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Modeling Of Covid-19 Utilizing Various Compartmental Models To Predict Infection Rates Throughout Michigan, Colleen M. Staniszewski

Honors Theses

Compartmental modeling is a method of employing math to create a visual representation of a disease interacting with a select population, typically used in epidemiology analyses. This project applies compartmental modeling equations to data collected on the various aspects of COVID-19 in Michigan. Comparing current data to past predictive models, as well as the visual representations that were developed through the various compartmental modeling methods, allows an assessment of the effects of the preventative measures taken by the state, the various rates at which the infection is able to spread, as well as the potential path and spread of the …

Presence Of Antibody-Dependent Cellular Cytotoxicity (Adcc) Against Sars-Cov-2 In Covid-19 Plasma, For Yue Tso, Salum J. Lidenge, Lisa K. Poppe, Phoebe B. Pena, Sara R. Privatt, Sydney J. Bennett, John R. Ngowi, Julius Mwaiselage, Michael Belshan, Jacob A. Siedlik, Morgan A. Raine, Juan B. Ochoa, Julia Garcia-Diaz, Bobby Nossaman, Lyndsey Buckner, W Mark Roberts, Matthew J. Dean, Augusto C. Ochoa, John T. West, Charles Wood

Nebraska Center for Virology: Faculty Publications

Background Neutralizing-antibody (nAb) is the major focus of most ongoing COVID-19 vaccine trials. However, nAb response against SARS-CoV-2, when present, decays rapidly. Given the myriad roles of antibodies in immune responses, it is possible that antibodies could also mediate protection against SARS-CoV-2 via effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), which we sought to explore here. Methods Plasma of 3 uninfected controls and 20 subjects exposed to, or recovering from, SARS CoV-2 infection were collected from U.S. and sub-Saharan Africa. Immunofluorescence assay was used to detect the presence of SARS-CoV-2 specific IgG antibodies in the plasma samples. SARS-CoV-2 specific …

Drug Repurposing For Next-Generation Combination Therapies Against Multidrug-Resistant Bacteria, Yuan Liu, Ziwen Tong, Jingru Shi, Ruichao Li, Mathew Upton, Zhiqiang Wang

School of Biomedical Sciences

No abstract provided.

Time Series Forecasting Using Tree Based Methods, El Houssainy A. Rady, Haitham Fawzy, Amal Mohamed Abdel Fattah

Journal of Statistics Applications & Probability

This paper aims to use the tree-based methods for time series data forecasting and compare between Decision Tree (DT), Random Forest (RF), Gradient Boosted Trees (GBT) and ARIMA model to predict monthly gold prices. The time series data for the monthly gold prices was used during the period from Nov-1989 to Dec-2019, which represents 362 observations. ARIMA, DT, RF, and GBT models were fitted based on 90% of data as training set. Then, their accuracy was compared using the statistical measure RMSE. The results indicated that RF was better than DT, GBT and ARIMA (0,1,1) in predicting future gold prices, …

2021-03-03_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

March 3, 2021 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

An Update On The Leading Covid-19 Vaccines, Ahmed A. Eladely, Javaria Anwer Mbbs, Ashwini Gotimukul Mbbs, Manish Kc Mbbs, Jessica Petrey Msls, Alex Glynn Ma, Ruth M. Carrico Phd, Dnp, Julio A. Ramirez Md

The University of Louisville Journal of Respiratory Infections

We reviewed the COVID-19 vaccines that reached phase III of clinical development. For each of the 10 vaccines identified, we described the technology used for vaccine development, the available data from phase III clinical trials, data on vaccine safety, and the role of new SARS-CoV-2 variants on vaccine efficacy.

A Surgical Ppe Task Force Can Improve Ppe Selection During A Covid-19 Pandemic, Rosemary Pine, Daphny Peneza, Mary Margaret Evans

Creating Healthy Work Environments (CHWE)

The impact of the Surgical Services Task Force on the front line staff caring for patients with COVID-19 was studied. The purpose of this project was to ensure safety of front line staff and confirm the positive effect of having a trained observer who can assist with donning and doffing.

The Missouri Miner, March 3, 2021

The Missouri Miner Newspaper

No abstract provided.

Bridging The Gap: Using Reservoir Ecology And Human Serosurveys To Estimate Lassa Virus Spillover In West Africa, Andrew J. Basinski, Elisabeth Fichet-Calvet, Anna R. Sjodin, Tanner J. Varrelman, Christopher H. Remien, Nathan C. Layman, Brian H. Bird, David J. Wolking, Corina Monagin, Bruno M. Ghersi, Peter A. Barry, Michael A. Jarvis, Paul E. Gessler, Scott L. Nuismer

School of Biomedical Sciences

Forecasting the risk of pathogen spillover from reservoir populations of wild or domestic animals is essential for the effective deployment of interventions such as wildlife vaccination or culling. Due to the sporadic nature of spillover events and limited availability of data, developing and validating robust, spatially explicit, predictions is challenging. Recent efforts have begun to make progress in this direction by capitalizing on machine learning methodologies. An important weakness of existing approaches, however, is that they generally rely on combining human and reservoir infection data during the training process and thus conflate risk attributable to the prevalence of the pathogen …

Research Metric Analysis Of The Aga Khan University Medical College, Karachi On Scopus Database 2010-2019, Muhammad Yousuf Ali Mr, Peter Gatiti, Ikram Ul Haq

Library Philosophy and Practice (e-journal)

This paper analysis the research output of the faculty, staff and researchers affiliated to the Aga Khan University (AKU) Medical College, Pakistan from 1st January 2010 to 31st December 2019. The paper maps AKU research by analyzing publications by authors with Aga Khan University institutional affiliation that are indexed in Scopus, a citation database of the peer-reviewed literature. Researchers rely on data from Web of Science, Scopus and Google Scholar to assess scholarly communication. However, this study choose Scopus as it is one of largest multidisciplinary databases covering over 23000 journal titles in comparison to Web of Science which covers …

2021-03-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Mathematics Colloquium | What Is Behavioral Epidemiology And What Does Math Have To Do With It? March 17, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Covid-19 Newsletter (Vol. 61), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Prediction Of Obstructive Sleep Apnea Using Fast Fourier Transform Of Overnight Breath Recordings, Nicole L. Molin, Clifford Molin, Rohan J. Dalpatadu, Ashok K. Singh

Mathematical Sciences Faculty Research

The objective of this study is to address the problem of predicting the risk of obstructive sleep apnea (OSA) from overnight breath recordings collected by a subject using a smartphone or an iPhone. The dataset used in this study was collected at a health care facility and consists of breathing amplitudes of 42 subjects using the smart phone App ZeeAppnea. A total of four data mining multi-level classifiers are used on the Fast Fourier Transform (FFT) of each time series, and prediction accuracies are computed. The Random Forest (RF) and the Support Vector Machine (SVM) classifiers yielded the best results, …

Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Aortic Occlusion: A Case Report, Artem Minalyan, Franklin L. Thelmo, Vincent Chan, Stephanie Tzarnas, Faizan Ahmed

Department of Medicine Faculty Papers

Background: Severe acute respiratory syndrome coronavirus 2 infection can lead to a constellation of viral and immune symptoms called coronavirus disease 2019. Emerging literature increasingly supports the premise that severe acute respiratory syndrome coronavirus 2 promotes a prothrombotic milieu. However, to date there have been no reports of acute aortic occlusion, itself a rare phenomenon. We report a case of fatal acute aortic occlusion in a patient with coronavirus disease 2019.

Case report: A 59-year-old Caucasian male with past medical history of peripheral vascular disease presented to the emergency department for evaluation of shortness of breath, fevers, and dry cough. …

Charting A Different Course, Nadia Schadlow

The US Army War College Quarterly: Parameters

No abstract provided.

Brucella Melitensis-Induced Transaminitis., Rajesh Essrani Md, Anastasia Shnitser Md

Department of Medicine

Brucellosis is infrequently reported in the United States and is mostly an occupational hazard among workers engaged in livestock raising and processing. It is a systemic infectious disease and can involve the liver in varying ways, ranging from benign subclinical increases in serum aminotransferase levels to ominous chronic suppurative disease. It is endemic in many countries, primarily those of the Mediterranean region. It is usually treated with antibiotics. We present a case of a 37-year-old female who developed

Sars-Cov-2 Antibodies Detected In Human Breast Milk Postvaccination, Jill K. Baird, Shawn M. Jensen, Walter Urba, Bernard A Fox, Jason R Baird

Articles, Abstracts, and Reports

Importance The SARS-CoV-2 pandemic has infected over a hundred million people worldwide, with almost 2.5 million deaths at the date of this publication. In the United States, Pfizer-BioNTech and Moderna vaccines were first administered to the public starting in December 2020, and no lactating women were included in the initial trials of safety/efficacy. Research on SARS-CoV-2 vaccination in lactating women and the potential transmission of passive immunity to the infant through breast milk is needed to guide patients, clinicians and policy makers during the worldwide effort to curb the spread of this virus.

Objective To determine whether SARS-CoV-2 specific immunoglobins …

Tuberculosis And Non-Communicable Disease Multimorbidity: An Analysis Of The World Health Survey In 48 Low- And Middle-Income Countries, Brendon Stubbs, Kamran Siddiqi, Helen Elsey, Najma Siddiqi, Ruimin Ma, Eugenia Romano, Sameen Siddiqi, Ai Koyanagi

Community Health Sciences

Tuberculosis (TB) is a leading cause of mortality in low- and middle-income countries (LMICs). TB multimorbidity [TB and ≥1 non-communicable diseases (NCDs)] is common, but studies are sparse. Cross-sectional, community-based data including adults from 21 low-income countries and 27 middle-income countries were utilized from the World Health Survey. Associations between 9 NCDs and TB were assessed with multivariable logistic regression analysis. Years lived with disability (YLDs) were calculated using disability weights provided by the 2017 Global Burden of Disease Study. Eight out of 9 NCDs (all except visual impairment) were associated with TB (odds ratio (OR) ranging from 1.38-4.0). Prevalence …

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Against the Grain

No abstract provided.

Discovery Of Clioquinol And Analogues As Novel Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Ace2 And Ace2 - Spike Protein Interaction In Vitro, Omonike A. Olaleye, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi

Faculty Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) approved drug, and two of its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); and 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) as potent inhibitors of SARS-CoV-2 infection-induced cytopathic effect in vitro. In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin-converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 …

Wofford Today Spring 2021, Wofford College. Office Of Marketing And Communications

Wofford Today

No abstract provided.

Wellness Through Answers News V36:No.2 March-April 2021, Wendy Urciuoli

Articles - Patient Care

No abstract provided.

Wellness Through Answers News V36:No.2 March-April 2021, Wendy Urciuoli

Articles - Patient Care

No abstract provided.

Artificial Intelligence Based Point-Of-Care Test Device For Urinary Dipstick Analysis For Urinary Tract Infection, Huchegowda R, Huchegowda C

Manipal Journal of Pharmaceutical Sciences

No abstract provided.

Assessment Of Knowledge, Attitude And Perception Of Medical And Pharmd Students Towards Antimicrobial Stewardship, Shivakumar M, Amal Balakrishnakurup K. Jintu

Manipal Journal of Pharmaceutical Sciences

No abstract provided.

A Review On The Correlation Of Traditional Plants Used For Antiviral Therapy As A Possible Treatment For Covid-19, Sonal D. S, Shahin H. D, Pallavi K, Nishmitha G. Dsouza, Biju P, Mohammad Asif Iqbal C, Mohammad Gulzar Ahmed

Manipal Journal of Pharmaceutical Sciences

No abstract provided.

Gene Variants Of Coagulation Related Proteins That Interact With Sars-Cov-2, David Holcomb, Aikaterini Alexaki, Nancy Hernandez, Ryan Hunt, Jacob Kames, Nobuko Hamasaki-Katagiri, Anton A. Komar, Michael Dicuccio, Chava Kimchi-Sarfaty

Biological, Geological, and Environmental Faculty Publications

Increased blood clotting, especially in the lungs, is a common complication of COVID-19. Infectious diseases cause inflammation, which in turn can contribute to increased blood clotting. However, the extent of clot formation that is seen in the lungs of COVID-19 patients suggests that there may be a more direct link. We identified three human proteins that are involved indirectly in the blood clotting cascade and have been shown to interact with proteins of SARS virus, which is closely related to the novel coronavirus. We examined computationally the interaction of these human proteins with the viral proteins. We looked for genetic …

Dynamics Behaviors Of A Hybrid Switching Epidemic Model With Le ́Vy Noise, Amine El Koufi, Abdelkrim Bennar, Noura Yousfi

Applied Mathematics & Information Sciences

The present paper investigates the dynamical behaviors of a stochastic SIRS epidemic model with telegraphic noise and Le ́vy noise. First, we establish the existence of a unique global positive solution for stochastic model. Furthermore, by constructing some suitable Lyapunov functions, we show that if R0 ≤ 1 and under some conditions on the parameters, then the solution of stochastic system fluctuates around the disease-free equilibrium, and if R0 > 1 the solution of stochastic system fluctuates around the disease- endemic equilibrium of the deterministic model. Finally, we present numerical simulations to support the theoretical results