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2021

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The Effects Of Boric Acid Sugar Bait On Wolbachia Trans-Infected Male Aedes Albopictus (Zap Males®) In Laboratory Conditions, Vindhya S. Aryaprema, Whitney A. Qualls, Karen L. Dobson, Stephen L. Dobson, Rui-De Xue Dec 2021

The Effects Of Boric Acid Sugar Bait On Wolbachia Trans-Infected Male Aedes Albopictus (Zap Males®) In Laboratory Conditions, Vindhya S. Aryaprema, Whitney A. Qualls, Karen L. Dobson, Stephen L. Dobson, Rui-De Xue

Entomology Faculty Publications

The field release of Wolbachia trans-infected male mosquitoes, as well as the use of toxic sugar baits, is a novel and promising candidate technique for integrated mosquito management programs. However, the methods of action of the two techniques may not be complementary, because the Wolbachia method releases mosquitoes into the environment expecting a wild population reduction in subsequent generations while the toxic baits are intended to reduce the wild population by killing mosquitoes. This laboratory study was conducted to evaluate the effectiveness of boric acid toxic sugar baits on Wolbachia trans-infected male Aedes albopictus, relative to wild-type Ae. albopictus …


Smallest U.S. Population Growth In History: More Deaths, Fewer Births, And Less Immigration, Kenneth M. Johnson Dec 2021

Smallest U.S. Population Growth In History: More Deaths, Fewer Births, And Less Immigration, Kenneth M. Johnson

Carsey Publications

In this brief, author Kenneth Johnson reports that the U.S. population grew by just 393,000 between July of 2020 and July of 2021 according to new Census Bureau estimates—the lowest rate of annual population gain in history and the smallest numeric gain in more than 100 years. Diminished immigration from abroad contributed, but the driver of this minimal population gain was that there were only 148,000 more births than deaths. This is the smallest natural gain in more than 80 years. COVID-19 played a central role in this small population gain. In addition to 475,000 deaths directly attributable to COVID-19 …


Focus, 2021, Fall, Andrews University Dec 2021

Focus, 2021, Fall, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.


1962 - July 2, Carolyn Brown Dodge Dec 2021

1962 - July 2, Carolyn Brown Dodge

Carolyn Brown Dodge Letters

Carolyn Dodge resided in Ellensburg, Washington, in the Badger Pocket area on a farm with her family and her letters describe her daily life as a farm wife and later as the wife of a potato broker in the Quincy Basin. She also wrote letters to her cousin at her residences in Kittitas and Quincy, Washington, following her time in Ellensburg.


Effects Of A Reminiscence Learning Experience On Registered Nurses' Attitudes Toward And Empathy With Older Adults, William J. Puentes Dec 2021

Effects Of A Reminiscence Learning Experience On Registered Nurses' Attitudes Toward And Empathy With Older Adults, William J. Puentes

Dissertations

Negative attitudes toward older adults are endemic to the nursing profession, as well as society in general. With older adults accounting for an ever increasing proportion of health care services, it is imperative that nurse educators develop continuing education activities that have a positive impact on registered nurses' attitudes toward older adults. The purpose of this study was to evaluate the effects of participation in a reminiscence learning experience (RLE) on registered nurses' attitudes toward and empathy with older adults.


State Of Tennessee Advisory Council On Workers' Compensation, 2021 Summary Of Significant Tennessee Supreme Court Workers' Compensation Decision, Tennessee. Department Of Treasury. Dec 2021

State Of Tennessee Advisory Council On Workers' Compensation, 2021 Summary Of Significant Tennessee Supreme Court Workers' Compensation Decision, Tennessee. Department Of Treasury.

Worker's Compensation Reports

No abstract provided.


Colonial Necrocapitalism, State Secrecy, And The Palestinian Freedom Tunnel, Nadera Shalhoub-Kevorkian, Stephanie Wahab Dec 2021

Colonial Necrocapitalism, State Secrecy, And The Palestinian Freedom Tunnel, Nadera Shalhoub-Kevorkian, Stephanie Wahab

School of Social Work Faculty Publications and Presentations

Secrecy and the use of “secret information” as capital in the hands of the state is mobilised by affective racialised machineries, cultivated on “security” grounds. Securitised secrecy is an assemblage of concealed operations juxtaposing various forms of invasions and dispossessions. It is a central strategy in the politico-economic life of the state to increase its scope of domination. Secrecy is used and abused to entrap and penetrate political subjects and entities. This article explores the necrocapitalist utilisation of secrecy embedded in the coloniser’s attempt to distort the mind of the colonised. Built from the voices of those affected by secrecy’s …


Cross Talk Between Arf1 And Rhoa Coordinates The Formation Of Cytoskeletal Scaffolds During Chlamydia Infection, Adam Haines, Jordan Wesolowski, Nathan M Ryan, Tiago Monteiro-Brás, Fabienne Paumet Dec 2021

Cross Talk Between Arf1 And Rhoa Coordinates The Formation Of Cytoskeletal Scaffolds During Chlamydia Infection, Adam Haines, Jordan Wesolowski, Nathan M Ryan, Tiago Monteiro-Brás, Fabienne Paumet

Department of Microbiology and Immunology Faculty Papers

Chlamydia trachomatis is an obligate intracellular bacterium that has developed sophisticated mechanisms to survive inside its infectious compartment, the inclusion. Notably, Chlamydia weaves an extensive network of microtubules (MTs) and actin filaments to enable interactions with host organelles and enhance its stability. Despite the global health and economic burden caused by this sexually transmitted pathogen, little is known about how actin and MT scaffolds are integrated into an increasingly complex virulence system. Previously, we established that the chlamydial effector InaC interacts with ARF1 to stabilize MTs. We now demonstrate that InaC regulates RhoA to control actin scaffolds. InaC relies on …


Attention Deficit Hyperactivity Disorder And Bipolar Disorder: Diagnosis, Treatments, And Clinical Considerations: A Narrative Review, Amber N. Edinoff, Tucker L. Apgar, Jasmine J. Rogers, Joshua D. Harper, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye Dec 2021

Attention Deficit Hyperactivity Disorder And Bipolar Disorder: Diagnosis, Treatments, And Clinical Considerations: A Narrative Review, Amber N. Edinoff, Tucker L. Apgar, Jasmine J. Rogers, Joshua D. Harper, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

Pacific Faculty Work

Attention-deficit Hyperactivity Disorder is one of the most common childhood mental health disorders, affecting about 5.6% of the population worldwide. Several studies have specifically shown a high prevalence of comorbid mood disorders, such as depression and bipolar disorder (BD), in those diagnosed with ADHD. Several common symptoms of ADHD are also found in BD, which are characterized by alternating periods of euthymia and mood disturbances. The inattention and impulsivity of ADHD can be seen in manic and hypomanic episodes of BD. Over the past decade, there has been an increased interest in research between the correlation of ADHD and pediatric …


Full Issue 15.3 Dec 2021

Full Issue 15.3

Genocide Studies and Prevention: An International Journal

No abstract provided.


Collective Healing To Address Legacies Of Transatlantic Slavery: Opportunities And Challenges, Scherto R. Gill, Garrett Thomson Dec 2021

Collective Healing To Address Legacies Of Transatlantic Slavery: Opportunities And Challenges, Scherto R. Gill, Garrett Thomson

Genocide Studies and Prevention: An International Journal

In this article, we show how pathways to justice and reconciliation pertaining to the transatlantic slavery should begin with collective healing processes. To illustrate this conclusion, we first employ a four-fold conceptual framework for understanding collective healing that consists in: (1) acknowledging historical dehumanizing acts; (2) addressing the harmful effects of dehumanisation; (3) embracing relational rapprochement; and (4) co-imagining and co-creating conditions for systemic justice. Based on this framework, we then examine existing collective healing practices in different contexts that are aimed at addressing legacies of transatlantic slavery. In doing so, we further identify challenges and pose critical questions concerning …


Ongoing Genocides And The Need For Healing: The Cases Of Native And African Americans, Benjamin P. Bowser, Carl O. Word, Kate Shaw Dec 2021

Ongoing Genocides And The Need For Healing: The Cases Of Native And African Americans, Benjamin P. Bowser, Carl O. Word, Kate Shaw

Genocide Studies and Prevention: An International Journal

The elimination of Native peoples and the enslavement of Africans in the U.S. more than qualify as acts of historical state sponsored genocide. A feature of both genocides is that they ended as institutional practices but have continued culturally and psychologically. The primary contemporary legacy of these genocides is racism which reinforces historical trauma and grief. Suggestions are made for how healing for Native and African Americans can begin despite ongoing racism. This includes psychological counseling for White Americans with beliefs in White supremacy. Suggestions are also made for how reconciliation can begin at the county-level between descendants of slave …


A Dance Of Shadows And Fires: Conceptual And Practical Challenges Of Intergenerational Healing After Mass Atrocity, Brandon Hamber, Ingrid Palmary Dec 2021

A Dance Of Shadows And Fires: Conceptual And Practical Challenges Of Intergenerational Healing After Mass Atrocity, Brandon Hamber, Ingrid Palmary

Genocide Studies and Prevention: An International Journal

The legacy of mass atrocity—including colonialism, slavery or specific manifestations such as apartheid—continue long after their demise. Applying a temporal intergenerational lens adds complications. We argue that mass atrocity creates for subsequent generations a deep psychological rupture akin to witnessing past atrocities. This creates a moral liability in the present. Healing is a process dependent on the authenticity (evident in discourse and action) with which we address contemporary problems. A further overriding task is to open social and political space for divergent voices. Acknowledgement of mass atrocity requires more than one-off events or institutional responses (the grand apology, the truth …


Book Review: Are Perpetrators Under-Researched?, Christian Gudehus Dec 2021

Book Review: Are Perpetrators Under-Researched?, Christian Gudehus

Genocide Studies and Prevention: An International Journal

No abstract provided.


Information Seeking Behavior On Youtube's Recommendation System For Undergraduate Students In Surabaya Indonesia, Youngjoon Yang, Edi Dwi Riyanto, Imam Yuadi Dec 2021

Information Seeking Behavior On Youtube's Recommendation System For Undergraduate Students In Surabaya Indonesia, Youngjoon Yang, Edi Dwi Riyanto, Imam Yuadi

Library Philosophy and Practice (e-journal)

YouTube is the most used social media platform in the world where users search for information through various search tools provided. This study aims to analyze the behavior of information-seeking on YouTube among undergraduate students in Surabaya, Indonesia. We examined their information-seeking behavior and its implementation in daily life. We also evaluated the information needs and interests. This research conducted online questionnaires that were sent to undergraduate students from 27 August 2021 to 6 September 2021 and received 143 responses. We then analyzed the data based on the response results and statistics from Google Forms. The results showed that they …


State V. Toledo Respondent's Brief Dckt. 48866 Dec 2021

State V. Toledo Respondent's Brief Dckt. 48866

Not Reported

No abstract provided.


Els In A Michigan 9-12 School: Educators’ Perceptions And Cultural Considerations, Melissa Lynn Dean Dec 2021

Els In A Michigan 9-12 School: Educators’ Perceptions And Cultural Considerations, Melissa Lynn Dean

Masters Theses

This research investigates the perceptions of administrators and specialists in one diversely enrolled Michigan secondary school. Particularly, the purpose was to determine to what extent English learners (ELs), especially those of non-Western backgrounds, are being accommodated and considered by educators and policy. To examine this, three participants were successfully recruited- a language acquisition administrator, a language acquisition specialist, and an assistant principal. They were then each interviewed once to learn of their perceptions and beliefs on these topics. This research finds that although administrators and specialists may be knowledgeable and advocate for their ELs in creative and culturally competent ways, …


Informing Effective Simulation Pedagogy In Nursing Simulation, Sherry L. Barnard Dec 2021

Informing Effective Simulation Pedagogy In Nursing Simulation, Sherry L. Barnard

Dissertations

Simulation methods are now widely used in nursing education programs. Several studies have been conducted that examine the effect of simulation on student outcomes in learning (Alinier, Hunt, Gordon, & Harwood, 2006; Arnold, et al, 2009; Rosen, Salas, Silvestri, Wu, & Lazzara, 2008), however, little has been discovered regarding models of faculty support and guidance during simulation. The factors that influence student learning in the simulation experience suggest faculty be a guide by offering cueing and support before, during, and after the simulation process (Parsh, Roberts, & Green, 2010). It is also suggested that debriefing be non-judgmental and a time …


A Nationally Representative Survey Of Depression Symptoms Among Jordanian Adolescents: Associations With Depression Stigma, Depression Etiological Beliefs, And Likelihood To Seek Help For Depression, Latefa Ali Dardas Dec 2021

A Nationally Representative Survey Of Depression Symptoms Among Jordanian Adolescents: Associations With Depression Stigma, Depression Etiological Beliefs, And Likelihood To Seek Help For Depression, Latefa Ali Dardas

Dissertations

Arab adolescents are considered a particularly vulnerable population to depression. The substantial lack of mental health services and the stigma associated with mental illness on the one hand; and poverty, unemployment, and lack of reasonable hopes for a decent future in the context of corruption of regimes and perceived social injustice on the other, call for establishing committed and effective policies to tackle depression and its associated stigma among Arab adolescents at risk for or diagnosed with depression. However, there is a substantial lack of research that can inform the current profile of adolescent depression in the Arab region. We …


The Health-Related Quality Of Life Of Adults With Down Syndrome, Rebecca Jermyn Graves Dec 2021

The Health-Related Quality Of Life Of Adults With Down Syndrome, Rebecca Jermyn Graves

Dissertations

The purpose of this study was to examine the health-related quality of life (HRQOL) and factors associated with the HRQOL of adults with Down syndrome (DS) as reported by adults with DS and their caregivers. The study was designed to compare measures of HRQOL, health problems, health risks, and health-care utilization of adults with DS based on self-report with those from caregiver-report and to explore associations between HRQOL and health problems, health risks, health-care utilization, adaptive behavior, and demographic characteristics.


Police Use Of Social Media Technologies, Akpomudiare Darlynton Adegor Dec 2021

Police Use Of Social Media Technologies, Akpomudiare Darlynton Adegor

Theses and Dissertations

This study used a qualitative research design to analyze how the Little Rock Police Department (LRPD) utilizes social media technologies to promote its community policing philosophy. I conducted a content analysis on 586 tweets by LRPD and 992 public responses posted between May 2020 and May 2021. From my analysis, I found that LRPD social media platforms support both community policing and problem-solving. LRPD uses social media for interactions, connections, and partnerships with community members. The second notable finding was that the public is responsive and receptive to LRPD’s use of social media to connect with them. However, LRPD’s level …


Simulated Presence Use For Quality Of Life Maintenance And Reduction Of Symptoms Of Distress In Persons Living With Dementia In Long-Term Care, Erin E. Bush Dec 2021

Simulated Presence Use For Quality Of Life Maintenance And Reduction Of Symptoms Of Distress In Persons Living With Dementia In Long-Term Care, Erin E. Bush

Dissertations

Nursing home residents with dementia often have an array of neuropsychiatric symptoms, including dementia-related agitation. It is theorized that many of these agitation symptoms occur due to unmet psychosocial needs that could be met by the presence of a caring nursing staff member, family member, or friend.

The purpose of this study was to determine whether live simulated presence improves dementia-related agitation when offered, identify barriers and facilitators to simulated presence between caregivers and residents of long-term care during the COVID-19 pandemic, and to determine if live simulated presence by a caregiver delivered one-on-one improved quality of life in long-term …


Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet Dec 2021

Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet

Pathology Research and Scholarship

BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.

METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …


Dysregulation Of Dna Methylation And Epigenetic Clocks In Prostate Cancer Among Puerto Rican Men, Anders Berglund, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Raymond Linares, Joshua Marcial, Caren Abreu-Takemura, Natasha Moreno, Ryan Putney, Ratna Chakrabarti, Hui Yi Lin, Kosj Yamoah, Carlos Diaz Osterman, Liang Wang, Jasreman Dhillon, Youngchul Kim, Seung Joon Kim, Gilberto Ruiz-Deya, Jong Y. Park Dec 2021

Dysregulation Of Dna Methylation And Epigenetic Clocks In Prostate Cancer Among Puerto Rican Men, Anders Berglund, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Raymond Linares, Joshua Marcial, Caren Abreu-Takemura, Natasha Moreno, Ryan Putney, Ratna Chakrabarti, Hui Yi Lin, Kosj Yamoah, Carlos Diaz Osterman, Liang Wang, Jasreman Dhillon, Youngchul Kim, Seung Joon Kim, Gilberto Ruiz-Deya, Jong Y. Park

School of Public Health Faculty Publications

In 2021, approximately 248,530 new prostate cancer (PCa) cases are estimated in the United States. Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. The objective of this study was to assess DNA methylation patterns between aggressive and indolent PCa along with ancestry proportions in 49 H/L men from Puerto Rico (PR). Prostate tumors were classified as aggressive (n = 17) and indolent (n = 32) based on the Gleason score. Genomic DNA samples were extracted by macro-dissection. DNA methylation patterns were assessed using the Illumina EPIC DNA methylation platform. We used ADMIXTURE to estimate global ancestry proportions. …


Winter 2021 Dec 2021

Winter 2021

In The Loop

2021 Emmy Nominees; Animator Tapped by Cartoon Network; IndieCade Horizons 2021; Hack4Space; Security Daemons Prevail; Role Models: DePaul Originals Game Studio students build industry-level skills that benefit themselves and others; Frames and Fortune: Eugene Bush programmed his indie video studio with patience and planning; Reality Check: Heather Snyder Quinn augments reality to question systems of unchecked power


The “Ebb And Flow” Of Documentation: Does The Transition Between Two Electronic Medical Records Systems Affect Emergency Department Efficiency?, Michelle Angeline Md, Erica B. Shaver Md, Christopher Kiefer Md, Kimberly D. Quedado Phd, Melinda Sharon, Stephen Davis Phd, Kyle Hurst Md, Christopher S. Goode Md, Thomas C. Marshall Md Dec 2021

The “Ebb And Flow” Of Documentation: Does The Transition Between Two Electronic Medical Records Systems Affect Emergency Department Efficiency?, Michelle Angeline Md, Erica B. Shaver Md, Christopher Kiefer Md, Kimberly D. Quedado Phd, Melinda Sharon, Stephen Davis Phd, Kyle Hurst Md, Christopher S. Goode Md, Thomas C. Marshall Md

Faculty & Staff Scholarship

Background: Electronic Medical Record (EMR) systems are electronic databases for compiling patient records. As healthcare networks expand, it is critical for providers to have access to patient data more broadly. As a result individual healthcare facilities must adjust to enterprise wide EMRs.

Objective: This study examined the operational effects of transitioning from an Emergency Department (ED) specific EMR to an enterprise wide EMR by evaluating throughput metrics in a community ED.

Methods: During a 6-month transition period (July-December 2017) in a community-based, academic ED located in North Central West Virginia, length of stay (LOS) and the following operational metrics were …


Tricuspid Valve Intervention At The Time Of Pulmonary Valve Replacement In Adults With Congenital Heart Disease: A Systematic Review And Meta-Analysis, Jef Van Den Eynde, Connor P Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, Shelby Kutty Dec 2021

Tricuspid Valve Intervention At The Time Of Pulmonary Valve Replacement In Adults With Congenital Heart Disease: A Systematic Review And Meta-Analysis, Jef Van Den Eynde, Connor P Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, Shelby Kutty

Open Access Publications

Background Tricuspid regurgitation (TR) is a common finding in adults with congenital heart disease referred for pulmonary valve replacement (PVR). However, indications for combined valve surgery remain controversial. This study aimed to evaluate early results of concomitant tricuspid valve intervention (TVI) at the time of PVR. Methods and Results Observational studies comparing TVI+PVR and isolated PVR were identified by a systematic search of published research. Random-effects meta-analysis was performed, comparing outcomes between the 2 groups. Six studies involving 749 patients (TVI+PVR, 278 patients; PVR, 471 patients) met the eligibility criteria. In the pooled analysis, both TVI+PVR and PVR reduced TR …


Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction In Nonhuman Primate Tb Granulomas, Bindu Singh, Dhiraj K Singh, Shashank R Ganatra, Ruby A Escobedo, Shabaana Khader, Larry S Schlesinger, Deepak Kaushal, Smriti Mehra Dec 2021

Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction In Nonhuman Primate Tb Granulomas, Bindu Singh, Dhiraj K Singh, Shashank R Ganatra, Ruby A Escobedo, Shabaana Khader, Larry S Schlesinger, Deepak Kaushal, Smriti Mehra

Open Access Publications

Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population comprised of immature myeloid cells and myeloid progenitors with very potent immunosuppressive potential. MDSCs are reported to be abundant in the lungs of active tuberculosis (TB) patients. We sought to perform an in-depth study of MDSCs during latent TB infection (LTBI) and active TB (ATB) using the nonhuman primate (NHP) model of pulmonary TB. We found a higher proportion of granulocytic, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in the lungs of ATB animals compared to those with LTBI or naive control animals. Active disease in the lung, but not LTBI, was …


Ccr2 Signaling Restricts Sars-Cov-2 Infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, Mehul S Suthar Dec 2021

Ccr2 Signaling Restricts Sars-Cov-2 Infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, Mehul S Suthar

Open Access Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current evidence suggests that severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined. Here, we characterize a mouse model of SARS-CoV-2 infection and find that early CCR2 signaling restricts the viral burden in the lung. We find that a recently developed mouse-adapted SARS-CoV-2 (MA-SARS-CoV-2) strain as well as the emerging B.1.351 variant trigger an inflammatory response in the lung characterized by the expression of …


Goals Of Care Documentation: Insights From A Pilot Implementation Study, Marie C. Haverfield, Ariadna Garcia, Karleen F. Giannitrapani, Anne Walling, Joseph Rigdon, David B. Bekelman, Natalie Lo, Lisa S. Lehmann, Josephine Jacobs, Natalia Festa, Karl A. Lorenz Dec 2021

Goals Of Care Documentation: Insights From A Pilot Implementation Study, Marie C. Haverfield, Ariadna Garcia, Karleen F. Giannitrapani, Anne Walling, Joseph Rigdon, David B. Bekelman, Natalie Lo, Lisa S. Lehmann, Josephine Jacobs, Natalia Festa, Karl A. Lorenz

Faculty Research, Scholarly, and Creative Activity

Context
The Life Sustaining Treatment Decision Initiative is a national effort by the Veterans Health Administration to ensure goals of care documentation occurs among all patients at high risk of life-threatening events.
Objectives
Examine likelihood to receive goals of care documentation and explore associations between documentation and perceived patient care experience at the individual and site level.
Methods
Retrospective, quality improvement analysis of initiative pilot data from four geographically diverse Veterans Affairs (VA) sites (Fall 2014-Winter 2016) before national roll-out. Goals of care documentation according to gender, marital status, urban/rural status, race/ethnicity, age, serious health condition, and Care Assessment Needs …