Digital Commons Network^™

Quantification Of The Negative Impact Of Sedation And Inotropic Support On Achieving Early Mobility In Burn Patients In Icu: A Single Center Observational Study, Lauren Bright, Lisa Van Der Lee, Dana Hince, Fiona M. Wood, Dale W. Edgar

IHR Papers and Journal Articles

Introduction: Early rehabilitation for burns survivors in the intensive care unit (ICU) is arguably more challenging than the general population. Early achievement of functional verticality milestones (FVMs) has the potential to ameliorate the detrimental effects of bed rest and immobility observed in ICU patients and reduce healthcare costs. However, the time to achieving FVMs after burn injury is influenced by factors such as sedation practices, cardiovascular stability, mechanical ventilation, acute skin reconstruction and length of stay (LOS) during the acute intensive care period.

Objectives/Aims: The aims of this study were to identify the association between early achievement of FVMs and …

Reducing Hospital Discharges Back Into Homelessness, Jake Turvey, Isaac Wood, Lisa Wood, Amanda Stafford

IHR Papers and Journal Articles

No abstract provided.

Post-Stroke Lateropulsion And Rehabilitation Outcomes: A Retrospective Analysis, Jessica Nolan, Erin Godecke, Katrina Spilsbury, Barbara Singer

IHR Papers and Journal Articles

Purpose: A person with post-stroke lateropulsion actively pushes themselves toward their hemiplegic side, or resists moving onto their non-hemiplegic side. This study aimed to determine the association of lateropulsion severity with: • Change in function (Functional Independence Measure – FIM) and lateropulsion severity (Four-Point Pusher Score – 4PPS) during inpatient rehabilitation; • Inpatient rehabilitation length of stay (LOS); • Discharge destination from inpatient rehabilitation.

Methods: Retrospective data for 1,087 participants (aged ≥65 years) admitted to a stroke rehabilitation unit (2005–2018) were analysed using multivariable regression models.

Results: Complete resolution of lateropulsion was seen in 69.4% of those with mild lateropulsion …

Is There An Association Between The Vaginal Microbiome And First Trimester Miscarriage? A Prospective Observational Study, Monica Shahid, Julie A. Quinlivan, George Mendz, Michael Peek, Natalia Castaño-Rodríguez

IHR Papers and Journal Articles

Aim

To examine whether there are differences in the vaginal microbiome of women who miscarry compared to those who have normal pregnancy outcomes.

Methods

Prospective observational study conducted at the Canberra Hospital, Australia, with 24 participant women in the first trimester of pregnancy. The vaginal microbiomes of the 24 women were characterized using sequencing analysis of the V4 region of the 16S rRNA gene employing an Illumina MiSeq instrument with QIAGEN reagents. Vaginal microbiome data were correlated with pregnancy clinical metadata.

Results

Ordination plots showed differences in the composition of microbiomes of women who miscarried and controls. In nulliparous women, …

Influence Of Age And Maturation Status On Sprint Acceleration Characteristics In Junior Australian Football, Toby Edwards, Jonathon Weakley, Harry G. Banyard, Ashley Cripps, Benjamin Piggott, G. Gregory Haff, Christopher Joyce

Health Sciences Papers and Journal Articles

This study aimed to investigate the influence of chronological age and maturation status on sprint acceleration characteristics in junior Australian football (AF) players. Biological maturity of 109 subjects was assessed and subjects were grouped according to predicted years from peak height velocity (PHV) (pre-, mid-, and post-PHV) and chronological age (13 years, 14 years, and 15 years). A one-way multivariate analysis of variance and magnitude-based decisions were used to determine between-group differences. Instantaneous velocity was measured during two maximal 30m sprints via radar gun with the velocity-time data used to derive the force, velocity, and power characteristics. Chronologically, the greatest …

Wellbeing And Nature Connectedness For Emerging Adult Undergraduates After A Short Expedition: A Small Pilot Study, Michael J.A Down, Paola Chivers, Prudence Kirsch, Duncan Picknoll

Health Sciences Papers and Journal Articles

Issue addressed: Emerging adult university undergraduates are a vulnerable population due to various life stressors. Previous studies have reported a range of positive outcomes from outdoor expeditions for this population. This small pilot study aimed to investigate the impacts of an outdoor expedition on wellbeing and connectedness to nature and possible confounding by gender and living environment.

Methods: A sample of 54 Health and Physical Education emerging adult undergraduates in the second year of their four-year degree completed a 3-day/2-night immersion expedition. Pre-post differences and a repeated-measures analysis with confounders examined the expedition's impact on scores from the Warwick-Edinburgh Mental …

Open Science In Kenya: Where Are We?, Kennedy W. Mwangi, Nyabuti Mainye, Daniel O. Ouso, Kevin Esoh, Angela W. Muraya, Charles K. Mwangi, Careen Naitore, Pauline Karega, Gilbert Kibet-Rono, Sebastian Musundi, Jennifer Mutisya, Elizabeth Mwangi, Cavin Mgawe, Silviane Miruka, Caleb K. Kibet

All Peer-Reviewed Publications

According to the United Nations Educational, Scientific, and Cultural Organization (UNESCO), Open Science is the movement to make scientific research and data accessible to all. It has great potential for advancing science. At its core, it includes (but is not limited to) open access, open data, and open research. Some of the associated advantages are promoting collaboration, sharing and reproducibility in research, and preventing the reinvention of the wheel, thus saving resources. As research becomes more globalized and its output grows exponentially, especially in data, the need for open scientific research practices is more evident — the future of modern …

Microbial Contaminants In Wild Harvested And Traded Edible Long-Horned Grasshopper, Ruspolia Differens (Orthoptera: Tettigoniidae) In Uganda, S. Labu, S. Subramanian, F. M. Khamis, P. Akite, P. Kasangaki, M. Chemurot, C. M. Tanga, F. L.O. Ombura, J. P. Egonyu

All Peer-Reviewed Publications

This study investigated the relative abundance and identity of microbial contaminants of the edible long-horned grasshopper (Ruspolia differens) harvested from the wild and traded in informal markets in Uganda, to reveal high health risk points. Raw samples of whole R. differens were collected from wild vegetation, trapping sites and markets. Additionally, samples of plucked and deep-fried ready-to-eat R. differens were collected from the markets. The samples were cultured on standard media for microbial quantification, and pure cultures were characterised using molecular techniques. Bacterial and fungal counts in deep fried ready-to-eat R. differens were ~3 and 2-fold lower, respectively, than in …

Black Soldier Fly Larval Meal In Feed Enhances Growth Performance, Carcass Yield And Meat Quality Of Finishing Pigs, S. Y. Chia, C. M. Tanga, I. M. Osuga, A. O. Alaru, D. M. Mwangi, M. Githinji, T. Dubois, S. Ekesi, J. J.A. Van Loon, M. Dicke

All Peer-Reviewed Publications

Using black soldier fly (BSF, Hermetia illucens) larvae as a novel protein source substituting fishmeal (FM) in animal feeds is globally gaining momentum. BSF can be reared on agro-industrial residues. However, incorporating BSF larval meal (BSFLM) into finisher pig diets has received inadequate attention. This study evaluated the effects of replacing dietary FM with BSFLM on growth, carcass traits and meat quality of finisher pigs. A control diet (including FM: 0% BSFLM) was compared with four dietary levels of replacement of FM with BSFLM at 25, 50, 75 or 100%. Forty hybrid pigs (crossbreeds of purebred Large White and Landrace) …

Effect Of Zebra Skin-Derived Compounds On Field Catches Of The Human African Trypanosomiasis Vector Glossina Fuscipes Fuscipes, Olabimpe Y. Olaide, David P. Tchouassi, Abdullahi A. Yusuf, Christian W.W. Pirk, Daniel K. Masiga, Rajinder K. Saini, Baldwyn Torto

All Peer-Reviewed Publications

The riverine tsetse fly Glossina fuscipes fuscipes is a major vector of trypanosome pathogens causing African trypanosomiasis. This fly species uses a combination of olfactory and visual cues to locate its hosts. Previously, traps and targets baited with visual cues have been used in vector control, but the development of olfactory-based tools has been challenging. Recently, repellents have shown promise as olfactory-based tools in tsetse vector control. Here, we evaluated a three-component blend comprising 6-methyl-5-hepten-2-one, acetophenone and geranyl acetone (blend K), previously identified as a repellent for savannah tsetse flies in zebra skin odor, on G. f. fuscipes populations. Using …

Assessing And Understanding Non-Responsiveness Of Maize And Soybean To Fertilizer Applications In African Smallholder Farms, Dries Roobroeck, Cheryl A. Palm, Generose Nziguheba, Ray Weil, Bernard Vanlauwe

All Peer-Reviewed Publications

Use of mineral fertilizers is essential to enhance crop productivity in smallholder farming systems of Sub-Saharan Africa, but various studies have reported ‘non-responsiveness’ where application of inorganic fertilizers does not lead to satisfactory yield gains. This phenomenon is not well defined nor are its extent and causes well understood. In order to close these knowledge gaps, we assessed the effects of commonly recommended nitrogen (N), phosphorus (P) and/or potassium (K) fertilizer inputs on maize grain and soybean production on farmer fields across prevalent land slope and/or soil texture gradients (2 × 2 matrix) in four agroecosystems over two growing seasons. …

Low-Cost Technology For Recycling Agro-Industrial Waste Into Nutrient-Rich Organic Fertilizer Using Black Soldier Fly, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Komi K.M. Fiaboe, Dorothy Nakimbugwe, Fathiya M. Khamis, Sevgan Subramanian, Musyoka M. Wangu, Thomas Dubois, Sunday Ekesi, Chrysantus M. Tanga

All Peer-Reviewed Publications

Efforts to recycle organic waste using black soldier fly (BSF) larvae into high-quality alternative protein ingredients in animal feeds and organic fertilizers have gained momentum worldwide. However, there is limited information on waste manipulation to increase nutrient retention for enhanced larval performance and frass fertilizer quality. In the present study, brewer's spent grain with a carbon to nitrogen (C/N) ratio of 11 (control) was amended with sawdust to obtain substrates with C/N ratios of 15, 20, 25 and 30. The effects of substrate C/N ratios on BSF larval yield, waste degradation, biomass conversion efficiency, compost maturity and nutrient levels of …

Revisiting The Modified Baermann Extraction Method: Extraction Efficiency Of Radopholus Similis Using Different Extraction Materials, Kanan Saikai, Situma Wanjala, Celestine Oduori, Danny Coyne

All Peer-Reviewed Publications

In order to determine the threat that plant-parasitic nematodes pose to crop production, it is essential to establish an accurate estimation of their presence. The extraction efficiency from soil, therefore, is a critical step in establishing disease pressures presented by nematodes or the conditions of soil health. To achieve high nematode extraction efficiency, various methods and modifications have been developed over time (Oostenbrink, 1954; Seinhorst, 1956; Harrison & Green, 1976; Viaene et al., 2021) with variations being introduced locally, depending on the availability or access to certain materials. The simple extraction method was conceived and introduced by Baermann (1917), with …

Effect Of Alternative Rearing Substrates And Temperature On Growth And Development Of The Cricket Modicogryllus Conspersus (Schaum), G. Ssepuuya, F. Sengendo, C. Ndagire, J. Karungi, K. K.M. Fiaboe, J. Efitre, D. Nakimbugwe

All Peer-Reviewed Publications

The increasing demand for animal protein in sub-Saharan Africa has led to insects being considered an alternative protein source for food and feed. In Uganda, chicken mash, containing fish meal as the protein source is commonly used to rear crickets. However, fishmeal is an expensive protein source that is also human food. This study therefore aimed at establishing an alternative preferred (consumed in the highest quantity) plant leaf diet for raising the Modicogryllus conspersus cricket, and the most suitable temperature for hatchability and egg development. The effect of (a) three diets (cassava leaves + cocoyam leaves + milk weed leaves; …

An Overview Of Antimicrobial Compounds From African Edible Insects And Their Associated Microbiota, Cynthia M. Mudalungu, Chrysantus M. Tanga, Segenet Kelemu, Baldwyn Torto

All Peer-Reviewed Publications

The need for easily biodegradable and less toxic chemicals in drug development and pest control continues to fuel the exploration and discovery of new natural molecules. Like certain plants, some insects can also respond rapidly to microbial infections by producing a plethora of immune-induced molecules that include antibacterial and antifungal peptides/polypeptides (AMPs), among other structurally diverse small molecules. The recent recognition that new natural product-derived scaffolds are urgently needed to tackle life-threatening pathogenic infections has been prompted by the health threats posed by multidrug resistance. Although many researchers have concentrated on the discovery of AMPs, surprisingly, edible insect-produced AMPs/small molecules …

Prevalence And Factors Associated With Mental Health Symptoms In Adults Undergoing Covid-19 Testing, Ikponmwosa Osaghae, Linh K Nguyen, Tong Han Chung, Olivia Moffitt, Yen-Chi L Le, Mark B Suh, Pooja N Prasad, Eric J Thomas, Christine D Gordon, Kevin O Hwang

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVE: Understanding the mental health impact of the COVID-19 pandemic on persons receiving COVID-19 testing will help guide mental health interventions. We aimed to determine the association between sociodemographic factors and mental health symptoms at 8 weeks (baseline) after a COVID-19 test, and compare prevalence of mental health symptoms at baseline to those at 16-week follow-up.

MATERIALS AND METHODS: Prospective cohort study of adults who received outpatient COVID-19 testing at primary care clinics. Logistic regression analyses were used to assess the association between sociodemographic characteristics and COVID-19 test results with mental health symptoms. Mental health symptoms reported at …

“Conservation Agriculture, " Possible Climate Change Adaptation Option In Taita Hills, Kenya, Lilian Motaroki, Gilbert Ouma, Dorcas Kalele

All Peer-Reviewed Publications

The vicious cycle of food insecurity in Kenya and Africa at large is partly attributed to the high reliance on rainfed agriculture, which makes production systems vulnerable to the adverse impacts of climate change and variability. Conservation agriculture (CA) has been disseminated as a climate-smart practice that operates on three main principles to realize the multiple benefits of making crop production systems more resilient to climate change impacts, enhancing food security, and providing environmental services, such as carbon sequestration. As a major source of livelihood in the Taita Hills, agriculture is constrained by climate change owing to its rainfed nature. …

Dietary Organic Acids Modulate Gut Microbiota And Improve Growth Performance Of Nursery Pigs, Xiaoyuan Wei, Kristopher A. Bottoms, Hans H. Stein, Laia Blavi, Casey L. Bradley, Jon Bergstrom, Joshua Knapp, Robert Story, Charles Maxwell, Tsungcheng Tsai, Jiangchao Zhao

Animal Science Faculty Publications and Presentations

Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.035%, 0.070%, and 0.105%) of sodium butyrate combined with 0.5% benzoic acid on the growth performance of nursery pigs. At the UA, an additional negative …

Correlation Between Concentrations Of Four Heavy Metals In Cord Blood And Childhood Blood Of Jamaican Children, Mohammad H Rahbar, Maureen Samms-Vaughan, Manouchehr Hessabi, Jan Bressler, Shezeen Gillani, Megan L Grove, Sydonnie Shakspeare-Pellington, Katherine A Loveland

Faculty, Staff and Student Publications

This study investigated whether the concentrations of four metals [lead (Pb), mercury (Hg), manganese (Mn), and aluminum (Al)] are correlated in cord blood and childhood blood samples from Jamaican children. Cord blood samples were obtained from 21 pregnant women enrolled in the second Jamaican Birth Cohort Study from July 1, 2011 to September 30, 2011, and blood samples were drawn from their children who participated in a follow up study when the children were 4–8 years old. Correlations were assessed by the Pearson or the Spearman’s rank correlation coefficient. The mean ages of children at the childhood visit and their …

Endmt Regulation By Small Rnas In Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress, Roberta Giordo, Yusra M A Ahmed, Hilda Allam, Salah Abusnana, Lucia Pappalardo, Gheyath K Nasrallah, Arduino Aleksander Mangoni, Gianfranco Pintus

Faculty, Staff and Student Publications

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts through a process known as endothelial to mesenchymal transition (EndMT). During EndMT, endothelial cells lose their typical phenotype to acquire mesenchymal features, characterized by the development of invasive and migratory abilities as well as the expression of typical mesenchymal products such as α-smooth …

Improving Patient-Specific Assessments Of Regional Aortic Mechanics Via Quantitative Magnetic Resonance Imaging With Early Applications In Patients At Elevated Risk For Thoracic Aortopathy, Patrick A. Jones

Theses and Dissertations

Unstable aortic aneurysms and dissections are serious cardiovascular conditions associated with high mortality. The current gold standards for assessment of stability, however, rely on simple geometric measurements, like cross-sectional area or increased diameter between follow-up scans, and fail to incorporate information about underlying aortic mechanics. Displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) has been used previously to determine heterogeneous circumferential strain patterns in the aortas of healthy volunteers. Here, I introduce technical improvements to DENSE aortic analysis and early pilot application in patients at higher risk for the development of aortopathies. Modifications to the DENSE aortic postprocessing …

Flourish: Combating Food Insecurity & Promoting Wellness On A College Campus, Jocelyn Zavala

Theses and Dissertations

MOTIVATION In the past, it has been assumed that students enrolled in college are fairly privileged individuals unlikely to face challenges associated with poverty (Haskett et al., 2020). That assumption has been challenged in the past few decades and a survey released last year by the Hope Center for College, Community and Justice indicated that 45% of today’s higher education students face food insecurity (Goldrick-Rab et al., 2019). According to VCU’s Dean of Students Office, it is a situation in which a student lacks access to enough nutritious food in order to live a healthy, active life. Food insecurity can …

Reanimator/Reflection: 
Creating Mirrors Through Time 
With Ai, Sound, Video And Live-Generated Art In The Dark Age Of The Covid-19 Pandemic, Eric Millikin

Theses and Dissertations

For my MFA thesis exhibition entitled Reanimator/Reflection, I used artificial intelligence to create three new works of sound and live-generated video art, each based on mirror reflections and 100-year-old racist post-pandemic horror literature by early 20th century American author H. P. Lovecraft. The themes of these writings mirror the issues of our current time. The primary works of Lovecraft that I referenced in the exhibition are “Herbert West: Reanimator,” (1922) a serialized tale about graduate school experiments which attempted to return the dead to life during a plague, and “Nyarlathotep,” (1920) a prose poem that suggests even our dreams …

Effects Of Buprenorphine Treatment On Myelin Following Traumatic Brain Injury In A Rat Model, Jane Ryu

Theses and Dissertations

Traumatic brain injury (TBI) is a common phenomenon, accounting for significant cost and adverse health effects. While there is information about focal pathologies following TBI, knowledge of more diffuse processes is lacking, particularly regarding how analgesics affect this pathology. As Buprenorphine (Bup) is the most commonly used analgesic in experimental TBI models, the current study investigated the effects of the opioid analgesic Buprenorphine-sustained release-Lab (Bup-SR-Lab) on physiology and myelin alterations at 1d and 4w following central fluid percussion injury (cFPI) in adult male rats. Microscopic assessments were performed at 1 day and 4w post-injury. Myelin pathology was assessed by evaluating …

Heavy Hold: A Physical Score, Alexandra Velozo

Theses and Dissertations

This document is a collection of essays, stories, and fictional interviews that are in conversation with my performance, teaching, and sculpture practice. My research and work considers chronic illness, disability, the historic cultural connection between swamplands and illness, the medical industrial complex, medical theater, the medical gaze, disabled performers, metatactile space, sensory learning, and access.

Mechanistic Insights Of Mitochondrial Reactive Oxygen Species In Alzheimer's Disease Models, Jakob C. Green

Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disease that results in impaired cognition, disorientation, confusion, poor judgement, and behavioral changes. The mitochondrial cascade hypothesis (MCH), which postulates that accumulating oxidative stress and mitochondrial dysfunction plays an integral role in the development of the disease, potentially upstream, in conjunction with or independent of Aβ and tau. The literature supports the critical role of mitochondrial dysfunction in the progression and development of AD, but is inconclusive about what precise role, as initiator or delegate, it performs. Regardless, the impact that oxidative stress and mitochondrial dysfunction have on AD deserves further study and investigation. …

A Psychometric Evaluation Of The Best In Class Adherence And Competence Scale, Katrina A. Markowicz

Theses and Dissertations

It is critical to utilize treatment integrity instruments to support the evaluation of evidence-based programs in early classroom contexts. However, in the early childhood field, guidelines for collecting treatment integrity data are underdeveloped. Consequently, most treatment integrity instruments employed in the field solely assess adherence, vary in design features and have little psychometric evidence supporting their use. As such, this represents a gap in the field that might slow efforts to implement evidence-based programs. The current study examines the score reliability and validity of an observational treatment integrity instrument (The BEST in CLASS Adherence and Competence Scale [BiCACS]; Sutherland et …

Influence Of Immigration Status On The 10-Year Trajectories Of Psychosocial Functioning In Individuals With Traumatic Brain Injury, Chimdindu Ohayagha

Theses and Dissertations

The population of racially/ethnically diverse groups within the U.S. is growing at an exponential rate. The U.S. Census Bureau estimated the number of foreign-born individuals in the U.S. to be nearly 40 million or 13% of the total population (Grieco et al., 2012). Racially/ethnically diverse groups in the U.S. have a higher incidence of traumatic brain injury (TBI; Gary et al., 2009). Although racial/ethnic disparities have been documented in numerous outcomes, research has yet to thoroughly explore differences in rehabilitation outcomes for immigrants relative to U.S.-born individuals. The purpose of this study was to compare the functional and mental health …

Evaluating Patient And Health Care Provider Acceptance Of A Personal Health Record In An Integrated Health Care System In The Kingdom Of Saudi Arabia, Consuela C. Yousef

Theses and Dissertations

With the shift to patient- and person-centered care, personal health records (PHRs) have been touted as a strategy to empower patients, improve patient-provider communication, and support self-management. Health care organizations around the world have implemented PHRs in a global push to meet three aims of health care—improve access to care, reduce costs, and increase the quality of care. The capabilities that PHRs support vary by organizations, yet basic functions include allowing patients to view their laboratory results, refill prescription medications, and request appointments. More advanced PHRs enable patient-centered communication through secure messaging.

As the burden of chronic disease grows, PHRs …

The Role Of Insurance Coverage In Outpatient Substance Use Disorder Treatment Referral, Utilization, And Outcomes, Huyen Pham

Theses and Dissertations

Opioid-related overdoses increased dramatically in recent years. Medicaid plays a predominant role in paying for opioid use disorder (OUD) treatment. However, there is a critical gap in understanding the role of Medicaid coverage in referrals to treatment, treatment utilization, and treatment retention. The three studies used observational and quasi-experimental (i.e., natural experiment) designs leveraging state and year variation in Medicaid expansion to characterize the role of Medicaid coverage in OUD treatment. We found that individuals with OUD with Medicaid insurance were more likely to use outpatient treatment, whereas those who were uninsured were more likely to use self-help groups only. …