Digital Commons Network^™

Thrombosis With Thrombocytopenia Syndrome After Administration Of Azd1222 Or Ad26.Cov2.S Vaccine For Covid-19: A Systematic Review, Usama Waqar, Shaheer Ahmed, Syed M H Ali Gardezi, Muhammad Sarmad Tahir, Zain Ul Abidin, Ali Hussain, Natasha Bahadur Ali, Syed Faisal Mahmood

Medical College Documents

Background: Cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported following vaccination with AZD1222 or Ad26.COV2.S. This review aimed to explore the pathophysiology, epidemiology, diagnosis, management, and prognosis of TTS.
Methods: A systematic review was conducted to identify evidence on TTS till 4th September 2021. Case reports and series reporting patient-level data were included. Descriptive statistics were reported and compared across patients with different sexes, age groups, vaccines, types of thrombosis, and outcomes.
Findings: Sixty-two studies reporting 160 cases were included from 16 countries. Patients were predominantly females with a median age of 42.50 (22) years. AZD1222 was administered …

Transient Ascaris Suum Larval Migration Induces Intractable Chronic Pulmonary Disease And Anemia In Mice, Yifan Wu, Evan Li, Morgan Knight, Grace Adeniyi-Ipadeola, Li-Zhen Song, Alan R Burns, Ana Clara Gazzinelli-Guimaraes, Ricardo Fujiwara, Maria Elena Bottazzi, Jill E Weatherhead

Faculty, Staff and Students Publications

Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host's lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that …

Bicuspid Aortic Valve In Pregnancy Complicated By Aortic Valve Vegetation, Aortic Root Abscess, And Aortic Insufficiency, Shan He, Christopher A Huynh, Yi Deng, Sandeep Markan, Anvinh Nguyen

Faculty, Staff and Students Publications

A 39-year-old patient presented to our Labor and Delivery unit with fever and nausea in the context of recent bacteriuria. She was found to be in sepsis due to an incidental bicuspid aortic valve (BAV) complicated by aortic valvular vegetations, severe aortic insufficiency, and aortic root abscess, requiring an emergent cesarean section. Three days after delivery, the patient successfully underwent a mechanical aortic valve replacement and root reconstruction. In this case report, medical, surgical, and anesthetic management of parturient patients with BAV are discussed. The management of this congenital valvulopathy and vasculopathy is complicated by the extensive hemodynamic and cardiovascular …

Clinical And Microbiological Outcomes Of Ceftazidime-Avibactam Treatment In Adults With Gram-Negative Bacteremia: A Subset Analysis From The Phase 3 Clinical Trial Program, John E Mazuski, Florian Wagenlehner, Antoni Torres, Yehuda Carmeli, Joseph W Chow, Dalia Wajsbrot, Gregory G Stone, Paurus Irani, David Bharucha, Karen Cheng, Margaret Tawadrous

2020-Current year OA Pubs

INTRODUCTION: This exploratory analysis assessed efficacy and safety outcomes in patients with Gram-negative bacteremia treated with ceftazidime-avibactam or comparator across five phase 3, randomized, controlled, multi-center trials in adults with complicated intra-abdominal infection (cIAI), complicated urinary tract infection (cUTI)/pyelonephritis, hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP).

METHODS: In each trial, RECLAIM and RECLAIM 3 (cIAI; NCT01499290/NCT01726023), REPRISE (cIAI/cUTI; NCT01644643), RECAPTURE (cUTI; NCT01595438/NCT01599806), and REPROVE (HAP/VAP; NCT01808092), patients were randomized 1:1 to intravenous ceftazidime-avibactam (plus metronidazole for those with cIAI) or comparators (carbapenems in > 97% patients) for 5-21 days. Efficacy assessments included clinical and microbiological responses at the test-of-cure visit in …

Population Connectivity In Voles (Microtus Sp.) As A Gauge For Tall Grass Prairie Restoration In Midwestern North America, Marlis R. Douglas, Steven M. Mussmann, Tyler Chafin, Whitney J.B. Anthonysamy, Mark A. Davis, Matthew P. Mulligan, Robert L. Schooley, Wade Louis, Michael E. Douglas

Biological Sciences Faculty Publications and Presentations

Ecological restoration can promote biodiversity conservation in anthropogenically fragmented habitats, but effectiveness of these management efforts need to be statistically validated to determine ’success.’ One such approach is to gauge the extent of recolonization as a measure of landscape permeability and, in turn, population connectivity. In this context, we estimated dispersal and population connectivity in prairie vole (Microtus ochrogaster; N = 231) and meadow vole (M. pennsylvanicus; N = 83) within five tall-grass prairie restoration sites embedded within the agricultural matrix of midwestern North America. We predicted that vole dispersal would be constrained by the …

Does Precise Case Disclosure Limit Precautionary Behavior? Evidence From Covid-19 In Singapore, Aljoscha Janssen, Matthew H. Shapiro

Research Collection School Of Economics

Limiting the spread of contagious diseases can involve both government-managed and voluntary efforts. Governments have a number of policy options beyond direct intervention that can shape individuals’ responses to a pandemic and its associated costs. During its first wave of COVID-19 cases, Singapore was among a few countries that attempted to adjust behavior through the announcement of detailed case information. Singapore's Ministry of Health maintained and shared precise, daily information detailing local travel behavior and residences of COVID-19 cases. We use this policy along with device-level cellphone data to quantify how local and national COVID-19 case announcements trigger differential behavioral …

Correction To: 2021 Taxonomic Update Of Phylum Negarnaviricota (Riboviria: Orthornavirae), Including The Large Orders Bunyavirales And Mononegavirales (Archives Of Virology, (2021), 166, 12, (3513-3566), 10.1007/S00705-021-05143-6), Jens H. Kuhn, Scott Adkins, Bernard R. Agwanda, Rim Al Kubrusli, Sergey V. Alkhovsky, Gaya K. Amarasinghe, Tatjana Avšič-Županc, María A. Ayllón, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Christopher F. Basler, Sina Bavari, Martin Beer, Nicolas Bejerman, Andrew J. Bennett, Dennis A. Bente, Éric Bergeron, Brian H. Bird, Carol D. Blair, Kim R. Blasdell, Dag Ragnar Blystad, Jamie Bojko, Wayne B. Borth, Steven Bradfute, Rachel Breyta, Thomas Briese, Paul A. Brown

All Peer-Reviewed Publications

Unfortunately, the inclusion of original names (in non-Latin script) of the following authors caused problems with author name indexing in PubMed. Therefore, these original names were removed from XML data to correct the PubMed record. Mengji Cao, Yuya Chiaki, Hideki Ebihara, Jingjing Fu, George Fú Gāo, Tong Han, Jiang Hong, Ni Hong, Seiji Hongo, Masayuki Horie, Dàohóng Jiāng, Fujio Kadono, Hideki Kondō, Kenji Kubota, Shaorong Li, Longhui Li, Jiànróng Lǐ, Huazhen Liu, Tomohide Natsuaki, Sergey V. Netesov, Anna Papa, Sofia Paraskevopoulou, Liying Qi, Takahide Sasaya, Mang Shi, Xiǎohóng Shí, Zhènglì Shí, Yoshifumi Shimomoto, Jin‑Won Song, Ayato Takada, Shigeharu Takeuchi, Yasuhiro …

2021-11-30_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated three times a week on Mondays, Wednesdays and Fridays.

Syndromic Surveillance System data is obtained from approximately 216 facilities participating in syndromic surveillance (139 Emergency Departments (ED), 77 Urgent Care) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, …

Covid Research Inequalities: Highlighting The Need For Increased Minority Participation In Clinical Trials, Olivia C. Perlstein

Seton Hall Law Review

No abstract provided.

The Effectiveness And Safety Of Favipiravir In Covid-19 Hospitalized Patients At Tertiary Referral Hospital, Bali, Indonesia, Herni Damayanti, I Gede K Sajinadiyasa, Hindun Wilda Risni, Rani Sauriasari

Kesmas

COVID-19 is a major public health problem, with still questionable specific cure. Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). Effectivity was measured by assessing the clinical condition at the end of the isolation period of 14 days. The favipiravir …

Shaving The Surgical Site And Infection In Lumbar Spine Surgery, Mazin Jawad

Iraqi Postgraduate Medical Journal

BACKGROUND: Spine surgeons ordinarily shave the skin of the surgery locality before operation start. Nevertheless,  data from some surgical series proposes that preoperative shaving may enhance the post-surgical infection incidence. OBJECTIVE: To conclude whether shaving the surgical site before lumbar spine surgery induces infection in                     the post-operative period and whether presurgical shaving is compulsory. METHODS: A prospective cohort study had conducted over two years at the Department of neurosurgery, Medical City, Baghdad, Iraq, starting from July 2018. A total of 186 patients scheduled to undergo spinal   surgery were randomly allocated into 2 groups: those in whom the site of operation …

Impact Of Covid-19 On Mental Health Of Physicians In Baghdad, Iraq, Lubna Naji, Hussein Meften, Marwa Ahmed, Jawad Al-Diwan, Nesif Al Hemiary, Mushtaq Hashim

Iraqi Postgraduate Medical Journal

BACKGROUND: Healthcare professionals are vulnerable to adverse mental health consequences explained by their working in close contacts with COVID-19 patients. Publication on mental health of healthcare professional in Iraq is scarce. OBJECTIVE: To comment on mental health disorders among healthcare professional dealing with COVID-19 patients. METHODS: A total of 100 healthcare professionals were included in the study. They were selected conveniently. Hospital anxiety and depression scale was used. Data collected by a physician. RESULTS: The age of participants was 35.5 ± 8.7 years with a male to female ratio of 1.7:1. Of the participants, 63% got COVID-19. Anxiety and depression …

Prevalence Of Incomplete Vaccination Andassociated Factors In Children (2-5 Years) Attending Primary Health Care Centers In Diyala, 2019, Shaimaa Ali, Yousif Abdul Raheem

Iraqi Postgraduate Medical Journal

BACKGROUND:  Childhood immunization is one of the most cost-effective interventions in health care delivery. OBJECTIVE: Prevalence of vaccinated, partially vaccinated and unvaccinated  children  (2-5 years) attending Primary Health Care and the possible risk factors  for incomplete vaccination among them and to assess mothers’ knowledge about vaccination and finding out if it was associated with incomplete vaccination. PATIENTS AND METHODS: A cross-sectional survey carried out in three primary health care centers in Khanaqin district/ Diyala Province/ Iraq from the first of March until the end of June /2019. The immunization status of children was obtained from mothers and verified by their …

A Comparative Study Of Single Dose Versus Multiple Dose Prophylactic Ceftriaxone In Laparoscopic Cholecystectomy, Sanaa Husein, Ali Al-Gharawi, Mowafaq Ghareeb

Iraqi Postgraduate Medical Journal

BACKGROUND: Although laparoscopic cholecystectomy became the gold standard for the treatment of gallstone disease, there is some risk of surgical site infection that required prophylactic antibiotic. Prophylaxis for low risk patients is still controversial as well as whether single or multiple doses is needed. AIM OF STUDY: Compare between single vs. multiple dose of antibiotic prophylaxis in laparoscopic cholecystectomy in terms of post-operative infection and cost. METHODS: A prospective study conducted at Baghdad Teaching Hospital, from January 2017 to March 2018. 200 patients admitted for elective laparoscopic cholecystectomy randomly divided in two equal groups: single dose (SD) group was given …

Evaluation Of Predictive Value Of Placental Alpha Microglobulin-1 Compared To Fetal Fibronectin In Symptomatic Preterm Delivery, Gul Abbas Awchi, Ayla Ghalib

Iraqi Postgraduate Medical Journal

BACKGROUND: Placental alpha microglobulin-1 (PAMG-1) is an important biomarker for the detection of preterm labor and premature rupture of fetal membrane, also fetal fibronectin leak observed into the vagina if                        a preterm delivery is likely to occur and can be measured by a screening test. OBJECTIVE: To compare the rapid bedside test for (placental alpha microglobulin-1) with the instrumented fetal fibronectin test for prediction of imminent spontaneous preterm delivery among women with symptoms of preterm labor. PATIENT AND METHODS: A prospective observational study, it included 86 pregnant women between 24 – 35 weeks of gestation with singleton pregnancy, viable fetus, …

Assessment Of Knowledge And Attitudes Of Medical Students On Tuberculosis, Arwa Abbas, Salam Mohammed

Iraqi Postgraduate Medical Journal

BACKGROUND: Tuberculosis is one of the most common communicable diseases world wild and continues to be a major global health problem. It causes disease among millions of people each year, and, after HIV, it ranks as the second leading cause of death from an infectious disease worldwide. TB is a public health priority in Iraq. A report published by the World Health Organization highlighted ' the value of undergraduate tuberculosis training and outlined a systematic educational plan to ensure that students are provided with the necessary knowledge, skills, and attitudes essential to the effective management of tuberculosis. AIM OF STUDY: …

The Indonesian Strategy To Achieve Universal Health Coverage Through National Health Insurance System: Challenges In Human Resources, Atikah Adyas

Kesmas

Many countries are currently trying to achieve universal health insurance coverage in order to provide health protection for their population. Indonesia has received a strong political commitment to implement national health insurance including government support to finance the poor. The implementation of comprehensive national health insurance requires human resources, each of which has a role in fighting for noble goals for the welfare of all people. This paper is taken from the experience of Indonesia and several other countries as well as guidelines that can be used in exploring the role of human resources for the success of the implementation …

The Covid-19 Pandemic: Role Of Coping Humor And Internal Health Locus Of Control On Social Dysfunction And Anxiety & Depression, Muhammad Arief Sumantri, Zahrani Zahrani, Hilda Rosa Ainiyah, Azmul Fuady Idham

Kesmas

The concerns about the impact of social distancing on mental health have been widely discussed. This study aimed to know the predictive effect of coping humor and Internal Health Locus of Control (Internal HLoC) on social dysfunction and anxiety & depression during the implementation of the COVID-19 social distancing agenda. This study was also intended to assess the effect of humor content on coping humor. A quantitative approach was used as the method ofthe study with 243 online-recruited participants, and a PLS-SEM analysis was applied to find out the predictive effect in this study. The results and conclusions showed that …

Integrated Model Of A Family Approach And Local Support In Tuberculosis Case Finding Efforts In People With Hiv/Aids, Erni Astutik, Chatarina Umbul Wahyuni, Imelda F E Manurung, Geofrey Ssekalembe

Kesmas

The human immunodeficiency virus (HIV) remains a major global public health problem. People with HIV/acquired immune deficiency syndrome (AIDS) are more susceptible to opportunistic infections such as tuberculosis (TB). Therefore, families and community leaders need to help monitor people living with HIV/AIDS (PLWHA). This study aimed to analyze an integrated family approach and local support model to detect TB cases in PLWHA. This study used a case-control study in Kupang City, East Nusa Tenggara Province, in July 2020. The sample comprised 100 people (50 PLWHA with TB case and 50 controls) using total sampling and random sampling, respectively. The variables …

Predictors Of The Covid-19 Social Distancing Practice Among Undergraduate Health Students In Samarinda City, Indonesia: A Cross-Sectional Study, Siti Hadijah Aspan, Pramon Viwattanakulvanid

Kesmas

Social distancing is a health protocol recommended by the World Health Organization (WHO) for reducing the spread of COVID-19. Undergraduate health students play an important role in the dissemination of accurate information. This study identified predictors that influenced the COVID-19 social distancing practice and examined the sources of social distancing information among undergraduate health students in Samarinda City, Indonesia. This cross-sectionalonline survey study (March-April 2021) involved 422 undergraduate students from medicine, public health, and pharmacy faculties at Mulawarman University. Binary logistic regression was conducted to identify factors associated with the COVID-19 social distancing practice. The results showed that age (AOR …

The Seroprevalence Of Toxoplasma Gondii In Cats At The House Of Maternal Women With Toxoplasmosis In Badung, Indonesia, Made Subrata, Nyoman Mantik Astawa, Nyoman Tigeh Suryadi, Sang Gede Purnama, Kadek Karang Agustina, Ngakan Putu Anom Harjana, Made Damriyasa

Kesmas

Toxoplasmosis is a zoonotic disease caused by infection with the parasite called Toxoplasma gondii (T. gondii). The health and social impacts of the infectionare enormous, including miscarriage, hydrocephalus, blindness, and mental retardation. The occurrence of toxoplasmosis in maternal women cannot be se parated from cats around their houses. This study aimed to determine the seroprevalence of the parasite in cats found in the human carriers residences and identify the risk factors of toxoplasmosis in maternal women in Badung District, Bali Province, Indonesia. A total of 80 cat serum samples were obtained from two residential groups, 40 from the housing where …

How Risky People Of Getting Covid-19 Based On Their Daily Activities?, Fajar Ariyanti, Mustakim Mustakim, Moch T A Al Ayubi, Desty Pratiwi Marlisman

Kesmas

In Indonesia at the end of 2020, COVID-19 cases were increasing and predicted to continue, as it had not yet passed the peak of the pandemic curve. The government had implemented mobility restrictions to reduce exposure to COVID-19. This study aimed to identify the risk of people getting COVID-19 based on their daily activities. Using a cross-sectional design, this study took 315 respondents under non-probability sampling from September to October 2020. Thedata were analyzed using the Chi-square test with α 0.05. This study showed that the risk percentage of people infected with COVID-19 based on their daily activities was 15.56% …

National Council Licensure Examination For Registered Nurses (Nclex-Rn®) Success: Perceptions Of Accelerated Second-Degree Bachelor Of Science In Nursing Students, Vicki L. Brzoza

Dissertations

Most of the 50 states in the United States (U.S.) will experience a significant nursing shortage by the year 2030. Research finds that a bachelor of science in nursing (BSN) workforce is associated with better outcomes, fewer adverse events, and lower patient mortality than associate or diploma prepared nurses. BSN-prepared nurses are in great demand, and the accelerated second-degree bachelor of science in nursing (ABSN) programs may meet this need. This study investigates how to be successful in these ABSN programs. The purpose of this study was to describe the ABSN students' perceptions and experiences of what they believe to …

How Do Genetic Relatedness And Spatial Proximity Shape African Swine Fever Infections In Wild Boar?, Tomasz Podgórski, Kim M. Pepin, Anna Radko, Angelika Podbielska, Magdalena Łyjak, Grzegorz Woźniakowski, Tomasz Borowik

United States Department of Agriculture Wildlife Services: Staff Publications

The importance of social and spatial structuring of wildlife populations for disease spread, though widely recognized, is still poorly understood in many host-pathogen systems. In particular, system-specific kin relationships among hosts can create contact heterogeneities and differential disease transmission rates. Here, we investigate how distance-dependent infection risk is influenced by genetic relatedness in a novel host-pathogen system: wild boar (Sus scrofa) and African swine fever (ASF).We hypothesized that infection risk would correlate positively with proximity and relatedness to ASF-infected individuals but expected those relationships to weaken with the distance between individuals due to decay in contact rates and …

Active And Covert Infections Of Cricket Iridovirus And Acheta Domesticus Densovirus In Reared Gryllodes Sigillatus Crickets, Scott K. Sakaluk, Kristin Duffield, John Hunt, Ben M. Sadd, Brenda Oppert, José L. Ramirez, Karyna Rosario, Robert W. Behle

Faculty Publications – Biological Sciences

Interest in developing food, feed, and other useful products from farmed insects has gained remarkable momentum in the past decade. Crickets are an especially popular group of farmed insects due to their nutritional quality, ease of rearing, and utility. However, production of crickets as an emerging commodity has been severely impacted by entomopathogenic infections, about which we know little. Here, we identified and characterized an unknown entomopathogen causing mass mortality in a lab-reared population of Gryllodes sigillatus crickets, a species used as an alternative to the popular Acheta domesticus due to its claimed tolerance to prevalent entomopathogenic viruses. Microdissection of …

Outer Surface Protein C Typing Of Borrelia Burgdorferi In The Tick Populations Of The Upper Susquehanna River Basin, New York, Neha Shaikh, Emilie Ernst, Ariel S. Makower, Christine M. Hurley, Ralph M. Garruto, Michel Shamoon-Pour

Binghamton University Undergraduate Journal

Lyme disease, the most common zoonotic disease in the United States, is caused by the spirochete Borrelia burgdorferi. In order to manage and confront the notable rise in Lyme disease cases, it is crucial to cultivate a deeper understanding of B. burgdorferi and its genes. The outer surface protein C (ospC) gene is highly polymorphic and commonly used as a genetic marker due to its crucial role in establishing mammalian infection. We report novel data on the prevalence of B. burgdorferi ospC genotypes in the infected tick populations of the Upper Susquehanna River Basin of New York …

Repairing Medical Equipment In Times Of Pandemic, Ofer Tur-Sinai, Leah Chan Grinvald

Seton Hall Law Review

No abstract provided.

A Seventeenth-Century Air History In Conversation With Antony And Cleopatra, Laura S. Deluca

Binghamton University Undergraduate Journal

This article works to unpack the recurrences of air-related language utilized in Shakespeare’s Antony and Cleopatra. Throughout this play, the notions of breath, wind, air, and vapor are consistently referenced, demonstrating the way in which atmospheric intangibility was a key point of exploration for contemporary scientists and philosophers. Through this analysis, it is clear that Shakespeare employs breath in three ways: the breath of (public) life, a lack of breath, and, most importantly, breath as a symbol of power and autonomy, which at times overlaps with the breath of life in ways that demonstrate contemporary conceptualizations of living beings. The …

Nutrition, Atherosclerosis, Arterial Imaging, Cardiovascular Risk Stratification, And Manifestations In Covid-19 Framework: A Narrative Review., Smiksha Munjral, Puneet Ahluwalia, Ankush D Jamthikar, Anudeep Puvvula, Luca Saba, Gavino Faa, Inder M Singh, Paramjit S Chadha, Monika Turk, Amer M Johri, Narendra N Khanna, Klaudija Viskovic, Sophie Mavrogeni, John R Laird, Gyan Pareek, Martin Miner, David W Sobel, Antonella Balestrieri, Petros P Sfikakis, George Tsoulfas, Athanasios Protogerou, Prasanna Misra, Vikas Agarwal, George D Kitas, Raghu Kolluri, Jagjit Teji, Mustafa Al-Maini, Surinder K Dhanjil, Meyypan Sockalingam, Ajit Saxena, Aditya Sharma, Vijay Rathore, Mostafa Fatemi, Azra Alizad, Vijay Viswanathan, P K Krishnan, Tomaz Omerzu, Subbaram Naidu, Andrew Nicolaides, Jasjit S Suri

Heart and Vascular Articles

Background: Atherosclerosis is the primary cause of the cardiovascular disease (CVD). Several risk factors lead to atherosclerosis, and altered nutrition is one among those. Nutrition has been ignored quite often in the process of CVD risk assessment. Altered nutrition along with carotid ultrasound imaging-driven atherosclerotic plaque features can help in understanding and banishing the problems associated with the late diagnosis of CVD. Artificial intelligence (AI) is another promisingly adopted technology for CVD risk assessment and management. Therefore, we hypothesize that the risk of atherosclerotic CVD can be accurately monitored using carotid ultrasound imaging, predicted using AI-based algorithms, and reduced …

Pharmacist-Directed Vancomycin Therapeutic Drug Monitoring In Pediatric Patients: A Collaborative-Practice Model, Kashif Hussain, Rahila Ikram, Gul Ambreen, Muhammad Sohail Salat

Department of Biological & Biomedical Sciences

Background: Therapeutic drug monitoring (TDM) of Vancomycin (VCM) is required to prevent inappropriate dosage-associated bacterial resistance, therapeutic failure, and toxicities in pediatrics. Anecdotal experience and studies show that many healthcare institutions confront barriers while implementing TDM services, this study aimed to assess a pharmacist-directed VCM-TDM service for optimizing patient care in our institution.
Materials and methods: Patients aged 1 month-18 years who received intravenous VCM were included in this quasi-experimental study. The pre-implementation phase (March-June 2018) consisted of retrospective assessment of pediatric patients, the interventional phase (July 2018 to February 2020) included educational programs and the post-implementation phase (March-June 2020) …