aging, Madison Schank, Juan Zhao, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

According to the WHO, 38 million individuals were living with human immunodeficiency virus (HIV), 25.4 million of which were using antiretroviral therapy (ART) at the end of 2019. Despite ART-mediated suppression of viral replication, ART is not a cure and is associated with viral persistence, residual inflammation, and metabolic disturbances. Indeed, due to the presence of viral reservoirs, lifelong ART therapy is required to control viremia and prevent disease progression into acquired immune deficiency syndrome (AIDS). Successful ART treatment allows people living with HIV (PLHIV) to achieve a similar life expectancy to uninfected individuals. However, recent studies have illustrated the …

Hydroxychloroquine: A Comprehensive Review And Its Controversial Role In Coronavirus Disease 2019, Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya B. Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis

ETSU Faculty Works

Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus …

Selective Oxidative Stress Induces Dual Damage To Telomeres And Mitochondria In Human T Cells, Ling Wang, Zeyuan Lu, Juan Zhao, Madison Schank, Dechao Cao, Xindi Dang, Lam N. Nguyen, Lam N. Nguyen, Sushant Khanal, Jinyu Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

Oxidative stress caused by excess reactive oxygen species (ROS) accelerates telomere erosion and mitochondrial injury, leading to impaired cellular functions and cell death. Whether oxidative stress-mediated telomere erosion induces mitochondrial injury, or vice versa, in human T cells—the major effectors of host adaptive immunity against infection and malignancy—is poorly understood due to the pleiotropic effects of ROS. Here we employed a novel chemoptogenetic tool that selectively produces a single oxygen (1O2) only at telomeres or mitochondria in Jurkat T cells. We found that targeted 1O2 production at telomeres triggered not only telomeric DNA damage but also mitochondrial dysfunction, resulting in …

Pharmacy Student Opinions Related To Question, Persuade, And Refer (Qpr) Suicide Prevention Training, Alexandra Sutphin

MPA/MPP/MPFM Capstone Projects

Suicide is one of the leading causes of death in the United States (Centers for Disease Control and Prevention [CDC], 2017). The Coronavirus Disease 2019 (COVID-19) pandemic has increased concerns related to suicide, with additional attention placed on the potential long-term negative impact of COVID-19 on mental health. Pharmacists are healthcare providers who are readily accessible and underutilized in suicide prevention efforts. This study uses survey methodology and comparative analyses to develop recommendations for the timing and administration of Question, Persuade, and Refer (QPR) suicide prevention training in the Doctor of Pharmacy (PharmD) curriculum at the University of Kentucky College …

Covid-19 And Comparative Corporate Governance, Martin Gelter, Julia M. Puaschunder

Faculty Scholarship

With the pandemic caused by the novel coronavirus SARS-CoV-2 raging around the world, many countries’ economies are at a crucial juncture. The COVID-19 external shock to the economy has the potential to affect corporate governance profoundly. This Article explores its possible impact on comparative corporate governance. For an economy to operate successfully, a society must first find a politically sustainable social equilibrium. In many countries, historical crises—such as the Great Depression and World War II—have resulted in a reconfiguration of corporate governance institutions that set the course for generations. While it is not yet clear whether COVID-19 will have a …

Cost Of Co-Infection In Peromyscus Leucopus Mice, Ananya Sagar

Scripps Senior Theses

Abstract

Co-infections occur frequently across humans & wildlife, and can have effects on host health. Despite the prevalence of microparasite-helminth co-infections, majority of the research focuses either on singular infections or on concurrent infections in a laboratory setting. This fails to take into account the interspecific interactions between the multiple parasites and the host in natural settings. The interactions could be direct by resource competition, or indirect via the host immune system. In our research, we studied the relationship between nematodes and coccidia in their host, Peromyscus leucopus mice, at the Mountain Lake Biological Station, Virginia. We further evaluated the …

College Athletes’ Safe Return To Play: Perceptions Of Strength And Conditioning Training In A Midwest University, Reid Peters

The Journal of Advancing Education Practice

This study focused on exploring the lived experiences of student-athletes during the COVID-19 pandemic at a midwestern university in the United States of America. Survey responses from collegiate athletes regarding perceptions of strength and conditioning training during the pandemic uncovered meaningful information to inform practices of strength and conditioning personnel during unexpected disruption to daily operations. Sixteen student athletes from a Midwest university were the respondents providing feedback to open-ended survey questions during fall semester of the 2021-2022 academic year. Student perspectives offer important insight about cares and concerns that athletic administrators, coaches and institutional leaders should consider when developing …

Fracture Patterns: Communicating The Surreal Through Dance Film, Chloe C. Lesh

Scripps Senior Theses

This thesis project and its associated dance film were created in a surrealistic time period initiated by the pandemic. The resulting everyday surrealism ignited my interest within dreams, nightmares, and surreality[1], and how these cerebral and psychological experiences translate to physiological responses and movement. My dance film fracture is the manifestation of these themes. The film presents surrealistic imagery in an abstracted narrative and connects to personal struggles with surreality brought on by the pandemic. The movement, as well as the rationale for the choreographic, filming, and editing choices are explained. Dance films by Neels Castillon and …

Effects Of E-Cigarette Vapor On Zebrafish Cell Regeneration And Wound Healing, Alyssa A. Grismer, Jenna E. Pumneo, Brian Bagatto

Williams Honors College, Honors Research Projects

In regards to wound healing, smoking traditional tobacco cigarettes is known to have negative effects on wound healing (Akoz, 2002). An increased risk of skin necrosis has been observed in patients who smoke throughout the surgical process (Akoz, 2002). It is known that nicotine, whether introduced through inhalation or intravenously, leads to peripheral skin vasoconstriction (Akoz, 2002). The full physiological effects of e-cigarettes are not known and research is being done to improve our understanding on the effects that these products may have on our bodies. This research is intended for that purpose. Zebrafish have recently been used as a …

Climate-Induced Human Displacement And Conservation Lands, Jessica Owley

Articles

As climate change leads to both internal displacement and mass migrations, we need not only new places for people to live but also new locations for infrastructure projects and other public needs. Some of the most attractive areas for these new land uses are currently unoccupied land, including land set aside for conservation. Numerous laws restrict the availability and possible uses of public conservation land. Individual agreements and property restrictions encumber private conservation land, varying in the ease with which the restrictions can be modified. For example, privately protected areas in the United States are often encumbered with perpetual conservation …

Catching Up With Hpv Immunization: An Educational Video For College Students, Behrooz R. Soleimani

Doctor of Nursing Practice Projects

HPV is the most common sexually transmitted infection in the US, and it can lead to minor health problems such as genital warts and serious problems like cancer in men and women. HPV vaccination can effectively prevent HPV-related cancers and is recommended by ACIP to individuals aged 9-26. HPV vaccine uptake is low among adolescents and young adults in the US. College students have a window of opportunity to catch up with their HPV immunizations, and are often uninformed about HPV, the HPV vaccine, their eligibility to receive the HPV vaccine, and where they can obtain the HPV vaccine. An …

Screening For Adverse Childhood Experiences And Other Determinants Of Health In School Based Health Centers: A Program Evaluation, Olivia A. Domini

Doctor of Nursing Practice Projects

Introduction: Adverse Childhood Experiences (ACEs), such as abuse, neglect, and various household stressors, are common, connected, and contribute to multiple adverse health and wellbeing outcomes throughout life. Consequently, there has been a push to screen for adversity and toxic stress in primary care to facilitate prevention and early intervention. The purpose of this project was to evaluate and optimize the use of the Broad Level Integrated Screener (BLIS) in Neighborcare Health (NCH) School Based Health Centers (SBHCs) in Seattle, WA.

Methods: An online survey including nineteen Likert-scale questions and five open-ended free response questions was administered to all middle school …

Pandemics And International Law: The Need To Strengthen International Legal Frameworks After The Covid-19 Global Health Pandemic [Sierra Leone], Charles C. Jalloh

Articles

No abstract provided.

Co-Opting Coronavirus, Assailing Asylum, Ashley B. Armstrong

Faculty Publications

The Centers for Disease Control (CDC) issued an Order on March 26, 2020, under Title 42, Section 265 of the Public Health Service Act, in the name of combatting the spread of coronavirus. The Order has been called the “Asylum Ban” because it effectively has sealed the southern border to protection-seekers, resulting in the pushback of nearly 400,000 asylees and unaccompanied children. This Article argues that the Trump administration has contravened the rule of law by using the coronavirus pandemic as a convenient pretext to end asylum in the U.S., and by violating the rights of protection-seekers. In doing so, …

Identifying And Measuring Resilience Factors Among Children With Prenatal Substance Exposure In A Tribal Nation And In Association With Covid-19 Mortality, Helen Cecelia Russette

Graduate Student Theses, Dissertations, & Professional Papers

Background: Historical and contemporary trauma among Native Americans is linked to disparate health outcomes across the lifespan including the very recent coronavirus 2019 (COVID-19) outbreak. Early and prolonged exposure to positive family-child engagement activities and the natural environment (greenspace) act as protective factors against a range of maladaptive development across the lifespan. Yet, little is known regarding specific activities relevant among high-risk families in Tribal Nations and no evidence exists in terms of measuring that impact of greenspace against risk of COVID-19 mortality.

Purpose: 1) Partner with a Tribal Nation to develop a study to identify resilience promoting factors in …

Antibiotic Stewardship In Skin And Soft Tissue Infections, Shah Z. Ali, Jose Campo Maldonado

MEDI 9331 Scholarly Activities Clinical Years

Antibiotic use during inpatient hospitalizations have a significant impact on both patient care and healthcare costs. Using data collected over a one month period in 2019 from inpatient hospitalizations, we aim to determine the most common indicated uses for vancomycin and piperacillin-tazobactam, along with the average days of therapy for their use in treating skin and soft tissue infections.

The Effect Of The Investment Tax Credit Policy On Renewable Energy Resources In The United States Relative To Europe, Laura B. Epperson

Scripps Senior Theses

This paper aims to explore the effect of the Investment Tax Credit policy on the production and usage of renewable energy resources in the United States and whether the implementation of this policy in the US helped close the gap with European Countries. It focuses largely on the economic theory of incentives, cost/benefit analyses, and the theory of externalities. To analyze this, data was collected from the World Bank and the Quality of Government Dataset and the effectiveness of this policy was measured using four outcome variables: Renewable Energy Consumption, Fossil Fuel Consumption, Renewable Electricity Output, and Greenhouse Gas Emissions. …

Balancing Public Health And Privacy: Lessons From Digital Contact Tracing For Covid-19 Vaccination Tracking Efforts, Carmel Shachar

Saint Louis University Law Journal

The COVID-19 pandemic has brough the tension between individual privacy and public health initiative to the fore, in part because many of the solutions to the challenges of the pandemic proposed are digital. The first year of the pandemic has revealed that the Health Insurance Portability and Accountability Act is both too restrictive of traditional public health activities but also underprotective of important categories of health data. The failure of digital contact tracing applications to make a difference in combatting the pandemic during its early stages also illustrates the tension between individual privacy and public health surveillance. In order to …

2020 Domestic Legislative Review, Tara Cooley

Animal Law Review

The 116th Congress, second session, began January 3, 2020, and ended January 3, 2021. While Congress voted on key animal-related legislation, such as the Big Cat Public Safety Act, the COVID-19 pandemic slowed -- or even halted -- proposed legislation at the federal and state levels. Despite the slowdown, local voters proposed and enacted several key initiatives, including the California Ecosystems Protection Act and Orange County, Florida's Right to Clean Water initiative.9 In addition, federally enacted COVID-19-related legislation, such as the Coronavirus Aid, Relief, and Economic Security (CARES) Act, also addressed animalrelated issues. The World Health Organization (WHO) labeled COVID-19 …

Come Closer: Geographies Of Care, Anam Mehta

Pomona Senior Theses

Geographies of Care during the Covid-19 Pandemic and beyond.

Over The Top: Judges, Lawyers, And Covid-19 Rhetoric, Jonathan L. Entin

Health Matrix: The Journal of Law-Medicine

No abstract provided.

In These Unprecedented Times: A Critical Incidents Technique Examination Of Students’ Perceptions Of Satisfying And Dissatisfying Learning Experiences, Scott Swanson, J Charlene Davis, Mario V. Gonzalez Fuentes, Kim R. Robertson

School of Business Faculty Research

Higher education has and continues to be sharply disrupted due to the COVID-19 pandemic. In this paper, our focus is on the pandemic’s impact on higher education, specifically on undergraduate marketing students’ perceptions of learning experiences during the switch from traditional face-to-face learning to online approaches. Understanding student perspectives on which specific aspects of their learning experience were satisfying or dissatisfying offers faculty valuable insight as to how to navigate this (for many) new teaching environment and enhance student experiences and outcomes. Collecting data during spring semester 2020 offers a unique view from students as universities abruptly pivoted from previously …

Kean Program Review - Ba Biology 2019, Kean University

Evidence Inventory

Kean Program Review - BA Biology 2019

Simiode Expo 2021 - Minicourse M-R2 - Delay Differential Equations In Epidemiology, Nsoki Mavinga

Mathematics & Statistics Faculty Works

Many problems in epidemiology give rise to delay differential equations (DDEs). These are differential equations in which the current rate of change of the system depends not only on the current state but also on the history of the system; i.e. the system has memory. In this minicourse, we will discuss some key tools necessary to understand the applications involving DDEs. We will go through an example that illustrates the need and implementation of DDE in certain infectious diseases.

Rural Business Development Corporation Annual Report 2021, Department Of Primary Industries And Regional Development, Western Australia

All other publications

No abstract provided.

Toward Improving Physician/Patient Communication Regarding Invisible Chronic Illness (Ici): The Potential Of Mhealth Technology In Instructional Communication, Jami Leigh Warren, Karen Clancy, Christy F. Brady, Kendall Rump, Tayla New-Oglesby

Health and Clinical Sciences Faculty Publications

Patients that suffer from invisible chronic illness (ICI) such as autoimmune conditions, neurological conditions, and gastrointestinal problems often struggle to obtain a proper medical diagnosis due to a lack of objective indicators to help health-care providers diagnose patients with ICIs. Thus, researchers conducted interviews with 21 participants with Postural Orthostatic Tachycardia Syndrome (POTS) to determine what messages they received from health-care providers as they pursued a diagnosis, how they interpreted those messages, and what role mHealth technology may play in improving patient/provider communication and effective diagnosis/treatment of ICIs. Several themes regarding potential instructional communication intervention content emerged from the interview …

A General Multipatch Model Of Ebola Dynamics, Jorge Rebaza

College of Natural and Applied Sciences

A model for the transmission dynamics of Ebola virus in a multipatch network setting is studied. The model considers the contribution to the dynamics by people who are susceptible, infectious, isolated, deceased but still infectious and not yet buried, as well as the dynamics of the pathogen at interacting nodes or patches. Humans can move between patches carrying the disease to any patch in a region of n communities (patches). Both direct and indirect transmission are accounted for in this model. Matrix and graph-theoretic methods and some combinatorial identities are used to construct appropriate Lyapunov functions to establish global stability …

Global Stability Analysis Of A General Model Of Zika Virus, K. Bessey, M. Mavis, Jorge Rebaza, J. Zhang

College of Natural and Applied Sciences

Mathematical models of Zika virus dynamics are relatively new, and they mostly focus on either vector and horizontal, or vector and vertical transmission only. In this work,we first revisit a recent model that considers vector and vertical transmission, and we provide an alternative proof on the global stability of the disease-free equilibrium point. Then, a new and general model is presented which includes vector, horizontal and vertical transmission. For this new model, existence of both a disease-free and an endemic equilibrium is studied. Using matrix and graph-theoretic methods, appropriate Lyapunov functions are constructed and results on the global stability properties …

Improvements To A Framework For Gender And Emerging Infectious Diseases, Lynn Lieberman Lawry, Roberta Lugo-Robles, Vicki Mciver

Journal Articles: Epidemiology

No abstract provided.

1913 April, West Tennessee State Normal School Bulletin

Bulletins

Vol. 2, No. 1 of the West Tennessee State Normal School bulletin announcing the summer term, 1913 April.