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Epigenetic Clock And Methylation Studies In Elephants, Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesús E. Maldonado, Dennis L. Schmitt, For Complete List Of Authors, See Publisher's Website.

College of Agriculture

Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of 140 elephant blood samples of known age, at loci that are highly conserved between mammalian species, using a custom Infinium array (HorvathMammalMethylChip40). We present epigenetic clocks for Asian elephants (Elephas maximus), African elephants (Loxodonta africana), and both elephant species combined. Two additional human-elephant clocks were constructed by combining human and elephant samples. Epigenome-wide association studies identified elephant …

International Legal, Policy And Institutional Issues Raised By The Covid-19 [Portugal], Patrícia Galvão Teles

American University International Law Review

INTRODUCTION

Three basic sets of questions arise when we attempt to look back to what is now almost one year of probably the greatest pandemic in human history, and also when we look to the future to see what can be improved to fight epidemics and pandemics of this scale and nature. The first set of questions, for us as lawyers, are the legal issues that we are dealing with in regards to the existing legal framework, and how it is interpreted and applied in the event of a pandemic. The second set of questions are policy issues. Discussing the …

Ensuring Non-Discrimination In The Context Of Covid-19 Triage Protocols, Kate Holcombe

American University International Law Review

No abstract provided.

China's Crimes Against Humanity Upon The Uyghur People Under The Rome Statute Of The International Criminal Court, Alex Fox

Loyola University Chicago International Law Review

No abstract provided.

Viral Factors Influencing Early Infection Events During Ex-Vivo Kshv Infection, Ramina Nabiee

Pharmaceutical Sciences (PhD) Dissertations

The enigma of Kaposi Sarcoma Herpes Virus infection, and its persistence despite a quarter century of research on the virus, has given rise to an immediate need for addressing fundamental questions about basic immunology and virology knowledge regarding this virus. Kaposi Sarcoma Herpes Virus (KSHV), also known as Human Herpesvirus 8 (HHV8), is the etiological agent of Kaposi Sarcoma (KS) and other lymphoproliferative cancers, such as Multicentric Castleman’s Disease (MCD), Primary Effusion Lymphoma (PEL), and a newly discovered rare disease called KSHV Inflammatory Cytokines Syndrome (KICS). Epidemic KS, also known as AIDS-KS, is the most common cancer in untreated HIV …

Exploring Barriers To Care: Provider Efforts To Improve Retention In Urban-Rural Clusters, Kenyata M. Fletcher

Walden Dissertations and Doctoral Studies

AbstractOver the years, the infection rates for HIV in the United States has changed partly due to lack of engagement and medication adherence which can lead to substantial declines in individual health. Factors that contribute to the individual’s adherence can include transportation cost, childcare, and lack of finances to name a few. These barriers can often be decreased with the help of supportive service providers and improvement in the patient-provider relationship. Currently, there is limited research that explores how to reduce patient barriers to care, specifically in rural areas. This qualitative study examines how Illinois health care providers help HIV-positive …

Risk Factors Associated With Childhood Vaccination Coverage In Afghanistan, Iqbal Mawani

Walden Dissertations and Doctoral Studies

Globally, vaccination is among the most successful and cost-effective public health practices in the prevention of infectious diseases. The purpose of this study was to examine the child, parental, and geographical risk factors that influence childhood vaccination coverage in Afghanistan. The health belief model and socio-ecological model was used in this study as the theoretical framework to examine the effects of these risk factors on vaccination coverage among children in Afghanistan. Univariate, bivariate, and multivariate tests were conducted within the secondary data analysis of the 2015 Afghanistan national Demographic and Health Survey dataset. Of the 32,420 children aged 0 to …

Human Immunodeficiency Virus And Homelessness Among U.S.-Born And Foreign-Born Tuberculosis Cases In Georgia, Semra Ramosevac

Walden Dissertations and Doctoral Studies

According to the Centers for Disease Control and Prevention, tuberculosis (TB) is an infectious disease caused by bacteria and can easily spread in the U.S. and worldwide. TB infections in the U.S. have been much lower compared to other countries around the world in the last 40 years, but with the recent increase in an immigrant foreign-born population, there is a serious risk of the spread of TB. The goal of the study was to look into U.S.-born vs. foreign-born populations among TB/HIV/homeless cases in the state of GA from 2014 to 2018. The quantitative study was performed using secondary …

Educating Clinicians In A Nursing Facility To Proactively Manage Urinary Tract Infections, Setha Joseph

Walden Dissertations and Doctoral Studies

AbstractUrinary tract infections (UTIs) have been identified as the most common reason for hospital visits among adults. The Centers for Disease Control and Prevention indicates that the prevalence of UTIs in long-term care facilities ranges from 20%-50%. The purpose of this staff education project was to implement an educational program to increase staff knowledge of proactive management of urinary tract health with the ultimate goal of reducing acute illnesses at the skilled nursing facility (SNF). Knowles theory of adult learning informed curriculum development and Kirkpatrick's levels of training evaluation guided program evaluation. The project team planned, developed, implemented, and evaluated …

The Biden Administration’S Decision To Rejoin The World Health Organization: A Power Move Or A Faulty Move?, Veronica J. Mina

Maryland Journal of International Law

No abstract provided.

Price Gouging In The Time Of Covid-19: How U.S. Anti-Price Gouging Laws Fail Consumers, Spencer Warkentin

Maryland Journal of International Law

No abstract provided.

Medicine@Yale January/February 2021 Volume 16, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Table Of Contents

Journal of Health Care Law and Policy

No abstract provided.

The Effect Of Proprietary And Attribution Claims On Data Sharing During Infectious Disease Emergencies, Sam Halabi, Michelle Rourke, Rebecca Katz

Journal of Health Care Law and Policy

No abstract provided.

Vaccination, Disabled Children, And Parental Income, Karen Syma Czapanskiy

Journal of Health Care Law and Policy

No abstract provided.

Implementing Cardiac Testing To Mitigate The Risk Of Sudden Cardiac Death: An Evidence-To-Practice Review, Victoria J. Simpson, Zachary K. Winkelmann

Clinical Practice in Athletic Training

In the United States, sudden cardiac death (SCD) is the leading cause of fatality in young athletes during exercise. Allied healthcare professionals have used screening tools such as the 12-Element American Heart Association recommendations, the European Society of Cardiology (ESC) recommendations, and the International Olympic Committee guidelines to screen for cardiovascular abnormalities in athletes. Although each of these protocols consist of personal and family history questions complemented with a physical examination, a uniform screening strategy to identify athletes at risk of SCD does not exist. The purpose of this evidence to practice review is to summarize a systematic review regarding …

The Effect Of Covid-19-Related Stress On Registered Nurses In The United States, Samantha Jacqlyn Genova

Honors Undergraduate Theses

The United States, as of October 2021, is the country with the most reported COVID-19 cases and COVID-19 deaths in the world. Since the first case was confirmed, Registered Nurses working in the acute care setting have been at the forefront of this public health crisis. As the pandemic has continued, studies have been conducted to collect, analyze, and reveal the effect of COVID-19-related stress on Registered Nurses in the United States. This critical literature review takes eleven published studies related to this topic, discusses the commonalities between them, addresses limitations in the literature and offers recommendations for future research. …

Use Of Mechanical Pronation Beds In Acute Respiratory Distress Syndrome In The Intensive Care Unit: An Integrative Review Of The Literature, Amanda St. John

Honors Undergraduate Theses

The increasing rate of Acute Respiratory Distress Syndrome (ARDS) reinforces the need for additional resources to assist clinical staff with an individual's care and recovery. Pronation therapy involves physically rotating an individual from the posterior position to the prone position. Pronation therapy has successfully been used for individuals diagnosed with ARDS in Intensive Care Units for decades. However, manual pronation maneuvers by staff members poses risks for those who are critically ill and risk of physical injury to caregivers. Mechanical pronation beds have revolutionized the art of pronation therapy, minimizing risks, and decreasing possibility of kinking or pulling out life …

Race-Based Adjustment In Egfr Algorithms: An Integrative Literature Review, Leah E. Utt

Honors Undergraduate Theses

Background: There is a 3-fold risk of developing end stage kidney disease in Non-Hispanic African Americans compared to Non-Hispanic White Americans (Centers for Disease Control and Prevention, 2017). Estimated glomerular filtration rate (eGFR), one of the fundamental algorithms for coordinating treatment for kidney disease which factors in age, race, gender, and levels of creatinine, may pose an issue in this vulnerable population. Currently African Americans receive a correction factor between 1.21 and 1.16 to their eGFR to adjusting the value higher, potentially impacting appropriate kidney disease classification, and delaying beneficial interventions (National Kidney Foundation, 2020).

Methods: A systematic literature search …

Covid-19 And Digital Contact Tracing: Regulating The Future Of Public Health Surveillance, Divya Ramjee, Pollyanna Sanderson, Imran Malek

Cardozo Law Review de•novo

Digital surveillance tools are at the forefront of potential public health response strategies for the COVID-19 pandemic. The United States is in desperate need of a national-level contact tracing and exposure notification strategy to supplement traditional public health response efforts. This article addresses data privacy and security concerns, as well as epidemiological considerations, when developing digital contact tracing and exposure notification tools. It is both feasible and prudent that the United States establish a federal network for public health surveillance aided by digital tools, especially considering that waves of COVID-19 are expected to continue well into 2021 and while the …

Examining The Dunning-Kruger Effect In Autism Knowledge, Information Sourcing, And Endorsement Of Vaccination Policy, Alexandra Reed

PCOM Psychology Dissertations

The purpose of this study was to further examine the Dunning-Kruger effect as it relates to knowledge of autism, source of information, and endorsement of vaccination policy. Specifically, the study assessed the relationship between confidence in autism awareness and the belief that vaccines cause autism. It also examined the relationship between the source of information regarding autism and vaccines and vaccination attitudes. Last, it assessed whether individuals with higher confidence levels in the internet would be more likely to have both anti-vaccination attitudes and lower awareness of autism facts. Adult participants (N = 199) were surveyed on various social media …

Service Members’ Perspectives On Veteran Homelessness In Maryland And Virginia, Olasunkanmi G. Amosu

Walden Dissertations and Doctoral Studies

Homelessness among military veterans (HAMV) is a protracted problem. In November 2009, the U.S. Department of Veterans Affairs pledged to end the issue, but almost 12 years later, HAMV persists despite various solutions proposed. In January 2020, 37,252 veterans were reported as experiencing homelessness in the United States. The creation of previous solutions did not include the perspectives of service members. The purpose of this study was to bridge this gap in knowledge by discovering the views of service members on why veteran colleagues experience homelessness. The theoretical framework for this study was Allport’s trait theory. A qualitative case study …

The Power Of Exogenous Variables In Predicting West Nile Virus In South Carolina, Christopher Lee Glaze

Walden Dissertations and Doctoral Studies

Despite the availability of medical data, environmental surveillance tools, and heightened public awareness, West Nile Virus (WNv) remains a global health hazard. Reliable methods for predicting WNv outbreaks remain elusive, and environmental health managers must take preventive actions without the benefit of simple predictive tools. The purpose of this ex post facto research was to examine the accuracy and timeliness of exogenous data in predicting outbreaks of WNv in South Carolina. Decision theory, the CYNEFIN construct, and systems theory provided the theoretical framework for this study, allowing the researcher to broaden traditional decision theory concepts with powerful system-level precepts. Using …

Barriers To Effective Personal Protective Equipment Use In Public Health Workers, Sheila Storr-Mathis

Walden Dissertations and Doctoral Studies

Exposure to infections continues to be a significant concern for nursing practice and for other health care professionals. Personal protective equipment (PPE) minimizes occupational exposure; however, their use is subject to variability. This quality improvement project addressed the impact of an educational intervention on attitudes and barriers to proper use of PPE for public health workers at the study site. The health belief model and the literature review provided theoretical support for the project and evidence of current trends in PPE use. There were 44 employees who completed the preintervention survey and 22 who completed the postintervention survey to gauge …

Sociodemographic And Psychosocial Factors And Wellbeing Among Adults 65 And Older In England, Dainelle Clark

Walden Dissertations and Doctoral Studies

The increased number of older adults living longer parallels with the growth of public health concerns regarding the impact of sociodemographic and psychosocial factors (e.g., loneliness and social isolation) on older adults' wellbeing. The purpose of this quantitative study was to examine the association between loneliness, social isolation, the combined model of loneliness, and social isolation on wellbeing among older adults when accounting for age, gender, ethnicity, and social support. The socioecological model (SEM) was used to evaluate the multiple levels of environmental determinants for loneliness, social isolation, and wellbeing. The target population included older adults 65 years and older …

Race, Class, And Socioeconomic And Sentencing Laws In Opioid Cases, Phaedra Denise Jackson

Walden Dissertations and Doctoral Studies

AbstractThe purpose of the study was to explore social constructs and bureaucratic decisions to assess their effects on sentencing laws based on race, class, and socioeconomic status (SES). The research question guiding the study whether there was a relationship between race, class, SES, and arrests among opioid users. A cross-sectional correlational design using secondary data from Substance Abuse and Mental Health Services Administration 2010-2018 surveys of 265,442 participants and FBI Uniform Crime Reports were assessed to understand the bureaucracy of the opioid epidemic. Lipsky’s street-level bureaucracy theory was used to examine the historical, political, and racial structures within the judicial …

Knowledge And Perceptions Of Antibiotic Resistance Stewardship Among Prehealth And Agriculture Students, Claudia Maria Da Silva Carvalho

Walden Dissertations and Doctoral Studies

The global threat of antibiotic resistant infection has resulted in health organizations to compile an antibiotic stewardship program, in which the education of current/future medical prescribers and farmers is central for the preservation of current and future antimicrobial treatments. The purpose of this study was to assess and compare the knowledge and perceived threat of antibiotic and antibiotic resistance, as well as the perceived benefit of antibiotic stewardship, among undergraduate students in biology and agriculture at a state university in Kansas. Framed by the health belief model, a cross-sectional study was conducted using a structured online survey of 136 undergraduate …

Drug-Resistant Neisseria Gonorrhoeae; Identification Of At-Risk Groups In Florida By Regional Variation, Scott August Herber

Walden Dissertations and Doctoral Studies

Neisseria gonorrhoeae has been on the rise in the State of Florida since 2013. Florida currently follows the Centers for Disease Control and Prevention guidelines for identifying those at-risk for gonorrhea and drug resistant gonorrhea infections. These groups are narrowly defined and do not consider the different population dynamics throughout the State. This study examined the question of who is at-risk for contracting drug resistant strains of gonorrhea in the eight different regions of Florida based on the prescribed use of last-line-of-antibiotic-defense. Florida’s Surveillance Tools and Reporting System provided 12 years of secondary data from 2007 to 2018. The data …

Effects Of Hepatitis On Human Immunodeficiency Virus Viral Suppression, Andrenita Checoby West

Walden Dissertations and Doctoral Studies

Coinfection with human immunodeficiency virus (HIV) and viral hepatitis leads to unfavorable health outcomes, making treatment of HIV difficult and increasing the odds of HIV transmission. The purpose of this study is to assess whether viral hepatitis (B and C) hinders HIV viral suppression and impacts the white blood cell count (CD4) when a person is concurrently infected with both viruses. The syndemics theory guided this study. Two research questions tested whether there was an association between coinfection with viral hepatitis and HIV viral load suppression. The research design was quantitative case-control with secondary data from 65,626 reports of HIV, …

Prevalence Of Cymothoidae (Isopoda) Infestation In Bigeye Scad (Selar Crumenophtalmus) From Batangas, Philippines, Tanya Faye S. Muji, Joaquin R. Sorreta, Janice A. Ragaza

Biology Faculty Publications

Cymothoid isopod research is relatively scarce in the Philippines, despite the local economic significance of bigeye scad as an inexpensive source of protein and other nutrients. Isopod parasitism has also been shown to have detrimental effects on their fish hosts. The current study aimed to define the host-parasite relationship between cymothoid isopod and bigeye scad by determining cymothoid isopod prevalence, intensity, and host-parasite length correlations in bigeye scad (Selar crumenophthalmus) hosts sourced from Batangas, Philippines. Fish samples were sampled from the Tagaytay City Market in Cavite, which sources fish directly from Batangas. Fish samples were immediately measured and …