Digital Commons Network^™

Introduction: The Future Of Global Health Governance, Elizabeth Weeks, Anish Patel

Georgia Journal of International & Comparative Law

No abstract provided.

Racial Disparities In Healthcare: A Problem Due To Systemic Racism, Serah Ombongi

Alfie Scholars Conferences

We should make great efforts to achieve equal treatment in  the  healthcare sector despite the  color, gender, and  socio-economy of a person.  With the ongoing high cases, the COVID-19 pandemic has further revealed the racial inequality that  has been in existence  in the health care system for such a long time, the history of health inequality, and the statistical data relating to the population and particular groups affected. I will tell my  experience at the start as a healthcare worker with some of  the  feedback I have gotten from people from these affected communities, and I will provide the reasons …

How Many More Covid Variants Will We See?, Matt Windsor

Browse All News

No abstract provided.

Antifungal Efficacy Of Redox‐Active Natamycin Against Some Foodborne Fungi—Comparison With Aspergillus Fumigatus, Jong H. Kim, Christina C. Tam, Kathleen L. Chan, Luisa W. Cheng, Kirkwood M. Land, Mendel Friedman, Perng-Kuang Chang

Pacific Faculty Work

The fungal antioxidant system is one of the targets of the redox‐active polyene antifungal drugs, including amphotericin B (AMB), nystatin (NYS), and natamycin (NAT). Besides medical applications, NAT has been used in industry for preserving foods and crops. In this study, we investigated two parameters (pH and food ingredients) affecting NAT efficacy. In the human patho-gen, Aspergillus fumigatus, NAT (2 to 16 μg mL⁻¹) exerted higher activity at pH 5.6 than at pH 3.5 on a defined medium. In contrast, NAT exhibited higher activity at pH 3.5 than at pH 5.6 against food-borne fungal contaminants, Aspergillus flavus, Aspergillus …

Protection Levels Of N95-Level Respirator Substitutes Proposed During The Covid-19 Pandemic: Safety Concerns And Quantitative Evaluation Procedures, David Ballard, Alex Scott, Broc Burke, Jason Morris, Connie Gan, Jesse Hu, Udayabhanu Jammalamadaka, Sena Sayood, Stephen Liang, Bruno Maranhao, J. Tyler Bertroche, Nirah Shomer, Pamela Woodard, Kathleen Meacham, Et Al

Open Access Publications

OBJECTIVE: The COVID-19 pandemic has precipitated widespread shortages of filtering facepiece respirators (FFRs) and the creation and sharing of proposed substitutes (novel designs, repurposed materials) with limited testing against regulatory standards. We aimed to categorically test the efficacy and fit of potential N95 respirator substitutes using protocols that can be replicated in university laboratories.

SETTING: Academic medical centre with occupational health-supervised fit testing along with laboratory studies.

PARTICIPANTS: Seven adult volunteers who passed quantitative fit testing for small-sized (n=2) and regular-sized (n=5) commercial N95 respirators.

METHODS: Five open-source potential N95 respirator substitutes were evaluated and compared with commercial National Institute …

Global Respiratory Syncytial Virus-Related Infant Community Deaths, Natalie I. Mazur, Yvette N. Löwensteyn, Joukje E. Willemsen, Christopher J. Gill, Leah Forman, Lawrence M. Mwananyanda, Dianna M. Blau, Robert F. Breiman, Shabir A. Madhi, Abdul Momin Kazi

Department of Paediatrics and Child Health

Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.
Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed …

Respiratory Syncytial Virus-Associated Mortality Among Young Infants In Karachi, Pakistan: A Prospective Postmortem Surveillance Study, Abdul Momin Kazi, Obianuju G. Aguolu, Waliyah Mughis, Nazia Ahsan, Saima Jamal, Ayub Khan, Hanya M. Qureshi, Inci Yildirim, Fauzia A. Malik, Saad B. Omer

Department of Paediatrics and Child Health

Background: Respiratory syncytial virus (RSV) is an important cause of infant morbidity and mortality and a potential target for maternal immunization strategies. However, data on the role of RSV in young infant deaths in developing countries are limited.
Methods: We conducted a community-based mortality surveillance from August 2018-March 2020 for infants ≤6 months in Karachi, Pakistan. We tested (reverse transcription-polymerase chain reaction) nasopharyngeal swabs from deceased infants for presence of RSV. We performed verbal autopsies and calculated odds of RSV-associated mortality with 95% CIs and used multivariable logistic regression to evaluate associations.
Results: We collected 490 nasopharyngeal specimens from 1280 …

Genome Assemblies Across The Diverse Evolutionary Spectrum Of Leishmania Protozoan Parasites, Wesley C. Warren, Natalia S. Akopyants, Deborah E. Dobson, Christiane Hertz-Fowler, Lon-Fye Lye, Peter J. Myler, Gowthaman Ramasamy, Achchuthan Shanmugasundram, Fatima Silva-Franco, Sascha Steinbiss, Chad Tomlinson, Richard K. Wilson, Stephen M. Beverley

2020-Current year OA Pubs

We report the high-quality draft assemblies and gene annotations for 13 species and/or strains of the protozoan parasite genera

Challenges Of Assessing Community Mortality Due To Respiratory Viruses In Children Aged Less Than 5 Years, Mauricio T. Caballero, Ashish Satav, Christopher J. Gill, Saad B. Omer, Rachel C. Pieciak, Abdul Momin Kazi, Eric Af Simões, Fernando P. Polack

Department of Paediatrics and Child Health

Background: Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality due to the virus in developing countries is important.
Objective: Our aim in this study was to describe the obstacles, gaps, and challenges that investigators face in low-income, vulnerable regions in 4 developing countries on 3 continents.
Results: The main obstacles and challenges of ascertaining community mortality due to RSV …

Practical Pearl: Sexually Transmitted Infections - Sept. 2021, Paula Braverman Md

Pediatrics Practical Pearls: Referral Guidelines for Common Problems

No abstract provided.

We Are...Marshall, September 1, 2021, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Illegal Wildlife Trade In China, Anna Mcconkie

Ballard Brief

International wildlife trafficking has become a low-risk. high-return illegal trade. China is a top demand country for wildlife products, and the current level of demand is both detrimental and unsustainable. Demand for wildlife in traditional Chinese medicine and as status symbols and investments, high profitability for supplying parties, complex and corrupt trafficking structures, and ineffective government policies and enforcement all contribute to the problem of wildlife trafficking. In addition to biodiversity loss, illegal wildlife trafficking provides funding for militant groups and introduces zoonotic diseases. One way to reduce demand is through targeted consumer campaigns that educate the public on problems …

Trajectories Of Covid-19 Vaccine Intentions Among Us Adults: The Role Of Race And Ethnicity, Michael D. Niño, Brittany N. Hearne, Tianji Cai

Sociology and Criminology Faculty Publications and Presentations

Research examining whether intentions to get a COVID-19 vaccine change over time is scarce. Moreover, the deep and pervasive history of medical racism in the U.S. has created a context in which some racial and ethnic groups exhibit greater levels of COVID-19 vaccine hesitancy; yet few researchers have attempted to determine whether these patterns persist with time. The purpose of this study was twofold: (a.) assess the role of time in COVID-19 vaccine intentions from April 2020 to January 2021, and (b.) examine whether race and ethnicity shape COVID-19 vaccine intention trajectories. Data were drawn from 9 waves of the …

Incidence Of Yersinia Enterocolitica In Raw Farm And Market Milk Sample, Marwa Eltoukhy, Mohammed El-Sayed, Aisha Shoeib

Mansoura Veterinary Medical Journal

Objectives: This study was applied to investigate the incidence of Yersinia enterocolitica in raw farm and market milk and studying the quality drawbacks which might happen in milk as a result of its existence. Design: Observation study. Samples:Onehundred raw milk samples. Procedures: Fifty bulk tank milk (BTM), 25 individual milk & 25 market milk samples were collected from various dairy farms and supermarkets in Dakahlia Governorate, Egypt. The quality assessment of the samples began with evaluating the milk physical characteristics including color, odor, pH and the titratable acidity that reflected the hygienic quality of milk production on farm levels. Then …

Drug Susceptibility Of Plasmodium Falciparum In Eastern Uganda: A Longitudinal Phenotypic And Genotypic Study, Patrick K. Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, Stephen Orena, Victor Asua, Marvin Duvalsaint, Jennifer Legac, Sevil Chelebieva, Frida G. Ceja, Stephanie A. Rasmussen, Melissa D. Conrad, Samuel L. Nsobya, Ozkan Aydemir, Jeffrey A. Bailey, Brett R. Bayles, Philip J. Rosenthal, Roland A. Cooper

Natural Sciences and Mathematics | Faculty Scholarship

Background: Treatment and control of malaria depends on artemisinin-based combination therapies (ACTs) and is challenged by drug resistance, but thus far resistance to artemisinins and partner drugs has primarily occurred in southeast Asia. The aim of this study was to characterise antimalarial drug susceptibility of Plasmodium falciparum isolates from Tororo and Busia districts in Uganda.

Methods: In this prospective longitudinal study, P falciparum isolates were collected from patients aged 6 months or older presenting at the Tororo District Hospital (Tororo district, a site with relatively low malaria incidence) or Masafu General Hospital (Busia district, a high-incidence site) in eastern Uganda …

Shea Pediatric Leadership Council Commentary: Personal Protective Equipment During Care Of Children With Multisystem Inflammatory Syndrome In Children (Mis-C), Martha L. Muller, Latania K. Logan, Larry K. Kociolek, Judith A. Guzman-Cottrill, Allison H. Bartlett, Joshua K. Schaffzin, Karen A Ravin, Lorry G Rubin, Jason Lake, Carolyn Caughell, Lynn Ramirez-Avila, Shea Pediatric Leadership Council

Pediatrics Research and Scholarship

No abstract provided.

Rsif Pan-Africa Progress Report 2021 - English, Regional Scholarship And Innovation Fund (Rsif)

Rsif Reports and Institutional Documents

Rsif is the first Pan-African Science fund of its kind connecting innovative minds to resources for revolutionary solutions. It is the flagship product of PASET, an initiative led by African governments aimed at building skills of citizens of sub-Saharan Africa countries in the field of applied sciences, engineering, and technology for national economic growth on the continent. Rsif builds sustainable doctoral training, highly advanced research and innovation ecosystems to develop transformative technologies in Africa for economic growth and development. Contributing countries: Benin, Burkina Faso, Côte d’Ivoire, Ghana, Kenya, Mozambique, Nigeria, Rwanda and Senegal have made or are at the final …

Geo 508.01: Fundamentals Of Academic Research, Joel T. Harper

University of Montana Course Syllabi

No abstract provided.

Anty 210n.01: Introduction To Physical Anthropology, Randall Royce Skelton

University of Montana Course Syllabi

No abstract provided.

This Red Line Goes Straight To Your Heart By Madhur Anand, Rita Kaur Dhamoon

The Goose

Review of Madhur Anand's This Red Line Goes Straight to Your Heart

Scaup Depredation On Arkansas Baitfish And Sportfish Aquaculture, Stephen A. Clements, Brian S. Dorr, J. Brian Davis, Luke A. Roy, Carole R. Engle, Katie Hanson-Dorr, Anita M. Kelly

United States Department of Agriculture Wildlife Services: Staff Publications

Lesser scaup (Aythya affinis) and greater scaup (A. marila), hereafter scaup, consume a variety of aquatic invertebrates, plants, and occasionally small fish. Scaup have foraged on commercial aquaculture farms in the southern United States for decades. However, the types, abundance, and rate of fish exploitation by scaup on baitfish and sportfish farms are not well documented. Thus, information is needed to understand how fish and other foods influence scaup use of aquatic resources, and any potential economic effects of depredation of fish. From November–March in winters 2016–2017 and 2017–2018, we conducted 1,458 pond surveys to …

In Situ Imaging Of Bacterial Outer Membrane Projections And Associated Protein Complexes Using Electron Cryo-Tomography, Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R. Wood, Catherine M. Oikonomou, William J. Nicolas, Poorna Subramanian, Lori A. Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J. Dobro, Yongtao Zhu, Mark J. Mcbride, Ariane Briegel, Carrie L. Shaffer, Grant J. Jensen

Veterinary Science Faculty Publications

The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria. Despite this, our knowledge of the ultrastructure of these extensions and their associated protein complexes remains limited. Here, we surveyed the ultrastructure and formation of MEs and MVs, and their associated protein complexes, in tens of thousands of electron cryo-tomograms of ~90 bacterial species that we have collected for various projects over the past 15 years (Jensen lab database), in addition to data generated in the Briegel lab. We identified outer MEs and MVs …

Improving Skin And Soft Tissue Antibiotic Duration Concordance With National Guidelines In Pediatric Urgent Care Clinics, Megan Hamner, Amanda Nedved, Holly Austin, Donna Wyly, Alaina N. Burns, Diana King, Brian Lee, Rana El Feghaly

Posters

Introduction: Skin and soft tissue infections (SSTIs) are the second most common diagnosis leading to pediatric antibiotic prescriptions in the outpatient setting after respiratory diagnoses. Children with SSTIs often receive >7 days of antibiotics, although current guidelines recommend 5-7 days for most diagnoses. At CMH urgent care clinics (UCCs), only 58% patients received the recommended 5-7 days of antibiotics. We aimed to increase the percentage of patients receiving 5-7 days of oral antibiotics for SSTIs from 58% to 75% by December 31st, 2021. Methods: We formed a multidisciplinary team in April 2020. A provider survey assessed factors influencing prescribing habits. …

2021-September-01-Etsu And Vanderbilt Researchers Continue Partnership To Study Sepsis, University Marketing And Communication, East Tennessee State University

ETSU News

ETSU, Vanderbilt research partnership

JOHNSON CITY, TN – East Tennessee State University and Vanderbilt University Medical Center researchers are continuing a five-year partnership with a $2.1 million National Institutes of Health (NIH) grant to study trained immunity in sepsis.

Drs. David Williams (ETSU Quillen College of Medicine) and Ed Sherwood (Vanderbilt) have been awarded a grant by the NIH National Institute of General Medical Sciences. This competitive renewal grant titled “Training Innate Immunity: A …

Cellular Activity Of Salmonella Typhimurium Artab Toxin And Its Receptor-Binding Subunit, Elise Overgaard, Brad Morris, Omid Mohammad Mousa, Adriana Rodriguez, Leyla Cufurovic, Richard S. Beard, Juliette K. Tinker

Biology Faculty Publications and Presentations

Salmonellosis is among the most reported foodborne illnesses in the United States. The Salmonella enterica Typhimurium DT104 phage type, which is associated with multidrug-resistant disease in humans and animals, possesses an ADP-ribosylating toxin called ArtAB. Full-length artAB has been found on a number of broad-host-range non-typhoidal Salmonella species and serovars. ArtAB is also homologous to many AB₅ toxins from diverse Gram-negative pathogens, including cholera toxin (CT) and pertussis toxin (PT), and may be involved in Salmonella pathogenesis, however, in vitro cellular toxicity of ArtAB has not been characterized. artAB was cloned into E. coli and initially isolated …

Estimation Of Conditional Power For Cluster-Randomized Trials With Interval-Censored Endpoints, Kaitlyn Cook, Rui Wang

Statistical and Data Sciences: Faculty Publications

Cluster-randomized trials (CRTs) of infectious disease preventions often yield correlated, interval-censored data: dependencies may exist between observations from the same cluster, and event occurrence may be assessed only at intermittent study visits. This data structure must be accounted for when conducting interim monitoring and futility assessment for CRTs. In this article, we propose a flexible framework for conditional power estimation when outcomes are correlated and interval-censored. Under the assumption that the survival times follow a shared frailty model, we first characterize the correspondence between the marginal and cluster-conditional survival functions, and then use this relationship to semiparametrically estimate the cluster-specific …

Adherence To Clinical Follow-Up Recommendations For Liver Function Tests: A Cross-Sectional Study Of Patients With Hcv And Their Associated Risk Behaviors, Allison Dormanesh, Judy Huei-Yu Wang, Ranit Mishori, Paula Cupertino, Joshua Longcoy, Seble Kassaye, Linda M. Kaljee, Coleman Smith, Christopher A. Loffredo

Global Health Initiative Articles

This study examined whether patients with Hepatitis C virus (HCV) infection adhered to their physicians' recommendation and HCV clinical guidelines for obtaining a regular liver function test (LFT), and whether high-risk behaviors are associated with behavioral adherence. A cross-sectional survey was administered to 101 eligible patients with HCV who were recruited from health centers in New Jersey and Washington, DC. Adherence outcomes were defined as the patients' self-report of two consecutive receipts of LFTs in accordance with their physicians' recommended interval or the clinical guidelines for a LFT within 3-6 months. 67.4% of patients (66/98) reported a receipt of their …

Mental Health During Covid-19 Pandemic Among Caregivers Of Young Children In Kenya’S Urban Informal Settlements. A Cross-Sectional Telephone Survey, Vibian Angweny, Margaret Kabue, Esther Chongwo, Adam Mabrouk, Ezra Too, Rachel Odhiambo, Carophine Nasambu, Joyce Marangu, Derrick Ssewanyana, Eunice Njoroge, Eunice Ombech, Mercy Mokaya, Emmanuel Obulemire, Anil Khamis, Amina Abubakar

Institute for Human Development, East Africa

The emergence of COVID-19 has profoundly affected mental health, especially among highly vulnerable populations. This study describes mental health issues among caregivers of young children and pregnant women in three urban informal settlements in Kenya during the first pandemic year, and factors associated with poor mental health. A cross-sectional telephone survey was administered to 845 participants. Survey instruments included the Patient Health Questionnaire-9, General Anxiety Disorder-7 scale, COVID-19 Anxiety Scale, and questions on the perceived COVID-19 effects on caregiver wellbeing and livelihood. Data were analyzed using descriptive statistics, and univariate and multivariate analysis. Caregivers perceived COVID-19 as a threatening condition …

More-Than-Human And Deeply Human Perspectives On Covid-19, Elizabeth Lunstrum, Neel Ahuja, Bruce Braun, Rosemary Collard, Patricia J. Lopez, Rebecca W.Y. Wong

Global Studies Faculty Publications and Presentations

This multi-authored contribution explores what the COVID-19 pandemic demands of critical inquiry with a focus on the more-than-human. We show how COVID-19 is a complex series of multispecies encounters shaped by humans, non-human animals, and of course viruses. Central to these encounters is a politics of difference in which certain human lives are protected and helped to flourish while others, both human and animal, are forgotten if not sacrificed. Such difference encompasses practices of racialisation and racism, healthcare austerity, the circulation of capital, border-making, intervention into non-human nature, wildlife trade bans, anthropocentrism, and the exploitation of animal test subjects. The …

Pregnancy And Childbirth Expectations During Covid-19 In A Convenience Sample Of Women In The United States, Tishra Beeson, Amy Claridge, Amie Wojtyna, Debra Rich, Gracie Minks, Adrienne Larson

All Faculty Scholarship for the College of Education and Professional Studies

The COVID-19 pandemic has transformed the health care landscape and shifted individuals’ expectations for and interactions with essential health services, including pregnancy-related care. This study explores alterations to individuals’ pregnancy and childbirth decisions during an infectious disease pandemic. A convenience sample of 380 pregnant individuals with an expected delivery date between April and December 2020 consented to enroll and complete an online questionnaire on their pregnancy and childbirth expectations during the COVID-19 pandemic; a subset of respondents (n = 18) participated in semi-structured phone interviews. Survey data were analyzed quantitatively while interview data were analyzed using a thematic content …